Updated survey of the steroid-converting enzymes in human adipose tissues
Tài liệu tham khảo
Nielsen, 2003, Patterns and trends in food portion sizes, 1977–1998, JAMA, 289, 450, 10.1001/jama.289.4.450
Belanger, 2002, Adipose tissue intracrinology: potential importance of local androgen/estrogen metabolism in the regulation of adiposity, Horm. Metab. Res., 34, 737, 10.1055/s-2002-38265
Andres, 1980, Effect of obesity on total mortality, Int. J. Obes., 4, 381
Sims, 1982
Kramer, 2013, Are metabolically healthy overweight and obesity benign conditions? A systematic review and meta-analysis, Ann. Intern. Med., 159, 758, 10.7326/0003-4819-159-11-201312030-00008
Despres, 1990, Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease, Arteriosclerosis, 10, 497, 10.1161/01.ATV.10.4.497
Wajchenberg, 2000, Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome, Endocr. Rev., 21, 697, 10.1210/edrv.21.6.0415
Tchernof, 2013, Pathophysiology of human visceral obesity: an update, Physiol. Rev., 93, 359, 10.1152/physrev.00033.2011
Lemieux, 1993, Sex differences in the relation of visceral adipose tissue accumulation to total body fatness, Am. J. Clin. Nutr., 58, 463, 10.1093/ajcn/58.4.463
Wells, 2007, Sexual dimorphism of body composition, Best Pract. Res. Clin. Endocrinol. Metab., 21, 415, 10.1016/j.beem.2007.04.007
Siervogel, 2003, Puberty and body composition, Horm. Res., 60, 36, 10.1159/000071224
Van Loan, 1996, Total body composition: birth to old age, 205
Tchernof A. Sex differences in energy balance, body composition and body fat distribution. In: F.M. Brown, J. Wyckoff, A. Tsatsoulis (Eds.) Diabetes in women 2009.
Shen, 2003, Adipose tissue quantification by imaging methods: a proposed classification, Obes. Res., 11, 5, 10.1038/oby.2003.3
Smith, 2012, Visceral adipose tissue indicates the severity of cardiometabolic risk in patients with and without type 2 diabetes: results from the INSPIRE ME IAA study, J. Clin. Endocrinol. Metab., 97, 1517, 10.1210/jc.2011-2550
Borel, 2012, Visceral and not subcutaneous abdominal adiposity reduction drives the benefits of a 1-year lifestyle modification program, Obesity, 20, 1223, 10.1038/oby.2011.396
Despres, 2006, Abdominal obesity and metabolic syndrome, Nature, 444, 881, 10.1038/nature05488
Blouin, 2008, Androgens and body fat distribution, J. Steroid Biochem. Mol. Biol., 108, 272, 10.1016/j.jsbmb.2007.09.001
Peeke, 1995, Hypercortisolism and obesity, Ann. NY Acad. Sci., 771, 665, 10.1111/j.1749-6632.1995.tb44719.x
Beaulieu, 1990
Duclos, 2001, Fat distribution in obese women is associated with subtle alterations of the hypothalamic-pituitary-adrenal axis activity and sensitivity to glucocorticoids, Clin. Endocrinol., 55, 447, 10.1046/j.1365-2265.2001.01384.x
Pasquali, 2000, Activity of the hypothalamic-pituitary-adrenal axis in different obesity phenotypes, Int. J. Obes., 2, 47, 10.1038/sj.ijo.0801277
Westerbacka, 2003, Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver, J. Clin. Endocrinol. Metab., 88, 4924, 10.1210/jc.2003-030596
Seckl, 2004, Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue, Recent Prog. Horm. Res., 59, 359, 10.1210/rp.59.1.359
Hughes, 2010, Glucocorticoids turn over slowly in human adipose tissue in vivo, J. Clin. Endocrinol. Metab., 95, 4696, 10.1210/jc.2010-0384
Kotelevtsev, 1997, 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress, Proc. Natl. Acad. Sci. U. S. A., 94, 14924, 10.1073/pnas.94.26.14924
Masuzaki, 2001, A transgenic model of visceral obesity and the metabolic syndrome, Science, 294, 2166, 10.1126/science.1066285
Michailidou, 2007, Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity, Obesity, 15, 1155, 10.1038/oby.2007.618
Bujalska, 1999, Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase, Endocrinology, 140, 3188, 10.1210/endo.140.7.6868
Paulmyer-Lacroix, 2002, Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study, J. Clin. Endocrinol. Metab., 87, 2701
Paulsen, 2007, 11Beta-HSD type 1 expression in human adipose tissue: impact of gender, obesity, and fat localization, Obesity, 15, 1954, 10.1038/oby.2007.233
Desbriere, 2006, 11beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients, Obesity, 14, 794, 10.1038/oby.2006.92
Lee, 2008, Depot-specific regulation of the conversion of cortisone to cortisol in human adipose tissue, Obesity, 16, 1178, 10.1038/oby.2008.207
Veilleux, 2009, Omental adipose tissue type 1 11 beta-hydroxysteroid dehydrogenase oxoreductase activity, body fat distribution, and metabolic alterations in women, J. Clin. Endocrinol. Metab., 94, 3550, 10.1210/jc.2008-2011
Dube, 2014, 11beta-Hydroxysteroid dehydrogenase type 1 and 2 activity in subcutaneous adipose tissue in humans: implications in obesity and diabetes, J. Clin. Endocrinol. Metab.
