Ubiquitin-specific protease 3 facilitates cell proliferation by deubiquitinating pyruvate kinase L/R in gallbladder cancer

Wernberg, 2014, Gallbladder cancer, Surg Clin N Am, 94, 343, 10.1016/j.suc.2014.01.009 Tsang ME, Coburn NG, Ridgway PF. Gallbladder Cancer. In: Wright FC, Escallon JE, Cukier M, Tsang ME, Haeed U, editors. Surgical Oncology Manual. New York, NY: Springer, 2016. 115–125. Acharya, 2019, Management of gallbladder cancer in India, Chin Clin Oncol, 8, 35, 10.21037/cco.2019.07.03 Misra, 2003, Carcinoma of the gallbladder, Lancet Oncol, 4, 167, 10.1016/S1470-2045(03)01021-0 Sharma, 2017, Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update, World J Gastroenterol, 23, 3978, 10.3748/wjg.v23.i22.3978 Tiwari, 2020, Epigenetic biomarkers in gallbladder cancer, Trends Cancer, 6, 540, 10.1016/j.trecan.2020.03.003 Yadav, 2020, A novel clinically based staging system for gallbladder cancer, J Natl Compr Canc Ne, 18, 151 Song, 2020, Overview of current targeted therapy in gallbladder cancer, Signal Transduct Tar, 5, 230, 10.1038/s41392-020-00324-2 Baiu, 2018, Gallbladder cancer, JAMA, 320, 1294, 10.1001/jama.2018.11815 Horgan, 2012, Adjuvant therapy in the treatment of biliary tract cancer: a systematic review and meta-analysis, J Clin Oncol, 30, 1934, 10.1200/JCO.2011.40.5381 Yan, 2018, Smad Ubiquitination Regulatory Factor 1 (Smurf1) promotes thyroid cancer cell proliferation and migration via ubiquitin-dependent degradation of Kisspeptin-1, Cell Physiol Biochem, 49, 2047, 10.1159/000493715 Fang, 2018, Ubiquitin-specific protease 3 overexpression promotes gastric carcinogenesis and is predictive of poor patient prognosis, Cancer Sci, 109, 3438, 10.1111/cas.13789 Cui, 2014, USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors, Cell Res, 24, 400, 10.1038/cr.2013.170 Cheng, 2018, Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation, Proc Natl Acad Sci USA, 115, 5546, 10.1073/pnas.1719856115 Wu, 2019, USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5, J Biol Chem, 294, 17837, 10.1074/jbc.RA119.009102 Nie, 2015, Mineralocorticoid receptor suppresses cancer progression and the Warburg effect by modulating the miR-338-3p-PKLR axis in hepatocellular carcinoma, Hepatology, 62, 1145, 10.1002/hep.27940 Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013 Deberardinis, 2008, The biology of cancer: metabolic reprogramming fuels cell growth and proliferation, Cell Metab, 7, 11, 10.1016/j.cmet.2007.10.002 Hitosugi, 2014, Post-translational modifications and the Warburg effect, Oncogene, 33, 4279, 10.1038/onc.2013.406 Yang, 2019, The NQO1/PKLR axis promotes lymph node metastasis and breast cancer progression by modulating glycolytic reprogramming, Cancer Lett, 453, 170, 10.1016/j.canlet.2019.03.054 Wang, 2019, Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression, Mol Cancer, 18, 10.1186/s12943-019-1078-z Nguyen, 2016, PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis, J Clin Invest, 126, 681, 10.1172/JCI83587 Palmer, 2006, Measuring calcium signaling using genetically targetable fluorescent indicators, Nat Protoc, 1, 1057, 10.1038/nprot.2006.172 Lancini, 2014, Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells, J Exp Med, 211, 1759, 10.1084/jem.20131436 Schwickart, 2010, Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival, Nature, 463, 103, 10.1038/nature08646 Dupont, 2009, FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination, Cell, 136, 123, 10.1016/j.cell.2008.10.051 Nagai, 2009, Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death, Mol Cell, 36, 805, 10.1016/j.molcel.2009.10.016 Savio, 2016, USP9X controls EGFR fate by deubiquitinating the endocytic adaptor Eps15, Curr Biol, 26, 173, 10.1016/j.cub.2015.11.050 Li, 2016, Ubiquitin-specific protease 4 inhibits breast cancer cell growth through the upregulation of PDCD4, Int J Mol Med, 38, 803, 10.3892/ijmm.2016.2685 Li, 2018, The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistance through YAP1 stabilization, Oncogene, 37, 2422, 10.1038/s41388-018-0134-2 Zhou, 2019, Ubiquitin-specific protease 3 targets TRAF6 for deubiquitination and suppresses IL-1β induced chondrocyte apoptosis, Biochem Bioph Res Co, 514, 482, 10.1016/j.bbrc.2019.04.163 Rhie, 2021, Ubiquitin-specific Protease 3 Deubiquitinates and stabilizes Oct4 protein in human embryonic stem cells, Int J Mol Sci, 22, 5584, 10.3390/ijms22115584 Wu, 2019, Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer, J Exp Clin Cancer Res, 38, 277, 10.1186/s13046-019-1270-4 McFarlane, 2010, The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression, Cancer Res, 70, 3329, 10.1158/0008-5472.CAN-09-4152 Zhang, 2016, Suppression of Ubiquitin-Specific Peptidase 17 (USP17) inhibits tumorigenesis and invasion in non-small cell lung cancer cells, Oncol Res, 24, 263, 10.3727/096504016X14666990347392 Chen, 2018, A novel USP9X substrate TTK contributes to tumorigenesis in non-small-cell lung cancer, Theranostics, 8, 2348, 10.7150/thno.22901 Mathupala, 2009, Hexokinase-2 bound to mitochondria: cancer's stygian link to the “Warburg Effect” and a pivotal target for effective therapy, Semin Cancer Biol, 19, 17, 10.1016/j.semcancer.2008.11.006 Lim, 2016, EGFR signaling enhances aerobic glycolysis in triple-negative breast cancer cells to promote tumor growth and immune escape, Cancer Res, 76, 1284, 10.1158/0008-5472.CAN-15-2478 Fang, 2012, MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene, J Biol Chem, 287, 23227, 10.1074/jbc.M112.373084 Laplante, 2012, mTOR signaling in growth control and disease, Cell, 149, 274, 10.1016/j.cell.2012.03.017 Cavazzoni, 2012, Overcoming acquired resistance to letrozole by targeting the PI3K/AKT/mTOR pathway in breast cancer cell clones, Cancer Lett, 323, 77, 10.1016/j.canlet.2012.03.034 Saeki, 2017, Ubiquitin recognition by the proteasome, J Biochem, 161, 113 Ohtake, 2018, K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains, Proc Natl Acad Sci USA, 115, e1401, 10.1073/pnas.1716673115 Vijayaraj, 2021, The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation, Nat Commun, 12, 10.1038/s41467-021-22979-3