Tuftsin: On the 30-year anniversary of Victor Najjar’s discovery

Abdel–Meguid, 1987, Three-dimensional structure of a genetically engineered variant of porcine growth hormone, Proc Natl Acad Sci USA, 84, 6434, 10.1073/pnas.84.18.6434 Agarwal, 1994, Tuftsin-bearing liposomes as rifampin vehicles in treatment of tuberculosis in mice, Antimicrob Agents Chemother, 38, 588, 10.1128/AAC.38.3.588 Alekseenko, 1984, Action of proteolytic enzymes from the cytosol of human erythrocytes on tuftsin, the peptide activator of phagocytosis, Dokl Akad Nauk SSSR, 279, 226 Amoscato, 1981, Analysis of contaminants in commercial preparations of the tetrapeptide tuftsin by high-performance liquid chromatography, J Chromatogr, 205, 179, 10.1016/S0021-9673(00)81826-9 Amoscato, 1983, Receptor-mediated internalization of tuftsin by human polymorphonuclear leukocytes, J Reticuloendothel Soc, 34, 53 Amoscato, 1983, Receptor-mediated internalization of tuftsin, Ann NY Acad Sci, 419, 114, 10.1111/j.1749-6632.1983.tb37097.x Anderson, 1978, Conformational energy calculations on the contraceptive tetrapeptide H-Thr-Pro-Arg-Lys-OH, Macromolecules, 11, 812, 10.1021/ma60064a037 Arcoleo, 1997, Effect of partially modified retro-inverso-analogues derived from C-reactive protein on the induction of nitric oxide synthesis in peritoneal macrophages, Br J Pharmacol, 120, 1383, 10.1038/sj.bjp.0701050 Aronowski, 1985, Modification of morphine withdrawal, Life Sci, 37, 1649, 10.1016/0024-3205(85)90485-0 Ashmarin, 1991, The effect of tuftsin on fibrin polymerization in vitro and on the hemostatic system when administered intravenously to healthy animals, Izv Akad Nauk SSSR (Biol), 2, 302 Ashmarin, 1987, Tuftsin correction of drug-induced behavioral disturbances in rats, Biull Eksp Biol Med, 103, 178, 10.1007/BF00840332 Audhya, 1991, Bovine probursin tetradecapeptide contains amino acid sequence from somatostatin, tuftsin and bursin, Life Sci, 48, 773, 10.1016/0024-3205(91)90092-P Auriault, 1985, Regulatory role of a tripeptide (TKP) from the second constant domain of immunoglobulin G. I. Inhibition of rat and human macrophage activities, Int J Immunopharmac, 7, 73, 10.1016/0192-0561(85)90011-6 Auriault, 1983, Characterization and synthesis of a macrophage inhibitory peptide from the second constant domain of human immunoglobulin G, FEBS Lett, 153, 11, 10.1016/0014-5793(83)80109-4 Banks, 1985, Effect of tuftsin on in vivo development of 3-methylcholanthrene-induced primary fibrosarcoma and Lewis lung carcinoma in mice, J Natl Cancer Inst, 74, 1079 Bar–Shavit, 1980, Enhancement of phagocytosis—a newly found activity of substance P residing in its N-terminal tetrapeptide sequence, Biochem Biophys Res Commun, 94, 1445, 10.1016/0006-291X(80)90581-1 Bar–Shavit, 1979, Tuftsin-macrophage interaction, J Cell Physiol, 100, 55, 10.1002/jcp.1041000106 Bar–Shavit, 1982, Neurotensin—macrophage interaction, Neuropeptides, 2, 325, 10.1016/0143-4179(82)90070-1 Becherucci C, Perretti M, Nencioni L, Silvestri S, Parente L. Anti-inflammatory effect of tuftsin and its retro-inverso analogue in rat adjuvant arthritis. Agents Actions, Spec. No. 1992:C115–7. Begum, 1985, Effect of tuftsin, a neuropeptide and its derivatives on the content of nicotinamide coenzymes and the activity of cytochrome-C-oxidase of brain tissue, Ukr Biokhim Zh, 57, 82 Begum, 1985, Effect of the neuropeptide tuftsin and its derivatives on the metabolism in different brain structures, Farmakol Toksikol, 48, 41 Beretz A, Hiller Y, Gottlieb P, Fridkin M, Zakuth V, Spirer Z. The effect of tuftsin, its analogs and its conjugates with formyl chemotactic peptide on chemotaxis of human monocytes. Peptide Chemistry 1982, Osaka, Protein Res Found 1983:207–12. Bhakuni, 1986, Interactions of tuftsin with BSA, FEBS Lett, 205, 347, 10.1016/0014-5793(86)80926-7 Bhide, 1985, In vitro stimulation of macrophages by Quadrol [N,N,N′,N′-tetrakis(2-hydroxypropyl)ethylenediamine], J Immunopharmacol, 7, 303, 10.3109/08923978509026478 Bielefeldt–Ohmann, 1984, In vitro generation of hydrogen peroxide and of superoxide anion by bovine polymorphonuclear neutrophilic granulocytes, blood monocytes, and alveolar macrophages, Inflammation, 8, 251, 10.1007/BF00916415 Biondi, 1991, Synthesis of glycosylated tuftsin and tuftsin—containing Ig G fragment undecapeptide, Int J Peptide Protein Res, 37, 112, 10.1111/j.1399-3011.1991.tb00090.x Biondi, 1993, Synthesis and biological activity of [l-hydroxyproline]3-tuftsin analogue and its α- or β-O-d-glucosylated derivatives, Int J Peptide Protein Res, 41, 43, 10.1111/j.1399-3011.1993.tb00114.x Blobel, 1992, A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion, Nature, 356, 248, 10.1038/356248a0 Blok–Perkowska, 1984, Antibacterial properties of tuftsin and its analogs, Antimicrob Agents Chemother, 25, 134, 10.1128/AAC.25.1.134 Blumenstein, 1983, NMR studies of the conformation of tuftsin and a pentapeptide tuftsin inhibitor in solution, Ann NY Acad Sci, 419, 44, 10.1111/j.1749-6632.1983.tb37090.x Blumenstein, 1979, Nuclear magnetic resonance studies on the structure of tetrapeptide tuftsin, l-threonyl-l-lysyl-l-prolyl-l-arginine and its pentapeptide analogue l-threonyl-l-lysyl-l-prolyl-l-prolyl-l-arginine, Biochemistry, 18, 5247, 10.1021/bi00590a032 Bonnaud, 1982, Synthese de la tuftsine. Extrapolation, purification, choix d‘une methode en vue du developpement industriel, Boll Chim Farm, 121, 550 Bruley–Rosset, 1981, Macrophage activation by tuftsin and muramyl-dipeptide, Mol Cell Biochem, 41, 113, 10.1007/BF00225301 Bryant–Greenwood, 1991, The human relaxins, Mol Cell Endocrinol, 79, C125, 10.1016/0303-7207(91)90083-5 Buchta, 1986, Synthetic peptides from C-reactive protein containing tuftsin-related sequences, Peptides, 7, 961, 10.1016/0196-9781(86)90121-X Bulatova, 1989, Post-stress correlation of the functional activity of macrophages by tuftsin and its derivatives, Biull Eksp Biol Med, 108, 64, 10.1007/BF00839787 Bump, 1986, Isolation and subunit composition of tuftsin receptor, Proc Natl Acad Sci USA, 83, 7187, 10.1073/pnas.83.19.7187 Bump, 1984, Tuftsin (Thr-Lys-Pro-Arg), a natural modulator of macrophage activity, Mol Cell Biochem, 63, 137, 10.1007/BF00285221 Bump, 1988, Tuftsin stimulates growth of HL60 cells, FEBS Lett, 226, 303, 10.1016/0014-5793(88)81444-3 Bump, 1990, The characteristics of purified HL60 tuftsin receptors, Mol Cell Biochem, 92, 77, 10.1007/BF00220722 Caliendo, 1996, Synthesis and antinociceptive activity of peptides related to IL-1β 193–195 Lys-Pro-Thr, Biopolymers, 40, 479, 