Gilmour, 2006, Local amplification of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes, J. Immunol., 176, 7605, 10.4049/jimmunol.176.12.7605
Coutinho, 2012, 11beta-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice, Endocrinology, 153, 234, 10.1210/en.2011-1398
Wamil, 2011, Novel fat depot-specific mechanisms underlie resistance to visceral obesity and inflammation in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice, Diabetes, 60, 1158, 10.2337/db10-0830
Bujalska, 2008, A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis, J. Endocrinol., 197, 297, 10.1677/JOE-08-0050
Gathercole, 2010, Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes, J. Steroid Biochem. Mol. Biol., 122, 21, 10.1016/j.jsbmb.2010.03.060
Rosenstock, 2010, The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy, Diabetes Care, 33, 1516, 10.2337/dc09-2315
Ferrari, 2010, The role of 11beta-hydroxysteroid dehydrogenase type 2 in human hypertension, Biochim. Biophys. Acta, 1802, 1178, 10.1016/j.bbadis.2009.10.017
Engeli, 2004, Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss, Obes. Res., 12, 9, 10.1038/oby.2004.3
Milagro, 2007, 11-beta Hydroxysteroid dehydrogenase type 2 expression in white adipose tissue is strongly correlated with adiposity, J. Steroid Biochem. Mol. Biol., 104, 81, 10.1016/j.jsbmb.2006.10.006
Kershaw, 2005, Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity, Diabetes, 54, 1023, 10.2337/diabetes.54.4.1023
Veilleux, 2010, Expression of genes related to glucocorticoid action in human subcutaneous and omental adipose tissue, J. Steroid Biochem. Mol. Biol., 122, 28, 10.1016/j.jsbmb.2010.02.024
Brown, 2010, Central effects of estradiol in the regulation of food intake, body weight, and adiposity, J. Steroid Biochem. Mol. Biol., 122, 65, 10.1016/j.jsbmb.2009.12.005
Richard, 1986, Effects of ovarian hormones on energy balance and brown adipose tissue thermogenesis, Am. J. Physiol., 250, R245
D’Eon, 2005, Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways, J. Biol. Chem., 280, 35983, 10.1074/jbc.M507339200
Crandall, 1998, Identification of estrogen receptor β RNA in human breast and abdominal subcutaneous adipose tissue, Biochem. Biophys. Res. Commun., 248, 523, 10.1006/bbrc.1998.8997
Dieudonne, 2004, Evidence for functional estrogen receptors alpha and beta in human adipose cells: regional specificities and regulation by estrogens, Am. J. Physiol. Cell Physiol., 286, C655, 10.1152/ajpcell.00321.2003
Blouin, 2009, Pathways of adipose tissue androgen metabolism in women: depot differences and modulation by adipogenesis, Am. J. Physiol. Endocrinol. Metab., 296, E244, 10.1152/ajpendo.00039.2008
Pedersen, 1991, Nuclear estradiol binding in rat adipocytes: regional variations and regulatory influences of hormones, Biochim. Biophys. Acta, 1093, 80, 10.1016/0167-4889(91)90141-J
Watson, 1993, Biochemical and immunological characterization of oestrogen receptor in the cytosolic fraction of gluteal, omental and perirenal adipose tissue from sheep, J. Endocrinol., 139, 107, 10.1677/joe.0.1390107
Heine, 2000, Increased adipose tissue in male and female estrogen receptor-alpha knockout mice, Proc. Natl. Acad. Sci. U. S. A., 97, 12729, 10.1073/pnas.97.23.12729
Goulart, 2009, Estrogen receptor 1 gene polymorphisms and decreased risk of obesity in women, Metabolism, 58, 759, 10.1016/j.metabol.2009.01.003
Okura, 2003, Association of polymorphisms in the estrogen receptor alpha gene with body fat distribution, Int. J. Obes., 27, 1020, 10.1038/sj.ijo.0802378
Nilsson, 2007, Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis—a cohort study, BMC Med. Genet., 8, 73, 10.1186/1471-2350-8-73
Gambacciani, 1997, Body weight, body fat distribution, and hormonal replacement therapy in early postmenopausal women, J. Clin. Endocrinol. Metab., 82, 414, 10.1210/jcem.82.2.3735
Guthrie, 2003, Central abdominal fat and endogenous hormones during the menopausal transition, Fertil. Steril., 79, 1335, 10.1016/S0015-0282(03)00361-3
Guthrie, 2004, The menopausal transition: a 9-year prospective population-based study. The Melbourne Women's Midlife Health Project, Climacteric, 7, 375, 10.1080/13697130400012163
Keller, 2010, Perimenopausal obesity, J. Womens Health, 19, 987, 10.1089/jwh.2009.1547
Lovejoy, 2008, Increased visceral fat and decreased energy expenditure during the menopausal transition, Int. J. Obes., 32, 949, 10.1038/ijo.2008.25
Ryan, 2002, Hormone replacement therapy, insulin sensitivity, and abdominal obesity in postmenopausal women, Diabetes Care, 25, 127, 10.2337/diacare.25.1.127
