Update on Prevalence of Pain in Patients With Cancer: Systematic Review and Meta-Analysis

Journal of Pain and Symptom Management - Tập 51 Số 6 - Trang 1070-1090.e9 - 2016
M.H.J. van den Beuken-van Everdingen1,2, Laura Hochstenbach3,4, Elbert A.J. Joosten2,5, Vivianne C. G. Tjan‐Heijnen6,7, Daisy J.A. Janssen1,8
1Center of Expertise for Palliative Care, Maastricht University Medical Center+ (MUMC+), Maastricht, The Netherlands
2Department of Anesthesiology and Pain Management, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
3Department of Health Services Research, Maastricht University (UM), Maastricht, The Netherlands
4School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
5School of Mental Health and Neuroscience (MHeNs), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
6Department of Medical Oncology, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
7School for Oncology and Developmental Biology (GROW), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
8Department of Research and Education, Center of Expertise for Chronic Organ Failure (CIRO), Horn, the Netherlands

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2008

Kroenke, 2010, The association of depression and pain with health-related quality of life, disability, and health care use in cancer patients, J Pain Symptom Manage, 40, 327, 10.1016/j.jpainsymman.2009.12.023

Porter, 2011, Psychosocial issues in cancer pain, Curr Pain Headache Rep, 15, 263, 10.1007/s11916-011-0190-6

Rief, 2011, Long-term course of pain in breast cancer survivors: a 4-year longitudinal study, Breast Cancer Res Treat, 130, 579, 10.1007/s10549-011-1614-z

Breivik, 2009, Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes, Ann Oncol, 20, 1420, 10.1093/annonc/mdp001

Puetzler, 2014, Improvements in health-related quality of life by comprehensive cancer pain therapy: a pilot study with breast cancer outpatients under palliative chemotherapy, Oncol Res Treat, 37, 456, 10.1159/000365537

van den Beuken-van Everdingen, 2007, Prevalence of pain in patients with cancer: a systematic review of the past 40 years, Ann Oncol, 18, 1437, 10.1093/annonc/mdm056

Greco, 2014, Quality of cancer pain management: an update of a systematic review of undertreatment of patients with cancer, J Clin Oncol, 32, 4149, 10.1200/JCO.2014.56.0383

Hastie, 2014, An examination of global and regional opioid consumption trends 1980-2011, J Pain Palliat Care Pharmacother, 28, 259, 10.3109/15360288.2014.941132

Mantyh, 2014, Bone cancer pain: from mechanism to therapy, Curr Opin Support Palliat Care, 8, 83, 10.1097/SPC.0000000000000048

Leboeuf-Yde, 1995, The prevalence of low back pain in the literature. A structured review of 26 Nordic studies from 1954 to 1993, Spine, 20, 2112, 10.1097/00007632-199510000-00009

Egger, 2001

Oken, 1982, Toxicity and response criteria of the Eastern Cooperative Oncology Group, Am J Clin Oncol, 5, 649, 10.1097/00000421-198212000-00014

Serlin, 1995, When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function, Pain, 61, 277, 10.1016/0304-3959(94)00178-H

Andersen, 2012, Persistent pain after targeted intraoperative radiotherapy (TARGIT) or external breast radiotherapy for breast cancer: a randomized trial, Breast, 21, 46, 10.1016/j.breast.2011.07.011

Andersen, 2013, Persistent pain, sensory disturbances and functional impairment after immediate or delayed axillary lymph node dissection, Eur J Surg Oncol, 39, 31, 10.1016/j.ejso.2012.10.010

Beck, 2009, Symptom experiences and quality of life of rural and urban older adult cancer survivors, Cancer Nurs, 32, 359, 10.1097/NCC.0b013e3181a52533

Brant, 2011, Symptom trajectories in posttreatment cancer survivors, Cancer Nurs, 34, 67, 10.1097/NCC.0b013e3181f04ae9

Brown, 2013, The prevalence of lymphedema symptoms among survivors of long-term cancer with or at risk for lower limb lymphedema, Am J Phys Med Rehabil, 92, 223, 10.1097/PHM.0b013e31826edd97

Crew, 2007, Prevalence of joint symptoms in postmenopausal women taking aromatase inhibitors for early-stage breast cancer, J Clin Oncol, 25, 3877, 10.1200/JCO.2007.10.7573

Deshields, 2011, Documenting the symptom experience of cancer patients, J Support Oncol, 9, 216, 10.1016/j.suponc.2011.06.003

Dijkstra, 2007, Phantom breast sensations and phantom breast pain: a 2-year prospective study and a methodological analysis of literature, Eur J Pain, 11, 99, 10.1016/j.ejpain.2006.01.002

Gahm, 2010, Bilateral prophylactic mastectomy in women with inherited risk of breast cancer–prevalence of pain and discomfort, impact on sexuality, quality of life and feelings of regret two years after surgery, Breast, 19, 462, 10.1016/j.breast.2010.05.003

Garabeli Cavalli Kluthcovsky, 2012, Fatigue after treatment in breast cancer survivors: prevalence, determinants and impact on health-related quality of life, Support Care Cancer, 20, 1901, 10.1007/s00520-011-1293-7

Gartner, 2009, Prevalence of and factors associated with persistent pain following breast cancer surgery, JAMA, 302, 1985, 10.1001/jama.2009.1568

Green, 2011, Cancer-related chronic pain: examining quality of life in diverse cancer survivors, Cancer, 117, 1994, 10.1002/cncr.25761

Grosen, 2013, Persistent post-surgical pain following anterior thoracotomy for lung cancer: a cross-sectional study of prevalence, characteristics and interference with functioning, Eur J Cardiothorac Surg, 43, 95, 10.1093/ejcts/ezs159

Hansen, 2011, Phantom breast sensations are frequent after mastectomy, Dan Med Bull, 58, A4259

Hickey, 2011, Persistent pain after mastectomy with reconstruction, J Clin Anesth, 23, 482, 10.1016/j.jclinane.2011.01.009

Hoimyr, 2011, Persistent pain after lymph node excision in patients with malignant melanoma is neuropathic, Pain, 152, 2721, 10.1016/j.pain.2011.07.009