10.1002/(SICI)1097-0282(1996)40:5<479::AID-BIP5>3.0.CO;2-T Carroll, 1982, The effect of tuftsin on human monocyte cytotoxicity, J Biol Respond Modif, 1, 245 Caspritz, 1987, The immunopharmacology of immunotoxicology, and immunorestoration, Toxicol Pathol, 15, 320, 10.1177/019262338701500310 Catane, 1983, Toxicology and antitumor activity of tuftsin, Ann NY Acad Sci, 419, 251, 10.1111/j.1749-6632.1983.tb37111.x Catane, 1986, Initial clinical studies with tuftsin, Int J Immunother, 11, 81 Chan, 1994, Actions of selected proteins, peptides and amino acid derivatives on mouse embryonic development in vitro, Gen Pharmacol, 25, 1611, 10.1016/0306-3623(94)90362-X Chaudhuri, 1983, The similarity between tuftsin (Thr-Lys-Pro-Arg) receptors and tuftsin antibody, Ann NY Acad Sci, 419, 135, 10.1111/j.1749-6632.1983.tb37098.x Chaudhuri, 1981, Tuftsin receptor and tuftsin antibody show identical binding properties, Fed Proc, 40, 1737 Chebotareva, 1988, Comparative analysis of the morphochemical changes in the visual and sensorimotor cortical neurons of rats exposed to tuftsin, Tsitologiia, 30, 76 Chebotareva, 1990, A comparative analysis of the morphochemical changes in the neurons of the visual and sensorimotor cortices and the nucleus accumbens of rats administered tuftsin, Tsitologiia, 32, 41 Chipens, 1981, Elongated and cyclic analogues of tuftsin and rigin, 445 Chu, 1985, Effects of tuftsin on postsplenectomy sepsis, Surgery, 97, 701 Chu, 1990, Tuftsin increases survival in murine peritoneal carcinomatosis, J Biol Respond Modif, 9, 264 Churchill, 1991, Protein motifs that recognize structural features of DNA, TIBS, 16, 92 Cillari, 1994, The macrophage-activating tetrapeptide tuftsin induces nitric oxide synthesis and stimulates murine macrophages to kill Leishmania parasites in vitro, Infect Immun, 62, 2649, 10.1128/IAI.62.6.2649-2652.1994 Coleman, 1986, Regulation of macrophage phagocytosis, Eur J Clin Microbiol, 5, 1, 10.1007/BF02013451 Constantopoulos, 1972, Tuftsin, a natural and general phagocytosis-stimulating peptide affecting macrophages and polymorphonuclear granulocytes, Cytobios, 6, 97 Constantopoulos, 1973, Requirement for membrane sialic acid in the stimulation of phagocytosis by the natural tetrapeptide, tuftsin, J Biol Chem, 248, 3819, 10.1016/S0021-9258(19)43807-6 Constantopoulos, 1972, Tuftsin deficiency, J Pediatr, 80, 564, 10.1016/S0022-3476(72)80051-9 Corazza, 1991, Tuftsin deficiency in AIDS, Lancet, 337, 12, 10.1016/0140-6736(91)93331-3 Cornaglia–Ferraris, 1986, Sensory neuropeptides (substance P) and 4–11 SP enhance human neutrophils chemiluminescence; the role of l-arginine, Int J Immunopharmacol, 8, 463, 10.1016/0192-0561(86)90133-5 Csaba, 1986, Effect of tuftsin on the phagocytotic activity of the unicellular Tetrahymena. Does primary interaction develop imprinting?, Z Naturforsch (C), 41, 805, 10.1515/znc-1986-7-824 D’Ursi, 1992, Solution conformation of tuftsin, Biochemistry, 31, 9581, 10.1021/bi00155a010 Dagan, 1986, The tuftsin receptors, Receptors, 3, 243, 10.1016/B978-0-12-185203-0.50014-8 Dagan, 1986, Tuftsin analogues, J Med Chem, 29, 1961, 10.1021/jm00160a027 Dagan, 1987, Tuftsin and tuftsin conjugates potentiate immunogenic processes, J Biol Respond Modif, 6, 625 Dagan, 1988, Antigen-tuftsin conjugate signals IL-1 synthesis and secretion, J Biol Respond Modif, 7, 546 De Angelis, 1994, Analysis of a bioactive synthetic analogue of tuftsin by tandem mass spectrometry, Biol Mass Spectrom, 23, 262, 10.1002/bms.1200230504 Delmas, 1992, Studies on the influence of different cross-linking reagents on the immune response against a B-epitope, Bioconjug Chem, 3, 80, 10.1021/bc00013a013 Devillier, 1985, Peptides and histamine release from peritoneal mast cells, Eur J Pharmacol, 117, 89, 10.1016/0014-2999(85)90475-3 Dhawan, 1995, Polytuftsin, Immunol Lett, 46, 177, 10.1016/0165-2478(95)00044-6 Diezel, 1989, Immunostimulants-therapeutic aspects, Arch Geschwulstforsch, 59, 45 Dovedova, 1986, Effect of tuftsin on cerebral monoamine oxidase and acetylcholinesterase activity, Biull Eksp Biol Med, 102, 155, 10.1007/BF00836190 Dovedova, 1995, Effect of the tetrapeptide tuftsin on activity of the monoaminergic system of the brain in experimental pathology, Vopr Med Khim, 41, 23 Fatma, 1994, Chemotherapy of experimental filariasis, Acta Trop, 57, 55, 10.1016/0001-706X(94)90093-0 Ferreira, 1988, IL-1β as a potent hyperalgesic agent antagonized by a tripeptide analogue, Nature, 334, 698, 10.1038/334698a0 Fiedel, 1988, Influence of tuftsin-like synthetic peptides derived from C- reactive protein (CRP) on platelet behavior, Immunology, 64, 487 Filippini, 1989, Modulation of phagocytic activity in cultured Sertoli cells, Gametae Res, 23, 367, 10.1002/mrd.1120230402 Filira, 1990, Synthesis of O-glycosylated tuftsins by utilizing threonine derivatives containing an unprotected monosaccharide moiety, Int J Peptide Protein Res, 36, 85 Fitzwater, 1978, Conformational energy study of tuftsin, Macromolecules, 11, 805, 10.1021/ma60064a036 Florentin, 1978, In vivo immunostimulation by tuftsin, Cancer Immunol Immunother, 5, 211, 10.1007/BF00199631 Florentin, 1986, In vitro immunopharmacological properties of tuftsin (Thr-Lys-Pro-Arg) and some analogues, Methods Find Exp Clin Pharmacol, 8, 73 Fridkin, 1981, Tuftsin, Thr-Lys-Pro-Arg. Antatomy of immunologically active peptide, Mol Cell Biochem, 41, 73, 10.1007/BF00225299 Fridkin, 1989, Tuftsin, Crit Rev Biochem Mol Biol, 24, 1, 10.3109/10409238909082550 Fridkin, 1977, Tuftsin and some analogs. Synthesis and interaction with human polymorphonuclear leukocytes, Biochim Biophys Acta, 496, 203, 10.1016/0304-4165(77)90129-5 Fulcrand, 1991, Synthesis of tuftsin and postin by the combined use of Mtr and Pmc arginine side chain protections and OBg ester C-terminal protection, 98 Galasik–Bartoszek, 1991, [Hyp3]-tuftsin ([Hyp3]-TU) synthesis and biological activity, Int J Peptide Protein Res, 38, 176, 10.1111/j.1399-3011.1991.tb01426.x Gamalei, 1988, Use of fluorescein diacetate for research on macrophage activation, Tsitologiia, 30, 1426 Gamalei, 1989, Macrophage activation by synthetic peptides. I. Kinetic changes in the transport of fluorescein anions across the plasma membrane of macrophages, Tsitologiia, 31, 1050 Gamalei, 1989, Macrophage activation by synthetic peptides. II. The effect of oxidative burst products on the fluorescence kinetics of macrophages stained with fluorescein diacetate, Tsitologiia, 31, 1238 Gamalei, 1991, Macrophage activation by synthetic peptides. III. Changes in the membrane potential, Ca+2 content and