Two-Year Course of Subfoveal Pigment Epithelial Detachment in Eyes with Age-Related Macular Degeneration and Visual Acuity Better than 20/40

Ophthalmologica - Tập 228 Số 2 - Trang 102-109 - 2012
Takayuki Baba1, Masayasu Kitahashi1, Mariko Kubota-Taniai1, Toshiyuki Oshitari1, Shuichi Yamamoto1
1Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan

Tóm tắt

<b><i>Purpose:</i></b> To investigate the course of subfoveal pigment epithelial detachments (PEDs) in eyes with age-related macular degeneration (AMD) and best-corrected visual acuity (BCVA) ≥20/40. <b><i>Methods:</i></b> Thirty-seven eyes of 35 patients with a subfoveal PED were divided into an avascular PED group (n = 11), a vascularized PED group due to polypoidal choroidal vasculopathy (PCV, n = 14) and an occult choroidal neovascularization (CNV) group (n = 12). Intravitreal bevacizumab or ranibizumab was given as needed. The BCVA, central foveal thickness, PED thickness, and lesion size were measured at baseline and at 2 years after the initial examination. <b><i>Results:</i></b> The BCVA did not change significantly in the avascular group, decreased from 0.06 ± 0.11 to 0.23 ± 0.15 logMAR units in the PCV group and from 0.12 ± 0.12 to 0.71 ± 0.70 logMAR units in the CNV group. At 2 years, the central foveal and PED thicknesses were not significantly different among the 3 groups, and the lesion was significantly larger in the PCV and CNV groups than in the avascular group. <b><i>Conclusions:</i></b> The vascularized PED cases had a poorer visual outcome than avascular PEDs with anti-VEGF drugs at the 2-year follow-up.

Từ khóa


Tài liệu tham khảo

10.1016%2Fj.ajo.2007.03.047

10.1001%2Farchopht.121.10.1392

10.1007%2Fs10384-009-0669-4

10.1038%2Feye.2008.425

10.1038%2Feye.1991.2

10.1016%2Fj.ophtha.2008.01.021

10.1007%2FBF00166756

10.1016%2Fj.ophtha.2009.12.002

10.1136%2Fbjo.65.6.417

10.1016%2FS0002-9394%2801%2901218-1

10.1001%2Farchopht.1991.01080090066027

10.1016%2Fj.ajo.2009.01.024

10.1136%2Fbjo.2006.102467

10.1016%2Fj.ajo.2009.09.020

10.1038%2Fsj.eye.6701765

10.1097%2F00006982-200112000-00017

10.1001%2Farchopht.122.4.453

10.1097%2FIAE.0b013e3180cc2612

10.1097%2FIAE.0b013e3180cc2645

10.1016%2Fj.ajo.2007.03.024

10.1136%2Fbjo.2007.137075

10.1007%2Fs00417-009-1067-9

Thông tin
Thông tin xuất bản

Ophthalmologica

Tập 228 Số 2

102-109

Thông tin tác giả