Ishiyama, 2006, Results of a questionnaire survey for symptom of late complications caused by radiotherapy in breast conserving therapy, Breast Cancer, 13, 197, 10.2325/jbcs.13.197

Lengacher, 2012, Mindfulness based stress reduction in post-treatment breast cancer patients: an examination of symptoms and symptom clusters, J Behav Med, 35, 86, 10.1007/s10865-011-9346-4

Li, 2011, Persistent pain after breast cancer surgery in a Chinese population, Clin J Pain, 27, 481, 10.1097/AJP.0b013e31820e12b1

Mao, 2007, Symptom burden among cancer survivors: impact of age and comorbidity, J Am Board Fam Med, 20, 434, 10.3122/jabfm.2007.05.060225

Mejdahl, 2013, Persistent pain and sensory disturbances after treatment for breast cancer: six year nationwide follow-up study, BMJ, 346, f1865, 10.1136/bmj.f1865

Miaskowski, 2012, Identification of patient subgroups and risk factors for persistent breast pain following breast cancer surgery, J Pain, 13, 1172

Pettersson, 2013, Urethral pain among prostate cancer survivors 1 to 14 years after radiation therapy, Int J Radiat Oncol Biol Phys, 85, e29, 10.1016/j.ijrobp.2012.08.037

Peuckmann, 2009, Chronic pain and other sequelae in long-term breast cancer survivors: nationwide survey in Denmark, Eur J Pain, 13, 478, 10.1016/j.ejpain.2008.05.015

Rausch, 2012, SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors, Lung Cancer, 77, 217, 10.1016/j.lungcan.2012.02.017

Torvinen, 2013, Health-related quality of life in prostate cancer, Acta Oncol, 52, 1094, 10.3109/0284186X.2012.760848

van den Beuken-van Everdingen, 2007, High prevalence of pain in patients with cancer in a large population-based study in The Netherlands, Pain, 132, 312, 10.1016/j.pain.2007.08.022

Vistad, 2011, A study of chronic pelvic pain after radiotherapy in survivors of locally advanced cervical cancer, J Cancer Surviv, 5, 208, 10.1007/s11764-011-0172-z

Waldenström, 2011, Pain and mean absorbed dose to the pubic bone after radiotherapy among gynecological cancer survivors, Int J Radiat Oncol Biol Phys, 80, 1171, 10.1016/j.ijrobp.2010.04.007

Zucca, 2012, All's well that ends well? Quality of life and physical symptom clusters in long-term Cancer survivors across Cancer types, J Pain Symptom Manage, 43, 720, 10.1016/j.jpainsymman.2011.04.023

Akin, 2010, Quality of life, symptom experience and distress of lung cancer patients undergoing chemotherapy, Eur J Oncol Nurs, 14, 400, 10.1016/j.ejon.2010.01.003

Akin, 2013, A comparative descriptive study examining the perceptions of cancer patients, family caregivers, and nurses on patient symptom severity in Turkey, Eur J Oncol Nurs, 17, 30, 10.1016/j.ejon.2012.02.002

Bakitas, 2009, Effects of a palliative care intervention on clinical outcomes in patients with advanced cancer: the project ENABLE II randomized controlled trial, JAMA, 302, 741, 10.1001/jama.2009.1198

Bisht, 2011, Study of pain management in advanced cancer patients in a tertiary care hospital in India, Trop Doct, 41, 31, 10.1258/td.2010.100167

Bokhari, 2012, Pilot study of a survey to identify the prevalence of and risk factors for chronic neuropathic pain following breast Cancer surgery, Oncol Nurs Forum, 39, E141, 10.1188/12.ONF.E141-E149

Boonstra, 2013, Arthralgia during aromatase inhibitor treatment in early breast cancer patients: prevalence, impact, and recognition by healthcare providers, Cancer Nurs, 36, 52, 10.1097/NCC.0b013e31824a7e18

Brant, 2011, Symptom trajectories during chemotherapy in outpatients with lung cancer colorectal cancer, or lymphoma, Eur J Oncol Nurs, 15, 470, 10.1016/j.ejon.2010.12.002

Breen, 2009, Is symptom burden a predictor of anxiety and depression in patients with cancer about to commence chemotherapy?, Med J Aust, S99

Carlson, 2013, What goes up does not always come down: patterns of distress, physical and psychosocial morbidity in people with cancer over a one year period, Psychooncology, 22, 168, 10.1002/pon.2068

Finlay, 2009, Do phase 1 patients have greater needs for palliative care compared with other cancer patients?, Cancer, 115, 446, 10.1002/cncr.24025

Guirimand, 2010, Cancer-related symptom assessment in France: validation of the French M. D. Anderson Symptom Inventory, J Pain Symptom Manage, 39, 721, 10.1016/j.jpainsymman.2009.08.014

Gwede, 2008, Exploring the differential experience of breast cancer treatment-related symptoms: a cluster analytic approach, Support Care Cancer, 16, 925, 10.1007/s00520-007-0364-2

Hamaker, 2011, The value of a comprehensive geriatric assessment for patient care in acutely hospitalized older patients with cancer, Oncologist, 16, 1403, 10.1634/theoncologist.2010-0433

Hayes, 2010, Prevalence of upper-body symptoms following breast cancer and its relationship with upper-body function and lymphedema, Lymphology, 43, 178

Henry, 2008, Symptoms and treatment burden associated with cancer treatment: results from a cross-sectional national survey in the U.S, Support Care Cancer, 16, 791, 10.1007/s00520-007-0380-2

Karabulu, 2010, Symptom clusters and experiences of patients with cancer, J Adv Nurs, 66, 1011, 10.1111/j.1365-2648.2009.05254.x

Kenne Sarenmalm, 2007, Coping with recurrent breast cancer: predictors of distressing symptoms and health-related quality of life, J Pain Symptom Manage, 34, 24, 10.1016/j.jpainsymman.2006.10.017

Kirchheiner, 2013, Physical and psychosocial support requirements of 1,500 patients starting radiotherapy, Strahlenther Onkol, 189, 424, 10.1007/s00066-013-0329-y