the regulatory decrease of macrophage volume under the action of tuftsin and its antagonist, Tsitologiia, 33, 69 Gershonov, 1996, 1-Aminocyclobutanecarboxylic acid derivatives as novel structural elements in bioactive peptides, J Med Chem, 39, 4833, 10.1021/jm960390t Gershtein, 1997, Morphochemical changes in brain structures in the course of chronic haloperidol treatment and the correction of these changes with tuftsin, Mol Chem Neuropathol, 30, 213, 10.1007/BF02815099 Gershtein, 1990, The effect of tuftsin on various aspects of metabolism in the sensorimotor system of the animal brain, Vopr Med Khim, 36, 15 Gottlieb, 1982, Tuftsin analogs for probing its specific receptor site on phagocytic cells, Eur J Biochem, 125, 631, 10.1111/j.1432-1033.1982.tb06729.x Gottlieb, 1984, Receptor-mediated endocytosis of tuftsin by macrophage cells, Biochem Biophys Res Commun, 119, 203, 10.1016/0006-291X(84)91639-5 Gottlieb, 1983, Tuftsin receptors, Ann NY Acad Sci, 419, 93, 10.1111/j.1749-6632.1983.tb37095.x Gottlieb, 1983, Peptide fragments from the tuftsin containing domain of immunoglobulin G. Synthesis and biological activity, Biochem Biophys Res Commun, 115, 193, 10.1016/0006-291X(83)90988-9 Granoth, 1997, Tuftsin-THF-γ2 chimeric peptides, Immunopharmacology, 37, 43, 10.1016/S0162-3109(97)00002-7 Gupta, 1986, Protection of mice against Plasmodium berghei infection by a tuftsin derivative, FEBS Lett, 205, 351, 10.1016/0014-5793(86)80927-9 Guru, 1989, Drug targeting in Leishmania donovani infections using tuftsin-bearing liposomes as drug vehicles, FEBS Lett, 245, 204, 10.1016/0014-5793(89)80222-4 Hart, 1987, Steroids and tuftsin fail to prevent the induction of altered plasma proteinase homeostasis in mice bearing the B16 melanoma or treated with C. parvum, Int J Immunopharmacol, 9, 669, 10.1016/0192-0561(87)90037-3 Hartung, 1983, Tuftsin stimulates the release of oxygen radicals and thromboxane from macrophages, Immunol Lett, 6, 1, 10.1016/0165-2478(83)90021-4 He, 1989, Effect of splenectomy on phagocytic function of leukocytes, Chung Hua Wai Ko Tsa Chih, 27, 354 Henderson, 1979, Amino acid sequence homology between histone H5 and murine leukemia virus phosphoprotein p12, Science, 203, 1346, 10.1126/science.218289 Herman, 1984, Interaction on the antinociceptive effect between neurotensin and enkephalins or tuftsin, Acta Physiol Pol, 35, 442 Herman, 1985, l-Prolyl-l-arginyl fragment of tuftsin peptide chain elicits analgesic action, Naturwissenschaften, 72, 85, 10.1007/BF00508137 Herman, 1983, Central effects of tuftsin, Ann NY Acad Sci, 419, 156, 10.1111/j.1749-6632.1983.tb37100.x Herman, 1981, Tuftsin and d-Arg3-tuftsin possess analgesic action, Experientia, 37, 76, 10.1007/BF01965580 Herman, 1980, Analgesic activity of some tuftsin analogs, Naturwissenschaften, 67, 613, 10.1007/BF00396552 Hisatsune, 1978, Structure-activity relationship of tuftsin, a phagocytosis-stimulating peptide, and its analogs, Chem Pharm Bull, 26, 1006, 10.1248/cpb.26.1006 Holland, 1990, Interferon-gamma potentiates antibody affinity in mice with a genetically controlled defect in affinity maturation, Clin Exp Immunol, 82, 221, 10.1111/j.1365-2249.1990.tb05430.x Horsmanheimo, 1978, Effect of tuftsin on migration of polymorphonuclear and mononuclear human leukocytes in leukocyte migration agarose test, Clin Immunol Immunopathol, 11, 251, 10.1016/0090-1229(78)90048-X Ilin, 1986, Various neurochemical aspects of the action of the tetrapeptide tuftsin on limbic system structures, Arkh Anat Gistol Embriol, 90, 53 Ivanov, 1991, Synthetic carriers and adjuvants increase immunogenicity of the synthetic peptide, B-epitope from CS-protein of Plasmodium falciparum, Bioorg Khim, 17, 732 Ivanov, 1994, Dituftsin and polytuftsin induce an anti-peptide Ig G response to non-immunogenic peptides in mice, Immunol Invest, 23, 201, 10.3109/08820139409087800 Iyer, 1990, Modulation of human lepromatous monocyte-macrophage functions in vitro by tuftsin, Int J Immunopharmac, 12, 847, 10.1016/0192-0561(90)90004-7 Iyer, 1990, Effect of tuftsin stimulation on the microbicidal activity exerted by blood monocyte-macrophages of leprosy patients, Int J Immunopharmac, 12, 859, 10.1016/0192-0561(90)90005-8 Joshi, 1992, γ-Tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation, Nature, 356, 80, 10.1038/356080a0 Kahn, 1986, The design and synthesis of a nonpeptide mimic of an immunosuppressing peptide, Tetrahedron Lett, 27, 4841, 10.1016/S0040-4039(00)85077-7 Kain, 1989, Human peritoneal macrophage activity is increased by tuftsin, Immunol Lett, 21, 257, 10.1016/0165-2478(89)90113-2 Kamenskii, 1986, Temporal characteristics of the behavioral effects of tuftsin, Biull Eksp Biol Med, 101, 55 Kamenskii, 1988, Effect of the immunostimulator tuftsin on the heart rate and body temperature of albino rats, Fiziol Zh SSSR, 74, 547 Kamenskii, 1989, The selective action of the tetrapeptide tuftsin on the central nervous system when administered intranasally, Zh Vyssh Nerv Deiat, 39, 767 Kamysheva, 1989, Effect of tuftsin on the leucyl aminopeptidase activity of the subcellular components in cerebral cortical formation, Biull Eksp Biol Med, 107, 209, 10.1007/BF00833810 Kaur, 1991, Enzyme immunoassay of phagocytosis stimulating tetrapeptide “tuftsin” in normal and leprosy sera, Int J Lepr Other Mycobact Dis, 59, 576 Kaurov, 1986, Synthesis and biological activity of immunoglobulin G peptide fragments, Chem Pept Proteins, 3, 63 Kavai, 1981, Chemotactic and stimulating effect of tuftsin and its analogues on human monocytes, Immunol Lett, 2, 219, 10.1016/0165-2478(81)90046-8 Kazanowska, 1987, The influence of synthetic tuftsin and its analogs on the function of granulocytes of children with acute lymphoblastic leukemia, Arch Immunol Ther Exp, 35, 169 Kent, 1973, Polypeptide from oviductal contents that influences ovarian function, Biol Reprod, 8, 38, 10.1093/biolreprod/8.1.38 Khanasari, 1990, A thymosin-tuftsin conjugate as a new potential immunomodulator in cattle, Adv Vet Sci Comp Med, 35, 161, 10.1016/B978-0-12-039235-3.50012-5 Khare, 1993, Modulation of peripheral blood derived monocytes/macrophages from leprosy patients using ‘tuftsin’ for production of reactive oxygen intermediates, Lepr Rev, 64, 208 Khare, 1997, Quantitative assessment of tuftsin receptor expression and second messenger during in vitro differentiation of peripheral blood derived monocytes of leprosy patients, Mol Cell Biochem, 171, 1, 10.1023/A:1006861509742 Khare, 1997, Release of reactive nitrogen intermediates from the peripheral blood-derived monocytes/macrophages of leprosy patients stimulated in vitro by tuftsin, Lepr Rev, 68, 16 Kimura, 1992, Structure and expression of a human oxytocin receptor, Nature, 356, 526, 10.1038/356526a0 Klegeris, 1994, Rat brain microglia and peritoneal macrophages show similar responses to respiratory burst stimulants, J Neuroimmunol, 53, 83, 10.1016/0165-5728(94)90067-1 Klusha, 1987, Neuroimmunoregulatory properties of short protein fragments in rats exposed to immobilization stress, Biull Eksp Biol Med, 104, 186 Knyszynski, 1983, Inhibition by tuftsin of Rauscher virus leukemia development in mice, J Natl Cancer Inst, 71, 87 Kockum, 1984, Insect immunity. Isolation and sequence of two cDNA clones corresponding to acidic and basic attacins from Hyalophora cecropia, EMBO J, 3, 2071, 10.1002/j.1460-2075.1984.tb02093.x Koenig W, Seiler FR. Tetrapeptides with phagocytosis-stimulating action Ger. Offen. 