Rezvani, 2014, Ovarian hormone association with ASP and related receptor gene expression in adipose tissue depots in women, J Obes., 2014, 383102
Price, 1998, Estrogen regulation of adipose tissue lipoprotein lipase-possible mechanism of body fat distribution, Am. J. Obstet. Gynecol., 178, 101, 10.1016/S0002-9378(98)70634-9
Rebuffe-Scrive, 1987, Regional adipose tissue metabolism in men and postmenopausal women, Int. J. Obes., 11, 347
Jensen, 1994, Effects of estrogen on free fatty acid metabolism in humans, Am. J. Physiol., 266, E914
Tchernof, 2004, Ovarian hormone status and abdominal visceral adipose tissue metabolism, J. Clin. Endocrinol. Metab., 89, 3425, 10.1210/jc.2003-031561
Palin, 2003, 17beta-Estradiol and anti-estrogen ICI:compound 182,780 regulate expression of lipoprotein lipase and hormone-sensitive lipase in isolated subcutaneous abdominal adipocytes, Metabolism, 52, 383, 10.1053/meta.2003.50088
Anderson, 2001, The effects of androgens and estrogens on preadipocyte proliferation in human adipose tissue: influence of gender and site, J. Clin. Endocrinol. Metab., 86, 5045, 10.1210/jcem.86.10.7955
Dieudonne, 2000, Opposite effects of androgens and estrogens on adipogenesis in rat preadipocytes: evidence for sex and site-related specificities and possible involvement of insulin-like growth factor 1 receptor and peroxisome proliferator-activated receptor gamma2, Endocrinology, 141, 649, 10.1210/endo.141.2.7293
Labrie, 2003, Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone, Endocr. Rev., 24, 152, 10.1210/er.2001-0031
Edman, 1978, Effect of obesity on conversion of plasma androstenedione to estrone in ovulatory and anovulator young women, Am. J. Obstet. Gynecol., 130, 456, 10.1016/0002-9378(78)90288-0
MacDonald, 1978, Effect of obesity on conversion of plasma androstenedione to estrone in postmenopausal women with and without endometrial cancer, Am. J. Obstet. Gynecol., 130, 448, 10.1016/0002-9378(78)90287-9
Ackerman, 1981, Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture, J. Clin. Endocrinol. Metab., 53, 412, 10.1210/jcem-53-2-412
Simpson, 2004, Aromatase biologic relevance of tissue-specific expression, Semin. Reprod. Med., 11
Jones, 2000, Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity, Proc. Natl. Acad. Sci. U. S. A., 97, 12735, 10.1073/pnas.97.23.12735
Jones, 2001, Aromatase-deficient (ArKO) mice accumulate excess adipose tissue, J. Steroid Biochem. Mol. Biol., 79, 3, 10.1016/S0960-0760(01)00136-4
Zhao, 1995, Aromatase P450 gene expression in human adipose tissue. Role of a Jak/STAT pathway in regulation of the adipose-specific promoter, J. Biol. Chem., 270, 16449, 10.1074/jbc.270.27.16449
Simpson, 1997, Cytochromes P450 11: expression of the CYP19 (aromatase) gene: an unusual case of alternative promoter usage, Faseb J., 11, 29, 10.1096/fasebj.11.1.9034163
Zhao, 1995, Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes, Mol. Endocrinol., 9, 340
Rubin, 2000, Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy, Cancer Res., 60, 1604
Morimoto, 2002, Obesity, body size, and risk of postmenopausal breast cancer: the Women’s Health Initiative (United States), Cancer Causes Control, 13, 741, 10.1023/A:1020239211145
Ford, 2013, IGF1 dependence of dietary energy balance effects on murine Met1 mammary tumor progression, epithelial-to-mesenchymal transition, and chemokine expression, Endocr. Relat. Cancer, 20, 39, 10.1530/ERC-12-0329
Alikhani, 2013, Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model, Oncogene, 32, 961, 10.1038/onc.2012.113
Thakkar, 2013, Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: a meta-analysis using primary data of published studies, Metabolism, 62, 922, 10.1016/j.metabol.2013.01.014
Rao, 2012, Adjuvant endocrine therapy for breast cancer, Oncology, 26, 541
Luu-The, 2001, Analysis and characteristics of multiple types of human 17beta-hydroxysteroid dehydrogenase, J. Steroid Biochem. Mol. Biol., 76, 143, 10.1016/S0960-0760(00)00155-2
Lin, 2013, A challenge for medicinal chemistry by the 17beta-hydroxysteroid dehydrogenase superfamily: an integrated biological function and inhibition study, Curr. Top Med. Chem., 13, 1164, 10.2174/15680266113139990004
Martel, 1992, Distribution of 17 beta-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues, J. Steroid Biochem. Mol. Biol., 41, 597, 10.1016/0960-0760(92)90390-5
Bleau, 1974, The in vitro and in vivo uptake and metabolism of steroids in human adipose tissue, J. Clin. Endocrinol. Metab., 39, 236, 10.1210/jcem-39-2-236