Kubrak, 2010, Nutrition impact symptoms: key determinants of reduced dietary intake, weight loss, and reduced functional capacity of patients with head and neck cancer before treatment, Head Neck, 32, 290, 10.1002/hed.21174

Kurita, 2013, Pain characteristics and management of inpatients admitted to a comprehensive cancer centre: a cross-sectional study, Acta Anaesthesiol Scand, 57, 518, 10.1111/aas.12068

Lokker, 2013, Symptoms of patients with incurable head and neck cancer: prevalence and impact on daily functioning, Head Neck, 35, 868, 10.1002/hed.23053

Lovgren, 2008, Symptoms and problems with functioning among women and men with inoperable lung cancer—a longitudinal study, Lung Cancer, 60, 113, 10.1016/j.lungcan.2007.09.015

Morita, 2008, Palliative care needs of cancer outpatients receiving chemotherapy: an audit of a clinical screening project, Support Care Cancer, 16, 101, 10.1007/s00520-007-0271-6

Nakaguchi, 2013, Oncology nurses' recognition of supportive care needs and symptoms of their patients undergoing chemotherapy, Jpn J Clin Oncol, 43, 369, 10.1093/jjco/hyt003

Oberguggenberger, 2011, Is the toxicity of adjuvant aromatase inhibitor therapy underestimated? Complementary information from patient-reported outcomes (PROs), Breast Cancer Res Treat, 128, 553, 10.1007/s10549-011-1378-5

Schultheis, 2013, Quality of life and symptom evaluation in daily oncology practice: a survey of 150 patients with advanced gastrointestinal tumours receiving palliative chemotherapy, Onkologie, 36, 33, 10.1159/000346670

Spichiger, 2011, Prevalence of symptoms, with a focus on fatigue, and changes of symptoms over three months in outpatients receiving cancer chemotherapy, Swiss Med Wkly, 141, w13303

Storey, 2012, Clinically relevant fatigue in men with hormone-sensitive prostate cancer on long-term androgen deprivation therapy, Ann Oncol, 23, 1542, 10.1093/annonc/mdr447

Vaz, 2007, Quality of life of women with gynecologic cancer: associated factors, Arch Gynecol Obstet, 276, 583, 10.1007/s00404-007-0397-2

Yamagishi, 2009, Symptom prevalence and longitudinal follow-up in cancer outpatients receiving chemotherapy, J Pain Symptom Manage, 37, 823, 10.1016/j.jpainsymman.2008.04.015

Yildirim, 2011, Reliability and validity of the Turkish version of the Memorial Symptom Assessment Scale in cancer patients, Asian Pac J Cancer Prev, 12, 3389

Bausewein, 2010, Understanding breathlessness: cross-sectional comparison of symptom burden and palliative care needs in chronic obstructive pulmonary disease and cancer, J Palliat Med, 13, 1109, 10.1089/jpm.2010.0068

Black, 2011, The relationships among pain, nonpain symptoms, and quality of life measures in older adults with cancer receiving hospice care, Pain Med, 12, 880, 10.1111/j.1526-4637.2011.01113.x

Bradley, 2005, Symptom distress in patients attending an outpatient palliative radiotherapy clinic, J Pain Symptom Manage, 30, 123, 10.1016/j.jpainsymman.2005.02.015

Clark, 2012, Longitudinal pain reports in a palliative care population, J Palliat Med, 15, 1335, 10.1089/jpm.2012.0299

Elmqvist, 2009, Health-related quality of life during the last three months of life in patients with advanced cancer, Support Care Cancer, 17, 191, 10.1007/s00520-008-0477-2

Gomez-Batiste, 2010, Effectiveness of palliative care services in symptom control of patients with advanced terminal cancer: a Spanish, multicenter, prospective, quasi-experimental, pre-post study, J Pain Symptom Manage, 40, 652, 10.1016/j.jpainsymman.2010.02.026

Jimenez, 2011, Symptom clusters in advanced cancer, J Pain Symptom Manage, 42, 24, 10.1016/j.jpainsymman.2010.10.266

Justo Roll, 2009, Multidimensional problems among advanced cancer patients in cuba: awareness of diagnosis is associated with better patient status, J Pain Symptom Manage, 37, 325, 10.1016/j.jpainsymman.2008.02.015

Kang, 2013, Changes in symptom intensity among cancer patients receiving outpatient palliative care, J Pain Symptom Manage, 46, 652, 10.1016/j.jpainsymman.2012.11.009

Kirkova, 2012, Symptom prevalence in advanced cancer: age, gender, and performance status interactions, Am J Hosp Palliat Care, 29, 139, 10.1177/1049909111410965

Kwon, 2006, Symptoms in the lives of terminal cancer patients: which is the most important?, Oncology, 71, 69, 10.1159/000100450

Lasheen, 2009, Symptom variability during repeated measurement among hospice patients with advanced cancer, Am J Hosp Palliat Care, 26, 368, 10.1177/1049909109338352

McPherson, 2008, Family caregivers' assessment of symptoms in patients with advanced cancer: concordance with patients and factors affecting accuracy, J Pain Symptom Manage, 35, 70, 10.1016/j.jpainsymman.2007.02.038

Mercadante, 2013, Cancer pain management in an oncological ward in a comprehensive cancer center with an established palliative care unit, Support Care Cancer, 21, 3287, 10.1007/s00520-013-1899-z

Modonesi, 2005, Impact of palliative care unit admission on symptom control evaluated by the edmonton symptom assessment system, J Pain Symptom Manage, 30, 367, 10.1016/j.jpainsymman.2005.04.007

Mystakidou, 2007, Exploring the relationships between depression, hopelessness, cognitive status, pain, and spirituality in patients with advanced cancer, Arch Psychiatr Nurs, 21, 150, 10.1016/j.apnu.2007.02.002

Narducci, 2012, Symptom improvement as prognostic factor for survival in cancer patients undergoing palliative care: a pilot study, Support Care Cancer, 20, 1221, 10.1007/s00520-011-1207-8

Oi-Ling, 2005, Symptom distress as rated by advanced cancer patients, caregivers and physicians in the last week of life, Palliat Med, 19, 228, 10.1191/0269216305pm1001oa