2, 343, 034; Chem Abs 1975;83:10892. Kolobov, 1994, Conformational analysis and hemolytic activity of the 285–292 immunoglobulin G fragment and its analogues, Bioorg Khim, 20, 617 Konopińska, 1984, Influence of the peptide chain length of new elongated tuftsin analogs on phagocytosis process, Int J Peptide Protein Res, 24, 267, 10.1111/j.1399-3011.1984.tb00953.x Konopińska, 1983, Synthesis and biological investigations of new tuftsin analogs with elongated peptide chain, Int. J Peptide Protein Res, 22, 223, 10.1111/j.1399-3011.1983.tb02089.x Konopińska, 1981, Solid-phase synthesis of l-threonyl-l-glutamyl-l-prolyl-l-arginine, as the mutant analog of tuftsin, Arch Immunol Ther Exp, 29, 851 Konopińska, 1982, Synthesis of tuftsinyltuftsin with potential tumoricidal activity, Polish J Chem, 56, 1063 Konopińska, 1976, Synthetic and conformational studies with tuftsin and its analogues, 535 Konopińska, 1977, Partial sequences of histones with tuftsin activity, Int J Protein Peptide Res, 9, 71, 10.1111/j.1399-3011.1977.tb01839.x Konopińska, 1979, Tuftsin and its analogs. Part VII. Experimental proof of the hypothesis on functional conservatism in coding of tuftsin sequence, Polish J Chem, 53, 343 Kornberg, 1990, Tuftsin induces tissue factor-like activity in human mononuclear cells and in monocytic cell lines, Blood, 76, 814, 10.1182/blood.V76.4.814.814 Kozlov, 1986, Inhibition of the binding and activation of the first component of human complement. The effect of synthetic peptides, immunoglobulin fragments and various proteins, Biokhimiia, 51, 707 Krasowski, 1992, The effect of the calf spleen and calf thymus extracts, thymopentin and tuftsin, on the phagocytosis activity of neutrophilic granulocytes, Arzneimittelforschung, 42, 147 Kratzin, 1975, Primary structure of a monoclonal IgA immunoglobulin (IgA Tro.). II. Amino acid sequence of the H-chain, α-type, subgroup III. Structure of the complete IgA molecule, Hoppe–Seyler’s Z Physiol Chem, 356, 1337 Kraus–Berthier, 1991, Approaches to some biochemical mechanisms of action of tuftsin and analogues, Biochem Pharmacol, 41, 1411, 10.1016/0006-2952(91)90556-K Kraus–Berthier, 1993, In vivo immunopharmacological properties of tuftsin and four analogs, Immunopharmacology, 25, 261, 10.1016/0162-3109(93)90054-T Kreisberg, 1993, Cytokine mediation of the suppressive effect of ferritin on colony-stimulating factor-1 - dependent monocytopoiesis, J Immunol, 150, 5094, 10.4049/jimmunol.150.11.5094 Kubo, 1994, Stimulation of phagocytic activity of murine Kupffer cells by tuftsin, Hepatology, 19, 1044, 10.1002/hep.1840190433 Kudriashov, 1992, Fibrinolytic and anticoagulant complexes of low-molecular heparin with tuftsin, Biull Eksp Biol Med, 114, 609 Lavretskaya, 1981, Synthesis and influence on the central nervous system of the tetrapeptide tuftsin, Khim Pharm Zh, 15, 20 Lelekova, 1989, Effects of the femto- and picomolar concentrations of thyroliberin and tuftsin on the contractile activity of lymphatic vessels of the rat mesentery, Biull Eksp Biol Med, 108, 8, 10.1007/BF00839762 Leung–Tack, 1990, Modulation of phagocytosis-associated respiratory burst by human cystatin C, Exp Cell Res, 188, 16, 10.1016/0014-4827(90)90272-C Lever, 1985, Serum factors for opsonization of non-typable Haemophilus influenzae, J Med Microbiol, 20, 33, 10.1099/00222615-20-1-33 Levy, 1987, Ontogeny of the bovine neurohypophysial hormone precursors. III. Identification of neurohormones, neurophysins and copeptin in the early bovine fetus, Int J Peptide Protein Res, 29, 604, 10.1111/j.1399-3011.1987.tb02290.x Levy, 1989, Potential use of tuftsin in treatment of candida peritonis in a murine model, J Biol Regul Homeost Agents, 3, 71 Lewis, 1973, Chain reversals in proteins, Biochim Biophys Acta, 303, 211, 10.1016/0005-2795(73)90350-4 Liapina, 1993, The antithrombotic and thrombolytic activity of tuftsin, Biull Eksp Biol Med, 116, 451 Liu, 1976, Complete covalent structure of a human Ig A1 immunoglobulin, Science, 193, 1017, 10.1126/science.821146 Lokshina, 1985, Properties and specificity of cathepsin H from the bovine spleen, Vopr Med Khim, 31, 125 Louie, 1973, Modification of histones during spermatogenesis in trout. III. Levels of phosphohistone species and kinetics of phosphorylation of histone IIb1, J Biol Chem, 248, 3335, 10.1016/S0021-9258(19)44045-3 Lovedova, 1986, Metabolism and bioelectric activity of individual brain structures in response to the neuropeptide taftsine, Zh Nevropathol Psikhiatr, 86, 1025 Luftig, 1977, Sequence relationship between Rauscher leukemia virus (RLV) p65–70 (gag gene product) and tuftsin as monitored by the p65–70 proteolytic factor, J Cell Biol, 75, 397a Lukacs, 1984, Stimulating effect of tuftsin and its analogues on the defective monocyte chemotaxis in systemic lupus erythematosus, Immunopharmacology, 7, 171, 10.1016/0162-3109(84)90034-1 Lukas, 1981, Inhibition of C1-mediated immune hemolysis by monomeric and dimeric peptides from the second constant domain of human immunoglobulin G1, J Immunol, 127, 2555, 10.4049/jimmunol.127.6.2555 Martinez Cairo Cueto, 1994, In vitro effect of tuftsin (l-prolyl-l-arginine) on the oxidative capacity of polymorphonuclear lymphocytes in small-for-gestational-age newborn infants, Rev Alerg Mex, 41, 103 Martinez, 1981, Bactericidal activity of tuftsin, Mol Cell Biochem, 41, 123, 10.1007/BF00225303 Martinez, 1983, New synthetic and natural tuftsin-related compounds and evaluation of their phagocytosis-stimulating activity, Ann NY Acad Sci, 419, 23, 10.1111/j.1749-6632.1983.tb37088.x Martinez, 1977, Nouvelles syntheses et proprietes de la tuftsine, Eur J Med Chem-Chim Ther, 12, 511 Mathe, 