Ultra-highly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitro

Kola, 2004, Can the pharmaceutical industry reduce attrition rates?, Nat Rev Drug Discov, 3, 711, 10.1038/nrd1470 Bensoussan, 2006, Complementary and alternative medicine use by patients with inflammatory bowel disease: results from a postal survey, Gastroenterol Clin Biol, 30, 14, 10.1016/S0399-8320(06)73072-X Ernst, 2000, The role of complementary and alternative medicine in cancer, Lancet Oncol, 1, 176, 10.1016/S1470-2045(00)00031-0 U.S. Food and Drug Administration Chikramane, 2012, Why extreme dilutions reach non-zero asymptotes: a nanoparticulate hypothesis based on froth flotation, Langmuir, 28, 15864, 10.1021/la303477s Stovbun, 2012, Effects of physicochemical forms of phenazepam and Panavir on their action at ultra-low doses, Bull Exp Biol Med, 153, 455, 10.1007/s10517-012-1739-z Saha, 2013, Evidence in support of gene regulatory hypothesis: Gene expression profiling manifests homeopathy effect as more than placebo, Int J High Dilution Res, 12, 162 Bishayee, 2013, Evidence of an epigenetic modification in cell-cycle arrest caused by the use of ultra-highly-diluted Gonolobus condurango extract, J Pharmacopuncture, 16, 7, 10.3831/KPI.2013.16.024 Sikdar, 2014, Relative apoptosis-inducing potential of homeopa thic Condurango 6C and 30C in H460 lung cancer cells in vitro, J Pharmacopuncture, 17, 59, 10.3831/KPI.2014.17.008 Witt, 2007, The in vitro evidence for an effect of high homeopathic potencies — a systematic review of the literature, Complement Ther Med, 15, 128, 10.1016/j.ctim.2007.01.011 Khuda-Bukhsh, 1997, Potentized homoeopathic drugs act through regulation of gene-expression: a hypothesis to explain their mechanism and pathways of action in vitro, Complement Ther Med, 5, 43, 10.1016/S0965-2299(97)80090-8 De, 2012, Potentiated homeopathic drug Arsenicum Album 30C inhibits intracellular reactive oxygen species generation and up-regulates expression of arsenic resistance gene in arsenite-exposed bacteria Escherichia coli, J Chin Integr Med, 10, 210, 10.3736/jcim20120212 Das, 2012, Potential of the homeopathic remedy, Arnica Montana 30C, to reduce DNA damage in Escherichia coli exposed to ultraviolet irradiation through up-regulation of nucleotide excision repair genes, J Chin Integr Med, 10, 337, 10.3736/jcim20120314 Saha, 2012, Phenotypic evidence of ultra-highly diluted homeopathic remedies acting at gene expression level: a novel probe on experimental phage infectivity in bacteria, J Chin Integr Med, 10, 462, 10.3736/jcim20120416 Bell, 2012, A model for homeopathic remedy effects: low dose nanoparticles, allostatic cross-adaptation, and time-dependent sensitization in a complex adaptive system, BMC Complement Altern Med, 12, 191, 10.1186/1472-6882-12-191 Betti, 2010, A review of three simple plant models and corresponding statistical tools for basic research in homeopathy, ScientificWorldJournal, 10, 2330, 10.1100/tsw.2010.224 Sharma, 2010, Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents, Nat Rev Cancer, 10, 241, 10.1038/nrc2820 Fernandez, 2009, The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer, Genome Res, 19, 438, 10.1101/gr.083550.108 Paschos, 2010, Epigenetic reprogramming of host genes in viral and microbial pathogenesis, Trends Microbiol, 18, 439, 10.1016/j.tim.2010.07.003 Davenas, 1988, Human basophil degranulation triggered by very dilute antiserum against IgE, Nature, 333, 816, 10.1038/333816a0 Belon, 2004, Histamine dilutions modulate basophil activation, Inflamm Res, 53, 181, 10.1007/s00011-003-1242-0 Van Wijk, 1998, Homoeopathy and the mammalian cell: programmed cell recovery and new therapeutic strategies, 180 Nascarella, 2012, A method to evaluate hormesis in nanoparticle dose-responses, Dose Response, 10, 344, 10.2203/dose-response.10-025.Nascarella Demangeat, 2013, Nanosized solvent superstructures in ultramolecular aqueous dilutions: twenty years’ research using water proton NMR relaxation, Homeopathy, 102, 87, 10.1016/j.homp.2013.01.001 Montagnier, 2009, Electromagnetic detection of HIV DNA in the blood of AIDS patients treated by antiretroviral therapy, Interdiscip Sci, 1, 81, 10.1007/s12539-009-0036-7 Rey, 2003, Thermoluminescence of ultra-high dilutions of lithium chloride and sodium chloride, Physica A, 323, 67, 10.1016/S0378-4371(03)00047-5 Khuda-Bukhsh, 2003, Towards understanding molecular mechanisms of action of homeopathic drugs: an overview, Mol Cell Biochem, 253, 339, 10.1023/A:1026048907739 Saha, 2014, Berberine alters epigenetic modifications, disrupts microtubule network, and modulates HPV-18 E6-E7 oncoproteins by targeting p53 in cervical cancer cell HeLa: a mechanistic study including molecular docking, Eur J Pharmacol, 744, 132, 10.1016/j.ejphar.2014.09.048 Bellavite, 2012, Cellular and transcriptional responses of neurocytes following in vitro exposure to Gelsemium sempervirens, Int J High Dilution Res, 11, 113 Bigagli, 2014, Exploring the effects of homeopathic Apis mellifica preparations on human gene expression profiles, Homeopathy, 103, 127, 10.1016/j.homp.2014.01.003 Marotti, 2014, Transcriptome profiling of wheat seedlings following treatment with ultrahigh diluted arsenic trioxide, Evid Based Complement Alternat Med, 2014, 851263, 10.1155/2014/851263 Khuda-Bukhsh, 2014, Current trends in high dilution research with particular reference to gene regulatory hypothesis, Nucleus, 57, 3, 10.1007/s13237-014-0105-0 Sambrook, 2001, 6.28 Das, 2011, Potentized homeopathic drug Arsenicum Album 30C positively modulates protein biomarkers and gene expressions in Saccharomyces cerevisae exposed to arsenate, J Chin Integr Med, 9, 752, 10.3736/jcim20110709