USP25 Deficiency Exacerbates Acute Pancreatitis via Up-Regulating TBK1–NF-κB Signaling in Macrophages

Cellular and Molecular Gastroenterology and Hepatology - Tập 14 - Trang 1103-1122 - 2022
Xin Liu1, Wu Luo2, Jiahao Chen1, Chenghong Hu1, Rumbidzai N. Mutsinze1, Xu Wang1, Yanmei Zhang3, Lijiang Huang4, Wei Zuo4, Guang Liang1,3, Yi Wang1,4
1Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China
2Medical Research Center, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China
3School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang, China
4Department of Gastroenterology, Affiliated Xiangshan Hospital of Wenzhou Medial University, Xiangshan, Zhejiang, China

Tài liệu tham khảo

Petrov, 2019, Global epidemiology and holistic prevention of pancreatitis, Nat Rev Gastroenterol Hepatol, 16, 175, 10.1038/s41575-018-0087-5 Volzke, 2005, Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence, Digestion, 71, 97, 10.1159/000084525 Gukovskaya, 2016, New insights into the pathways initiating and driving pancreatitis, Curr Opin Gastroenterol, 32, 429, 10.1097/MOG.0000000000000301 Yadav, 2010, The role of alcohol and smoking in pancreatitis, Nat Rev Gastroenterol Hepatol, 7, 131, 10.1038/nrgastro.2010.6 Boxhoorn, 2020, Acute pancreatitis, Lancet, 396, 726, 10.1016/S0140-6736(20)31310-6 Schepers, 2019, Dutch Pancreatitis Study Group. Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis, Gut, 68, 1044, 10.1136/gutjnl-2017-314657 Lee, 2019, New insights into acute pancreatitis, Nat Rev Gastroenterol Hepatol, 16, 479, 10.1038/s41575-019-0158-2 Crockett, 2018, American Gastroenterological Association Institute guideline on initial management of acute pancreatitis, Gastroenterology, 154, 1096, 10.1053/j.gastro.2018.01.032 Chen, 2020, Macrophage-derived myeloid differentiation protein 2 plays an essential role in ox-LDL-induced inflammation and atherosclerosis, EBioMedicine, 53, 10.1016/j.ebiom.2020.102706 Sendler, 2018, Cathepsin B-mediated activation of trypsinogen in endocytosing macrophages increases severity of pancreatitis in mice, Gastroenterology, 154, 704, 10.1053/j.gastro.2017.10.018 Jakkampudi, 2016, NF-kappa B in acute pancreatitis: mechanisms and therapeutic potential, Pancreatology, 16, 477, 10.1016/j.pan.2016.05.001 Watanabe, 2017, Immunopathogenesis of pancreatitis, Mucosal Immunol, 10, 283, 10.1038/mi.2016.101 Zhao, 2018, STING Signaling promotes inflammation in experimental acute pancreatitis, Gastroenterology, 154, 1822, 10.1053/j.gastro.2018.01.065 Ge, 2020, Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: a troublesome trio for acute pancreatitis, Biomed Pharmacother, 132, 10.1016/j.biopha.2020.110770 Mayer, 2000, Inflammatory mediators in human acute pancreatitis: clinical and pathophysiological implications, Gut, 47, 546, 10.1136/gut.47.4.546 Habtezion, 2015, Inflammation in acute and chronic pancreatitis, Curr Opin Gastroenterol, 31, 395, 10.1097/MOG.0000000000000195 Montecucco, 2014, Treatment with Evasin-3 abrogates neutrophil-mediated inflammation in mouse acute pancreatitis, Eur J Clin Invest, 44, 940, 10.1111/eci.12327 Folias, 2014, Aberrant innate immune activation following tissue injury impairs pancreatic regeneration, PLoS One, 9, 10.1371/journal.pone.0102125 Valero, 1999, USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2, Genomics, 62, 395, 10.1006/geno.1999.6025 Zhu, 2021, Emerging roles of ubiquitin-specific protease 25 in diseases, Front Cell Dev Biol, 9, 10.3389/fcell.2021.698751 Ding, 2017, Chloroquine attenuates lipopolysaccharide-induced inflammatory responses through upregulation of USP25, Can J Physiol Pharmacol, 95, 481, 10.1139/cjpp-2016-0303 Zhong, 2012, Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25, Nat Immunol, 13, 1110, 10.1038/ni.2427 Zhong, 2013, Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3, Sci Signal, 6, ra35, 10.1126/scisignal.2003708 Zhong, 2013, Ubiquitin-specific proteases 25 negatively regulates virus-induced type i interferon signaling, PLoS One, 8, 10.1371/journal.pone.0080976 Dawra, 2007, Development of a new mouse model of acute pancreatitis induced by administration of L-arginine, Am J Physiol Gastrointest Liver Physiol, 292, G1009, 10.1152/ajpgi.00167.2006 Hu, 2020, Macrophages in pancreatitis: mechanisms and therapeutic potential, Biomed Pharmacother, 131, 10.1016/j.biopha.2020.110693 Wang, 2010, Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression, Lab Invest, 90, 654, 10.1038/labinvest.2010.44 Lombardi, 1975, Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet, Am J Pathol, 79, 465 Lin, 2015, Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6, Proc Natl Acad Sci U S A, 112, 11324, 10.1073/pnas.1509968112 Li, 2014, miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25, Mol Cancer, 13, 166, 10.1186/1476-4598-13-166 Wang, 2020, The deubiquitinase USP25 supports colonic inflammation and bacterial infection and promotes colorectal cancer, Nat Cancer, 1, 811, 10.1038/s43018-020-0089-4 Xu, 2017, USP25 regulates Wnt signaling by controlling the stability of tankyrases, Genes