Tumor‐associated macrophages (TAMs) as biomarkers for gastric cancer: A review

Chronic Diseases and Translational Medicine - Tập 4 - Trang 156-163 - 2018
Meri R. Räihä1, Pauli A. Puolakkainen1
1Department of Surgery, Helsinki University Hospital and University of Helsinki, Helsinki 00014, Finland

Tóm tắt

AbstractGastric adenocarcinoma is one of the most common types of cancer worldwide, with an incidence of a million new cases annually. In addition to having a high mortality rate due to often delayed detection and its poor response to cancer therapy, it also spreads aggressively. Inflammation has been shown to play a role in carcinogenesis. Consequently, macrophages are important in phagocytosis, antigen presenting and producing cytokines and growth factors. As a response to microenvironmental signals, they may polarize into tumor resisting M1 or tumor promoting M2 macrophages. Recently, studies have indicated that M2‐type macrophage resembling tumor‐associated macrophages (TAMs) might be used as an independent prognostic factor for gastric cancer. This review will discuss the possible use of TAMs as prognostic tools for gastric cancer and whether they are suitable for use in clinical environment.

Tài liệu tham khảo

10.1016/S0895-4356(02)00534-6 10.1016/j.ejca.2014.01.029 10.1158/1055-9965.EPI-13-1057 10.3322/caac.21262 10.1007/s10120-011-0041-5 10.1136/gut.33.5.606 10.3892/ol.2016.4337 Hu B., 2012, Gastric cancer: classification, histology and application of molecular pathology, J Gastrointest Oncol, 3, 251 10.1111/apm.1965.64.1.31 10.1093/annonc/mdg726 10.1155/2017/9624760 10.1007/s00424-017-1945-7 10.3390/cancers6031670 10.1155/2012/568783 10.3390/cancers8100097 10.3390/cancers9060068 Ishigami S., 2003, Tumor‐associated macrophage (TAM) infiltration in gastric cancer, Anticancer Res, 23, 4079 10.1186/1479-5876-9-216 10.3109/0284186X.2012.718444 Sarode P., 2017, LSC‐2017‐reprogramming of tumor associated macrophages by modulating Wnt/ß‐catenin signaling in lung cancer, Eur Respir J, 50, OA4859 10.1038/nrclinonc.2016.217 10.1038/bjc.2011.189 10.1186/s13045-017-0430-2 10.1016/j.ccr.2012.02.022 10.7150/ijbs.8879 10.1007/s12307-015-0173-y 10.1002/(SICI)1097-0142(20000515)88:10<2220::AID-CNCR4>3.0.CO;2-C 10.3892/or_00000873 10.1186/s12885-015-1114-3 10.1080/08820139.2016.1229790 10.5301/jbm.5000244 10.1002/eji.1830260207 10.1016/j.biopha.2015.12.004 10.1245/s10434-014-3522-z 10.2147/OTT.S103112 10.4238/gmr15049040 10.1016/j.jss.2013.08.024 10.1007/s10120-014-0422-7 10.1007/s10120-017-0713-x 10.1371/journal.pone.0050946 10.3748/wjg.v21.i34.9916 10.1002/cncr.24609 10.3748/wjg.v18.i18.2253 10.1093/annonc/mdu542 10.1371/journal.pone.0144192 10.1016/j.jprot.2012.03.046 10.2217/imt-2016-0135 10.3748/wjg.v22.i3.1202
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Chronic Diseases and Translational Medicine

Tập 4

156-163

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