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Cập nhật về Viêm Khớp Phản Ứng Sau Nhiễm Trùng Liên Cầu: Tổng Quan Về Một Bệnh Bị Quên
Tóm tắt
Bài tổng quan theo chủ đề này cố gắng xây dựng các khái niệm về Viêm Khớp Phản Ứng Sau Nhiễm Trùng Liên Cầu (PSRA) như một thực thể độc lập và thảo luận về các tiêu chí chẩn đoán phổ biến. Nó sử dụng một chiến lược tìm kiếm để tổng hợp tất cả các đặc điểm lâm sàng của PSRA được báo cáo từ khắp nơi trên thế giới và cũng thảo luận ngắn gọn về các tùy chọn xét nghiệm và điều trị. Có nhiều bệnh tự miễn được mô tả sau các nhiễm trùng do liên cầu. Viêm khớp phản ứng sau nhiễm liên cầu (PSRA) là một loại viêm khớp vô trùng, tự giới hạn, xảy ra như một hệ quả miễn dịch của nhiễm trùng do liên cầu. Mặc dù PSRA có vẻ giống như viêm khớp do sốt thấp khớp về mặt bề ngoài, nhưng nó là một thực thể riêng biệt. Nó cũng khác với viêm khớp phản ứng cổ điển. PSRA đã được công nhận trên toàn cầu và thường gặp hơn trong thời gian gần đây, có thể do sự nâng cao nhận thức của các bác sĩ lâm sàng. Tuy nhiên, nghiên cứu về hiện tượng miễn dịch bí ẩn này vẫn còn hạn chế. Hầu hết các giả thuyết chấp nhận được cho rằng sự bắt chước phân tử đã làm nhạy cảm hóa hệ thống miễn dịch với các peptide màng hoạt dịch như keratin, vimentin và laminin, dẫn đến viêm khớp ở những cá nhân có khuynh hướng di truyền. Còn nhiều điều phải học hỏi từ căn bệnh độc đáo này về những biến đổi của hệ thống miễn dịch.
Từ khóa
#Viêm Khớp Phản Ứng #Nhiễm Trùng Liên Cầu #Hệ Miễn Dịch #Hệ Quả Miễn Dịch #Bệnh Tự MiễnTài liệu tham khảo
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