Unexpected formation of 6,7-dihydrobenzo[4′,5′]imidazo-[1′,2′: 1,6]pyrimido[5,4-a]indolizine derivative in the alkylation of 2-amino-1-(benzimidazol-2-yl)-3-(4-methoxybenzoyl)indolizine

Russian Journal of General Chemistry - Tập 81 - Trang 2172-2175 - 2011
T. A. Saraeva1, G. E. Khoroshilov1, V. S. Brovarets2, R. I. Zubatyuk3, O. V. Shishkin3
1Taras Shevchenko Lugansk National University, Lugansk, Ukraine
2Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine
3Institute of Single Crystals, National Academy of Sciences of Ukraine, Kharkov, Ukraine

Tóm tắt

An attempt to effect exhaustive alkylation of 2-amino-1-(benzimidazol-2-yl)-3-(4-methoxybenzoyl) indolizine with alkyl iodides in boiling acetone led to the formation of 6,6-dimethyl-8-(4-methoxybenzoyl)-6,7-dihydrobenzo[4′,5′]imidazo[1′,2′: 1,6]pyrimido[5,4-a]indolizine instead of expected N-alkyl derivatives. The product structure was proved by X-ray analysis.

Tài liệu tham khảo

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