Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis

Kidney International - Tập 89 - Trang 127-134 - 2016
Andrew S. Terker1, Chong Zhang2, Kayla J. Erspamer1, Gerardo Gamba3,4, Chao-Ling Yang1,5, David H. Ellison1,5
1Division of Nephrology & Hypertension, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA
2Department of Nephrology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
3Molecular Physiology Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Universidad Nacional Autónoma de México, Mexico City, Mexico
4Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico
5VA Portland Health Care System, Portland, OR, USA

Tài liệu tham khảo

Addison, 1928, The use of sodium cholride, potassium chloride, sodium bromide, and potassium bormide in cases of arterial hypertension which are amenable to potassium chloride, Can Med Assoc J, 18, 281 Adrogue, 2007, Sodium and potassium in the pathogenesis of hypertension, N Engl J Med, 356, 1966, 10.1056/NEJMra064486 Young, 1985, Analysis of long-term potassium regulation, Endocr Rev, 6, 24, 10.1210/edrv-6-1-24 Terker, 2015, Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride, Cell Metab, 21, 39, 10.1016/j.cmet.2014.12.006 Wilson, 2001, Human hypertension caused by mutations in WNK kinases, Science, 293, 1107, 10.1126/science.1062844 Wilson, 2003, Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4, Proc Natl Acad Sci USA, 100, 680, 10.1073/pnas.242735399 Yang, 2003, WNK kinases regulate thiazide-sensitive Na-Cl cotransport, J Clin Invest, 111, 1039, 10.1172/JCI17443 Piala, 2014, Chloride sensing by WNK1 involves inhibition of autophosphorylation, Sci Signal, 7, ra41, 10.1126/scisignal.2005050 Pacheco-Alvarez, 2006, The Na+:Cl– cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion, J Biol Chem, 281, 28755, 10.1074/jbc.M603773200 Weinstein, 2005, A mathematical model of rat distal convoluted tubule. I. Cotransporter function in early DCT, Am J Physiol Renal Physiol, 289, F699, 10.1152/ajprenal.00043.2005 Vitzthum, 2014, Functional coupling of renal K+ and Na+ handling causes high blood pressure in Na+ replete mice, J Physiol, 592, 1139, 10.1113/jphysiol.2013.266924 Castaneda-Bueno, 2014, Modulation of NCC activity by low and high K+ intake: insights into the signaling pathways involved, Am J Physiol Renal Physiol, 306, F1507, 10.1152/ajprenal.00255.2013 van der Lubbe, 2013, K+-induced natriuresis is preserved during Na+ depletion and accompanied by inhibition of the Na+-Cl– cotransporter, Am J Physiol Renal Physiol, 305, F1177, 10.1152/ajprenal.00201.2013 Vallon, 2009, Expression and phosphorylation of the Na +-Cl– cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1, Am J Physiol Renal Physiol, 297, F704, 10.1152/ajprenal.00030.2009 Wade, 2015, SPAK mediated NCC regulation in response to low K+ diet, Am J Physiol Renal Physiol, 308, F923, 10.1152/ajprenal.00388.2014 Rinehart, 2005, WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl– cotransporters required for normal blood pressure homeostasis, Proc Natl Acad Sci USA, 102, 16777, 10.1073/pnas.0508303102 Bazua-Valenti, 2015, Revisiting the NaCl cotransporter regulation by with-no-lysine kinases, Am J Physiol Cell Physiol, 308, C779, 10.1152/ajpcell.00065.2015 Chávez-Canales, 2014, The WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the NaCl cotransporter via SPAK, an effect antagonized by WNK4, Hypertension, 64, 1047, 10.1161/HYPERTENSIONAHA.114.04036 Ko, 2012, A new model of the distal convoluted tubule, Am J Physiol Renal Physiol, 303, F700, 10.1152/ajprenal.00139.2012 Castaneda-Bueno, 2012, Activation of the renal Na+:Cl– cotransporter by angiotensin II is a WNK4-dependent process, Proc Natl Acad Sci USA, 109, 7929, 10.1073/pnas.1200947109 Takahashi, 2014, WNK4 is the major WNK kinase positively regulating NCC in the mouse kidney, Biosci Rep, 9, e00107, 10.1042/BSR20140047 Bazua-Valenti, 2014, The Effect of WNK4 on the Na+-Cl– cotransporter