Type 2 diabetes mellitus, cognitive impairment and dementia

Diabetic Medicine - Tập 16 Số 2 - Trang 93-112 - 1999
Robert Stewart1, Danae Liolitsa2
1Section of Old Age Psychiatry, Institute of Psychiatry, London, UK
2Department of Neuroscience, Institute of Psychiatry, London, UK

Tóm tắt

Summary Aims We set out to examine the evidence for an association between cognitive impairment or dementia and the presence of Type 2 diabetes mellitus (DM). We also sought evidence of potential mechanisms for such an association. Methods A literature search of three databases was performed and the reference lists of the papers so identified were examined, using English language papers only. Results We found evidence of cross‐sectional and prospective associations between Type 2 DM and cognitive impairment, probably both for memory and executive function. There is also evidence for an elevated risk of both vascular dementia and Alzheimer’s disease in Type 2 DM albeit with strong interaction of other factors such as hypertension, dyslipidaemia and apolipoprotein E phenotype. Both vascular and non‐vascular factors are likely to play a role in dementia in diabetes. Conclusions Current classification structures for dementia may not be adequate in diabetes, where mixed pathogenesis is likely. Further research into the mechanisms of cognitive impairment in Type 2 DM may allow us to challenge the concept of dementia, at least in these patients, as an irremediable disease.Diabet. Med. 16, 93–112 (1999)

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Tài liệu tham khảo

10.1136/bmj.308.6944.1604

10.1161/01.STR.27.12.2230

10.1016/S0140-6736(96)09328-2

Meuter F, 1980, Psychometric evaluation of performance in diabetes mellitus., Horm Metab Res., 9, 9

10.1016/0002-9343(84)90186-4

Mattlar C‐E, 1985, Neuropsychological cognitive performance of patients with type‐2 diabetes., Scand J Rehab Med., 17, 101, 10.2340/165019778517101105

10.1016/0531-5565(86)90051-3

10.1080/03610738708259294

Mooradian AD, 1988, Cortical function in elderly non‐insulin dependent diabetic patients., Arch Intern Med., 148, 2369, 10.1001/archinte.1988.00380110035007

10.1007/BF02580939

10.2337/diacare.13.1.16

’Ren U, 1990, The mental efficiency of the elderly person with type II diabetes mellitus., J Am Ger Soc., 38, 505, 10.1111/j.1532-5415.1990.tb02398.x

Jagusch W, 1992, Cognitive function and metabolic state in elderly diabetic patients., Diab Nutr Metab., 5, 265

10.1016/0197-4580(92)90095-F

10.1111/j.1532-5415.1993.tb06480.x

10.1007/BF02435039

Worrall G, 1993, Effect of type II diabetes mellitus on cognitive function., J Fam Pract., 36, 639

10.2337/diacare.17.8.891

10.1016/S0011-393X(05)80266-8

10.1111/j.1464-5491.1995.tb00569.x

10.2337/diacare.18.5.681

10.1016/0168-8227(95)01150-1

10.1016/0167-4943(96)86942-1

10.1016/0167-4943(96)86911-1

10.2337/diacare.20.1.32

10.2337/diacare.20.3.438

10.1111/j.1532-5415.1997.tb00943.x

10.1037/0033-2909.110.3.451

10.1093/oxfordjournals.aje.a008974

10.1002/(SICI)1096-9136(199706)14:6<421::AID-DIA382>3.0.CO;2-F

10.1037/0021-843X.105.1.97

10.1037/0882-7974.10.1.30

10.1093/oxfordjournals.aje.a115051

10.1093/geronj/48.6.P271

Breteler MmB.Cognitive Decline in the Elderly.Published Thesis ISBN 90–90006241–6.1993.

10.1111/j.1532-5415.1993.tb01883.x

10.1001/archneur.1993.00540020040015

10.1159/000110358

10.1093/ageing/24.5.421

Kalmijn S, 1995, Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men., Diabetologia., 38, 1096, 10.1007/BF00402181

Amato L, 1996, Non‐insulin‐dependent diabetes mellitus is associated with a greater prevalence of depression in the elderly., Diabetes Metab., 22, 314

10.1046/j.1365-2796.1997.00196.x

10.1093/gerona/53A.2.M147

10.2337/diacare.20.9.1388

Harris MI, 1987, Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20–74 yr., Diabetes., 36, 523, 10.2337/diab.36.4.523

10.1007/s001250050588

10.1002/ana.410150406

10.1212/WNL.40.11.1698

10.1159/000110750

10.1136/jnnp.51.12.1489

10.1161/01.STR.28.3.526

10.1111/j.1532-5415.1988.tb01804.x

10.1111/j.1365-2796.1993.tb00684.x

10.1177/000331979304400802

10.1111/j.1532-5415.1996.tb01857.x

10.1001/archneur.1993.00540070034011

10.1212/WNL.34.7.939

10.1161/01.STR.23.9.1225

10.1002/ana.410330603

Kokeman E, 1960, Dementia after ischemic stroke: a population‐based study in Rochester., Minnesota. Neurology 1996, 19, 154

10.1161/01.STR.27.7.1205

10.1161/01.STR.29.1.75

10.1212/WNL.45.6.1161

Ott A, 1997, Risk of Dementia.

