Tumor necrosis factor-α, its related immunoregulatory long non-coding RNA (THRIL) and micro-RNA 145 as potential biomarkers in lupus nephritis patients

Gheita, 2021, Adult systemic lupus erythematosus in Egypt: The nation-wide spectrum of 3661 patients and world-wide standpoint, Lupus, 30, 1526, 10.1177/09612033211014253 Lim, 2019, Racial disparities in mortality associated with systemic lupus erythematosus - Fulton and DeKalb counties, Georgia, 2002–2016, MMWR Morb Mortal Wkly Rep, 68, 419, 10.15585/mmwr.mm6818a4 Higazi, 2023, Potential role of circulating miRNA-146a and serum kallikrein 1 as biomarkers of renal disease in biopsy-proven lupus nephritis patients, Egypt Rheumatol, 45, 73, 10.1016/j.ejr.2022.11.001 Mok, 2010, Biomarkers for lupus nephritis: A critical appraisal, J Biomed Biotechnol, 2010, 638413, 10.1155/2010/638413 Fanouriakis, 2020, 2019 Update of the Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA–EDTA) recommendations for the management of lupus nephritis, Ann Rheum Dis, 79, 713, 10.1136/annrheumdis-2020-216924 Pacheco-Lugo, 2019, Plasma cytokines as potential biomarkers of kidney damage in patients with systemic lupus erythematosus, Lupus, 28, 34, 10.1177/0961203318812679 Mihaylova, 2020, Long non-coding RNAs as new biomarkers in lupus nephritis: A connection between present and future, Cureus, 12, e9003 Ghorbaninezhad, 2022, Tumor necrosis factor-α in systemic lupus erythematosus: Structure, function and therapeutic implications (Review), Int J Mol Med, 49, 1, 10.3892/ijmm.2022.5098 El-Dakrony, 2017, Clinical significance of tumor necrosis factor-α-863 C/A and -1031 T/C promoter polymorphisms in systemic lupus erythematosus patients: Relation to disease activity and damage, Egypt Rheumatol, 39, 223, 10.1016/j.ejr.2017.04.008 Azkalany, 2012, Clinical significance of serum TNFα and -308 G/A promoter polymorphism and serum Il-6 and -174 G/C promoter polymorphism in systemic lupus erythematosus patients, Egypt Rheumatol, 34, 119, 10.1016/j.ejr.2012.05.003 Statello, 2021, Gene regulation by long non-coding RNAs and its biological functions, Nat Rev Mol Cell Biol, 22, 96, 10.1038/s41580-020-00315-9 Chen, 2020, LncRNA THRIL aggravates sepsis-induced acute lung injury by regulating miR-424/ROCK2 axis, Mol Immunol, 126, 111, 10.1016/j.molimm.2020.07.021 Li, 2014, The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL, Proc Natl AcadSci U S A, 111, 1002, 10.1073/pnas.1313768111 O’Brien, 2018, Overview of microRNA biogenesis, mechanisms of actions, and circulation, Front Endocrinol (Lausanne), 3, 402, 10.3389/fendo.2018.00402 Roointan, 2023, Candidate MicroRNA Biomarkers in Lupus Nephritis: A Meta-analysis of profiling studies in kidney, blood and urine samples, Mol Diagn Ther, 27, 141, 10.1007/s40291-022-00627-w Nejad, 2018, A guide to miRNAs in inflammation and innate immune responses, FEBS J, 285, 3695, 10.1111/febs.14482 Doberstein, 2013, MicroRNA-145 Targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients, Neoplasia, 15, 10.1593/neo.121222 Liao, 2022, MiR-145 participates in the development of lupus nephritis by targeting CSF1 to regulate the JAK/STAT signaling pathway, Cytokine, 154, 10.1016/j.cyto.2022.155877 Aringer, 2019, 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus, Ann Rheum Dis, 78, 1151, 10.1136/annrheumdis-2018-214819 Petri, 2006, Combined oral contraceptives in women with systemic lupus erythematosus, Obstet Gynecol Surv, 61, 251, 10.1097/01.ogx.0000206335.34330.35 Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method, Methods, 25, 402, 10.1006/meth.2001.1262 Fouad, 2019, Diagnostic potential of metastasis-associated-lung-adenocarcinoma-transcript-1 (MALAT-1) and TNFα and hnRNPL related immunoregulatory long non-coding RNA (THRIL) in systemic lupus erythematosus patients: Relation to disease activity, Egypt Rheumatol, 41, 197, 10.1016/j.ejr.2018.11.002 Xipell, 2023, From systemic lupus erythematosus to lupus nephritis: The evolving road to targeted therapies, Autoimmun Rev, 22, 10.1016/j.autrev.2023.103404 Anders, 2020, Lupus nephritis, Nat Rev Dis Primers, 6, 7, 10.1038/s41572-019-0141-9 Sabry, 2006, Proinflammatory cytokines (TNF-alpha and IL-6) in Egyptian patients with SLE: its correlation with disease activity, Cytokine, 35, 148, 10.1016/j.cyto.2006.07.023 Mahmoud, 2005, Serum neopterin, tumor necrosis factor-α and soluble tumor necrosis factor receptor II (p75) levels and disease activity in Egyptian female patients with systemic lupus erythematosus, Clin Biochem, 38, 134, 10.1016/j.clinbiochem.2004.11.002 Tesar, 2002, Soluble cytokine receptors in renal vasculitis and lupus nephritis, Med Sci Monit, 8, BR24-9 Liu, 2023, Plasma soluble tumor necrosis factor receptor I as a biomarker of lupus nephritis and disease activity in systemic lupus erythematosus patients, Ren Fail, 45, 10.1080/0886022X.2023.2174355 Gómez, 2004, Th1/Th2 cytokines in patients with systemic lupus erythematosus: is tumor necrosis factor α protective?, Semin Arthritis Rheum, 33, 404, 10.1016/j.semarthrit.2003.11.002 Lu, 2012, Decreased microRNA(miR)-145 and increased miR-224 expression in T cells from patients with systemic lupus erythematosus involved in lupus immunopathogenesis, Clin Exp Immunol, 171, 91, 10.1111/j.1365-2249.2012.04676.x Ding, 2015, Association of miRNA-145 expression in vascular smooth muscle cells with vascular damages in patients with lupus nephritis, Int J Clin Exp Pathol, 8, 12646 Costa-Reis, 2015, The role of microRNAs and human epidermal growth factor receptor 2 in proliferative lupus nephritis, Arthritis Rheumatol, 67, 2415, 10.1002/art.39219 Cai, 2019, MicroRNA-145 involves in the pathogenesis of renal vascular lesions and may become a potential therapeutic target in patients with juvenile lupus nephritis, Kidney Blood Press Res, 44, 643, 10.1159/000500923 Lin, 2020, Expression and diagnostic value of plasma miR-145 and miR-183 in children with lupus nephritis, Zhongguo Dang Dai ErKeZaZhi, 22, 632 Duroux-Richard, 2015, MicroRNA profiling of B cell subsets from systemic lupus erythematosus patients reveals promising novel biomarkers, Int J Mol Sci, 16, 16953, 10.3390/ijms160816953 Navarro-Quiroz, 2017, Profiling analysis of circulating microRNA in peripheral blood of patients with class IV lupus nephritis, PLoS One, 12, 10.1371/journal.pone.0187973 Schwartz, 2014, The pathogenesis, diagnosis and treatment of lupus nephritis, Curr Opin Rheumatol, 26, 502, 10.1097/BOR.0000000000000089