1987, Do tuftsin and bestatin constitute a biopharmacological immunoregulatory system?, Cancer Detect Prev, 1, 445 Mathe, 1991, Bestatin, an aminopeptidase inhibitor with a multi-pharmacological function, Biomed Pharmacother, 45, 49, 10.1016/0753-3322(91)90122-A Mathe, 1996, Will killing the last HIV1 particle cure AIDS patients?, Biomed Pharmacother, 50, 473, 10.1016/S0753-3322(97)89277-3 Matsushima, 1991, Structural and immunological evidence for the identity of prolyl aminopeptidase with leucyl aminopeptidase, Biochem Biophys Res Commun, 178, 1459, 10.1016/0006-291X(91)91057-J Matsuura S, Takasaki A, Hiratani H, Kotera T, Fujiwara S. Tetrapeptide promoting phagocytosis activity of leukocyte. Japan Kokai 1975;75:13,373, Chem Abs 83, 114937e. Mezo, 1990, Synthesis and functional studies of tuftsin analogs containing isopeptide bond, Peptides, 11, 405, 10.1016/0196-9781(90)90036-5 Mineeva, 1990, Effect of tuftsin and hydroxymethacil on tyrosine hydroxylase of macrophages in chronic stress, Biull Eksp Biol Med, 109, 327, 10.1007/BF00840029 Mitsuma, 1984, Effects of tuftsin on thyrotropin secretion in rats, J Aichi Med Univ Assoc, 12, 185 Mitsuma, 1985, Tuftsin stimulates thyrotropin secretion in rats, Experientia, 41, 113, 10.1007/BF02005904 Mizutani, 1993, Possible action of human placental aminopeptidase N in feto-placental unit, Res Commun Chem Pathol Pharmacol, 82, 65 Moore, 1989, Neurotensin regulation of macrophage colony-stimulating factor-stimulated in vitro myelopoiesis, J Immunol, 142, 2689, 10.4049/jimmunol.142.8.2689 Moore, 1988, Substance P augmentation of CSF-1-stimulated in vitro myelopoiesis. A two-signal progenitor restricted, tuftsin-like effect, J Immunol, 141, 2699, 10.4049/jimmunol.141.8.2699 Morel, 1992, Molecular cloning and expression of a rat VIa arginine vasopressin receptor, Nature, 356, 523, 10.1038/356523a0 Moreno, 1994, Regulation of progression through the G1 phase of the cell cycle by the rum 1+ gene, Nature, 367, 236, 10.1038/367236a0 Mutt, 1974, Structure of the porcine vasoactive intestinal octacosapeptide. Amino acid sequence. Use of kallikrein in its determination, Eur J Biochem, 42, 581, 10.1111/j.1432-1033.1974.tb03373.x Nader, 1989, Effects of corticotropin-releasing factor (CRF), tuftsin and dermorphin on behavior of squirrel monkeys maintained by different events, Peptides, 10, 1199, 10.1016/0196-9781(89)90013-2 Nagaoka, 1981, Inactivation of phagocytosis-stimulating activity of tuftsin by polymorphonuclear neutrophils. A possible role of leucine aminopeptidase as an ecto-enzyme, Biochim Biophys Acta, 675, 85, 10.1016/0304-4165(81)90072-6 Naim, 1987, The identification of serum tuftsin by reverse-phase HPLC and mass spectrometry, Anal Biochem, 164, 221, 10.1016/0003-2697(87)90389-7 Naim, 1989, The lack of antigenicity of tuftsin, Immunol Invest, 18, 817, 10.3109/08820138909030601 Naim, 1991, The effect of anti-tuftsin antibody on the phagocytosis of bacteria by human neutrophils, Immunol Invest, 20, 499, 10.3109/08820139109082630 Naim, 1991, The generation of antibody in mice to tuftsin, Immunol Invest, 20, 351, 10.3109/08820139109057761 Nair, 1978, Interactions of radiolabeled tuftsin with human neutrophils, Immunochemistry, 15, 901, 10.1016/0161-5890(78)90125-6 Najjar, 1974, The physiological role of γ-globulin, Adv Enzymol, 41, 129 Najjar, 1978, Molecular basis of familial and acquired phagocytosis deficiency involving the tetrapeptide, Thr-Lys-Pro-Arg, tuftsin, Exp Cell Biol, 46, 114 Najjar, 1979, The clinical and physiological aspects of tuftsin deficiency syndromes exhibiting defective phagocytosis, Klin Wochenschr, 57, 751, 10.1007/BF01478032 Najjar VA. Biological and biochemical characteristics of the tetrapeptide tuftsin, Thr-Lys-Pro-Arg. Adv Exp Med Biol 121A (Macrophages Lymphocytes, Pt. A):1980:131–47. Najjar, 1982, Cytophilic γ-globulin and tuftsin, Surv Immunol Res, 1, 9, 10.1007/BF02918236 Najjar, 1983, Tuftsin, a natural activator of phagocyte cells, Ann NY Acad Sci, 419, 1, 10.1111/j.1749-6632.1983.tb37086.x Najjar, 1989, Covalent peptide transfer to cell membrane proteins (peptidyl transferase), FEBS Lett, 253, 129, 10.1016/0014-5793(89)80944-5 Najjar, 1981, Tuftsin (Thr-Lys-Pro-Arg), a physiological activator of phagocytic cells, 459 Najjar, 1972, A new phagocytosis-stimulating tetrapeptide hormone, tuftsin, and its role in disease, J Reticuloendothel Soc, 12, 197 Najjar, 1968, The physiological role of the lymphoid system. VII. The disappearance of leukokinin activity following splenectomy, Biochemistry, 7, 2376, 10.1021/bi00846a046 1983, Ann NY Acad Sci, 419, 1, 10.1111/j.1749-6632.1983.tb37086.x Najjar, 1981, Tuftsin, a natural activator of phagocytic functions including tumoricidal activity, Mol Cell Biochem, 41, 3, 10.1007/BF00225292 Najjar, 1986, Tuftsin, Methods in Enzymol, 132, 318, 10.1016/S0076-6879(86)32016-0 Najjar, 1983, The antineoplastic effects of tuftsin and tuftsinyltuftsin on B16/5B melanoma and L1210 cells, Ann NY Acad Sci, 419, 261, 10.1111/j.1749-6632.1983.tb37112.x Najjar, 1970, ‘Tuftsin’: a natural phagocytosis stimulating peptide, Nature, 228, 672, 10.1038/228672a0 Nawrocka, 1988, Further investigation on the origin of tuftsin analgesic potency, Polish J Chem, 62, 263 Nawrocka, 1980, Tuftsin analogs with d-amino acid residues, Int J Peptide Protein Res, 16, 200, 10.1111/j.1399-3011.1980.tb02953.x Nawrocka–Bolewska, 1991, Further investigations on the antinociceptive activity of tuftsin analogs, Pol J Pharmacol Pharm, 43, 281 Nicolaides, 1985, Anti-writhing activity of some peptides related to neurotensin and tuftsin, Int J Peptide Protein Res, 25, 435, 10.1111/j.1399-3011.1985.tb02198.x Nieber, 1988, Effect of the N-terminal tetrapeptide of substance P SP(1–4) and tuftsin on the pre- and postsynaptic transmitter outflow in rat adrenal gland slices, Biomed Biochim Acta, 47, 663 Nikiforovich, 1978, Calculation of stable conformations of tuftsin, Bioorg Khim, 4, 1427 Nikiforovich, 1994, Computational molecular modeling in peptide drug design, Int J Peptide Protein Res, 44, 513, 10.1111/j.1399-3011.1994.tb01140.x Nikiforovich, 1984, Biologically active conformation of tuftsin, Int J Peptide Protein Res, 23, 271, 10.1111/j.1399-3011.1984.tb02719.x Nikolov, 1992, Crystal structure of TFIID TATA-box binding protein, Nature, 360, 40, 10.1038/360040a0 Nishioka, 1978, Migration enhancement by tuftsin of human mononuclear cells and its effect on the migration inhibition factor test with tumor antigen, Gann, 69, 569 Nishioka, 1979, Anti-tumor effect of the physiological