Type 2 Diabetes, sarcopenic obesity and Mediterranean food pattern: Considerations about the therapeutic effect and the problem of maintaining weight loss and healthy habits. The outpatient experience of two clinical cases

Nolan, 2011, Type 2 diabetes across generations: from pathophysiology to prevention and management, Lancet, 378, 169, 10.1016/S0140-6736(11)60614-4 Samson, 2014, Metabolic syndrome, Endocrinol Metab Clin N Am, 43, 1, 10.1016/j.ecl.2013.09.009 Vladimirovna Pakhomova, 2020, Antidiabetic effects of bisamide derivative of dicarboxylic acid in metabolic disorders, Int J Mol Sci, 21 Zhang, 2020, Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation, Diabetologia, 63, 811, 10.1007/s00125-020-05090-y Plenkowska, 2020, The correlation between the MRI-evaluated ectopic fat accumulation and the incidence of diabetes mellitus and hypertension depends on body mass index and waist circumference ratio, PloS One, 15 Al-Mrabeh, 2020, Hepatic lipoprotein export and remission of human type 2 diabetes after weight loss, Cell Metabol, 31, 233, 10.1016/j.cmet.2019.11.018 Willett, 2019, Food in the Anthropocene: the EAT-Lancet Commission on healthy diets from sustainable food systems, Lancet Reynolds, 2019, Carbohydrate quality and human health: a series of systematic reviews and meta-analyses, Lancet, 10.1016/S0140-6736(18)31809-9 Tay, 2019, Low-carbohydrate diets in type 2 diabetes, Lancet Diabetes Endocrinol, 10.1016/S2213-8587(18)30368-1 Nathan, 2002, Initial management of glycemia in type 2 diabetes mellitus, N Engl J Med, 347, 1342, 10.1056/NEJMcp021106 Janssen, 2020, Burden of disease of type 2 diabetes mellitus: cost of illness and quality of life estimated using the Maastricht Study, Diabet Med, 10.1111/dme.14285 Ji, 2020, Self-management behaviors, glycemic control, and metabolic syndrome in type 2 diabetes, Nurs Res, 69, E9, 10.1097/NNR.0000000000000401 Lou, 2020, Effectiveness of a clinic-based randomized controlled intervention for type 2 diabetes management: an innovative model of intensified diabetes management in Mainland China (C-IDM study), BMJ Open Diabetes Res Care, 8, 10.1136/bmjdrc-2019-001030 Becker, 2020, Associations between self-management behavior and sociodemographic and disease-related characteristics in elderly people with type 2 diabetes - new results from the population-based KORA studies in Germany, Prim Care Diabetes, 10.1016/j.pcd.2020.01.004 Mirahmadizadeh, 2020, Adherence to medication, diet and physical activity and the associated factors amongst patients with type 2 diabetes, Diabetes Ther, 11, 479, 10.1007/s13300-019-00750-8 Alcubierre, 2020, Spanish people with type 2 diabetes show an improved adherence to the mediterranean diet, Nutrients, 12, 10.3390/nu12020560 Usitupa, 2019, Prevention of type 2 diabetes by lifestyle changes: a systematic review and meta-analysis, Nutrients, 11, 10.3390/nu11112611 Taylor, 2018, Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for β cell recovery, Cell Metabol, 28, 547, 10.1016/j.cmet.2018.07.003 Gomez Peralta, 2020, When does diabetes start? Early detection and intervention in type2 diabetes mellitus, Rev Clin Esp Wang, 2020, Promising treatment for type 2 diabetes: fecal microbiota transplantation reverses insulin resistance and impaired islets, Front Cell Infect Microbiol, 9455 Chen, 2018, Gut microbiome in obesity, metabolic syndrome, and diabetes, Curr Diabetes Rep, 18, 129, 10.1007/s11892-018-1104-3 Vallianou, 2018, Microbiome and diabetes: where are we now?, Diabetes Res Clin Pract, 146, 111, 10.1016/j.diabres.2018.10.008 Ding, 2020, Gut microbiota: closely tied to the regulation of circadian clock in the development of type 2 diabetes mellitus, Chin Med J, 133, 817, 10.1097/CM9.0000000000000702 Lean, 2018, Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial, Lancet, 391, 541, 10.1016/S0140-6736(17)33102-1 Taylor, 2018, Clinical and metabolic features of the randomised controlled diabetes remission clinical trial (DiRECT) cohort, Diabetologia, 61, 589, 10.1007/s00125-017-4503-0 Taylor, 2018, VLCD for weight loss and remission of type 2 diabetes? - authors' reply, Lancet, 392, 1307, 10.1016/S0140-6736(18)31892-0 Bagetta, 2020, Mediterranean products as promising source of multi-target agents in the treatment of metabolic syndrome, Eur J Med Chem, 186, 111903, 