Tumors: Too sweet to remember?
Tóm tắt
Immunity, based on a natural and an educated system, is responsible for recognition and elimination of infectious particles, cellular waste, modified self and transformed cells. This dual system guarantees that dangerous particles are removed immediately after appearance and that a memory with maturated weapons exists, if the organism is re-infected by the same particle. For malignant cells, however, the immune response seems to be restricted to innate immunity, because at least for the humoral response, all so far detected tumor-specific antibodies belong to the natural immunity. In this review we try to explain why malignant cells might be "too sweet" to induce a memory.
Tài liệu tham khảo
Parham P: Innate immunity: The unsung heroes. Nature. 2003, 423 (6935): 20. 10.1038/423020a
Vollmers HP, Brandlein S: The "early birds": natural IgM antibodies and immune surveillance. Histol Histopathol. 2005, 20 (3): 927-937.
Medzhitov R: Toll-like receptors and innate immunity. Nat Rev Immunol. 2001, 1 (2): 135-145. 10.1038/35100529
Medzhitov R, Janeway CA: Decoding the patterns of self and nonself by the innate immune system. Science. 2002, 296 (5566): 298-300. 10.1126/science.1068883
Brandlein S, Pohle T, Ruoff N, Wozniak E, Muller-Hermelink HK, Vollmers HP: Natural IgM antibodies and immunosurveillance mechanisms against epithelial cancer cells in humans. Cancer Res. 2003, 63 (22): 7995-8005.
Chalifour A, Jeannin P, Gauchat JF, Blaecke A, Malissard M, N'Guyen T, Thieblemont N, Delneste Y: Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production. Blood. 2004, 104 (6): 1778-1783. 10.1182/blood-2003-08-2820
Akira S, Uematsu S, Takeuchi O: Pathogen recognition and innate immunity. Cell. 2006, 124 (4): 783-801. 10.1016/j.cell.2006.02.015
Kaisho T, Akira S: Toll-like receptor function and signaling. J Allergy Clin Immunol. 2006, 117 (5): 979-87; quiz 988. 10.1016/j.jaci.2006.02.023
Gay NJ, Gangloff M, Weber AN: Toll-like receptors as molecular switches. Nat Rev Immunol. 2006, 6 (9): 693-698. 10.1038/nri1916
Pasare C, Medzhitov R: Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol. 2005, 560: 11-18.
Klein J: Private and public antigens of the mouse H-2 system. Nature. 1971, 229 (5287): 635-637. 10.1038/229635a0
Benacerraf B, McDevitt HO: Histocompatibility-linked immune response genes. Science. 1972, 175 (19): 273-279. 10.1126/science.175.4019.273
Zinkernagel RM, Doherty PC: The discovery of MHC restriction. Immunol Today. 1997, 18 (1): 14-17. 10.1016/S0167-5699(97)80008-4
Snell GD: The immunogenetics of tumor transplantation. Cancer Res. 1952, 12 (8): 543-546.
Dausset J: [Iso-leuko-antibodies.]. Acta Haematol. 1958, 20 (1-4): 156-166.
Fuster MM, Esko JD: The sweet and sour of cancer: glycans as novel therapeutic targets. Nat Rev Cancer. 2005, 5 (7): 526-542. 10.1038/nrc1649
Nakagoe T, Sawai T, Tsuji T, Jibiki MA, Nanashima A, Yamaguchi H, Yasutake T, Ayabe H, Arisawa K, Ishikawa H: Difference in prognostic value between sialyl Lewis(a) and sialyl Lewis(x) antigen levels in the preoperative serum of gastric cancer patients. J Clin Gastroenterol. 2002, 34 (4): 408-415. 10.1097/00004836-200204000-00005
Satoh H, Ishikawa H, Yamashita YT, Takahashi H, Ishikawa S, Kamma H, Ohtsuka M, Hasegawa S: Predictive value of preoperative serum sialyl Lewis X-i antigen levels in non-small cell lung cancer. Anticancer Res. 1998, 18 (4B): 2865-2868.
