Two discreet subsets of CD8 T cells modulate PLP91–110 induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice

Libbey, 2010, Studies in the modulation of experimental autoimmune encephalomyelitis, J Neuroimmune Pharmacol, 5, 168, 10.1007/s11481-010-9215-x Sospedra, 2005, Immunology of multiple sclerosis, Annu Rev Immunol, 23, 683, 10.1146/annurev.immunol.23.021704.115707 Tsunoda, 1996, Two models for multiple sclerosis: experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis virus, J Neuropathol Exp Neurol, 55, 673, 10.1097/00005072-199606000-00001 Luckey, 2011, Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: studies using HLA transgenic mice, J Autoimmun, 37, 122, 10.1016/j.jaut.2011.05.001 Mangalam, 2004, Identification of T cell epitopes on human proteolipid protein and induction of experimental autoimmune encephalomyelitis in HLA class II-transgenic mice, EurJ Immunol, 34, 280, 10.1002/eji.200324597 Mangalam, 2008, HLA class II transgenic mice mimic human inflammatory diseases, Adv Immunol, 97, 65, 10.1016/S0065-2776(08)00002-3 Tsuchida, 1994, Autoreactive CD8+ T-cell responses to human myelin protein-derived peptides, Proc Natl Acad Sci U S A, 91, 10859, 10.1073/pnas.91.23.10859 Jurewicz, 1998, MHC class I-restricted lysis of human oligodendrocytes by myelin basic protein peptide-specific CD8 T lymphocytes, J Immunol, 160, 3056 Biddison, 1997, Chemokine and matrix metalloproteinase secretion by myelin proteolipid protein-specific CD8+ T cells: potential roles in inflammation, J Immunol, 158, 3046 Lucchinetti, 1997, The controversy surrounding the pathogenesis of the multiple sclerosis lesion, Proc Mayo Clin, 72, 665, 10.1016/S0025-6196(11)63576-3 Bugawan, 2000, High-resolution HLA class I typing in the CEPH families: analysis of linkage disequilibrium among HLA loci, Tissue Antigens, 56, 392, 10.1034/j.1399-0039.2000.560502.x Babbe, 2000, Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction, J Exp Med, 192, 393, 10.1084/jem.192.3.393 Gay, 1997, The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. identification and characterization of the primary demyelinating lesion, Brain, 120, 1461, 10.1093/brain/120.8.1461 Lassmann, 1998, Neuropathology in multiple sclerosis: new concepts, Mult Scler, 4, 93, 10.1177/135245859800400301 Shresta, 1998, How do cytotoxic lymphocytes kill their targets?, Curr Opin Immunol, 10, 581, 10.1016/S0952-7915(98)80227-6 Trapani, 2000, Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo, Curr Opin Immunol, 12, 323, 10.1016/S0952-7915(00)00094-7 Huseby, 2001, A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis, J Exp Med, 194, 669, 10.1084/jem.194.5.669 Sun, 2001, Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice, J Immunol, 166, 7579, 10.4049/jimmunol.166.12.7579 Aristimuno, 2010, IFNbeta-1a therapy for multiple sclerosis expands regulatory CD8+ T cells and decreases memory CD8+ subset: a longitudinal 1-year study, Clin Immunol, 134, 148, 10.1016/j.clim.2009.09.008 Aristimuno, 2008, Expansion of regulatory CD8+ T-lymphocytes and fall of activated CD8+ T-lymphocytes after i.v. methyl-prednisolone for multiple sclerosis relapse, J Neuroimmunol, 204, 131, 10.1016/j.jneuroim.2008.08.009 Fletcher, 2010, T cells in multiple sclerosis and experimental autoimmune encephalomyelitis, Clin Exp Immunol, 162, 1, 10.1111/j.1365-2249.2010.04143.x Tennakoon, 2006, Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis, J Immunol, 176, 7119, 10.4049/jimmunol.176.11.7119 Zozulya, 2008, The role of CD8 suppressors versus destructors in autoimmune central nervous system inflammation, Hum Immunol, 69, 797, 10.1016/j.humimm.2008.07.014 Jiang, 1995, Murine CD8+ T cells that specifically delete autologous CD4+ T cells expressing V beta 8 TCR: a role of the Qa-1 molecule, Immunity, 2, 185, 10.1016/S1074-7613(95)80079-4 Jiang, 1992, Role of CD8+ T cells in