American Psychiatric Association., 1987, Diagnostic and Statistical Manual of Mental Disorders

10.1093/oxfordjournals.aje.a009106

10.1093/ajh/4.1.79S

10.1136/bmj.312.7034.801

10.2165/00003495-199200441-00026

10.1136/bmj.312.7034.805

10.1016/S0891-6632(88)80011-4

10.1161/01.CIR.85.6.2197

10.1111/j.1532-5415.1997.tb00970.x

10.1097/00004691-199503000-00004

10.2337/diacare.6.2.180

10.1037/0735-7044.107.6.926

10.1111/j.1464-5491.1993.tb00110.x

Hung J, 1984, The Minnesota Diabetes Complications Clinical Trial cognitive functions under long‐term maximized and standard metabolic controls., Diabete Metabolisme., 10, 48

10.1007/s001250050602

10.7326/0003-4819-124-4-199602150-00001

10.1007/BF00400236

10.1111/j.1464-5491.1994.tb00301.x

10.1126/science.7027439

10.2337/diacare.20.2.135

10.1159/000109800

10.1212/WNL.44.10.1885

10.1111/j.1532-5415.1996.tb00908.x

10.1212/WNL.48.3.668

10.1006/exnr.1995.1062

10.1001/jama.1997.03540340047031

10.1172/JCI115014

10.1073/pnas.89.24.12043

Chew W, 1991, Hyperglycemia augments ischemic brain injury., Am J Neuroradiol., 12, 603

10.1136/bmj.314.7090.1303

McCall AL., 1992, The impact of diabetes on the CNS., Diabetes., 41, 557, 10.2337/diab.41.5.557

10.1159/000213342

10.1007/BF00417687

10.1126/science.6338589

Mooradian AD., 1987, Blood–brain barrier choline transport is reduced in diabetic rats., Diabetes., 36, 1094, 10.2337/diab.36.10.1094

10.1007/BF00400594

Greene DA Sima Aaf Stevens MJ Feldman EL Lattimer SA.Complications: neuropathy pathogenetic considerations.Diabetes Care.; 15: 1902–251992.

10.1016/0891-6632(91)90010-M

10.1007/BF00274782

Vlassara H, 1994, Pathogenic effects of advanced glycosylation: Biochemical, biologic, and clinical implications for diabetes and aging., Lab Invest., 70, 138

10.1016/0197-4580(96)00116-9

10.1006/bbrc.1997.6944

10.1016/S0304-3940(96)13275-4

10.1006/exnr.1996.6339

10.1016/S0304-3940(97)00266-8

Ledesma MD, 1994, Analysis of microtubule‐associated protein tau glycation in paired helical filaments., J Biol Chem., 269, 21614, 10.1016/S0021-9258(17)31849-5

10.1124/mol.52.1.54

10.1038/382685a0

10.1210/en.138.5.1886

10.1212/WNL.49.5.1306

10.1073/pnas.84.23.8628

10.1073/pnas.94.9.4772

10.1038/nbt0694-591

10.1126/science.280.5363.517

10.1007/978-1-4684-5949-4_41

10.1002/mrm.1910080210

10.1016/0006-8993(84)91028-X

10.1111/j.1471-4159.1992.tb09387.x

10.1038/378785a0

10.1073/pnas.93.19.10228

Lawrence JC, 1997, New insights into the role and mechanism of glycogen synthase activation by insulin., Diabetes., 46, 541, 10.2337/diab.46.4.541

10.1074/jbc.271.48.30765

10.1007/BF00212031

10.1172/JCI118705

10.1210/jc.81.4.1657

10.1093/hmg/4.8.1313

10.1007/s001250050771

10.1016/S0306-4522(96)00577-5

10.1074/jbc.272.31.19547

10.2337/diab.37.12.1595

10.2337/diacare.20.5.792

10.1161/01.HYP.22.5.771

10.1111/j.1532-5415.1993.tb07458.x

10.1136/bmj.315.7115.1045

10.1016/0140-6736(93)91728-5

Uusitupa Mij, 1996, Apolipoprotein E phenotype modifies metabolic and hemodynamic abnormalities related to central obesity in women., Am J Clin Nutr., 64, 131, 10.1093/ajcn/64.2.131

10.1016/0021-9150(93)90096-D

10.1093/geronj/48.4.M117

10.1016/1056-8727(95)00106-9

10.1016/0168-8227(90)90042-R

10.1002/ana.410250402

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Diabetic Medicine

Tập 16 Số 2

93-112

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