Ultrasonic cardiogram and MiRNA-21 analysis of cardiac dysfunction in patients with cardiac arrest following cardiopulmonary resuscitation

Kuo, 2013, Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFκB signaling via attenuating ROS generation, Int. J. Cardiol., 168, 270, 10.1016/j.ijcard.2012.09.080 Olson, 2015, Up-regulation of MicroRNA-21 mediates isoflurane-induced protection of cardiomyocytes, Anesthesiology, 122, 795, 10.1097/ALN.0000000000000567 Tong, 2015, MiR-21 protected cardiomyocytes against doxorubicin-induced apoptosis by targeting BTG2, Int. J. Mol. Sci., 16, 14511, 10.3390/ijms160714511 Patil, 2015, Cardiac arrest: resuscitation and reperfusion, Circ. Res., 116, 2041, 10.1161/CIRCRESAHA.116.304495 Li, 2012, Argonaute 2 complexes selectively protect the circulating MicroRNAs in cell-secreted microvesicles, PLoS One, 7, e46957, 10.1371/journal.pone.0046957 Bedreag, 2016, Using circulating miRNAs as biomarkers for the evaluation and monitoring of the mitochondrial damage in the critically ill polytrauma patients, Clin. Lab., 8, 1397 Da Silva, 2017, Circulating MicroRNAs as potential biomarkers of atrial fibrillation, Biomed. Res. Int., 2017 Chen, 2014, Implication of miRNAs for inflammatory bowel disease treatment: systematic review, World J. Gastrointest. Pathophysiol., 5, 63-70, 10.4291/wjgp.v5.i2.63 Mehdipour, 2018, Diagnostic and prognostic relevance of salivary microRNA-21, -125a, -31 and -200a levels in patients with oral lichen planus - a short report, Cell. Oncol., 41, 329, 10.1007/s13402-018-0372-x Díaz-Piña, 2018, The Role of ADAR1 and ADAR2 in the regulation of miRNA-21 in idiopathic pulmonary fibrosis, Lung, 196, 393, 10.1007/s00408-018-0115-9 Cheng, 2007, MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy?, Am. J. Pathol., 170, 0, 10.2353/ajpath.2007.061170 Wang, 2010, Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans, Eur. Heart J., 31, 659, 10.1093/eurheartj/ehq013 Cheng, 2010, Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia /reperfusion injury via anti-apoptosis through its target PDCD4, Cardiovasc. Res., 87, 431, 10.1093/cvr/cvq082 Villar, 2013, Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients, Int. J. Cardiol., 167, 2875, 10.1016/j.ijcard.2012.07.021 Rooij, 2008, Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis, 105, 13027 Ham, 2015, let-7b suppresses apoptosis andautophagy of human mesenchymal stem cells transplanted intoischemia/reperfusion injured heart 7by targeting caspase-3, StemCell Res. Therapy, 6, 1 Zhou Y., Chen Q., Lew K.S., et al. Discovery of potential therapeutic miRNA targets in cardiac ischemia–reperfusion injury. J. Cardiovasc. Pharmacol. Ther., 21(3), 296–309. Lalaoui, 2015, The molecularrelationships between apoptosis, autophagy and necroptosis, Semin Cell DevBiol., 39, 63, 10.1016/j.semcdb.2015.02.003 Duan, 2012, Expression of MicroRNA-1 and MicroRNA-21 in different protocols of ischemic conditioning in an isolated rat heart model, Cardiology, 122, 36, 10.1159/000338149 Gupta, 2016, miR-21 promotes fibrosis in an acute cardiac allograft transplantation model, Cardiovasc. Res., 110, 215, 10.1093/cvr/cvw030 Sayed, 2010, MicroRNA-21 Is a Downstream Effector of AKT that mediates its antiapoptotic effects via suppression of fas ligand, J. Biol. Chem., 285, 20281, 10.1074/jbc.M110.109207 Yang, 2014, MicroRNA-21 protects against ischemiareperfusion and hypoxia reperfusion induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt dependent mechanism, Mol. Med. Rep., 9, 2213, 10.3892/mmr.2014.2068 Mathur, 2015, Assessment of cardiac function by echocardiography, Curr. Treat. Opt. Cardiovasc. Med., 17, 36, 10.1007/s11936-015-0397-7 Flato, 2015, Echocardiography for prognostication during the resuscitation of intensive care unit patients with non-shockable rhythm cardiac arrest, Resuscitation, 92, 1, 10.1016/j.resuscitation.2015.03.024 Liu, 2016, Transesophageal echocardiography to assess mitral valve movement and flow during long term cardiopulmonary resuscitation: How cardiac effects fade with time, Int. J. Cardiol., 223, 693, 10.1016/j.ijcard.2016.08.274 Preston, 2015, A description of echocardiography in life support use during cardiac arrest in an Emergency Department before and after a training programme, Eur. J. Emerg. Med., 22, 10.1097/MEJ.0000000000000231 Ozen, 2016, Assessment of ventricular wall motion with focused echocardiography during cardiac arrest to predict survival, Turk. J. Emerg. Med., 16, 12, 10.1016/j.tjem.2015.08.001 Roy, 2009, MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensinhomologue, Cardiovas Res., 82, 21, 10.1093/cvr/cvp015 Kukreja, 2011, MicroRNAs: new playersin cardiac injury and protection, Mol. Pharmacol., 80, 558, 10.1124/mol.111.073528 Thum, 2008, MicroRNA-21 contributesto myocardial disease by stimulating MAP kinase signaling in fibroblasts, Nature, 456, 980, 10.1038/nature07511