Park, 2006, EuroQol and survival prediction in terminal cancer patients: a multicenter prospective study in hospice-palliative care units, Support Care Cancer, 14, 329, 10.1007/s00520-005-0889-1

Peters, 2006, Quality of life of cancer patients receiving inpatient and home-based palliative care, J Adv Nurs, 53, 524, 10.1111/j.1365-2648.2006.03754.x

Saini, 2006, Comparative pilot study of symptoms and quality of life in cancer patients and patients with end stage renal disease, Palliat Med, 20, 631, 10.1177/0269216306070236

Shin, 2011, Cross-cultural application of the Korean version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 15-Palliative Care, J Pain Symptom Manage, 41, 478, 10.1016/j.jpainsymman.2010.05.009

Spichiger, 2011, Symptom prevalence and changes of symptoms over ten days in hospitalized patients with advanced cancer: a descriptive study, Eur J Oncol Nurs, 15, 95, 10.1016/j.ejon.2010.06.005

Wilberg, 2012, Oral health is an important issue in end-of-life cancer care, Support Care Cancer, 20, 3115, 10.1007/s00520-012-1441-8

Wilson, 2009, Prevalence and correlates of pain in the Canadian national palliative care survey, Pain Res Manag, 14, 365, 10.1155/2009/251239

Abu-Saad Huijer, 2012, Health-related quality of life among breast cancer patients in Lebanon, Eur J Oncol Nurs, 16, 491, 10.1016/j.ejon.2011.11.003

Beck, 2005, Pain, sleep disturbance, and fatigue in patients with cancer: using a mediation model to test a symptom cluster, Oncol Nurs Forum, 32, 542, 10.1188/05.ONF.E48-E55

Brown, 2011, A symptom cluster and sentinel symptom experienced by women with lung cancer, Oncol Nurs Forum, 38, E425, 10.1188/11.ONF.E425-E435

Graves, 2007, Distress screening in a multidisciplinary lung cancer clinic: prevalence and predictors of clinically significant distress, Lung Cancer, 55, 215, 10.1016/j.lungcan.2006.10.001

Holtan, 2007, Prevalence of pain in hospitalised cancer patients in Norway: a national survey, Palliat Med, 21, 7, 10.1177/0269216306073127

Hong, 2011, Change in cancer pain management in Korea between 2001 and 2006: results of two nationwide surveys, J Pain Symptom Manage, 41, 93, 10.1016/j.jpainsymman.2010.03.025

Kjaer, 2011, Impact of symptom burden on health related quality of life of cancer survivors in a Danish cancer rehabilitation program: a longitudinal study, Acta Oncol, 50, 223, 10.3109/0284186X.2010.530689

Kuo, 2011, The prevalence of pain in patients attending sarcoma outpatient clinics, Sarcoma, 2011, 813483, 10.1155/2011/813483

Laugsand, 2010, Health care providers underestimate symptom intensities of cancer patients: a multicenter European study, Health Qual Life Outcomes, 8, 104, 10.1186/1477-7525-8-104

Manitta, 2011, The symptom burden of patients with hematological malignancy: a cross-sectional observational study, J Pain Symptom Manage, 42, 432, 10.1016/j.jpainsymman.2010.12.008

Mercadante, 2008, Prevalence and treatment of cancer pain in Italian oncological wards centres: a cross-sectional survey, Support Care Cancer, 16, 1203, 10.1007/s00520-008-0456-7

Nuhu, 2009, Psychological and physical effects of pain on cancer patients in Ibadan, Nigeria, Afr J Psychiatry (johannesbg), 12, 64

Priscilla, 2011, Quality of life among patients with hematological cancer in a Malaysian hospital, Med J Malaysia, 66, 117

Reyes-Gibby, 2006, Status of cancer pain in Hanoi, Vietnam: a hospital-wide survey in a tertiary cancer treatment center, J Pain Symptom Manage, 31, 431, 10.1016/j.jpainsymman.2005.10.005

Salminen, 2008, Needs of developing the skills of palliative care at the oncology ward: an audit of symptoms among 203 consecutive cancer patients in Finland, Support Care Cancer, 16, 3, 10.1007/s00520-007-0252-9

Sharma, 2012, Sleep problems in cancer patients: prevalence and association with distress and pain, Psychooncology, 21, 1003, 10.1002/pon.2004

Steegers, 2008, Effect of axillary lymph node dissection on prevalence and intensity of chronic and phantom pain after breast cancer surgery, J Pain, 9, 813

Williams, 2010, Prevalence of pain in head and neck cancer out-patients, J Laryngol Otol, 124, 767, 10.1017/S002221511000040X

Yen, 2012, The prevalence and management of pain in gynaecological malignancy within the outpatient setting, Internet J Pain Symptom Contr Palliat Care, 9, 6

Feyer, 2008, Frequency of side effects in outpatient cancer care and their influence on patient satisfaction—a prospective survey using the PASQOC questionnaire, Support Care Cancer, 16, 567, 10.1007/s00520-008-0422-4

O'Connor, 2012, Pain in patients attending a specialist cancer service: prevalence and association with emotional distress, J Pain Symptom Manage, 43, 29, 10.1016/j.jpainsymman.2011.03.010

Velloso, 2010, Functional performance of upper limb and quality of life after sentinel lymph node biopsy of breast cancer, Rev Bras Fisioter, 15, 146, 10.1590/S1413-35552011000200010

Al Qadire, 2013, Cancer pain in Jordan: prevalence and adequacy of treatment, Int J Palliat Nurs, 19, 125, 10.12968/ijpn.2013.19.3.125

Giesinger, 2011, Quality of life trajectory in patients with advanced cancer during the last year of life, J Palliat Med, 14, 904, 10.1089/jpm.2011.0086

Hoekstra, 2006, Using the symptom monitor in a randomized controlled trial: the effect on symptom prevalence and severity, J Pain Symptom Manage, 31, 22, 10.1016/j.jpainsymman.2005.06.014