tetrapeptide tuftsin, Br J Cancer, 39, 342, 10.1038/bjc.1979.59 Nishioka, 1981, Tuftsin, Life Sci, 28, 1081, 10.1016/0024-3205(81)90684-6 Nishioka, 1983, In vivo and in vitro antitumor activities of tuftsin, Am NY Acad Sci, 419, 234, 10.1111/j.1749-6632.1983.tb37109.x Nishioka, 1972, The characteristics, isolation and synthesis of the phagocytosis stimulating peptide, tuftsin, Biochem Biophys Res Commun, 47, 172, 10.1016/S0006-291X(72)80025-1 Nishioka, 1991, Stability of sterile saline solutions of synthetic tuftsin, a naturally occurring immunomodulating peptide, Pept Res, 4, 230 Nishioka, 1986, Prophylaxis of Candida albicans infection with tuftsin, J Antimicrob Chemother, 17, 361, 10.1093/jac/17.3.361 Nishioka, 1991, A comparative study of [Leu1]-tuftsin and tuftsin, a natural phagocytosis-stimulating peptide, Int J Biochem, 23, 627, 10.1016/0020-711X(87)90058-9 Nishioka, 1996, Tuftsin and tuftsin analogs, Curr Med Chem, 3, 153, 10.2174/092986730303220225100557 Nishioka, 1995, Enhanced phagocytosis activity of cyclic analogs of tuftsin, Biochem Pharmacol, 49, 735, 10.1016/0006-2952(94)00520-V Nishioka, 1973, The chemical synthesis of the phagocytosis-stimulating tetrapeptide tuftsin (Thr-Lys-Pro-Arg) and its biological properties, Biochim Biophys Acta, 310, 230, 10.1016/0005-2795(73)90025-1 Nishioka, 1990, Tuftsin-enhanced thymidine incorporation by murine splenic monocytes, Int J Immunopharmac, 12, 905, 10.1016/0192-0561(90)90010-K Nishioka, 1994, Studies of human granulocyte phagocytosis stimulation by tuftsin, J Surg Res, 56, 94, 10.1006/jsre.1994.1016 Noyes RD, Babcock GF, Nishioka K. Antitumor activity of tuftsin on murine melanoma in vivo. Cancer Treat Rep 1981;65:673–5; 65. O’Connor, 1992, Quenched molecular dynamics simulations of tuftsin and proposed cyclic analogues, J Med Chem, 35, 2870, 10.1021/jm00093a021 Obuchowicz, 1993, The analgesic activity of some tuftsin- and tuftsin inhibitor-like fragments of the viral coat proteins, Pol J Pharmacol, 45, 269 Ohta, 1991, Application of an anhydrotrypsin-immobilized precolumn for selective separation of peptides having arginine or lysine at their C-termini by column-switching HPLC, J Chromatogr, 543, 59, 10.1016/S0021-9673(01)95755-3 Olivera, 1984, Purification and sequence of a presynaptic peptide toxin from Conus geographus venom, Biochemistry, 23, 5087, 10.1021/bi00317a001 Orr, 1979, Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7, Proc Natl Acad Sci USA, 76, 4395, 10.1073/pnas.76.9.4395 Owais, 1993, Tuftsin-bearing liposomes as drug vehicles in the treatment of experimental aspergillosis, FEBS Lett, 326, 56, 10.1016/0014-5793(93)81760-W Paradowski, 1991, Effect of tuftsin and its partial sequences on the arterial blood pressure in guinea-pigs, Arch Immunol Ther Exp, 39, 147 Paradowski, 1991, Effects of IP tuftsin administration on histamine concentration in tissues of guinea-pigs, Arch Immunol Ther Exp, 39, 153 Paradowski, 1991, Effects of intravenous tuftsin administration on histamine concentration in tissues of rabbits and guinea-pigs, Arch Immunol Ther Exp, 39, 159 Paradowski, 1992, The influence of tuftsin partial sequences on histamine level in guinea pig and rat tissues, Arch Immunol Ther Exp, 40, 207 Paradowski, 1983, The influence of tuftsin on blood pressure in animals, Ann NY Acad Sci, 419, 164, 10.1111/j.1749-6632.1983.tb37101.x Paulesu, 1992, Effect of tuftsin and its retro-inverso analogue on the release of interferon (IFN-gamma) and tumor necrosis factor (TNF-alpha) by human leucocytes, Immunol Lett, 34, 7, 10.1016/0165-2478(92)90020-O Pawan, 1994, Construction of a synthetic immunogen, Vaccine, 12, 819, 10.1016/0264-410X(94)90291-7 Petukhova, 1992, Peptidergic modulation of learning a motoric food-procuring conditioned reflex skill, Neurosci Behav Physiol, 22, 357, 10.1007/BF01186626 Phillips, 1987, In vitro effects of prostaglandin E1, prostaglandin E2, indomethacin, histamine and tuftsin on chemiluminescence response of bovine polymorphonuclear leukocytes, Vet Immunol Immunopathol, 14, 233, 10.1016/0165-2427(87)90092-4 Plata–Salaman, 1989, Immunomodulators and feeding regulation, Brain Behav Immun, 3, 193, 10.1016/0889-1591(89)90036-6 Plata–Salaman, 1991, Immunoregulators in the nervous system, Neurosci Biobehav Rev, 15, 185, 10.1016/S0149-7634(05)80001-6 Pohajdak, 1986, Chemotaxis of large granular lymphocytes, J Immunol, 136, 278, 10.4049/jimmunol.136.1.278 Polevshchikov, 1993, Stimulation of oxygen metabolism in human blood phagocytes as affected by tuftsin- like peptides derived from C- reactive protein molecule, Bull Eksp Biol Med, 115, 55 Polevshchikov, 1994, Tuftsin- like peptides from a C- reactive protein molecule as regulators of lymphocyte proliferation, Vopr Med Khim, 40, 4 Popova, 1992, Prolonged action of tuftsin in penicillin epilepsy, Biull Eksp Biol Med, 114, 56, 10.1007/BF00790061 Popova, 1995, The effect of tuftsin on the function of the brain structures in rats with a dysfunctioning dopamine system, Fiziol Zh Im I M Sechenova, 81, 29 Popova, 1996, The correlation of the behavioral, bioelectrical and cytobiochemical characteristics of the effect of tuftsin, Zh Vyssh Nerv Deiat Im I P Pavlova, 46, 163 Potts, 1976, Parathyroid hormone and calcitonin, 119 Potts, 1971, Calcitonin, Curr Top Exp Endocrinol, 1, 151, 10.1016/B978-0-12-153201-7.50011-9 Price, 1993, Modulation of the intracellular survival of Brucella abortus by tuftsin and muramyl dipeptide, Vet Immunol Immunopathol, 36, 265, 10.1016/0165-2427(93)90024-X Ramamoorthy, 1992, Chemical modification of the monkey brain cytosolic aminopeptidase that cleaves enkephalin to its constituent amino acids. Evidence for essential tyrosine residue (residues), Biochem Int, 27, 861 Rauner, 1976, Proline endopeptidase and exopeptidase activity in polymorphonuclear granulocytes, Mol Cell Biochem, 10, 77, 10.1007/BF01742201 Robey, 1987, Proteolysis of human C-reactive protein produces peptides with potent immunomodulating activity, J Biol Chem, 262, 7053, 10.1016/S0021-9258(18)48201-4 Rocchi, 1987, Synthesis and biological activity of tuftsin and rigin derivatives containing monosaccharides or monosaccharide derivatives, Int J Peptide Protein Res, 29, 262, 10.1111/j.1399-3011.1987.tb02253.x Rocchi, 1984, Derivatization of synthetic tuftsin and rigin with carbohydrates, 431 Rocchi, 1987, Synthesis of modified tuftsin containing monosaccharides or monosaccharide derivatives, Int J Peptide Protein Res, 29, 250, 10.1111/j.1399-3011.1987.tb02252.x Rocchi, 1991, Glyco-tuftsin derivatives modulate IL-1 and TNF