Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress

Cell Research - Tập 27 Số 5 - Trang 657-674 - 2017
Hong Peng1, Jiao Yang1, Guangyi Li1, Qing You1, Wen Han1, Tianrang Li1, Daming Gao1, Xu Xie1, Byung‐Hoon Lee2, Juan Du3, Jian Hou3, Tao Zhang4, Hai Rao5, Ying Huang6, Qingrun Li1, Rong Zeng1, Lijian Hui6, Hongyan Wang1, Xia Qin7, Xuemin Zhang7, Yongning He6, Masaaki Komatsu8, Ivan Đikić9, Daniel Finley2, Ronggui Hu1
1Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai, 200031, China
2Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, 02115, MA, USA
3Department of Hematology, Changzheng Hospital, The Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China
4Department of Laboratory Medicine, Huashan Hospital, Fudan University, 12 Central Urumqi Road, Shanghai, 200040, China
5Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, 78229, Texas, USA
6Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China
7State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences, Beijing, 100850, China
8Department of Biochemistry, School of Medicine Niigata University, 757, Ichibancho, Asahimachidori, Chuo-ku, Niigata, 951-8510, Japan
9Molecular Signaling, Institute of Biochemistry II, Goethe University School of Medicine, Frankfurt am Main, 60590, Germany

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