Ubiquitin C-Terminal Hydrolase-L1 Activity Induces Polyubiquitin Accumulation in Podocytes and Increases Proteinuria in Rat Membranous Nephropathy

Kriz, 1996, Stability and leakiness: opposing challenges to the glomerulus, Kidney Int, 49, 1570, 10.1038/ki.1996.227 Mundel, 2002, Podocyte biology and response to injury, J Am Soc Nephrol, 13, 3005, 10.1097/01.ASN.0000039661.06947.FD Kriz, 1998, Progression of glomerular diseases: is the podocyte the culprit?, Kidney Int, 54, 687, 10.1046/j.1523-1755.1998.00044.x Kriz, 1996, A frequent pathway to glomerulosclerosis: deterioration of tuft architecture-podocyte damage-segmental sclerosis, Kidney Blood Press Res, 19, 245, 10.1159/000174083 Couser, 2006, Cellular and molecular biology of membranous nephropathy, J Nephrol, 19, 699 Hochstrasser, 1995, Ubiquitin, proteasomes, and the regulation of intracellular protein degradation, Curr Opin Cell Biol, 7, 215, 10.1016/0955-0674(95)80031-X Goldberg, 1995, Functions of the proteasome: the lysis at the end of the tunnel, Science, 268, 522, 10.1126/science.7725095 Kalderon, 1996, Protein degradation: de-ubiquitinate to decide your fate, Curr Biol, 6, 662, 10.1016/S0960-9822(09)00443-6 Rolfe, 1997, The ubiquitin-mediated proteolytic pathway as a therapeutic area, J Mol Med, 75, 5, 10.1007/s001090050081 Wilkinson, 1997, Regulation of ubiquitin-dependent processes by deubiquitinating enzymes, FASEB J, 11, 1245, 10.1096/fasebj.11.14.9409543 Wilkinson, 1989, The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase, Science, 246, 670, 10.1126/science.2530630 Hegde, 1997, Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia, Cell, 89, 115, 10.1016/S0092-8674(00)80188-9 Sakurai, 2006, Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation, J Cell Sci, 119, 162, 10.1242/jcs.02716 Liu, 2002, The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility, Cell, 111, 209, 10.1016/S0092-8674(02)01012-7 Choi, 2004, Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases, J Biol Chem, 279, 13256, 10.1074/jbc.M314124200 Gong, 2006, Ubiquitin hydrolase Uch-L1 rescues beta-amyloid–induced decreases in synaptic function and contextual memory, Cell, 126, 775, 10.1016/j.cell.2006.06.046 Chung, 2003, New insights into Parkinson's disease, J Neurol, 250, III15 Shirato, 2000, Protein gene product 9.5 is selectively localized in parietal epithelial cells of Bowman's capsule in the rat kidney, J Am Soc Nephrol, 11, 2381, 10.1681/ASN.V11122381 Diomedi-Camassei, 2005, Protein gene product 9.5 and ubiquitin are expressed in metabolically active epithelial cells of normal and pathologic human kidney, Nephrol Dial Transplant, 20, 2714, 10.1093/ndt/gfi124 Franch, 2002, Pathways of proteolysis affecting renal cell growth, Curr Opin Nephrol Hypertens, 11, 445, 10.1097/00041552-200207000-00012 Debigare, 2003, Proteolysis, the ubiquitin-proteasome system, and renal diseases, Am J Physiol Renal Physiol, 285, F1, 10.1152/ajprenal.00244.2002 Meyer-Schwesinger, 2009, A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies, J Pathol, 217, 452, 10.1002/path.2446 Salant, 1988, Experimental glomerulonephritis, Methods Enzymol, 162, 421, 10.1016/0076-6879(88)62096-9 Schiwek, 2004, Stable expression of nephrin and localization to cell-cell contacts in novel murine podocyte cell lines, Kidney Int, 66, 91, 10.1111/j.1523-1755.2004.00711.x Moffat, 2006, A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen, Cell, 124, 1283, 10.1016/j.cell.2006.01.040 Meyer-Schwesinger, 2009, Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling, Am J Physiol Renal Physiol, 296, F1088, 10.1152/ajprenal.90746.2008 Meyer, 2007, A new mouse model of immune-mediated podocyte injury, Kidney Int, 72, 841, 10.1038/sj.ki.5002450 Abramoff, 2004, Image processing with ImageJ, Biophotonics Int, 11, 36 Panzer, 2006, Compartment-specific expression and function of the chemokine IP-10/CXCL10 in a model of renal endothelial microvascular