Troponine dosée avec un test de haute sensibilité : éléments de réponse aux questions fréquemment posées
Tóm tắt
L’évolution rapide des méthodes de dosage des troponines cardiaques (cTn) vers une meilleure sensibilité analytique (cTn de haute sensibilité ou cTn HS) s’accompagne de nombreuses données de la littérature, mais encore incomplètes. En l’absence de standardisation des cTn et de données consensuelles sur l’utilisation et l’interprétation des résultats, les auteurs de cette revue proposent, à partir d’une revue de la littérature, et de façon multidisciplinaire, des éléments de réponses aux questions fréquemment posées. En conclusion, le bon usage des cTn HS repose sur la connaissance : 1) des caractéristiques propres de la méthode utilisée, en particulier de la précision obtenue au 99e percentile d’une population de référence ; 2) des facteurs de variation de la valeur du 99e percentile ; 3) de la forte individualité des dosages de cTn HS, pour lesquels la notion de cinétique individuelle est plus informative que la simple référence à des valeurs usuelles. La significativité des variations entre deux dosages n’est pas encore documentée pour toutes les méthodes HS. La collaboration entre cliniciens et biologistes est nécessaire à une meilleure utilisation des troponines au quotidien.
Tài liệu tham khảo
Panteghini M (2005) Standardization of cardiac troponin I measurements: the way forward? Clin Chem 51:1594–1597
Apple FS, Wu AH, Jaffe AS, et al (2007) Analytical issues for biomarkers of heart failure. Circulation 116:e95–e98
Apple FS, Collinson PO (2012) Analytical characteristics of high-sensitivity cardiac troponin assays. Clin Chem 58:54–61
Tate J, Barth J, Bunk D, et al (2010) International Federation of Clinical Chemestry and Laboratory Medicine (IFCC) Working Group on Standaridization of troponine I. Analytical characteristics of commercial and research cardiac troponine I and T assays declared by the manufacturer. http://www.ifcc.org/media/102202/IFCC_Troponin_Table_vDec_2010_FINAL_ug_L_28Jan11.pdf (dernier accès le 2 février 2014)
Thygesen K, Mair J, Giannitsis E, et al (2012) Study group on biomarkers in cardiology of ESC working group on acute cardiac care. How to use high-sensitivity cardiac troponins in acute cardiac care. Eur Heart J 33:2252–2257
Koerbin G, Tate J, Potter JM, et al (2012) Characterisation of a highly sensitive troponin I assay and its application to a cardio-healthy population. Clin Chem Lab Med 50:871–878
Thygesen K, Alpert JS, Jaffe AS, et al (2012) Joint ESC/ACCF/ AHA/WHF Task Force for the Universal Definition of Myocardial. Third universal definition of myocardial infarction. Eur Heart J 33:2551–2567
Pajunen P, Koukkunen H, Ketonen M, et al (2005) The validity of the finnish hospital discharge register and causes of death register data on coronary heart disease. Eur J Cardiovasc Prev Rehabil 12:132–137
Cardinaels EP, Mingels AM, Jacobs LH, et al (2012) A comprehensive review of upper reference limits reported for (high-) sensitivity cardiac troponin assays: the challenges that lie ahead. Clin Chem Lab Med 50:791–806
Collinson PO, Heung YM, Gaze D, et al (2012) Influence of population selection on the 99th percentile reference value for cardiac troponin assays. Clin Chem 58:219–225
Hortowitz GL, Altaie S, Boyd JC, et al (2008) Defining, establishing and verifying reference intervals in the clinical laboratory; approved guideline, 3rd ed. Clinical and Laboratory Standards Institute (CLSI) document EP28-A3c, Wayne PA, United States of America
Clerico A, Giannoni A, Prontera C, Giovannini S (2009) high-sensitivity troponin: a new tool for pathophysiological investigation and clinical practice. Adv Clin Chem 49:1–30
