Two-dimensional superlattice films of gold nanoparticle-polystyrene composites: a bioactive platform for bone homeostasis maintenance

Springer Science and Business Media LLC - Tập 6 Số 5 - 2023
Zaikai Zhuang1, Lijuan Zheng2, Gwo‐Ching Gong3, Qiangqiang Li1, Yong Zhang1, Qiang Yong4, Yusen Huang3, Tian Liu5, Peng Wang1,6,7,2, Zhirui Guo7, Qing Jiang1,6,7
1Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, People’s Republic of China
2State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, People’s Republic of China
3Lab Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China
4Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing, People’s Republic of China
5Department of Chemical Engineering, McMaster University, Hamilton, Canada
6Institute of Medical 3D Printing, Nanjing University, Nanjing, People’s Republic of China
7Jiangsu Engineering Research Center for 3D Bioprinting, Nanjing, People’s Republic of China

Tóm tắt

AbstractOsseo-integration between the implant and bone is a crucial factor to create a strong, durable bond that allows the implant to function effectively. However, regular implant surface with poor osseo-integration ability may cause aseptic loosening, resulting in the failure of implants. Herein, a serial of macroscopic one-particle thick superlattice films generated by self-assembly of diverse size of gold nanoparticles (GNPs) were termed as SFGs and were considered as bioactive implant coatings for enhancing osseo-integration. A hydroquinone-assisted seed method is established to fabricate homogenous GNPs with controllable sizes (20, 60, and 90 nm), which were further employed as building blocks to generate macroscopic one-particle thick superlattice films of GNPs (SFGs-20, SFGs-60, and SFGs-90) with the assistance of ploystryrene. The SFGs present a size-dependent performance on bone homeostasis, where SFGs-90 demonstrated the most pronounced facilitation of osteogenic differentiation of osteoblasts as well as deactivation of osteoclasts compared with SFGs-20 and SFGs-60. Considering the universal applicability of SFGs for depositing on various substrates, these SFGs with enhanced osseo-integration capabilities could serve as a bioactive platform for surface modification of orthopedic implants, effectively addressing the issue of aseptic loosening. Graphical abstract Two-dimensional superlattice films of gold nanoparticle-polystyrene composites exhibit enhanced osteogenic-stimulation and osteoclastic-inhibition effects for regulating bone homeostasis maintenance.

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