injury, J Am Soc Nephrol, 17, 454, 10.1681/ASN.2005040364 Bonegio, 2005, Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy, J Am Soc Nephrol, 16, 2063, 10.1681/ASN.2004030180 Liu, 2003, Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line, Chem Biol, 10, 837, 10.1016/j.chembiol.2003.08.010 Kundu, 2008, Autophagy: basic principles and relevance to disease, Annu Rev Pathol, 3, 427, 10.1146/annurev.pathmechdis.2.010506.091842 Finley, 1987, The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses, Cell, 48, 1035, 10.1016/0092-8674(87)90711-2 Chernova, 2003, Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of the free ubiquitin pool, J Biol Chem, 278, 52102, 10.1074/jbc.M310283200 Papa, 1993, The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene, Nature, 366, 313, 10.1038/366313a0 Swaminathan, 1999, The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast, Mol Biol Cell, 10, 2583, 10.1091/mbc.10.8.2583 Chen, 1995, Consequences of the overexpression of ubiquitin in yeast: elevated tolerances of osmostress, ethanol and canavanine, yet reduced tolerances of cadmium, arsenite and paromomycin, Biochim Biophys Acta, 1268, 59, 10.1016/0167-4889(95)00044-S Wilkinson, 2000, Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome, Semin Cell Dev Biol, 11, 141, 10.1006/scdb.2000.0164 Saigoh, 1999, Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice, Nat Genet, 23, 47, 10.1038/12647 Das, 2006, Structural basis for conformational plasticity of the Parkinson's disease–associated ubiquitin hydrolase UCH-L1, Proc Natl Acad Sci USA, 103, 4675, 10.1073/pnas.0510403103 Osaka, 2003, Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron, Hum Mol Genet, 12, 1945, 10.1093/hmg/ddg211 Vigouroux, 2004, Linkage between the proteasome pathway and neurodegenerative diseases and aging, Mol Neurobiol, 30, 201, 10.1385/MN:30:2:201 Lansbury, 2006, Improving synaptic function in a mouse model of AD, Cell, 126, 655, 10.1016/j.cell.2006.08.011 Wang, 2006, Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice, Mol Reprod Dev, 73, 40, 10.1002/mrd.20364 Ardley, 2004, UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease, J Neurochem, 90, 379, 10.1111/j.1471-4159.2004.02485.x Piotrowski, 1997, Inhibition of the 26 S proteasome by polyubiquitin chains synthesized to have defined lengths, J Biol Chem, 272, 23712, 10.1074/jbc.272.38.23712 Chen, 2005, Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake, Circ Res, 97, 1018, 10.1161/01.RES.0000189262.92896.0b Liu, 2006, Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts, FASEB J, 20, 362, 10.1096/fj.05-4869fje Hartleben, 2010, Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice, J Clin Invest, 120, 1084, 10.1172/JCI39492 Maisonneuve, 2000, Distribution of primary renal diseases leading to end-stage renal failure in the United States, Europe, and Australia/New Zealand: results from an international comparative study, Am J Kidney Dis, 35, 157, 10.1016/S0272-6386(00)70316-7 McNaught, 2002, Proteasome inhibition causes nigral degeneration with inclusion bodies in rats, Neuroreport, 13, 1437, 10.1097/00001756-200208070-00018 McNaught, 2006, Protein aggregation in the pathogenesis of familial and sporadic Parkinson's disease, Neurobiol Aging, 27, 530, 10.1016/j.neurobiolaging.2005.08.012 Apostol, 2003, A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila, Proc Natl Acad Sci USA, 100, 5950, 10.1073/pnas.2628045100 Beck, 2009, M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy, N Engl J Med, 361, 11, 10.1056/NEJMoa0810457 Kerjaschki, 1996, Molecular mechanisms of glomerular injury in rat experimental membranous nephropathy (Heymann nephritis), J Am Soc Nephrol, 7, 2518, 10.1681/ASN.V7122518 Kerjaschki, 1989, Transcellular transport and membrane insertion of the C5b-9 membrane attack complex of complement by glomerular epithelial cells in experimental membranous nephropathy, J Immunol, 143, 546, 10.4049/jimmunol.143.2.546