Homsi, 2006, Symptom evaluation in palliative medicine: patient report vs systematic assessment, Support Care Cancer, 14, 444, 10.1007/s00520-005-0009-2

Johnsen, 2009, Symptoms and problems in a nationally representative sample of advanced cancer patients, Palliat Med, 23, 491, 10.1177/0269216309105400

Khan, 2012, Comparing baseline symptom severity and demographics over two time periods in an outpatient palliative radiotherapy clinic, Support Care Cancer, 20, 549, 10.1007/s00520-011-1120-1

Latvala, 2009, Anaemia and other predictors of fatigue among patients on palliative therapy for advanced cancer, Anticancer Res, 29, 2569

Oechsle, 2013, Symptom burden in palliative care patients: perspectives of patients, their family caregivers, and their attending physicians, Support Care Cancer, 21, 1955, 10.1007/s00520-013-1747-1

O'Leary, 2009, A comparative study of the palliative care needs of heart failure and cancer patients, Eur J Heart Fail, 11, 406, 10.1093/eurjhf/hfp007

Paiva, 2013, Prevalence, predictors, and prognostic impact of fatigue among Brazilian outpatients with advanced cancers, Support Care Cancer, 21, 1053, 10.1007/s00520-012-1625-2

Teunissen, 2006, Prognostic significance of symptoms of hospitalised advanced cancer patients, Eur J Cancer, 42, 2510, 10.1016/j.ejca.2006.05.025

Tishelman, 2007, Symptom prevalence, intensity, and distress in patients with inoperable lung cancer in relation to time of death, J Clin Oncol, 25, 5381, 10.1200/JCO.2006.08.7874

Torvik, 2008, Pain in elderly hospitalized cancer patients with bone metastases in Norway, Int J Palliat Nurs, 14, 238, 10.12968/ijpn.2008.14.5.29491

Wang, 2011, Symptoms and quality of life of advanced cancer patients at home: a cross-sectional study in Shanghai, China, Support Care Cancer, 19, 789, 10.1007/s00520-010-0884-z

Schumacher, 2014, Pain medication management processes used by oncology outpatients and family caregivers part II: home and lifestyle contexts, J Pain Symptom Manage, 48, 784, 10.1016/j.jpainsymman.2013.12.247

Yoneda, 2015, Contribution of acidic extracellular microenvironment of cancer-colonized bone to bone pain, Biochim Biophys Acta, 1848, 2677, 10.1016/j.bbamem.2015.02.004

Rivera, 2014, Efficacy of sublingual fentanyl vs. oral morphine for cancer-related breakthrough pain, Adv Ther, 31, 107, 10.1007/s12325-013-0086-4

Kongsgaard, 2014, The use of Instanyl(R) in the treatment of breakthrough pain in cancer patients: a 3-month observational, prospective, cohort study, Support Care Cancer, 22, 1655, 10.1007/s00520-014-2128-0

Deandrea, 2014, Prevalence of breakthrough cancer pain: a systematic review and a pooled analysis of published literature, J Pain Symptom Manage, 47, 57, 10.1016/j.jpainsymman.2013.02.015

University of Wisconsin-Madison, Pain & Policy Studies Group. Opioid Consumption Data. 2013. Available from http://www.painpolicy.wisc.edu/opioid-consumption-data. Accessed February 10, 2015.

Ventafridda, 1987, A validation study of the WHO method for cancer pain relief, Cancer, 59, 850, 10.1002/1097-0142(19870215)59:4<850::AID-CNCR2820590432>3.0.CO;2-1

Walker, 1988, Evaluation of WHO analgesic guidelines for cancer pain in a hospital-based palliative care unit, J Pain Symptom Manage, 3, 145, 10.1016/0885-3924(88)90160-1

Zech, 1995, Validation of World Health Organization guidelines for cancer pain relief: a 10-year prospective study, Pain, 63, 65, 10.1016/0304-3959(95)00017-M

Felleiter, 2005, Use of the World Health Organization guidelines on cancer pain relief before referral to a specialized pain service, Schmerz, 19, 265, 10.1007/s00482-004-0338-y

Azevedo Sao Leao Ferreira, 2006, The WHO analgesic ladder for cancer pain control, twenty years of use. How much pain relief does one get from using it?, Support Care Cancer, 14, 1086, 10.1007/s00520-006-0086-x

Caraceni, 2012, Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC, Lancet Oncol, 13, e58, 10.1016/S1470-2045(12)70040-2

Nabal, 2012, The role of paracetamol and nonsteroidal anti-inflammatory drugs in addition to WHO Step III opioids in the control of pain in advanced cancer. A systematic review of the literature, Palliat Med, 26, 305, 10.1177/0269216311428528

Finnerup, 2015, Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis, Lancet Neurol, 14, 162, 10.1016/S1474-4422(14)70251-0

Clark, 1999, 'Total pain', disciplinary power and the body in the work of Cicely Saunders, 1958-1967, Soc Sci Med, 49, 727, 10.1016/S0277-9536(99)00098-2

Zaza, 2002, Cancer pain and psychosocial factors: a critical review of the literature, J Pain Symptom Manage, 24, 526, 10.1016/S0885-3924(02)00497-9

Syrjala, 2014, Psychological and behavioral approaches to cancer pain management, J Clin Oncol, 32, 1703, 10.1200/JCO.2013.54.4825

Kwon, 2014, Overcoming barriers in cancer pain management, J Clin Oncol, 32, 1727, 10.1200/JCO.2013.52.4827

Jacobsen, 2009, Patient-related barriers to cancer pain management: a systematic exploratory review, Scand J Caring Sci, 23, 190, 10.1111/j.1471-6712.2008.00601.x

Miaskowski, 2001, Lack of adherence with the analgesic regimen: a significant barrier to effective cancer pain management, J Clin Oncol, 19, 4275, 10.1200/JCO.2001.19.23.4275

Marie, 2013, Optimal patient education for cancer pain: a systematic review and theory-based meta-analysis, Support Care Cancer, 21, 3529, 10.1007/s00520-013-1995-0

Adam, 2015, Educational interventions for cancer pain. A systematic review of systematic reviews with nested narrative review of randomized controlled trials, Patient Educ Couns, 98, 269, 10.1016/j.pec.2014.11.003