Hayashi N, Nakamori S, Okami J, Nagano H, Dono K, Umeshita K, Sakon M, Narimatsu H, Monden M: Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1, 3-galactosyltransferase 5 gene in human pancreatic cancer tissue. Pathobiology. 2004, 71 (1): 26-34. 10.1159/000072959
Schroeder JA, Adriance MC, Thompson MC, Camenisch TD, Gendler SJ: MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion. Oncogene. 2003, 22 (9): 1324-1332. 10.1038/sj.onc.1206291
Kobata A, Amano J: Altered glycosylation of proteins produced by malignant cells, and application for the diagnosis and immunotherapy of tumours. Immunol Cell Biol. 2005, 83 (4): 429-439. 10.1111/j.1440-1711.2005.01351.x
Nakamura K, Tanaka Y, Shitara K, Hanai N: Construction of humanized anti-ganglioside monoclonal antibodies with potent immune effector functions. Cancer Immunol Immunother. 2001, 50 (5): 275-284. 10.1007/PL00006689
Fredman P, Hedberg K, Brezicka T: Gangliosides as therapeutic targets for cancer. BioDrugs. 2003, 17 (3): 155-167. 10.2165/00063030-200317030-00002
Le Pendu J, Marionneau S, Cailleau-Thomas A, Rocher J, Le Moullac-Vaidye B, Clement M: ABH and Lewis histo-blood group antigens in cancer. Apmis. 2001, 109 (1): 9-31. 10.1111/j.1600-0463.2001.tb00011.x
Hakomori S: Glycosylation defining cancer malignancy: new wine in an old bottle. Proc Natl Acad Sci U S A. 2002, 99 (16): 10231-10233. 10.1073/pnas.172380699
Dube DH, Bertozzi CR: Glycans in cancer and inflammation--potential for therapeutics and diagnostics. Nat Rev Drug Discov. 2005, 4 (6): 477-488. 10.1038/nrd1751
Macario AJ, Conway de Macario E: Sick chaperones, cellular stress, and disease. N Engl J Med. 2005, 353 (14): 1489-1501. 10.1056/NEJMra050111
Hendershot LM: The ER function BiP is a master regulator of ER function. Mt Sinai J Med. 2004, 71 (5): 289-297.
Misra UK, Gonzalez-Gronow M, Gawdi G, Pizzo SV: The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling. J Immunol. 2005, 174 (4): 2092-2097.
Delpino A, Piselli P, Vismara D, Vendetti S, Colizzi V: Cell surface localization of the 78 kD glucose regulated protein (GRP 78) induced by thapsigargin. Mol Membr Biol. 1998, 15 (1): 21-26.
Ma Y, Hendershot LM: The role of the unfolded protein response in tumour development: friend or foe?. Nat Rev Cancer. 2004, 4 (12): 966-977. 10.1038/nrc1505
Zhai L, Kita K, Wano C, Wu Y, Sugaya S, Suzuki N: Decreased cell survival and DNA repair capacity after UVC irradiation in association with down-regulation of GRP78/BiP in human RSa cells. Exp Cell Res. 2005, 305 (2): 244-252. 10.1016/j.yexcr.2005.01.002
Li J, Lee AS: Stress induction of GRP78/BiP and its role in cancer. Curr Mol Med. 2006, 6 (1): 45-54. 10.2174/156652406775574523
Rauschert N, Brandlein S, Holzinger E, Hensel F, Müller-Hermelink HK, Vollmers HP: A new tumor-specific variant of GRP78 as target for antibody-based therapy. Lab Invest. 2007
Hensel F, Hermann R, Schubert C, Abe N, Schmidt K, Franke A, Shevchenko A, Mann M, Muller-Hermelink HK, Vollmers HP: Characterization of glycosylphosphatidylinositol-linked molecule CD55/decay-accelerating factor as the receptor for antibody SC-1-induced apoptosis. Cancer Res. 1999, 59 (20): 5299-5306.
Hensel F, Brandlein S, Eck M, Schmidt K, Krenn V, Kloetzer A, Bachi A, Mann M, Muller-Hermelink HK, Vollmers HP: A novel proliferation-associated variant of CFR-1 defined by a human monoclonal antibody. Lab Invest. 2001, 81 (8): 1097-1108.