10.1016/j.ejmech.2019.111903 Santulli, 2019, We are what we eat: impact of food from short supply chain on metabolic syndrome, J Clin Med, 8 Esposito, 2014, Mediterranean diet and type 2 diabetes, Diabetes Metab Res Rev, 30, 34, 10.1002/dmrr.2516 Georgoulis, 2014, Mediterranean diet and diabetes: prevention and treatment, Nutrients, 6, 1406, 10.3390/nu6041406 Ramezan, 2019, Mediterranean dietary patterns and risk of type 2 diabetes in the Islamic Republic of Iran, East Mediterr Health J, 25, 896, 10.26719/emhj.19.035 Salas-Salvadò, 2019, Dietary patterns emphasizing the consumption of plant foods in the management of type 2 diabetes: a narrative review, Adv Nutr, 10, S320, 10.1093/advances/nmy102 Tuttolomondo, 2019, Metabolic and vascular effect of the mediterranean diet, Int J Mol Sci, 20 Reynolds, 2019, Carbohydrate quality and human health: a series of systematic reviews and meta-analyses, Lancet, 393, 434, 10.1016/S0140-6736(18)31809-9 Esposito, 2017, Mediterranean diet for type 2 diabetes: cardiometabolic benefits, Endocrine, 56, 27, 10.1007/s12020-016-1018-2 Ditano-Vazquez, 2019, The fluid aspect of the mediterranean diet in the prevention and management of cardiovascular disease and diabetes: the role of polyphenol content in moderate consumption of wine and olive oil, Nutrients, 11, 10.3390/nu11112833 Kaye, 2020, Deficiency of prebiotic fibre and insufficient signalling through gut metabolite sensing receptors leads to cardiovascular disease, Circulation, 141, 1393, 10.1161/CIRCULATIONAHA.119.043081 Fan, 2020, α-Linolenic acid-enriched butter attenuated high fat diet-induced insulin resistance and inflammation by promoting bioconversion of n-3 PUFA and subsequent oxylipin formation, J Nutr Biochem, 76, 108285, 10.1016/j.jnutbio.2019.108285 Romacho, 2020, DPP4 deletion in adipose tissue improves hepatic insulin sensitivity in diet-induced obesity, Am J Physiol Endocrinol Metab, 318, E590, 10.1152/ajpendo.00323.2019 Tran, 2020, “Western diet”-induced adipose inflammation requires a complex gut microbiota, Cell Mol Gastroenterol Hepatol, 9, 313, 10.1016/j.jcmgh.2019.09.009 Zinoecker, 2018, The western diet-microbiome-host interaction and its role in metabolic disease, Nutrients, 10 Churuangsuk, 2019, Lower carbohydrate and higher fat intakes are associated with higher hemoglobin A1c: findings from the UK National Diet and Nutrition Survey 2008-2016, Eur J Nutr, 10.1007/s00394-019-02122-1 2018, 55 2018, Lifestyle management: standards of medical care in diabetes—2018, Diabetes Care, 41, S38 Zamboni, 2019, Sarcopenia and obesity, Curr Opin Clin Nutr Metab Care, 22, 13, 10.1097/MCO.0000000000000519 Kim, 2015, The implications of sarcopenia and sarcopenic obesity on cardiometabolic disease, J Cell Biochem, 116, 1171, 10.1002/jcb.25077 Kreidieh, 2018, Association between sarcopenic obesity, type 2 diabetes, and hypertension in overweight and obese treatment-seeking adult women, J Cardiovasc Dev Dis, 5 Bhaskaran, 2018, Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3.6 million adults in the UK, Lancet Diabetes Endocrinol, 6, 944, 10.1016/S2213-8587(18)30288-2 Yiqiao, 2019, Within-trial cost and 1-year cost-effectiveness of the DiRECT/Counterweight-Plus weight management programme to achieve remission of type 2 diabetes, Lancet Diabetes Endocrinol, 7, 169, 10.1016/S2213-8587(18)30346-2 Lean, 2018, Keeping it off: the challenge of weight-loss maintenance, Lancet Diabetes Endocrinol, 6, 681, 10.1016/S2213-8587(17)30405-9 Soderlund, 2018, Effectiveness of motivational interviewing for improving physical activity self-management for adults with type 2 diabetes: a review, Chron Illness, 14, 54, 10.1177/1742395317699449 Bird, 2017, Update on the effects of physical activity on insulin sensitivity in humans, BMJ Open Sport Exerc Med, 2, 10.1136/bmjsem-2016-000143 Mutie, 2020, Different domains of self-reported physical activity and risk of type 2 diabetes in a population-based Swedish cohort: the Malmö diet and Cancer study, BMC Publ Health, 20, 261, 10.1186/s12889-020-8344-2 Lucas, 2019, The 21-st-century great food transformation, Lancet, 393, 386, 10.1016/S0140-6736(18)33179-9 Garber, 2017, AACE/ACE consensus steatment, managment T2D algorithm, Executive Summary Emdocr Pract, 23 Associazione Medici Diabetologi (Amd)- Società Italiana di Diabetologia (SID), 2018, 55 2018