Abela, 2009, Symptom management by a community palliative care team, Malta Med J, 21, 12

Abu-Saad Huijer, 2012, Quality of palliative care. Perspective of Lebanese patients with cancer, J Med Liban, 60, 91

Achterberg, 2010, Pain in European long-term care facilities: cross-national study in Finland, Italy and the Netherlands, Pain, 148, 70, 10.1016/j.pain.2009.10.008

Alshemmari, 2010, Symptom burden in hospitalized patients with cancer in kuwait and the need for palliative care, Am J Hosp Palliat Care, 27, 446, 10.1177/1049909110362438

Alsirafy, 2010, Pain prevalence in advanced cancer patients in Egypt, Eur J Palliat Care, 17, 303

Aslan, 2011, Prevalence of cancer pain in outpatients registered to a cancer therapy center in Turkey, Asian Pac J Cancer Prev, 12, 1373

Barbera, 2010, Symptom burden and performance status in a population-based cohort of ambulatory cancer patients, Cancer, 116, 5767, 10.1002/cncr.25681

Bekelman, 2009, Symptom burden, depression, and spiritual well-being: a comparison of heart failure and advanced cancer patients, J Gen Intern Med, 24, 592, 10.1007/s11606-009-0931-y

Bergmann, 2011, Arm symptoms and overall survival in Brazilian patients with advanced breast cancer, Asian Pac J Cancer Prev, 12, 2939

Borgsteede, 2007, Symptoms in patients receiving palliative care: a study on patient-physician encounters in general practice, Palliat Med, 21, 417, 10.1177/0269216307079821

Butt, 2008, Use of a single-item screening tool to detect clinically significant fatigue, pain, distress, and anorexia in ambulatory cancer practice, J Pain Symptom Manage, 35, 20, 10.1016/j.jpainsymman.2007.02.040

Camps, 2005, Weekly paclitaxel as second/third-line treatment in advanced non-small cell lung cancer patients: efficacy and tolerability, Anticancer Res, 25, 4611

Chen, 2006, Symptom clusters in cancer patients, Support Care Cancer, 14, 825, 10.1007/s00520-006-0019-8

Cheng, 2009, Measuring the symptom experience of Chinese cancer patients: a validation of the Chinese version of the memorial symptom assessment scale, J Pain Symptom Manage, 37, 44, 10.1016/j.jpainsymman.2007.12.019

Cheng, 2005, Measuring symptom prevalence, severity and distress of cancer survivors, Clin Effect Nurs, 9, 154, 10.1016/j.cein.2006.08.007

Cheung, 2009, Symptom clusters in patients with advanced cancers, Support Care Cancer, 17, 1223, 10.1007/s00520-009-0577-7

Choi, 2013, Factors that affect quality of dying and death in terminal cancer patients on inpatient palliative care units: perspectives of bereaved family caregivers, J Pain Symptom Manage, 45, 735, 10.1016/j.jpainsymman.2012.04.010

Chow, 2008, Symptom clusters in cancer patients with brain metastases, Clin Oncol (R Coll Radiol), 20, 76, 10.1016/j.clon.2007.09.007

Cohen, 2012, Symptoms and quality of life in diverse patients undergoing hematopoietic stem cell transplantation, J Pain Symptom Manage, 44, 168, 10.1016/j.jpainsymman.2011.08.011

De Raaf, 2013, Systematic monitoring and treatment of physical symptoms to alleviate fatigue in patients with advanced cancer: a randomized controlled trial, J Clin Oncol, 31, 716, 10.1200/JCO.2012.44.4216

de Santiago, 2012, A new palliative care consultation team at the oncology department of a university hospital: an assessment of initial efficiency and effectiveness, Support Care Cancer, 20, 2199, 10.1007/s00520-012-1476-x

Delgado-Guay, 2009, Symptom distress, interventions, and outcomes of intensive care unit cancer patients referred to a palliative care consult team, Cancer, 115, 437, 10.1002/cncr.24017

Dumitrescu, 2007, Changes in symptoms and pain intensity of cancer patients after enrollment in palliative care at home, J Pain Symptom Manage, 34, 488, 10.1016/j.jpainsymman.2007.05.004

Elsayem, 2010, Predictors of inpatient mortality in an acute palliative care unit at a comprehensive cancer center, Support Care Cancer, 18, 67, 10.1007/s00520-009-0631-5

Fadol, 2008, Psychometric testing of the MDASI-HF: a symptom assessment instrument for patients with cancer and concurrent heart failure, J Card Fail, 14, 497, 10.1016/j.cardfail.2008.01.012

Fainsinger, 2005, A multicenter study of the revised Edmonton Staging System for classifying cancer pain in advanced cancer patients, J Pain Symptom Manage, 29, 224, 10.1016/j.jpainsymman.2004.05.008

Fox, 2006, Symptom clusters and quality of life in survivors of lung cancer, Oncol Nurs Forum, 33, 931, 10.1188/06.ONF.931-936

Franceschini, 2013, Relationship between the magnitude of symptoms and the quality of life: a cluster analysis of lung cancer patients in Brazil, J Bras Pneumol, 39, 23

Garcia de Paredes, 2011, First evidence of oncologic neuropathic pain prevalence after screening 8615 cancer patients. Results of the On study, Ann Oncol, 22, 924, 10.1093/annonc/mdq449

Georges, 2005, Differences between terminally ill cancer patients who died after euthanasia had been performed and terminally ill cancer patients who did not request euthanasia, Palliat Med, 19, 578, 10.1191/0269216305pm1069oa

Gerbershagen, 2008, Prevalence, severity, and chronicity of pain and general health-related quality of life in patients with localized prostate cancer, Eur J Pain, 12, 339, 10.1016/j.ejpain.2007.07.006

Ghosn, 2011, Experience with palliative care in patients with advanced cancer at a tertiary care hospital in a developing country, Support Care Cancer, 19, 573, 10.1007/s00520-010-1056-x

Gooneratne, 2007, Sleep and quality of life in long-term lung cancer survivors, Lung Cancer, 58, 403, 10.1016/j.lungcan.2007.07.011

