Unexplained international differences in clinical outcomes after acute myocardial infarction and fibrinolytic therapy: Lessons from the Hirulog and Early Reperfusion or Occlusion (HERO)-2 trial

Mackay J, Mensah G, editors. Atlas of heart disease and stroke. Geneva: World Health Organization; 2004. Available at: http://www.who.int/cardiovascular_diseases/resources/atlas/en/index.html. Last accessed June 2008. Fox, 2002, Management of acute coronary syndromes. Variations in practice and outcome. Findings from the Global Registry of Acute Coronary Events (GRACE), Eur Heart J, 23, 1177, 10.1053/euhj.2001.3081 Wong, 2002, [editorial] Has the mortality rate from acute myocardial infarction fallen substantially in recent years?, Eur Heart J, 23, 689, 10.1053/euhj.2001.3054 Kuch, 2002, What is the real hospital mortality from acute myocardial infarction? Epidemiological vs clinical view, Eur Heart J, 23, 715, 10.1053/euhj.2001.2947 Gaziano, 2005, Cardiovascular disease in the developing world and its cost-effective management, Circulation, 112, 3547, 10.1161/CIRCULATIONAHA.105.591792 Yusuf, 2005, Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation, JAMA, 293, 427, 10.1001/jama.293.4.427 Antman, 2006, Enoxaparin versus Unfractionated Heparin with Fibrinolysis for ST-Elevation Myocardial Infarction, N Engl J Med, 354, 1477, 10.1056/NEJMoa060898 Yusuf, 2006, Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial, JAMA, 295, 1519, 10.1001/jama.295.13.joc60038 Yusuf, 2001, Global burden of cardiovascular diseases. Part II: Variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies, Circulation, 104, 2855, 10.1161/hc4701.099488 Mathers, 2006, Projections of global mortality and burden of disease from 2002 to 2030, PLoS Med, 3, e442, 10.1371/journal.pmed.0030442 Gaziano, 2010, Growing epidemic of coronary heart disease in low- and middle-income countries, Curr Probl Cardiol, 35, 72, 10.1016/j.cpcardiol.2009.10.002 Orlandini, 2006, Outcomes of patients in clinical trials with ST segment elevation myocardial infarction among countries with different gross national incomes, Eur Heart J, 27, 527, 10.1093/eurheartj/ehi701 Boersma, 2003, Acute myocardial infarction, Lancet, 361, 847, 10.1016/S0140-6736(03)12712-2 McDermott, 2007, The international pandemic of chronic cardiovascular disease, JAMA, 297, 1197, 10.1001/jama.297.11.1253 Sikri, 2007, A history of streptokinase use in acute myocardial infarction, Tex Heart Inst J, 34, 318 Hirulog and Early Reperfusion or Occlusion (HERO)-2 Trial Investigators, 2001, Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 randomised trial, Lancet, 358, 1855, 10.1016/S0140-6736(01)06887-8 Akkerhuis, 2000, Geographic variability in outcomes within an international trial of glycoprotein IIb/IIIa inhibition in patients with acute coronary syndromes. Results from PURSUIT, Eur Heart J, 21, 371, 10.1053/euhj.1999.1743 Giugliano, 2001, Geographic variation in patient and hospital characteristics, management and clinical outcomes in ST-elevation myocardial infarction treated with fibrinolysis. Results from InTIME-II., Eur Heart J, 22, 1702, 10.1053/euhj.2001.2583 Domanski, 2004, Geographic variability in patient characteristics, treatment and outcome in an international trial of magnesium in acute myocardial infarction, Control Clin Trials, 25, 553, 10.1016/j.cct.2004.08.005 The World Bank World Health Organization, 2001 Austin, 2001, An introduction to multilevel regression models, Can J Public Health, 92, 150, 10.1007/BF03404950 Lee, 1995, Predictors of 30-day mortality in the era of reperfusion for acute myocardial infarction. Results from an international trial of 41 021 patients, Circulation, 91, 1659, 10.1161/01.CIR.91.6.1659 Morrow, 2001, A simple risk index for rapid initial triage of patients with