Dev, 31, 1024, 10.1101/gad.300889.117 Li, 2021, Role of interleukin-17 in acute pancreatitis, Front Immunol, 12 Thomson, 2018, The immune imbalance in the second hit of pancreatitis is independent of IL-17A, Pancreatology, 18, 246, 10.1016/j.pan.2018.01.007 Peng, 2021, The role of pancreatic infiltrating innate immune cells in acute pancreatitis, Int J Med Sci, 18, 534, 10.7150/ijms.51618 Gukovskaya, 2017, Autophagy, inflammation, and immune dysfunction in the pathogenesis of pancreatitis, Gastroenterology, 153, 1212, 10.1053/j.gastro.2017.08.071 Jakkampudi, 2017, Acinar injury and early cytokine response in human acute biliary pancreatitis, Sci Rep, 7, 10.1038/s41598-017-15479-2 Wan, 2021, The role of neutrophils and neutrophil extracellular traps in acute pancreatitis, Front Cell Dev Biol, 8, 10.3389/fcell.2020.565758 Tokoro, 2020, Interactions between neutrophils and platelets in the progression of acute pancreatitis, Pancreas, 49, 830, 10.1097/MPA.0000000000001585 Merza, 2015, Neutrophil extracellular traps induce trypsin activation, inflammation, and tissue damage in mice with severe acute pancreatitis, Gastroenterology, 149, 1920, 10.1053/j.gastro.2015.08.026 Huang, 2021, Placental chorionic plate-derived mesenchymal stem cells ameliorate severe acute pancreatitis by regulating macrophage polarization via secreting TSG-6, Stem Cell Res Ther, 12, 337, 10.1186/s13287-021-02411-9 Wu, 2020, Macrophage phenotypic switch orchestrates the inflammation and repair/regeneration following acute pancreatitis injury, EBioMedicine, 58, 12, 10.1016/j.ebiom.2020.102920 Liu, 2021, MALAT1 shuttled by extracellular vesicles promotes M1 polarization of macrophages to induce acute pancreatitis via miR-181a-5p/HMGB1 axis, J Cell Mol Med, 25, 9241, 10.1111/jcmm.16844 Hoque, 2011, TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis, Gastroenterology, 141, 358, 10.1053/j.gastro.2011.03.041 Sendler, 2020, NLRP3 inflammasome regulates development of systemic inflammatory response and compensatory anti-inflammatory response syndromes in mice with acute pancreatitis, Gastroenterology, 158, 253, 10.1053/j.gastro.2019.09.040 Li, 2020, The interplay between the gut microbiota and NLRP3 activation affects the severity of acute pancreatitis in mice, Gut Microbes, 11, 1774, 10.1080/19490976.2020.1770042 Saeki, 2012, CCL2-induced migration and SOCS3-mediated activation of macrophages are involved in cerulein-induced pancreatitis in mice, Gastroenterology, 142, 10.1053/j.gastro.2011.12.054 Manohar, 2021, Novel circulating and tissue monocytes as well as macrophages in pancreatitis and recovery, Gastroenterology, 161, 2014, 10.1053/j.gastro.2021.08.033 Wen, 2019, USP25 promotes endotoxin tolerance via suppressing K48-linked ubiquitination and degradation of TRAF3 in Kupffer cells, Mol Immunol, 106, 53, 10.1016/j.molimm.2018.12.017 Shen, 2018, IL-17 induces macrophages to M2-like phenotype via NF-kappaB, Cancer Manag Res, 10, 4217, 10.2147/CMAR.S174899 Yuan, 2020, Modulation of Wnt/beta-catenin signaling in IL-17A-mediated macrophage polarization of RAW264.7 cells, Braz J Med Biol Res, 53, e9488, 10.1590/1414-431x20209488 Meng, 2021, A20/Nrdp1 interaction alters the inflammatory signaling profile by mediating K48-and K63-linked polyubiquitination of effectors MyD88 and TBK1, J Biol Chem, 297, 10.1016/j.jbc.2021.100811 Zhao, 2016, Inhibition of osteopontin reduce the cardiac myofibrosis in dilated cardiomyopathy via focal adhesion kinase mediated signaling pathway, Am J Transl Res, 8, 3645 Sui, 2021, SARS-CoV-2 membrane protein inhibits type I interferon production through ubiquitin-mediated degradation of TBK1, Front Immunol, 12, 10.3389/fimmu.2021.662989 Park, 2018, HIF1-alpha regulates acinar cell function and response to injury in mouse pancreas, Gastroenterology, 154, 1630, 10.1053/j.gastro.2018.01.037 Jancso, 2020, Mutation that promotes activation of trypsinogen increases severity of secretagogue-induced pancreatitis in mice, Gastroenterology, 158, 1083, 10.1053/j.gastro.2019.11.020 Dawra, 2008, An improved method for extracting myeloperoxidase and determining its activity in the pancreas and lungs during pancreatitis, Pancreas, 37, 62, 10.1097/MPA.0b013e3181607761 Romac, 2018, Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis, Nat Commun, 9, 1715, 10.1038/s41467-018-04194-9 Wildi, 2007, Suppression of transforming growth factor beta signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations, Gut, 56, 685, 10.1136/gut.2006.105833 Hernandez, 2020, Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy, Sci Transl Med, 12, 10.1126/scitranslmed.aay5186 Kawabata, 1988, Highly sensitive peptide-4-methylcoumaryl-7-amide substrates for blood-clotting proteases and trypsin, Eur J Biochem, 172, 17, 10.1111/j.1432-1033.1988.tb13849.x Gukovskaya, 2002, Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis, Gastroenterology, 122, 974, 10.1053/gast.2002.32409 Gukovsky, 2004, Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells, Gastroenterology, 126, 554, 10.1053/j.gastro.2003.11.017