Unveiling Molecular Events in the Brain by Noninvasive Imaging

Neuroscientist - Tập 17 Số 5 - Trang 539-559 - 2011
Jan Klohs1, Markus Rudin1,2
1Institute for Biomedical Engineering, ETH & University of Zürich, Switzerland
2Institute of Pharmacology and Toxicology, University of Zurich, Switzerland

Tóm tắt

Neuroimaging allows researchers and clinicians to noninvasively assess structure and function of the brain. With the advances of imaging modalities such as magnetic resonance, nuclear, and optical imaging; the design of target-specific probes; and/or the introduction of reporter gene assays, these technologies are now capable of visualizing cellular and molecular processes in vivo. Undoubtedly, the system biological character of molecular neuroimaging, which allows for the study of molecular events in the intact organism, will enhance our understanding of physiology and pathophysiology of the brain and improve our ability to diagnose and treat diseases more specifically. Technical/scientific challenges to be faced are the development of highly sensitive imaging modalities, the design of specific imaging probe molecules capable of penetrating the CNS and reporting on endogenous cellular and molecular processes, and the development of tools for extracting quantitative, biologically relevant information from imaging data. Today, molecular neuroimaging is still an experimental approach with limited clinical impact; this is expected to change within the next decade. This article provides an overview of molecular neuroimaging approaches with a focus on rodent studies documenting the exploratory state of the field. Concepts are illustrated by discussing applications related to the pathophysiology of Alzheimer’s disease.

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Tài liệu tham khảo

Aslund A, 2009, Chem Biol, 4, 673

10.1002/jmri.22001

10.1016/j.neuroimage.2009.12.070

10.1002/nbm.1396

10.1016/j.jim.2007.02.009

10.1007/s00228-003-0643-x

10.1016/S0140-6736(06)69113-7

10.1093/brain/116.3.497

10.1117/1.2968262

10.1016/j.mri.2007.03.017

10.1002/jmri.20675

10.2174/157340509787354741

10.1111/j.1749-6632.2000.tb06381.x

10.1016/S0140-6736(01)05625-2

10.1002/mrm.21951

10.1038/sj.jp.7210647

10.2310/7290.2008.0004

10.1001/archneur.64.1.108

10.1002/nbm.760

10.1093/brain/awl178

10.1002/andp.19484370105

10.1038/nbt0806-909

10.1038/nrneurol.2009.215

10.1007/978-0-387-22529-6_2

10.1038/nrn2420

10.1161/STROKEAHA.109.558197

10.1212/WNL.58.10.1476

10.1016/S0022-510X(99)00135-5

10.1016/S0022-510X(98)00043-4

10.1259/bjr/97295129

10.1097/01.wnr.0000177007.21732.7b

10.1038/nn1422

10.1038/nbt1085

10.1016/j.neuroimage.2008.10.038

10.1038/nrn1387

Ikonomovic MD, Klunk WE, Abrahamson EE, Mathis CA, Price JC, Tsopelas ND, and others. 2008. Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer’s disease. 131(Pt 6):1630–45.

10.1093/brain/awp062

10.1212/WNL.38.6.909

10.1038/nm1700

10.1016/j.neurobiolaging.2007.02.020

10.1046/j.1460-9568.2003.02716.x

10.1212/WNL.55.2.205

10.1073/pnas.0510237103

10.1016/j.bbrc.2005.12.112

10.1161/STROKEAHA.107.509844

10.1016/j.jneumeth.2009.03.002

10.1007/s00395-008-0702-7

10.1523/JNEUROSCI.2990-05.2005

10.1212/WNL.52.4.691

10.1073/pnas.0901194106

10.1098/rsta.2008.0092

10.1101/gad.1047403

10.1002/jmri.21731

Mielke R, 1994, Dementia, 5, 36

10.1111/j.1460-9568.2009.06987.x

10.1002/mrm.1190

10.1523/JNEUROSCI.23-23-08231.2003

Mueggler T, 2010, Eur Neuropsychopharmacol

10.1523/JNEUROSCI.22-16-07218.2002

10.1016/j.jalz.2005.06.003

10.1096/fj.05-4145fje

10.1097/00002093-199505000-00006

10.1038/nrneurol.2009.217

10.1038/nm729

10.1097/CCM.0b013e3181921349

10.2174/156720509787602861

Phelps ME, 2004, PET—molecular imaging and its biological applications

Piper S, Biomed Opt Express

10.1021/bi0359574

10.1038/nature04871

10.1016/j.nbd.2010.06.002

10.1021/ja9047043

10.1002/mrm.10541

10.1007/s00259-007-0708-7

10.1002/(SICI)1099-1492(200002)13:1<43::AID-NBM608>3.0.CO;2-S

10.1161/01.RES.44.1.127

10.1016/S1474-4422(06)70550-6

10.1016/S1474-4422(10)70043-0

10.1212/WNL.50.1.152

10.1142/p379

Rudin M, 2008, Curr Opin Drug Discov Dev, 11, 606

10.1038/nrd1007

10.1002/syn.20055

10.1002/mrm.21179

10.1016/j.mri.2007.02.017

10.1002/mrm.1910080210

10.1038/nrc1187

10.1038/nmeth819

10.1002/hipo.20573

10.1007/978-0-387-22529-6_7

10.1007/s00702-005-0312-6

Tjuvajev JG, 1996, Cancer Res, 56, 4087

Tung CH, 2000, Cancer Res, 60, 4953

10.1016/j.neurobiolaging.2007.11.005

10.1136/jnnp.73.2.134

10.2144/03342bi01

10.1523/JNEUROSCI.21-05-01619.2001

10.1002/jmri.20584

10.2967/jnumed.109.069088

10.1016/j.neuroscience.2008.10.005

10.1016/j.biopsych.2008.04.021

10.1080/00018730010006608

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Neuroscientist

Tập 17 Số 5

539-559

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