Irfan A, Twerenbold R, Reiter M, et al (2012) Determinants of high-sensitivity troponin T among patients with a noncardiac cause of chest pain. Am J Med 125:491–498
Menacer S, Claessens YE, Meune C, et al (2013) Reference range values of troponin measured by sensitive assays in elderly patients without any cardiac signs/symptoms. Clin Chim Acta 417:45–47
Comité européen de normalisation (2012) Laboratoires de biologie médicale: exigences concernant la qualité et la compétence (ISO 15189:2012), AFNOR, France
Ray P, Le Manach Y, Riou B, Houle TT (2010) Statistical evaluation of a biomarker. Anesthesiology 112:1023–1040
Reiter M, Twerenbold R, Reichlin T, et al (2011) Early diagnosis of acute myocardial infarction in the elderly using more sensitive cardiac troponin assays. Eur Heart J 32:1379–1389
Meune C, Balmelli C, Vogler E, et al (2013) Consideration of high-sensitivity troponin values below the 99th percentile at presentation: does it improve diagnostic accuracy? Int J Cardiol 168:3752–3757
Lippi G, Gnocchi C, Cervellin G (2013) Evaluation of diagnostic accuracy of 75th percentile threshold for a contemporary sensitive and a high-sensitivity cardiac troponin I immunoassays. Int J Cardiol 168:5045–5046
Twerenbold R, Jaffe A, Reichlin T, et al (2012) high-sensitive troponin T measurements: what do we gain and what are the challenges? Eur Heart J 33:579–586
de Lemos JA (2013) Increasingly sensitive assays for cardiac troponins. JAMA 309:2262–2269
Keller T, Zeller T, Peetz D, et al (2009) Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 361:868–877
Reichlin T, Hochholzer W, Bassetti S, et al (2009) Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med 361:858–867
Hamm CW, Bassand JP, Agewall S, et al (2011) ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 32: 2999–3054
Chenevier-Gobeaux C, Meune C, Freund Y, et al (2013) Influence of age and renal function on high-sensitivity cardiac troponin t diagnostic accuracy for the diagnosis of acute myocardial infarction. Am J Cardiol 111:1701–1707
Reichlin T, Schindler C, Drexler B, et al (2012) One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. Arch Intern Med 172:1211–1218
Fraser CG (2001) Biological variation: from principles to practice. AACC Press, United States of America, p 75
Wu AHB, Lu QA, Todd J, et al (2009) Short- and long-term biological variation in cardiac troponin I measured with a high-sensitivity assay: implications for clinical practice. Clin Chem 55:52–58
Scharnhorst V, Krasznai K, van’t Veer M, Michels RH (2012) Variation of cardiac troponin I and T measured with sensitive assays in emergency department patients with noncardiac chest pain. Clin Chem 58:1208–1214
Goldberg J, IIriarte B, Protsko J (2011) Short and long-term biological variability of troponin-I determination using the Architect Stat high sensitive troponin-I assay. Clin Chem 57:A97
Vasile VC, Saenger AK, Kroning JM, et al (2011) Biologic variation of a novel cardiac troponin I assay. Clin Chem 57:1080–1081
Nordenskjöld AM, Ahlström H, Eggers KM, et al (2013) Short- and long-term individual variation in cardiac troponin in patients with stable coronary artery disease. Clin Chem 59:401–409
Reichlin T, Irfan A, Twerenbold R, et al (2011) Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circulation 124:136–145
Mueller M, Biener M, Vafaie M, et al (2012) Absolute and relative kinetic changes of high-sensitivity cardiac troponin T in acute coronary syndrome and in patients with increased troponin in the absence of acute coronary syndrome. Clin Chem 58:209–218
Wildi K, Reichlin T, Twerenbold R, et al (2013) Serial changes in high-sensitivity cardiac troponin I in the early diagnosis of acute myocardial infarction. Int J Cardiol 168:4103–4110
