Unliganded human mutant α7 nicotinic receptors are modulated by Ca2+ and trace levels of Zn2+

Armstrong, 2001, Comparative effects of metal chelating agents on the neuronal cytotoxicity induced by copper (Cu2+), iron (Fe3+) and zinc in the hippocampus, Brain Research, 16, 51, 10.1016/S0006-8993(00)03195-4 Arslan, 1985, Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+, Journal of Biological Chemistry, 260, 2719, 10.1016/S0021-9258(18)89421-2 Assaf, 1984, Release of endogenous Zn2+ from brain tissue during activity, Nature, 308, 734, 10.1038/308734a0 Bertrand, 1992, Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain, Proceedings of the National Academy of Sciences USA, 89, 1261, 10.1073/pnas.89.4.1261 Bertrand, 1997, Paradoxical allosteric effects of competitive inhibitors on neuronal alpha7 nicotinic receptor mutants, NeuroReport, 8, 3591, 10.1097/00001756-199711100-00034 Broide, 2002, Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation, Molecular Pharmacology, 61, 695, 10.1124/mol.61.3.695 Changeux, 2001, Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors, Current Opinion in Neurobiology, 11, 369, 10.1016/S0959-4388(00)00221-X Eddins, 2002, Permeant but not impermeant divalent cations enhance activation of nondesensitizing alpha(7) nicotinic receptors, American Journal Physiology Cellular Physiology, 282, C796, 10.1152/ajpcell.00453.2001 Engel, 1996, New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome, Human Molecular Genetics, 5, 1217, 10.1093/hmg/5.9.1217 Fonck, 2003, Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive α4 nicotinic receptors, Journal of Neuroscience, 23, 2582, 10.1523/JNEUROSCI.23-07-02582.2003 Fucile, 1996, Identification of a determinant of AChR gating kinetics in the extracellular portion of the γ subunit, European Journal of Neuroscience, 8, 2564, 10.1111/j.1460-9568.1996.tb01550.x Fucile, 2000, Human neuronal threonine-for-leucine-248 alpha 7 mutant nicotinic acetylcholine receptors are highly Ca2+ permeable, Proceedings of the National Academy of Sciences USA, 97, 3643, 10.1073/pnas.050582497 Fucile, 2002, Serotonin antagonizes the human neuronal α7 nicotinic acetylcholine receptor and becomes an agonist after L248T α7 mutation, Neuroscience, 110, 169, 10.1016/S0306-4522(01)00567-X Fucile, 2002, The single-channel properties of human acetylcholine α7 receptors are altered by fusing α7 to the green fluorescent protein, Proceedings of the National Academy of Sciences USA, 99, 3956, 10.1073/pnas.052699599 Galzi, 1996, Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor, EMBO Journal, 15, 5824, 10.1002/j.1460-2075.1996.tb00969.x Grosman, 2000, Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12’mutants, Journal of General Physiology, 115, 621, 10.1085/jgp.115.5.621 Jackson, 1984, Spontaneous openings of the acetylcholine receptor channel, Proceedings of the National Academy of Sciences USA, 81, 3901, 10.1073/pnas.81.12.3901 Jackson, 1990, Spontaneous and agonist-induced openings of an acetylcholine receptor channels composed of bovine muscle alpha-, beta- and delta-subunits, Plfügers Archiv, 417, 129, 10.1007/BF00370689 Katz, 1973, The binding of acetylcholine to receptors and its removal from the synaptic cleft, Journal of Physiology, 231, 549, 10.1113/jphysiol.1973.sp010248 Lena, 1997, Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders, Current Opinion in Neurobiology, 7, 672, 10.1016/S0959-4388(97)80088-8 Mulle, 1992, Potentiation of nicotinic receptor response by external calcium in rat central neurons, Neuron, 9, 937, 10.1016/0896-6273(92)90208-U Nai, 2003, Relating neuronal nicotinic acetylcholine receptor subtypes defined by subunit composition and channel function, Molecular Pharmacology, 63, 311, 10.1124/mol.63.2.311 Ohno, 1995, Congenital mysthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the ε subunit, Proceedings of the National Academy of Sciences USA, 92, 758, 10.1073/pnas.92.3.758 Palma, 1996, Threonine-for-leucine mutation within domain M2 of the neuronal α7 nicotinic receptor converts 5-hydroxytryptamine from antagonist to agonist, Proceedings of the National Academy of Sciences USA, 93, 11231, 10.1073/pnas.93.20.11231 Palma, 1998, Effects of Zn2+ on wild and mutant neuronal α7 nicotinic receptors, Proceedings of the National Academy of Sciences USA, 95, 10246, 10.1073/pnas.95.17.10246 Palma, 1999, Strychnine activates neuronal α7 nicotinic receptors after mutations in the leucine ring and transmitter binding site domains, Proceedings of the National Academy of Sciences USA, 96, 13421, 10.1073/pnas.96.23.13421 Revah, 1991, Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor, Nature, 353, 846, 10.1038/353846a0 Smart, 1994, Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc, Progress in Neurobiology, 42, 393, 10.1016/0301-0082(94)90082-5 Zhou, 1999, Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes, Proceedings of the National Academy of Sciences USA, 96, 10466, 10.1073/pnas.96.18.10466 Zuo, 1997, Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene, Nature, 388, 769, 10.1038/42009