Gough, 2011, Symptom burden, survival and palliative care in advanced soft tissue sarcoma, Sarcoma, 2011, 325189, 10.1155/2011/325189

Halawi, 2012, Physical symptom profile for adult cancer inpatients at a Lebanese cancer unit, Eur J Intern Med, 23, e185, 10.1016/j.ejim.2012.08.018

Harding, 2011, The prevalence and burden of symptoms amongst cancer patients attending palliative care in two African countries, Eur J Cancer, 47, 51, 10.1016/j.ejca.2010.08.003

Helzlsouer, 2012, A prospective study of aromatase inhibitor therapy, vitamin D, C-reactive protein and musculoskeletal symptoms, Breast Cancer Res Treat, 131, 277, 10.1007/s10549-011-1729-2

Hickey, 2010, Severity of acute pain after breast surgery is associated with the likelihood of subsequently developing persistent pain, Clin J Pain, 26, 556, 10.1097/AJP.0b013e3181dee988

Hirakawa, 2006, Symptoms and care of elderly patients dying at home of lung, gastric, colon, and liver cancer, Japan Med Assoc J, 49, 140

Hoffman, 2007, Relationships among pain, fatigue, insomnia, and gender in persons with lung cancer, Oncol Nurs Forum, 34, 785, 10.1188/07.ONF.785-792

Im, 2007, Gender and ethnic differences in cancer pain experience: a multiethnic survey in the United States, Nurs Res, 56, 296, 10.1097/01.NNR.0000289502.45284.b5

Inoue, 2009, Prevalence of skeletal complications and their impact on survival of hormone refractory prostate cancer patients in Japan, Urology, 73, 1104, 10.1016/j.urology.2008.07.062

Iritani, 2011, Impact of dementia on cancer discovery and pain, Psychogeriatrics, 11, 6, 10.1111/j.1479-8301.2010.00344.x

Johnson, 2005, Palliative care needs of cancer patients in U.S. nursing homes, J Palliat Med, 8, 273, 10.1089/jpm.2005.8.273

Kim, 2012, Prevalence and management of pain by different age groups of Korean Cancer patients, Am J Hosp Palliat Care, 30, 393, 10.1177/1049909112452624

Lal, 2012, An experience with 156 patients attending a newly organized pain and palliative care clinic in a tertiary hospital, Indian J Cancer, 49, 293, 10.4103/0019-509X.104491

Lesperance, 2008, Colorectal complications of external beam radiation versus brachytherapy for prostate cancer, Am J Surg, 195, 616, 10.1016/j.amjsurg.2007.12.037

Lin, 2011, Symptom patterns of patients with head and neck cancer in a palliative care unit, J Palliat Med, 14, 556, 10.1089/jpm.2010.0461

Liu, 2011, Association between symptoms and their severity with survival time in hospitalized patients with far advanced cancer, Palliat Med, 25, 682, 10.1177/0269216311398301

Liu, 2013, Prevalence, intensity, and prognostic significance of common symptoms in terminally ill Cancer patients, J Palliat Med, 16, 752, 10.1089/jpm.2013.0028

Lukas, 2013, Pain characteristics and pain control in European nursing homes: cross-sectional and longitudinal results from the Services and Health for Elderly in Long TERm care (SHELTER) study, J Am Med Dir Assoc, 14, 421, 10.1016/j.jamda.2012.12.010

Meeske, 2007, Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report, Qual Life Res, 16, 947, 10.1007/s11136-007-9215-3

Mendoza, 2011, Measuring the symptom burden of lung cancer: the validity and utility of the lung cancer module of the M D Anderson Symptom Inventory, Oncologist, 16, 217, 10.1634/theoncologist.2010-0193

Mercadante, 2013, Pattern and characteristics of advanced cancer patients admitted to hospices in Italy, Support Care Cancer, 21, 935, 10.1007/s00520-012-1608-3

Mercadante, 2010, Breakthrough pain in oncology: a longitudinal study, J Pain Symptom Manage, 40, 183, 10.1016/j.jpainsymman.2010.01.010

Mota, 2012, Fatigue in colorectal cancer patients: prevalence and associated factors, Rev Lat Am Enfermagem, 20, 495, 10.1590/S0104-11692012000300010

Omran, 2012, Symptom distress of Jordanian patients with cancer receiving chemotherapy, Int J Nurs Pract, 18, 125, 10.1111/j.1440-172X.2012.02012.x

Pantilat, 2012, Longitudinal assessment of symptom severity among hospitalized elders diagnosed with cancer, heart failure, and chronic obstructive pulmonary disease, J Hosp Med, 7, 567, 10.1002/jhm.1925

Parsons, 2008, Alcoholism screening in patients with advanced cancer: impact on symptom burden and opioid use, J Palliat Med, 11, 964, 10.1089/jpm.2008.0037

Pelayo-Alvarez, 2013, Reliability and concurrent validity of the Palliative Outcome Scale, the Rotterdam Symptom Checklist, and the Brief Pain Inventory, J Palliat Med, 16, 867, 10.1089/jpm.2012.0625

Peng, 2006, Multidisciplinary management of cancer pain: a longitudinal retrospective study on a cohort of end-stage cancer patients, J Pain Symptom Manage, 32, 444, 10.1016/j.jpainsymman.2006.05.017

Porta-Sales, 2005, Patient appointment process, symptom control and prediction of follow-up compliance in a palliative care outpatient clinic, J Pain Symptom Manage, 30, 145, 10.1016/j.jpainsymman.2005.03.008

Price, 2013, Physical symptoms, coping styles and quality of life in recurrent ovarian cancer: a prospective population-based study over the last year of life, Gynecol Oncol, 130, 162, 10.1016/j.ygyno.2013.03.031

Puhse, 2012, Chronic pain has a negative impact on sexuality in testis cancer survivors, J Androl, 33, 886

Rannestad, 2007, Pain and quality of life among long-term gynecological cancer survivors: a population-based case-control study, Acta Obstet Gynecol Scand, 86, 1510, 10.1080/00016340701743116