Keller T, Zeller T, Ojeda F, et al (2011) Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. JAMA 306:2684–2693
Biener M, Mueller M, Vafaie M, et al (2013) Comparison of a 3-hour versus a 6-hour sampling-protocol using high-sensitivity cardiac troponin T for rule-out and rule-in of non-STEMI in an unselected emergency department population. Int J Cardiol 167:1134–1140
Kelley WE, Januzzi JL, Christenson RH (2009) Increases of cardiac troponin in conditions other than acute coronary syndrome and heart failure. Clin Chem 55:2098–2112
Wu AH (2009) Interpretation of high sensitivity cardiac troponin I results: reference to biological variability in patients who present to the emergency room with chest pain: case report series. Clin Chim Acta 401:170–174
Conde D, Costabel JP, Pedernera G, Trivi M (2013) Relationship between high-sensitive troponin T levels in patients with acute coronary syndrome with ST elevation and complex coronary lesions. Am J Emerg Med 31:1145
Boden H, Ahmed TAN, Velders MA, et al (2013) Peak and fixed-time high-sensitive troponine for prediction of infarct size, impaired left ventricular function, and adverse outcomes in patients with first ST-segment elevation myocardial infarction receiving percutaneous coronary intervention. Am J Cardiol 111:1387–1393
Conde D, Costabel JP, Campos R, Trivi M (2013) high-sensitive troponin T levels and complex cornary lesions. Am J Emerg Med 31:1141
Conde D, Elissamburu P, Lalor N, Rodriguez L (2013) Fourth-generation troponin I and infarct size in patients with ST-elevation myocardial infarction. Am J Emerg Med, in press
Bates KJ, Hall EM, Fahie-Wilson MN, et al (2010) Circulating immunoreactive cardiac troponin forms determined by gel filtration chromatography after acute myocardial infarction. Clin Chem 56:952–958
Jaffe AS, Vasile VC, Milone M, et al (2011) Diseased skeletal muscle: a noncardiac source of increased circulating concentrations of cardiac troponin T. J Am Coll Cardiol 58:1819–1824
Hickman PE, Potter JM, Aroney C, et al (2010) Cardiac troponin may be released by ischemia alone, without necrosis. Clin Chim Acta 411:318–323
Omland T, de Lemos JA, Sabatine MS, et al (2009) A sensitive cardiac troponin T assay in stable coronary artery disease. N Engl J Med 361:2538–2547
Saunders JT, Nambi V, de Lemos JA, et al (2011) Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the atherosclerosis risk in community study. Circulation 123:1367–1376
Wallace TW, Abdullah SM, Drazner MH, et al (2006) Prevalence and determinants of troponin T elevation in the general population. Circulation 113:1958–1965
de Lemos JA, Drazner MH, Omland T, et al (2010) Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA 304:2503–2512
Haaf P, Drexler B, Reichlin T, et al (2012) High sensitivity cardiac troponin in the distinction of acute myocardial infarction from acute cardiac non-coronary artery disease. Circulation 126:31–40
Panteghini M (2009) Assay-related issues in the measurement of cardiac troponins. Clin Chim Acta 402:88–93
Florkowski C, Wallace J, Walmsley T, George P (2010) The effect of hemolysis on current troponin assays—a confounding preanalytical variable? Clin Chem 56:1195–1197
Adamczyk M, Brashear RJ, Mattingly PG (2009) Circulating cardiac troponin-I autoantibodies in human plasma and serum. Ann N Y Acad Sci 1173:67–74
Adamczyk M, Brashear RJ, Mattingly PG (2010) Coprevalence of autoantibodies to cardiac troponin I and T in normal blood donors. Clin Chem 56:676–677
Comité européen de normalisation (2006) Analyses de biologie délocalisées (ADBD). Exigences concernant la qualité et la compétence (ISO 22870:2006), AFNOR, France
Bingisser R, Cairns C, Christ M, et al (2012) Cardiac troponin: a critical review of the case for point-of-care testing in the ED. Am J Emerg Med 30:1639–1649