Bellemare, 2009, Differential estrogenic 17beta-hydroxysteroid dehydrogenase activity and type 12 17beta-hydroxysteroid dehydrogenase expression levels in preadipocytes and differentiated adipocytes, J. Steroid Biochem. Mol. Biol., 114, 129, 10.1016/j.jsbmb.2009.01.002
Corbould, 1998, Expression of types 1, 2, and 3 17beta-hydroxysteroid dehydrogenase in subcutaneous abdominal and intra-abdominal adipose tissue of women, J. Clin Endocrinol. Metab., 83, 187
Quinkler, 2004, Androgen generation in adipose tissue in women with simple obesity—a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5, J. Endocrinol., 183, 331, 10.1677/joe.1.05762
Moon, 2003, Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade, J. Biol. Chem., 278, 7335, 10.1074/jbc.M211684200
Sakurai, 2006, Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12, J. Steroid Biochem. Mol. Biol., 99, 174, 10.1016/j.jsbmb.2006.01.010
Adamski, 1992, Purification and properties of oestradiol 17 beta-dehydrogenase extracted from cytoplasmic vesicles of porcine endometrial cells, Biochem. J., 288, 375, 10.1042/bj2880375
Adamski, 1996, New 17 beta-hydroxysteroid dehydrogenases: molecular and cell biology of the type IV porcine and human enzymes, Ann. NY Acad. Sci., 784, 124, 10.1111/j.1749-6632.1996.tb16232.x
Suzuki, 1997, D-3-Hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein deficiency: a newly identified peroxisomal disorder, Am. J. Human Genet., 61, 1153, 10.1086/301599
Dieuaide-Noubhani, 1997, Evidence that multifunctional protein 2, and not multifunctional protein 1, is involved in the peroxisomal beta-oxidation of pristanic acid, Biochem. J., 325, 367, 10.1042/bj3250367
Dieuaide-Noubhani, 1996, Eur. J. Biochem., 240, 660, 10.1111/j.1432-1033.1996.0660h.x
Duan, 1996, Cloning and characterization of an ovarian-specific protein that associates with the short form of the prolactin receptor, J. Biol. Chem., 271, 15602, 10.1074/jbc.271.26.15602
Nokelainen, 1998, Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat, Mol. Endocrinol., 12, 1048
Marijanovic, 2003, Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis, Mol. Endocrinol., 17, 1715, 10.1210/me.2002-0436
Shehu, 2008, Prolactin receptor-associated protein/17beta-hydroxysteroid dehydrogenase type 7 gene (Hsd17b7) plays a crucial role in embryonic development and fetal survival, Mol. Endocrinol., 22, 2268, 10.1210/me.2008-0165
Seth, 2006, 17Beta-hydroxysteroid dehydrogenase type 7 (Hsd17b7) reverts cholesterol auxotrophy in NS0 cells, J. Biotechnol., 121, 241, 10.1016/j.jbiotec.2005.07.017
Saloniemi, 2012, The diversity of sex steroid action: novel functions of hydroxysteroid (17beta) dehydrogenases as revealed by genetically modified mouse models, J. Endocrinol., 212, 27, 10.1530/JOE-11-0315
Liu, 2005, Cloning and characterization of human form 2 type 7 17beta-hydroxysteroid dehydrogenase, a primarily 3beta-keto reductase and estrogen activating and androgen inactivating enzyme, J. Steroid Biochem. Mol. Biol., 94, 173, 10.1016/j.jsbmb.2005.01.023
MacKenzie, 2008, Depot-specific steroidogenic gene transcription in human adipose tissue, Clin. Endocrinol., 69, 848, 10.1111/j.1365-2265.2008.03262.x
Fomitcheva, 1998, Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues, J. Biol. Chem., 273, 22664, 10.1074/jbc.273.35.22664
Aziz, 1993, Downregulation of Ke 6, a novel gene encoded within the major histocompatibility complex, in murine polycystic kidney disease, Mol. Cell Biol., 13, 1847, 10.1128/MCB.13.3.1847
Pelletier, 2005, Localization of type 8 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization, J. Histochem. Cytochem., 53, 1257, 10.1369/jhc.5A6692.2005
Pletnev, 2005, Rational proteomics IV: modeling the primary function of the mammalian 17beta-hydroxysteroid dehydrogenase type 8, J. Steroid Biochem. Mol. Biol., 94, 327, 10.1016/j.jsbmb.2004.12.031
Blouin, 2009, Androgen metabolism in adipose tissue: recent advances, Mol. Cell Endocrinol., 301, 97, 10.1016/j.mce.2008.10.035
Zhang, 2008, Progesterone metabolism in adipose cells, Mol. Cell Endocrinol., 29, 76, 10.1210/me.2014-1256
Lacasa, 2001, Progesterone stimulates adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c gene expression potential mechanism for the lipogenic effect of progesterone in adipose tissue, J. Biol. Chem., 276, 11512, 10.1074/jbc.M008556200
Mendes, 1985, Effects of cortisol and progesterone on insulin binding and lipogenesis in adipocytes from normal and diabetic rats, J. Endocrinol., 106, 225, 10.1677/joe.0.1060225
Monjo, 2003, Direct effects of testosterone, 17 beta-estradiol, and progesterone on adrenergic regulation in cultured brown adipocytes: potential mechanism for gender-dependent thermogenesis, Endocrinology, 144, 4923, 10.1210/en.2003-0537
