Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination

Hiroki Fujimoto1,2, Masato Yoshihara2, Raymond Rodgers3, Shohei Iyoshi2,4, Kazumasa Mogi2, Emiri Miyamoto2, Sae Hayakawa2, Maia Hayashi2, Satoshi Nomura2, Kazuhisa Kitami5, Kaname Uno6,2, Mai Sugiyama7, Yoshihiro Koya7, Yoshihiko Yamakita7, Akihiro Nawa7, Atsushi Enomoto8, Carmela Ricciardelli1, Hiroaki Kajiyama2
1Discipline of Obstetrics and Gynaecology, Adelaide Medical School, Robinson Research Institute, University of Adelaide, Adelaide, Australia
2Department of Obstetrics and Gynaecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
3School of Biomedicine, Robinson Research Institute, The University of Adelaide, Adelaide, Australia
4Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg im Breisgau, Germany
5Department of Obstetrics and Gynaecology, Kitasato University School of Medicine, Sagamihara, Japan
6Division of Clinical Genetics, Department of Laboratory Medicine, Lund University Graduate School of Medicine, Lund, Sweden
7Bell Research Center-Department of Obstetrics and Gynaecology Collaborative Research, Nagoya University Graduate School of Medicine, Nagoya, Japan
8Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Tóm tắt

Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge. Further development in this field will lead to new strategies to treat EOC. In this review, we focus on the recent findings on how the TAF contributes to EOC malignancy. Furthermore, we will review the recent initiatives and future therapeutic strategies for targeting TAF in EOC.

Từ khóa


Tài liệu tham khảo