Type IIB von Willebrand Disease: Role of Qualitative Defects in Atherosclerosis and Endothelial Dysfunction

Clinical and Applied Thrombosis/Hemostasis - Tập 13 Số 4 - Trang 384-390 - 2007
Franca Bilora1, Ezio Zanon1, Alessandra Casonato1, Antonella Bertomoro1, F Petrobelli1, Monica Cavraro1, Enrico Campagnolo1, Antonio Girolami1
1Clinica Medica , Università di Padova, Padova, Italy?

Tóm tắt

Objective. To verify whether a hereditary bleeding tendency, such as von Willebrand disease (vWD) type IIB, protects against the onset of atherosclerosis. Participants and Methods. Twenty-four patients with vWD type IIB and 24 healthy controls, matched for common atherosclerotic risk factors. All patients were evaluated by color Doppler ultrasound of the common carotid, carotid bifurcation, common femoral artery, brachial artery, and abdominal aorta, investigating intima-media thickness (IMT) and presence of plaques in each arterial district. Flow mediated dilation (FMD) of the brachial artery was used to test endothelial function. Results. vWD type IIB patients presented no significant difference in IMT in any arterial district. FMD showed no differences between the 2 groups. Conclusions. The quantitative clotting defect characteristic of vWD type IIB does not seem to protect against atherosclerosis.

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Tài liệu tham khảo

Viles-Gonzalez JF, 2004, Mt Sinai J Med., 71, 197

10.1046/j.1538-7836.2003.00260.x

Barbui T., 1997, Br J Haematol., 35, 101

10.1111/j.1538-7836.2003.00523.x

10.1161/01.CIR.96.4.1102

10.1056/NEJM199503093321003

10.1161/01.CIR.98.4.294

Folsom AR, 1999, Circulation., 100, 736, 10.1161/01.CIR.100.7.736

10.1046/j.1365-2362.1997.2180766.x

10.1016/S1537-1891(02)00295-1

10.1161/01.RES.51.5.587

10.1161/01.ATV.5.1.67

10.1073/pnas.95.16.9524

10.1182/blood.V98.5.1424

10.1111/j.0954-6820.1966.tb02860.x

10.1002/ajh.2830440414

10.1055/s-0038-1649665

10.1161/hc3501.094232

10.1161/01.CIR.0000112567.53841.10

Tierney LM, 2000, Current Medical Diagnosis and Treatment, 39

10.1161/01.CIR.74.6.1399

Salonen JT, 1993, Circulation., 87, II

10.1161/01.STR.27.4.695

10.1172/JCI114688

10.1161/01.CIR.0000012543.55874.47

10.1016/S0002-9149(00)00857-2

10.1161/01.CIR.99.25.3227

10.1016/S0735-1097(01)01746-6

10.1161/01.CIR.92.12.3431

10.1002/clc.4960230805

10.1161/01.ATV.19.11.2795

10.1038/21224

10.1093/oxfordjournals.aje.a116078

10.1161/01.ATV.14.12.1885

Burke GL, 1995, Stroke, 96, 1432

10.1016/S0021-9150(00)00665-1

10.1097/00004424-200012000-00001

10.1055/s-0037-1613341

Castman G., 2003, Haematologica., 88, 94

10.1161/01.RES.51.5.587

10.1182/blood.V98.5.1424

10.1182/blood.V98.5.1424

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Thông tin xuất bản

Clinical and Applied Thrombosis/Hemostasis

Tập 13 Số 4

384-390

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