Rondinone, 1992, Progestins stimulate the differentiation of 3T3-L1 preadipocytes, J. Steroid Biochem. Mol. Biol., 42, 795, 10.1016/0960-0760(92)90087-Y
Shirling, 1981, Effect of progesterone on lipid metabolism in the intact rat, J. Endocrinol., 90, 285, 10.1677/joe.0.0900285
Wiper-Bergeron, 2003, Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex, Embo J., 22, 2135, 10.1093/emboj/cdg218
Hamosh, 1975, The effect of estrogen on the lipoprotein lipase activity of rat adipose tissue, J. Clin Invest., 55, 1132, 10.1172/JCI108015
Bjorntorp, 1997, Hormonal control of regional fat distribution, Hum. Reprod., 12, 21, 10.1093/humrep/12.suppl_1.21
Pedersen, 2003, Anti-glucocorticoid effects of progesterone in vivo on rat adipose tissue metabolism, Steroids, 68, 543, 10.1016/S0039-128X(03)00084-9
Xu, 1990, Progestin binds to the glucocorticoid receptor and mediates antiglucocorticoid effect in rat adipose precursor cells, J. Steroid Biochem., 36, 465, 10.1016/0022-4731(90)90089-B
Stelmanska, 2012, The gender- and fat depot-specific regulation of leptin, resistin and adiponectin genes expression by progesterone in rat, J. Steroid Biochem. Mol. Biol., 132, 160, 10.1016/j.jsbmb.2012.05.005
Veilleux, 2012, Glucocorticoid-induced androgen inactivation by aldo-keto reductase 1C2 promotes adipogenesis in human preadipocytes, Am. J. Physiol. Endocrinol. Metab., 302, E941, 10.1152/ajpendo.00069.2011
Penning, 2000, Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones, Biochem. J., 351, 67, 10.1042/0264-6021:3510067
Blanchette, 2005, Expression and activity of 20alpha-hydroxysteroid dehydrogenase (AKR1C1) in abdominal subcutaneous and omental adipose tissue in women, J. Clin. Endocrinol. Metab., 90, 264, 10.1210/jc.2004-0583
Blouin, 2006, Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men, J. Endocrinol., 191, 637, 10.1677/joe.1.06365
Blouin, 2005, Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue as positive correlates of adiposity in women, Am. J. Physiol. Endocrinol. Metab., 28, E398, 10.1152/ajpendo.00312.2004
Veilleux, 2009, Mechanisms of androgenic action in adipose tissue, Clin. Lipidol., 4, 367, 10.2217/clp.09.16
Pasquali, 1991, Effect of obesity and body fat distribution on sex hormones and insulin in men, Metabolism, 40, 101, 10.1016/0026-0495(91)90199-7
Seidell, 1990, Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels, Metabolism, 39, 897, 10.1016/0026-0495(90)90297-P
Garaulet, 2000, Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones, Eur. J. Endocrinol., 143, 657, 10.1530/eje.0.1430657
Tsai, 2004, Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat, Diabetes Care, 27, 861, 10.2337/diacare.27.4.861
Boyanov, 2003, Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency, Aging Male, 6, 1, 10.1080/tam.6.1.1.7
Saad, 2012, Androgen therapy in men with testosterone deficiency: can testosterone reduce the risk of cardiovascular disease, Diabetes Metab. Res. Rev., 28, 52, 10.1002/dmrr.2354
Woodhouse, 2004, Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men, J. Clin. Endocrinol. Metab., 89, 718, 10.1210/jc.2003-031492
Marin, 1992, The effects of testosterone treatment on body composition and metabolism in middle-aged obese men, Int. J. Obes., 16, 991
Traish, 2014, Long-term testosterone therapy in hypogonadal men ameliorates elements of the metabolic syndrome: an observational, long-term registry study, Int. J. Clin. Pract., 68, 314, 10.1111/ijcp.12319
Gruenewald, 2003, Testosterone supplementation therapy for older men: potential benefits and risks, J. Am. Geriatr. Soc., 51, 101, 10.1034/j.1601-5215.2002.51018.x
Tchernof, 2004, Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies, Eur. J. Endocrinol., 151, 1, 10.1530/eje.0.1510001
Field, 1994, The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men, J. Clin. Endocrinol. Metab., 79, 1310
Couillard, 2000, Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroid hormone concentrations in men: the HERITAGE family study, J. Clin. Endocrinol. Metab., 85, 1026
Tchernof, 1995, Reduced testosterone and adrenal C19 steroid levels in obese men, Metabolism, 44, 513, 10.1016/0026-0495(95)90060-8
Ravaglia, 1996, The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds, J. Clin. Endocrinol. Metab., 81, 1173
Nair, 2006, DHEA in elderly women and DHEA or testosterone in elderly men, N Engl. J. Med., 355, 1647, 10.1056/NEJMoa054629
Villareal, 2004, Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial, JAMA, 292, 2243, 10.1001/jama.292.18.2243