production, Int J Peptide Protein Res, 37, 161, 10.1111/j.1399-3011.1991.tb00265.x Rossomando, 1986, Characterization and cAMP inhibition of a lysyl-(N-epsilon-5‘-phospho)adenosyl phosphoamidase in Dictyostelium discoideum, Int J Biochem, 18, 481, 10.1016/0020-711X(86)90193-X Rossomando, 1987, HLAMP—a conjugate of hippuryllysine and AMP which contains a phosphoamide bond-stimulates chemotaxis in Dictyostelium discoideum, Differentiation, 35, 88, 10.1111/j.1432-0436.1987.tb00154.x Schantz, 1985, The effect of surgery on natural killer cell activity in head and neck cancer patients, Laryngoscope, 95, 588, 10.1288/00005537-198505000-00013 Scheller, 1984, Neuropeptides; mediators of behavior in Aplysia, Science, 225, 1300, 10.1126/science.6474178 Sebastiani, 1991, Conserved amino acid sequences among plant proteins sorted to protein bodies and plant vacuoles, Eur J Biochem, 199, 441, 10.1111/j.1432-1033.1991.tb16142.x Segal, 1983, The function of tuftsin and similar sequences in other proteins, Ann NY Acad Sci, 419, 168, 10.1111/j.1749-6632.1983.tb37102.x Sekacis, 1979, 1H and 13C-NMR studies of tuftsin conformation, Bioorg Khim, 5, 1617 Semenova, 1989, The role of the brain monoaminergic systems in the effects of tuftsin and its analog on animal emotional behavior, Fiziol Zh SSSR, 75, 759 Semenova, 1988, Characteristics of the action of psychostimulants on learning and memory in rats, Biull Eksp Biol Med, 106, 161, 10.1007/BF00840368 Semenova, 1988, Effect of tuftsin and its analog on learning, memory and exploratory behavior in rats, Zh Vyssh Nerv Deiat, 38, 1033 Seredenin, 1995, The characteristics of the anxiolytic action of tuftsin and its analog TP-7 on behavior and serotonin metabolism in the brain of rats with chronic deprivation of serotoninergic system activity, Eksp Klin Farmakol, 58, 3 Sergutina, 1991, A cytochemical study of the effect of tuftsin on the enzyme activity in functionally different formations of the brain in rats, Tsitologiia, 33, 67 Shephard, 1990, Peptides generated from C-reactive protein by a neutrophil membrane protease. Amino acid sequence and effects of peptides on neutrophil oxidative metabolism and chemotaxis, J Immunol, 145, 1469, 10.4049/jimmunol.145.5.1469 Shibata, 1988, Purification and characterization of an arginine-specific carboxypeptidase from Mycoplasma salivarium, J Bacteriol, 170, 1795, 10.1128/jb.170.4.1795-1799.1988 Shishova, 1985, Effect of tuftsin on the activity of energy metabolism enzymes in peritoneal macrophages, Biull Eksp Biol Med, 99, 306, 10.1007/BF00799071 Siddiqui, 1995, Single-step bulk purification of synthetic tetrapeptide tuftsin by HPLC, Indian J Biochem Biophys, 32, 55 Siemion, 1986, The works in the field of peptide immunomodulators, 127 Siemion, 1998, Anti-IL-1 activity of peptide fragments of IL-1 family proteins, Peptides, 19, 373, 10.1016/S0196-9781(97)00324-0 Siemion, 1981, Tuftsin analogs and their biological activity, Mol Cell Biochem, 41, 99, 10.1007/BF00225300 Siemion, 1990, The analgesic activity of some kyotorphin-tuftsin analogs, Pol J Pharmacol Pharm, 42, 177 Siemion, 1980, 13C Nuclear magnetic resonance and circular dichroism studies of the tuftsin conformation in water, Eur J Biochem, 112, 339, 10.1111/j.1432-1033.1980.tb07210.x Siemion, 1990, Antinociceptive action of the SP1–4 tetrapeptide and of some tuftsin analogs, Pol J Pharmacol Pharm, 42, 393 Siemion, 1990, Competition between tuftsin and HBV S-protein sequences, Int J Peptide Protein Res, 35, 428, 10.1111/j.1399-3011.1990.tb00069.x Siemion, 1991, The evidence on the possible IL-1α-tuftsin competition, Arch Immunol Ther Exp, 39, 605 Siemion, 1991, Competition between tuftsin and HIV-1, HIV-2 envelope protein sequences, Arch Immunol Ther Exp, 39, 469 Siemion, 1993, Suppression of tuftsin activity by the partial sequences of adenovirus type 2 proteins, Int J Peptide Protein Res, 41, 300, 10.1111/j.1399-3011.1993.tb00338.x Siemion, 1995, The immunosuppressive mini-domain of human lactoferrin, J Peptide Sci, 1, 295, 10.1002/psc.310010504 Siemion, 1993, Circular dichroism of the peptides of tuftsin-Kentsin group, Polish J Chem, 67, 2171 Singh, 1992, Respiratory burst in peritoneal exudate cells in response to a modified tuftsin, Experientia, 48, 994, 10.1007/BF01919150 Singh, 1986, Structural requirements for the recognition of luteinizing hormone releasing hormone (LHRH) by monoclonal and conventional anti-LHRH antibodies, Biochem Cell Biol, 64, 1372, 10.1139/o86-180 Singh, 1992, Immunospecificity and affinity studies on anti-luteinizing hormone releasing hormone antibodies developed by azo-LHRH-TT and azo-LHRH-BSA conjugates, Biochem Int, 27, 591 Singhal, 1984, Specific interactions of liposomes with PMN leukocytes upon incorporating tuftsin in their bilayer, FEBS Lett, 178, 109, 10.1016/0014-5793(84)81251-X Smith, 1986, The effects of tuftsin in the treatment of experimental Pseudomonas keratitis, Cornea, 5, 181, 10.1097/00003226-198605030-00012 Sorokin, 1989, Nonimmune-mediated phagocytosis by “premedullary” lung macrophages, Anat Rec, 223, 55, 10.1002/ar.1092230109 Spirer, 1980, Decreased serum tuftsin concentrations in sickle cell disease, Arch Dis Child, 55, 566, 10.1136/adc.55.7.566 Spirer, 1977, Radioimmunoassay of the phagocytosis-stimulating peptide tuftsin in normal and splenectomized subjects, Eur J Immunol, 7, 69, 10.1002/eji.1830070204 Spirer, 1975, The effect of tuftsin on the nitrous blue tetrazolium reduction of normal human polymorphonuclear leukocytes, J Clin Invest, 55, 198, 10.1172/JCI107912 Spirer, 1989, Tuftsin stimulates IL-1 production by human mononuclear cells, human spleen cells and mouse spleen cells in vitro, J Clin Lab Immunol, 28, 27 Stabinsky, 1980, On the mechanism of action of the phagocytosis-stimulating peptide tuftsin, Mol Cell Biochem, 30, 71, 10.1007/BF00227920 Stabinsky, 1978, Synthesis and biological activity of tuftsin and of [O = C<> Thr1]-tuftsin, Int J Peptide Protein Res, 12, 130, 10.1111/j.1399-3011.1978.tb02876.x Stabinsky, 1978, Specific binding sites for the phagocytosis stimulating peptide tuftsin on human polymorphonuclear leukocytes and monocytes, Biochim Biophys Res Comm, 83, 599, 10.1016/0006-291X(78)91032-X Stanworth, 1984, Use of synthetic peptides with immunoglobulin heavy chain sequences in the delineation of Fc effector function, Biochem Soc Trans, 12, 747, 10.1042/bst0120747a Sucharda–Sobczyk, 1979, Infrared spectroscopic investigations of tuftsin and its analogs, Eur J Biochem, 96, 131, 10.1111/j.1432-1033.1979.tb13022.x Sucharda–Sobczyk, 1980, The