Brandlein S, Beyer I, Eck M, Bernhardt W, Hensel F, Muller-Hermelink HK, Vollmers HP: Cysteine-rich fibroblast growth factor receptor 1, a new marker for precancerous epithelial lesions defined by the human monoclonal antibody PAM-1. Cancer Res. 2003, 63 (9): 2052-2061.
Slovin SF, Keding SJ, Ragupathi G: Carbohydrate vaccines as immunotherapy for cancer. Immunol Cell Biol. 2005, 83 (4): 418-428. 10.1111/j.1440-1711.2005.01350.x
Chen S, Fukuda M: Cell type-specific roles of carbohydrates in tumor metastasis. Methods Enzymol. 2006, 416: 371-380. 10.1016/S0076-6879(06)16024-3
Zilka A, Landau G, Hershkovitz O, Bloushtain N, Bar-Ilan A, Benchetrit F, Fima E, van Kuppevelt TH, Gallagher JT, Elgavish S, Porgador A: Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46. Biochemistry. 2005, 44 (44): 14477-14485. 10.1021/bi051241s
Aarnoudse CA, Garcia Vallejo JJ, Saeland E, van Kooyk Y: Recognition of tumor glycans by antigen-presenting cells. Curr Opin Immunol. 2006, 18 (1): 105-111. 10.1016/j.coi.2005.11.001
Ragupathi G, Koide F, Livingston PO, Cho YS, Endo A, Wan Q, Spassova MK, Keding SJ, Allen J, Ouerfelli O, Wilson RM, Danishefsky SJ: Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates. J Am Chem Soc. 2006, 128 (8): 2715-2725. 10.1021/ja057244+
Gilboa E: The promise of cancer vaccines. Nat Rev Cancer. 2004, 4 (5): 401-411. 10.1038/nrc1359
Ragupathi G, Livingston PO, Hood C, Gathuru J, Krown SE, Chapman PB, Wolchok JD, Williams LJ, Oldfield RC, Hwu WJ: Consistent antibody response against ganglioside GD2 induced in patients with melanoma by a GD2 lactone-keyhole limpet hemocyanin conjugate vaccine plus immunological adjuvant QS-21. Clin Cancer Res. 2003, 9 (14): 5214-5220.
Wang ZG, Williams LJ, Zhang XF, Zatorski A, Kudryashov V, Ragupathi G, Spassova M, Bornmann W, Slovin SF, Scher HI, Livingston PO, Lloyd KO, Danishefsky SJ: Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens. Proc Natl Acad Sci U S A. 2000, 97 (6): 2719-2724. 10.1073/pnas.97.6.2719
Hensel F, Knorr C, Hermann R, Krenn V, Muller-Hermelink HK, Vollmers HP: Mitogenic autoantibodies in Helicobacter pylori-associated stomach cancerogenesis. Int J Cancer. 1999, 81 (2): 229-235. 10.1002/(SICI)1097-0215(19990412)81:2<229::AID-IJC11>3.0.CO;2-U
Vollmers HP, Zimmermann U, Krenn V, Timmermann W, Illert B, Hensel F, Hermann R, Thiede A, Wilhelm M, Ruckle-Lanz H, Reindl L, Muller-Hermelink HK: Adjuvant therapy for gastric adenocarcinoma with the apoptosis-inducing human monoclonal antibody SC-1: first clinical and histopathological results. Oncol Rep. 1998, 5 (3): 549-552.
Pohle T, Brandlein S, Ruoff N, Muller-Hermelink HK, Vollmers HP: Lipoptosis: tumor-specific cell death by antibody-induced intracellular lipid accumulation. Cancer Res. 2004, 64 (11): 3900-3906. 10.1158/0008-5472.CAN-03-3149
Brändlein S: The human IgM antibody SAM-6 induces tumor-specific apoptosis with oxidized low-density lipoprotein. Mol Cancer Ther. 2007, 6 (1): 326-333. 10.1158/1535-7163.MCT-06-0399