Basu, 2007, Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women, Diabetes, 56, 753, 10.2337/db06-1504
Bhagra, 2008, Dehydroepiandrosterone in adrenal insufficiency and ageing, Curr. Opin. Endocrinol. Diabetes Obes., 15, 239, 10.1097/MED.0b013e3282fc7049
Srinivasan, 2009, Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women, J. Clin. Endocrinol. Metab., 94, 761, 10.1210/jc.2008-1774
Feher, 1976, Dehydroepiandrosterone concentration in adipose tissue of normal and overweight subjects, Horm. Metab. Res., 8, 372, 10.1055/s-0028-1093616
Szymczak, 1998, Concentration of sex steroids in adipose tissue after menopause, Steroids, 63, 319, 10.1016/S0039-128X(98)00019-1
Feher, 1982, A comparative study of steroid concentrations in human adipose tissue and the peripheral circulation, Clin. Chim. Acta, 126, 135, 10.1016/0009-8981(82)90029-8
Deslypere, 1985, Fat tissue: a steroid reservoir and site of steroid metabolism, J. Clin. Endocrinol. Metab., 61, 564, 10.1210/jcem-61-3-564
Borg, 1995, Long-lived testosterone esters in the rat, Proc. Natl. Acad. Sci. U. S. A., 9, 1545, 10.1073/pnas.92.5.1545
Bélanger, 2006, Omental and subcutaneous adipose tissue steroid levels in obese men, Steroids, 71, 674, 10.1016/j.steroids.2006.04.008
Anderson, 2002, The regulation of HSL and LPL expression by DHT and flutamide in human subcutaneous adipose tissue, Diabetes Obes. Metab., 4, 209, 10.1046/j.1463-1326.2002.00214.x
Monjo, 2005, alpha2- to beta3-Adrenoceptor switch in 3T3-L1 preadipocytes and adipocytes: modulation by testosterone, 17beta-estradiol, and progesterone, Am. J. Physiol. Endocrinol. Metab., 289, E145, 10.1152/ajpendo.00563.2004
Lacasa, 1997, Site-related specificities of the control by androgenic status of adipogenesis and mitogen-activated protein kinase cascade/c-fos signaling pathways in rat preadipocytes, Endocrinology, 138, 3181, 10.1210/endo.138.8.5290
Lacasa, 1995, Evidence for a regional-specific control of rat preadipocyte proliferation and differentiation by the androgenic status, Endocrine, 3, 789, 10.1007/BF02935682
Singh, 2003, Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway, Endocrinology, 144, 5081, 10.1210/en.2003-0741
Singh, 2006, Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors, Endocrinology, 147, 141, 10.1210/en.2004-1649
Gupta, 2008, Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes, Mol. Cell Endocrinol., 296, 32, 10.1016/j.mce.2008.08.019
Blouin, 2010, Effects of androgens on adipocyte differentiation and adipose tissue explant metabolism in men and women, Clin. Endocrinol., 72, 176, 10.1111/j.1365-2265.2009.03645.x
Rice, 2010, Dehydroepiandrosterone (DHEA) treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue, Mol. Cell Endocrinol., 320, 51, 10.1016/j.mce.2010.02.017
Lea-Currie, 1999, Dehydroepiandrosterone and related steroids alter 3T3-L1 preadipocyte proliferation and differentiation, Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol., 123, 17, 10.1016/S0742-8413(99)00003-1
Rebuffé-Scrive, 1991, Effect of testosterone on abdominal adipose tissue in men, Int. J. Obes., 15, 791
Xu, 1990, The effects of androgens on the regulation of lipolysis in adipose precursor cells, Endocrinology, 126, 1229, 10.1210/endo-126-2-1229
Hernandez-Morante, 2008, Role of DHEA-S on body fat distribution: gender- and depot-specific stimulation of adipose tissue lipolysis, Steroids, 73, 209, 10.1016/j.steroids.2007.10.005
Dicker, 2004, Effect of testosterone on lipolysis in human pre-adipocytes from different fat depots, Diabetologia, 47, 420, 10.1007/s00125-003-1324-0
Pecquery, 1995, Enhancement of the expression of the alpha 2-adrenoreceptor protein and mRNA by a direct effect of androgens in white adipocytes, Biochem. Biophys. Res. Commun., 206, 112, 10.1006/bbrc.1995.1016
Pecquery, 1988, Influence of androgenic status on the alpha 2/beta-adrenergic control of lipolysis in white fat cells: predominant alpha 2-antilipolytic response in testosterone-treated-castrated hamsters, Endocrinology, 122, 2590, 10.1210/endo-122-6-2590
Xu, 1991, Testosterone increases lipolysis and the number of beta- adrenoceptors in male rat adipocytes, Endocrinology, 128, 379, 10.1210/endo-128-1-379
Xu, 1990, The effects of steroid hormones on adipocyte development, Int. J. Obes., 14, 159
Li, 1995, Effects of testosterone on triglyceride uptake and mobilization in different adipose tissues in male rats in vivo, Obes. Res., 3, 113, 10.1002/j.1550-8528.1995.tb00128.x
Varlamov, 2012, Androgen effects on adipose tissue architecture and function in nonhuman primates, Endocrinology, 153, 3100, 10.1210/en.2011-2111