influence of configuration changes in tuftsin peptide chain on its folding properties, Acta Biochim Polon, 27, 353 Suk, 1981, Increased expression of endogenous xenotropic murine retrovirus by treatment with the tetrapeptides, tuftsin and kentsin, J Gen Virol, 52, 189, 10.1099/0022-1317-52-1-189 Surkis, 1990, Polytuftsin, Int J Biochem, 22, 193, 10.1016/0020-711X(90)90183-4 Szendroi, 1993, Autologous spleen transplantation, Orv Hetil, 134, 125 Szendroi, 1997, Splenic autotransplantation after abdominal trauma in childhood. Clinical and experimental data, Acta Chir Hung, 36, 349 Szkaradkiewicz, 1992, Phagocytosis and microbicidal capacity of human monocytes in the course of HIV infection, Immunol Lett, 33, 145, 10.1016/0165-2478(92)90039-Q Tabata, 1988, Macrophage phagocytosis of biodegradable microspheres composed of l-lactic acid/glycolic acid homo- and copolymers, J Biomed Mater Res, 22, 837, 10.1002/jbm.820221002 Takada, 1985, Inhibition by various peptides of the activation of C1, the first component of complement, and the interaction of C gamma 2 domain of Ig G with C1q, Immunopharmacology, 9, 87, 10.1016/0162-3109(85)90004-9 Terashima, 1997, ADP-ribosylation of tuftsin suppresses its receptor-binding capacity and phagocytosis-stimulating activity to murine peritoneal macrophages, FEBS Lett, 412, 227, 10.1016/S0014-5793(97)00784-9 Thanos, 1993, Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro, J Neurosci, 13, 455, 10.1523/JNEUROSCI.13-02-00455.1993 Titov, 1995, Synthesis and immunological evaluation of the conjugates composed from a muramyl peptide GMDP and tuftsin, Int J Peptide Protein Res, 45, 348, 10.1111/j.1399-3011.1995.tb01048.x Tritsch, 1982, Positive correlation between superoxide release and intracellular adenosine deaminase activity during macrophage membrane perturbation regardless of nature or magnitude of stimulus, Mol Cell Biochem, 49, 49, 10.1007/BF00230995 Trudelle, 1987, Synthesis of a new carrier for immunization, Int J Peptide Protein Res, 30, 54, 10.1111/j.1399-3011.1987.tb03312.x Tsunoda, 1987, The effect of splenectomy in immature mice, Nippon Geka Gekkai Zasshi, 88, 318 Tumanian, 1987, Interstrain differences in changes in 5-nucleotidase activity in mouse macrophages in response to immunostimulation, Biull Eksp Biol Med, 104, 199 Turovetskii, 1994, Effect of tafcin on the functional activity and intracellular pH of mouse peritoneal macrophages, Biull Eksp Biol Med, 117, 265, 10.1007/BF02444159 Tzehoval, 1978, Tuftsin (an Ig-associated tetrapeptide) triggers the immunogenic function of macrophages, Proc Natl Acad Sci USA, 75, 3400, 10.1073/pnas.75.7.3400 Valdeavella, 1995, Simulations of conformers of tuftsin and a cyclic tuftsin analog, Int J Peptide Protein Res, 46, 372, 10.1111/j.1399-3011.1995.tb01071.x Valdman, 1982, Analysis of the neurochemical mechanisms of the psychotropic activity of tuftsin and its analogs, Biull Eksp Biol Med, 93, 57 Valdman, 1982, Comparative study of psychotropic activity of tuftsin and its analogs, Biull Eksp Biol Med, 93, 49 Valdman, 1981, Central effects of the tetrapeptide tuftsin, Biull Eksp Biol Med, 92, 31 Verdini, 1991, Immunostimulation by a partially modified retro-inverso-tuftsin analog containing Thr1 Ψ [NHCO](R,S)Lys2 modification, J Med Chem, 34, 3372, 10.1021/jm00116a005 Veretennikova, 1981, Rigin, another phagocytosis-stimulating tetrapeptide isolated from human Ig G. Confirmations of a hypothesis, Int J Peptide Protein Res, 17, 430, 10.1111/j.1399-3011.1981.tb02011.x Veretennikova, 1979, Synthesis and investigation of myotropic activity of tuftsin, Izv. AN Latv. SSR, Ser Chim, 4, 494 Veskov, 1995, The effect of the tetrapeptide tafcin on the bioelectrical activity of brain structures in various functional states of the central nervous system, Biull Eksp Biol Med, 119, 365, 10.1007/BF02445890 Vičar, 1976, Synthesis and properties of tuftsin, l-threonyl-l-lysyl-l-prolyl-l-arginine, Collection Czechoslov Chem Commun, 41, 3467, 10.1135/cccc19763467 Vishnevetskii, 1991, Use of tuftsin in experimental leprosy, Biull Eksp Biol Med, 112, 181, 10.1007/BF00839564 Voevodin, 1988, The action of tuftsin on the reaction of macrophage-suppressor formation in vitro and in vivo, Biull Eksp Biol Med, 106, 559 Wagle, 1989, Specific translocation of tuftsin (Thr-Lys-Pro-Arg), a natural immunomodulating peptide, into the nuclei of human monocytes, Biochem Biophys Res Commun, 159, 1147, 10.1016/0006-291X(89)92229-8 Wang, 1995, The mechanism for splenic promoting effects on liver cirrhosis, Chung Hua I Hsueh Tsa Chih, 75, 594 Warner, 1987, Combined immunotherapy and chemotherapy with tuftsin plus cyclophosphamide in the treatment of non-small-cell carcinoma of the lung, Chemioterapia, 6, 706 Watson, 1984, Are the proposed substance P receptor sub-types, substance P receptors?, Life Sci, 35, 797, 10.1016/0024-3205(84)90403-X Wieczorek, 1997, A hexapeptide VTKFYF from C-terminal part of IL-1 receptor antagonist, an inhibitor of IL-1 - IL-1 receptor interaction, Pol J Pharmacol, 49, 107 Wieczorek, 1995, The immunomodulatory diversity of the proteins of the transforming growth factor β (TGFβ) family, Int J Peptide Protein Res, 46, 113, 10.1111/j.1399-3011.1995.tb01326.x Wieczorek, 1994, The immunomodulatory activity of tetra- and tripeptides of tuftsin-kentsin group, Peptides, 15, 215, 10.1016/0196-9781(94)90005-1 Wiedermann, 1991, Priming of normal human neutrophils by tachykinins, Regul Pept, 36, 359, 10.1016/0167-0115(91)90069-S Wiedow, 1990, Elafin, J Biol Chem, 265, 14791, 10.1016/S0021-9258(18)77182-2 Wleklik, 1986, Suppression of Friend virus-induced leukemia in mice by tuftsin, J Gen Virol, 67, 2001, 10.1099/0022-1317-67-9-2001 Wleklik, 1987, Tuftsin induced tumor necrosis activity, Mol Cell Biochem, 75, 169, 10.1007/BF00229905 Wleklik, 1988, Tuftsin, a natural peptide with antiviral activity-structural basis of its action, Acta Virol, 32, 79 Xiong, 1993, p21 is a universal inhibitor of cyclin kinases, Nature, 366, 701, 10.1038/366701a0 Yang, 1996, Salt effects on peptide conformers, Biophys J, 71, 3022, 10.1016/S0006-3495(96)79495-X Yasumura, 1977, Synthesis of peptides related to tuftsin. II, Yakugaku Zasshi, 97, 324, 10.1248/yakushi1947.97.3_324 Zagrebelnyi, 1986, Expression of the gene for hybrid beta-lactamase pBR 322 with C-terminal fragment containing tuftsin (Thr-Lys-Pro-Arg), Bioorg Khim, 12, 1329 Zetter, 1985, An in vivo assay for chemoattractant activity, Lab Invest, 53, 362 Zoli, 1994, Splenic autotransplantation after splenectomy, Br J Surg, 81, 716, 10.1002/bjs.1800810530