is modulated by intracellular chloride, J Am Soc Nephrol, 26, 1781, 10.1681/ASN.2014050470 Lamprecht, 2006, Chloride and bicarbonate have similar affinities to the intestinal anion exchanger DRA (down regulated in adenoma), Pflugers Arch, 452, 307, 10.1007/s00424-006-0049-6 Boettger, 2002, Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4, Nature, 416, 874, 10.1038/416874a Beck, 1988, The distribution of potassium, sodium and chloride across the apical membrane of renal tubular cells: effect of acute metabolic alkalosis, Pflugers Arch, 411, 259, 10.1007/BF00585112 Yang, 2007, The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex, J Clin Invest, 117, 3403, 10.1172/JCI32033 Vidal-Petiot, 2013, WNK1-related familial hyperkalemic hypertension results from an increased expression of L-WNK1 specifically in the distal nephron, Proc Natl Acad Sci USA, 110, 14366, 10.1073/pnas.1304230110 Statland, 1973, Factors contributing to intra-individual variation of serum constituents. 1. Within-day variation of serum constituents in healthy subjects, Clin Chem, 19, 1374, 10.1093/clinchem/19.12.1374 Pocock, 1989, Diurnal variations in serum biochemical and haematological measurements, J Clin Pathol, 42, 172, 10.1136/jcp.42.2.172 Fijorek, 2014, Serum potassium, sodium and calcium levels in healthy individuals—literature review and data analysis, Folia Med Cracov, 54, 53 Zhang, 2014, Individuality of the plasma sodium concentration, Am J Physiol Renal Physiol, 306, F1534, 10.1152/ajprenal.00585.2013 Ohno, 2011, Immunolocalization of WNK4 in mouse kidney, Histochem Cell Biol, 136, 25, 10.1007/s00418-011-0827-x Glykys, 2014, Local impermeant anions establish the neuronal chloride concentration, Science, 343, 670, 10.1126/science.1245423 Thastrup, 2012, SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation, Biochem J, 441, 325, 10.1042/BJ20111879 Xu, 2002, Regulation of WNK1 by an autoinhibitory domain and autophosphorylation, J Biol Chem, 277, 48456, 10.1074/jbc.M207917200 Vitari, 2006, Functional interactions of the SPAK/ OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1, Biochem J, 397, 223, 10.1042/BJ20060220 Naito, 2011, Regulation of WNK1 kinase by extracellular potassium, Clin Exp Nephrol, 15, 195, 10.1007/s10157-010-0378-9 McCormick, 2011, A SPAK isoform switch modulates renal salt transport and blood pressure, Cell Metab, 14, 352, 10.1016/j.cmet.2011.07.009 Grimm, 2012, SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner, J Biol Chem, 287, 37673, 10.1074/jbc.M112.402800 DeFronzo, 1980, Hyperkalemia and hyporeninemic hypoaldosteronism, Kidney Int, 17, 118, 10.1038/ki.1980.14 Batlle, 1982, Distal renal tubular acidosis with intact capacity to lower urinary pH, Am J Med, 72, 751, 10.1016/0002-9343(82)90540-X Batlle, 1981, Hyperkalemic distal renal tubular acidosis associated with obstructive uropathy, N Engl J Med, 304, 373, 10.1056/NEJM198102123040701 Yang, 2007, The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex, J Clin Invest, 117, 3403, 10.1172/JCI32033 Yang, 2005, Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport, J Clin Invest, 115, 1379, 10.1172/JCI22452 Lin, 2012, Protein phosphatase 1 modulates the inhibitory effect of with-no-lysine kinase 4 on ROMK channels, Am J Physiol Renal Physiol, 303, F110, 10.1152/ajprenal.00676.2011 Bostanjoglo, 1998, 11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules, J Am Soc Nephrol, 9, 1347, 10.1681/ASN.V981347 McCormick, 2011, Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertension, Hypertension, 58, 888, 10.1161/HYPERTENSIONAHA.110.167809 Wang, 2004, Comparison of WNK4 and WNK1 kinase and inhibiting activities, Biochem Biophys Res Commun, 317, 939, 10.1016/j.bbrc.2004.03.132 Ushiro, 1998, Molecular cloning and characterization of a novel Ste20-related protein kinase enriched in neurons and transporting epithelia, Arch Biochem Biophys, 355, 233, 10.1006/abbi.1998.0736