Lanfranco, 2004, Serum adiponectin levels in hypogonadal males: influence of testosterone replacement therapy, Clin. Endocrinol., 60, 500, 10.1111/j.1365-2265.2004.02007.x
Page, 2005, Testosterone administration suppresses adiponectin levels in men, J. Androl., 26, 85
Jockenhovel, 1997, Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men, J. Clin. Endocrinol. Metab., 82, 2510, 10.1210/jcem.82.8.4174
Machinal-Quelin, 2002, Direct in vitro effects of androgens and estrogens on ob gene expression and leptin secretion in human adipose tissue, Endocrine, 18, 179, 10.1385/ENDO:18:2:179
Nishizawa, 2002, Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein, Diabetes, 51, 2734, 10.2337/diabetes.51.9.2734
Horenburg, 2008, Influence of sex hormones on adiponectin expression in human adipocytes, Horm. Metab. Res., 40, 779, 10.1055/s-0028-1083780
Hernandez-Morante, 2006, Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different fat depots in morbidly obese humans, Eur. J. Endocrinol., 155, 593, 10.1530/eje.1.02256
Malkin, 2004, The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men, J. Clin. Endocrinol. Metab., 89, 3313, 10.1210/jc.2003-031069
Wetzel, 2011, 17beta-HSD2 inhibitors for the treatment of osteoporosis: identification of a promising scaffold, Bioorg. Med. Chem., 19, 807, 10.1016/j.bmc.2010.12.013
Wu, 1993, Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity, J. Biol. Chem., 268, 12964, 10.1016/S0021-9258(18)31480-7
Corbould, 2002, The effect of obesity on the ratio of type 3 17beta-hydroxysteroid dehydrogenase mRNA to cytochrome P450 aromatase mRNA in subcutaneous abdominal and intra-abdominal adipose tissue of women, Int. J. Obes., 26, 165, 10.1038/sj.ijo.0801886
Wake, 2007, Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity, Clin. Endocrinol., 66, 440, 10.1111/j.1365-2265.2007.02755.x
Blouin, 2003, Local androgen inactivation in abdominal visceral adipose tissue, J. Clin. Endocrinol. Metab., 88, 5944, 10.1210/jc.2003-030535
Svensson, 2008, Regulation of human aldoketoreductase 1C3 (AKR1C3) gene expression in the adipose tissue, Cell Mol. Biol. Lett., 13, 599, 10.2478/s11658-008-0025-6
Quinkler, 2006, Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis, Gene, 380, 137, 10.1016/j.gene.2006.05.026
Azzouni, 2012, Role of 5alpha-reductase inhibitors in benign prostatic diseases, Prostate Cancer Prostatic Dis., 15, 222, 10.1038/pcan.2012.1
Samson, 2010, Biosynthesis of dihydrotestosterone by a pathway that does not require testosterone as an intermediate in the SZ95 sebaceous gland cell line, J. Invest. Dermatol., 130, 602, 10.1038/jid.2009.225
Andersson, 1990, Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases, Proc. Natl. Acad. Sci. U. S. A., 87, 3640, 10.1073/pnas.87.10.3640
Uemura, 2008, Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer, Cancer Sci., 99, 81
Tomlinson, 2008, Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss, Diabetes, 57, 1536, 10.2337/db08-0094
Tchernof, 1997, Androstane-3alpha,17beta-diol glucuronide as a steroid correlate of visceral obesity in men, J. Clin. Endocrinol. Metab., 82, 1528
Pritchard, 1998, Plasma adrenal, gonadal and conjugated steroids before and after long term overfeeding in identical twins, J. Clin. Endocrinol. Metab., 83, 3277
Pritchard, 1999, Plasma adrenal, gonadal, and conjugated steroids following long-term exercise-induced negative energy balance in identical twins, Metabolism, 48, 1120, 10.1016/S0026-0495(99)90125-7
Vandenput, 2007, Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men, J. Clin. Endocrinol. Metab., 92, 4130, 10.1210/jc.2007-0252
Tchernof, 1997, Expression of androgen metabolizing enzymes UDP-glucuronosyltransferases 2B15 and 2B17 in human subcutaneous and omental adipose tissue, Obes. Res., 5, 66S
Bujalska, 2002, 11beta-Hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol, Endocr. Res., 28, 449, 10.1081/ERC-120016822
Lessard, 2012, Interaction of the glucocorticoid and androgen receptors in adipogenesis, Chem. Biol., 19, 1079, 10.1016/j.chembiol.2012.09.003
Hartig, 2012, Feed-forward inhibition of androgen receptor activity by glucocorticoid action in human adipocytes, Chem. Biol., 19, 1126, 10.1016/j.chembiol.2012.07.020
Wang, 2012, The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients, J. Steroid Biochem. Mol. Biol., 132, 120, 10.1016/j.jsbmb.2012.02.003
Van Schothorst, 2005, Adipose gene expression patterns of weight gain suggest counteracting steroid hormone synthesis, Obes. Res., 13, 1031, 10.1038/oby.2005.121