Rayment, 2013, Neuropathic cancer pain: prevalence, severity, analgesics and impact from the European Palliative Care Research Collaborative-Computerised Symptom Assessment study, Palliat Med, 27, 714, 10.1177/0269216312464408

Reed, 2012, Quality of life and experience of care in women with metastatic breast cancer: a cross-sectional survey, J Pain Symptom Manage, 43, 747, 10.1016/j.jpainsymman.2011.05.005

Reyes-Gibby, 2012, Early referral to supportive care specialists for symptom burden in lung cancer patients: a comparison of non-Hispanic whites, Hispanics, and non-Hispanic blacks, Cancer, 118, 856, 10.1002/cncr.26312

Reyes-Gibby, 2007, Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation, J Pain Symptom Manage, 34, 244, 10.1016/j.jpainsymman.2006.11.007

Riechelmann, 2007, Symptom and medication profiles among cancer patients attending a palliative care clinic, Support Care Cancer, 15, 1407, 10.1007/s00520-007-0253-8

Saidi, 2008, Correlation of clinical data, anatomical site and disease stage in colorectal cancer, East Afr Med J, 85, 259, 10.4314/eamj.v85i6.9622

Salamonde, 2006, Clinical and therapeutic analysis of oncology patients treated at the pain and palliative care program of the hospital Universitario Clementino Fraga Filho in 2003, Rev Braz Anesthesiol, 56, 602

Sandgren, 2010, Symptoms, care needs and diagnosis in palliative cancer patients in acute care hospitals: a 5-year follow-up survey, Acta Oncol, 49, 460, 10.3109/02841860903463991

Sarna, 2008, Symptom severity 1 to 4 months after thoracotomy for lung cancer, Am J Crit Care, 17, 455, 10.4037/ajcc2008.17.5.455

Schrier, 2012, Association of fibromyalgia characteristics in patients with non-metastatic breast cancer and the protective role of resilience, Rheumatol Int, 32, 3017, 10.1007/s00296-011-2104-7

Semionov, 2012, Prevalence and management of symptoms during the last month of life, Isr Med Assoc J, 14, 96

Sherman, 2007, Symptom assessment of patients with advanced cancer and AIDS and their family caregivers: the results of a quality-of-life pilot study, Am J Hosp Palliat Care, 24, 350, 10.1177/1049909106299063

Simone, 2012, Cancer patient attitudes toward analgesic usage and pain intervention, Clin J Pain, 28, 157, 10.1097/AJP.0b013e318223be30

Skaug, 2007, Prevalence and predictors of symptoms in the terminal stage of lung cancer: a community study, Chest, 131, 389, 10.1378/chest.06-1233

Smith, 2010, The epidemiology of pain during the last 2 years of life, Ann Intern Med, 153, 563, 10.7326/0003-4819-153-9-201011020-00005

Smith, 2006, Symptomatic presentation of early colorectal cancer, Ann R Coll Surg Engl, 88, 185, 10.1308/003588406X94904

Spoozak, 2013, Performance status and symptom scores of women with gynecologic cancer at the end of life, Int J Gynecol Cancer, 23, 971, 10.1097/IGC.0b013e318291e5ef

Steel, 2010, Cancer-related symptom clusters, eosinophils, and survival in hepatobiliary cancer: an exploratory study, J Pain Symptom Manage, 39, 859, 10.1016/j.jpainsymman.2009.09.019

Stuver, 2012, Factors associated with pain among ambulatory patients with cancer with advanced disease at a comprehensive cancer center, J Oncol Pract, 8, e17, 10.1200/JOP.2011.000388

Tsai, 2010, Significance of symptom clustering in palliative care of advanced cancer patients, J Pain Symptom Manage, 39, 655, 10.1016/j.jpainsymman.2009.09.005

Tsoussis, 2007, Clinical burden of terminal phase in cancer patients, J BUON, 12, 383

Vergnenegre, 2013, Assessment of palliative care for advanced non-small-cell lung cancer in France: a prospective observational multicenter study (GFPC 0804 study), Lung Cancer, 82, 353, 10.1016/j.lungcan.2013.07.014

Walsh, 2006, Symptom clustering in advanced cancer, Support Care Cancer, 14, 831, 10.1007/s00520-005-0899-z

Wang, 2010, Impact of cultural and linguistic factors on symptom reporting by patients with cancer, J Natl Cancer Inst, 102, 732, 10.1093/jnci/djq097

Wang, 2010, Prognostic value of symptom burden for overall survival in patients receiving chemotherapy for advanced nonsmall cell lung cancer, Cancer, 116, 137, 10.1002/cncr.24703

Watanabe, 2011, A multicenter study comparing two numerical versions of the Edmonton Symptom Assessment System in palliative care patients, J Pain Symptom Manage, 41, 456, 10.1016/j.jpainsymman.2010.04.020

Yalcin, 2005, Frequency of symptoms in patients with advanced cancer, Turk J Cancer, 35, 177

Yan, 2006, Quality of life of patients with terminal cancer receiving palliative home care, J Palliat Med, 22, 261

Yennurajalingam, 2012, Clinical response to an outpatient palliative care consultation in patients with advanced cancer and cancer pain, J Pain Symptom Manage, 44, 340, 10.1016/j.jpainsymman.2011.09.014

Reyes-Gibby, 2006, Pain, depression, and fatigue in community-dwelling adults with and without a history of cancer, J Pain Symptom Manage, 32, 118, 10.1016/j.jpainsymman.2006.01.008

Haisfield-Wolfe, 2012, Prevalence and correlates of symptoms and uncertainty in illness among head and neck cancer patients receiving definitive radiation with or without chemotherapy, Support Care Cancer, 20, 1885, 10.1007/s00520-011-1291-9

So, 2009, The symptom cluster of fatigue, pain, anxiety, and depression and the effect on the quality of life of women receiving treatment for breast cancer: a multicenter study, Oncol Nurs Forum, 36, E205, 10.1188/09.ONF.E205-E214

Henningsohn, 2003, Time after surgery, symptoms and well-being in survivors of urinary bladder cancer, BJU Int, 91, 325, 10.1046/j.1464-410X.2003.04101.x