ST-elevation myocardial infarction: an InTIME II substudy, Lancet, 358, 1571, 10.1016/S0140-6736(01)06649-1 The Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 Investigators, 2001, Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction, Lancet, 358, 605, 10.1016/S0140-6736(01)05775-0 The InTIME II Investigators, 2000, Intravenous NPA for the treatment of infarcting myocardium early; InTIME-II, a double-blind comparison of single-bolus lanoteplase vs accelerated alteplase for the treatment of patients with acute myocardial infarction, Eur Heart J, 21, 2005, 10.1053/euhj.2000.2498 ASSENT-2 Investigators, 1999, Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 double-blind randomized trial, Lancet, 354, 716, 10.1016/S0140-6736(99)07403-6 GUSTO V Investigators, 2001, Reperfusion therapy for acute myocardial infarction with fibrinolytic therapy or combination reduced fibrinolytic therapy and platelet glycoprotein IIb/IIIa inhibition: the GUSTO V randomized trial, Lancet, 357, 1905, 10.1016/S0140-6736(00)05059-5 GUSTO Investigators, 1993, An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction, N Engl J Med, 329, 673, 10.1056/NEJM199309023291001 Shibata, 2001, Potential impact of socioeconomic differences on clinical outcomes in international clinical trials, Am Heart J, 1411, 1019, 10.1067/mhj.2001.115529 Hasdai, 2002, A prospective survey of the characteristics, treatments and outcomes of patients with acute coronary syndromes in Europe and the Mediterranean basin. The Euro Heart Survey of Acute Coronary Syndromes, Eur Heart J, 23, 1190, 10.1053/euhj.2002.3193 Kramer, 2003, International variation in the use of evidence-based medicines for acute coronary syndromes, Eur Heart J, 24, 2133, 10.1016/j.ehj.2003.09.018 Van de Werf, 1995, Variations in patient management and outcomes for acute myocardial infarction in the United States and other countries. Results from the GUSTO trial, JAMA, 273, 1586, 10.1001/jama.1995.03520440040034 Barbash, 1993, Comparative case fatality analysis of the International Tissue Plasminogen Activator/Streptokinase Mortality Trial: variation by country beyond predictive profile, J Am Coll Cardiol, 21, 281, 10.1016/0735-1097(93)90664-M Fox, 2000, Inter-regional differences and outcome in unstable angina: analysis of the international ESSENCE trial, Eur Heart J, 21, 1433, 10.1053/euhj.1999.1983 Gupta, 2003, International differences in in-hospital revascularization and outcomes following acute myocardial infarction. A multilevel analysis of patients in ASSENT-2, Eur Heart J, 24, 1640, 10.1016/S0195-668X(03)00433-0 Kaul, 2004, International differences in evolution of early discharge after acute myocardial infarction, Lancet, 363, 511, 10.1016/S0140-6736(04)15536-0 Chang, 2005, Are international differences in the outcomes of acute coronary syndromes apparent or real? A multilevel analysis, J Epidemiol Community Health, 59, 427, 10.1136/jech.2004.024984 Reed, 2006, Geographic variation in the treatment of acute myocardial infarction in the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial, Am Heart J, 152, 500, 10.1016/j.ahj.2006.02.032 Jha, 1996, Characteristics and mortality outcomes of thrombolysis trial participants and nonparticipants: a population-based comparison, J Am Coll Cardiol, 27, 1335, 10.1016/0735-1097(96)00018-6 Steinberg, 2007, Global outcomes of ST-elevation myocardial infarction: comparisons of the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment-Thrombolysis In Myocardial Infarction study 25 (ExTRACT-TIMI 25) registry and trial, Am Heart J, 154, 54, 10.1016/j.ahj.2007.03.047 2001, Why rank countries by health performance?, Lancet, 357, 1633, 10.1016/S0140-6736(00)04853-4 Navarro, 2000, Assessment of the World Health Report, Lancet, 356, 1598, 10.1016/S0140-6736(00)03139-1