Fujioka, 2012, Dehydroepiandrosterone reduces preadipocyte proliferation via androgen receptor, Am. J. Physiol. Endocrinol. Metab., 302, E694, 10.1152/ajpendo.00112.2011
Rajapaksha, 2011, Lipid-mediated unfolding of 3beta-hydroxysteroid dehydrogenase 2 is essential for steroidogenic activity, Biochemistry, 50, 11015, 10.1021/bi2016102
Yen, 1987, Cloning and expression of steroid sulfatase cDNA and the frequent occurrence of deletions in STS deficiency: implications for X–Y interchange, Cell, 49, 443, 10.1016/0092-8674(87)90447-8
Blouin, 2005, Contribution of age and declining androgen levels to features of the metabolic syndrome in men, Metabolism, 54, 1034, 10.1016/j.metabol.2005.03.006
Martel, 1994, Widespread tissue distribution of steroid sulfatase, 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD), 17 beta-HSD 5 alpha-reductase and aromatase activities in the rhesus monkey, Mol. Cell Endocrinol., 104, 103, 10.1016/0303-7207(94)90056-6
Valle, 2006, Tissue-specific transcriptional initiation and activity of steroid sulfatase complementing dehydroepiandrosterone sulfate uptake and intracrine steroid activations in human adipose tissue, J. Endocrinol., 190, 129, 10.1677/joe.1.06811
Yager, 2006, Estrogen carcinogenesis in breast cancer, N Engl. J. Med., 354, 270, 10.1056/NEJMra050776
Rose, 2001, Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation, J. Biol. Chem., 276, 23937, 10.1074/jbc.M011564200
Khalil, 1995, 7 alpha-Hydroxylation of the adrenal androgens dehydroepiandrosterone and androst-5-ene-3 beta, 17 beta-diol predominates in differentiating human adipose stromal cells, Ann. NY Acad. Sci., 774, 316, 10.1111/j.1749-6632.1995.tb17396.x-i1
Khalil, 1993, Metabolism of dehydroepiandrosterone by cultured human adipose stromal cells: identification of 7 alpha-hydroxydehydroepiandrosterone as a major metabolite using high performance liquid chromatography and mass spectrometry, J. Steroid Biochem. Mol. Biol., 46, 585, 10.1016/0960-0760(93)90186-Z
Marwah, 2006, Redox reactions of dehydroepiandrosterone and its metabolites in differentiating 3T3-L1 adipocytes: a liquid chromatographic-mass spectrometric study, Arch. Biochem. Biophys., 456, 1, 10.1016/j.abb.2006.09.023
Sedlackova, 2012, 7-oxygenated derivatives of dehydroepiandrosterone and obesity, Prague Med. Rep., 113, 147, 10.14712/23362936.2015.29
Sulcova, 2000, Effects of transdermal application of DHEA on the levels of steroids, gonadotropins and lipids in men, Physiol. Res., 49, 685
Morfin, 1994, Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice, J. Steroid Biochem. Mol. Biol., 50, 91, 10.1016/0960-0760(94)90176-7
Anuka, 2013, Expression and roles of steroidogenic acute regulatory (StAR) protein in ‘non-classical’, extra-adrenal and extra-gonadal cells and tissues, Mol. Cell Endocrinol., 371, 47, 10.1016/j.mce.2013.02.003
Hernandez-Morante, 2009, Expression of cortisol metabolism-related genes shows circadian rhythmic patterns in human adipose tissue, Int. J. Obes., 33, 473, 10.1038/ijo.2009.4
Campion, 2008, Vitamin C supplementation influences body fat mass and steroidogenesis-related genes when fed a high-fat diet, Int. J. Vitam. Nutr. Res., 78, 87, 10.1024/0300-9831.78.2.87
Puche, 2002, Expression and enzymatic activity of the P450c17 gene in human adipose tissue, Eur. J. Endocrinol., 146, 223, 10.1530/eje.0.1460223
Rondinone, 1993, Aldosterone stimulated differentiation of mouse 3T3-L1 cells into adipocytes, Endocrinology, 132, 2421, 10.1210/endo.132.6.8504747
Mathieu, 2009, Visceral obesity: the link among inflammation, hypertension, and cardiovascular disease, Hypertension, 53, 577, 10.1161/HYPERTENSIONAHA.108.110320
Boscaro, 2012, Visceral adipose tissue: emerging role of gluco- and mineralocorticoid hormones in the setting of cardiometabolic alterations, Ann. NY Acad. Sci., 1264, 87, 10.1111/j.1749-6632.2012.06597.x
Briones, 2012, Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction, Hypertension, 59, 1069, 10.1161/HYPERTENSIONAHA.111.190223
Pascoe, 1992, Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency, Proc. Natl. Acad. Sci. U. S. A., 89, 4996, 10.1073/pnas.89.11.4996
Ogishima, 1989, Isolation of aldosterone synthase cytochrome P-450 from zona glomerulosa mitochondria of rat adrenal cortex, J. Biol. Chem., 264, 10935, 10.1016/S0021-9258(18)60408-9
Curnow, 1991, The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex, Mol. Endocrinol., 5, 1513, 10.1210/mend-5-10-1513
MacKenzie, 2012, Non-adrenal synthesis of aldosterone: a reality check, Mol. Cell Endocrinol., 350, 163, 10.1016/j.mce.2011.06.026