murine experimental allergic encephalomyelitis, Science New York NY, 256, 1213, 10.1126/science.256.5060.1213 Koller, 1990, Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells, Science New York NY, 248, 1227, 10.1126/science.2112266 Das, 2000, Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis, Hum Immunol, 61, 279, 10.1016/S0198-8859(99)00135-4 Mangalam, 2008, HLA-DQ6 (DQB1*0601)-restricted T cells protect against experimental autoimmune encephalomyelitis in HLA-DR3.DQ6 double-transgenic mice by generating anti-inflammatory IFN-gamma, J Immunol, 180, 7747, 10.4049/jimmunol.180.11.7747 Pavelko, 2003, Interleukin-6 protects anterior horn neurons from lethal virus-induced injury, J Neurosci, 23, 481, 10.1523/JNEUROSCI.23-02-00481.2003 Inaba, 1992, Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor, J Exp Med, 176, 1693, 10.1084/jem.176.6.1693 Giri, 2004, 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase, J Neurosci, 24, 479, 10.1523/JNEUROSCI.4288-03.2004 Chen, 2009, Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms, Eur J Immunol, 39, 3423, 10.1002/eji.200939441 Cortesini, 2001, CD8+CD28- T suppressor cells and the induction of antigen-specific, antigen-presenting cell-mediated suppression of Th reactivity, Immunol Rev, 182, 201, 10.1034/j.1600-065X.2001.1820116.x Cosmi, 2003, Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes, Blood, 102, 4107, 10.1182/blood-2003-04-1320 Najafian, 2003, Regulatory functions of CD8+CD28- T cells in an autoimmune disease model, J Clin Invest, 112, 1037, 10.1172/JCI17935 Rifa'i, 2004, Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis, J Exp Med, 200, 1123, 10.1084/jem.20040395 Rifa'i, 2008, CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells, Int Immol, 20, 937, 10.1093/intimm/dxn052 Goverman, 2005, The role of CD8(+) T cells in multiple sclerosis and its animal models, Curr Drug Targets, 4, 239, 10.2174/1568010053586264 Whitacre, 2004, Spotlight on CD8 T cells in MS, Blood, 103, 3999, 10.1182/blood-2004-03-1148 Koh, 1992, Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice, Science New York NY, 256, 1210, 10.1126/science.256.5060.1210 Abdul-Majid, 2003, Comparing the pathogenesis of experimental autoimmune encephalomyelitis in CD4-/- and CD8-/- DBA/1 mice defines qualitative roles of different T cell subsets, J Neuroimmunol, 141, 10, 10.1016/S0165-5728(03)00210-8 Dittel, 2008, CD4 T cells: balancing the coming and going of autoimmune-mediated inflammation in the CNS, Brain Behav Immun, 22, 421, 10.1016/j.bbi.2007.11.010 Goverman, 2011, Immune tolerance in multiple sclerosis, Immunol Rev, 241, 228, 10.1111/j.1600-065X.2011.01016.x Klebb, 1996, Interleukin-2 is indispensable for development of immunological self-tolerance, Clin Immunol Immunopathol, 81, 282, 10.1006/clin.1996.0190 Filaci, 2011, CD8(+) T regulatory/suppressor cells and their relationships with autoreactivity and autoimmunity, Autoimmunity, 44, 51, 10.3109/08916931003782171 Shi, 2009, Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg, Eur J Immunol, 39, 2106, 10.1002/eji.200939314 Shi, 2008, Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells, Immunology, 124, 121, 10.1111/j.1365-2567.2007.02747.x Endharti, 2005, Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells, J Immunol, 175, 7093, 10.4049/jimmunol.175.11.7093 Willenborg, 1999, IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide, J Immunol, 163, 5278 Lee, 2008, Essential role of CD8+CD122+ regulatory T cells in the recovery from experimental autoimmune encephalomyelitis, J Immunol, 180, 825, 10.4049/jimmunol.180.2.825 Willenborg, 1996, IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis, J Immunol, 157, 3223 Zozulya, 2009, The level of B7 homologue 1 expression on brain DC is decisive for CD8 Treg cell recruitment into the CNS during EAE, Eur J Immunol, 39, 1536, 10.1002/eji.200839165