Triterpenic acids-enriched fraction from Cyclocarya paliurus attenuates non-alcoholic fatty liver disease via improving oxidative stress and mitochondrial dysfunction

Biomedicine & Pharmacotherapy - Tập 104 - Trang 229-239 - 2018
Meng-ge Zhao1,2,3, Xue-ping Sheng1,2,3, Ya-ping Huang1,2,3, Yi-ting Wang1,2,3, Cui-hua Jiang2,3, Jian Zhang2,3, Zhi-qi Yin1
1Department of TCMs Pharmaceuticals & State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China
2Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
3Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China

Tài liệu tham khảo

Satapathy, 2015, Epidemiology and natural history of nonalcoholic fatty liver disease, Semin. Liver Dis., 35, 221, 10.1055/s-0035-1562943 Angulo, 2002, Nonalcoholic fatty liver disease, N. Engl. Med., 346, 1221, 10.1056/NEJMra011775 Gariani, 2013, Non-alcoholic fatty liver disease and insulin resistance: from bench to bedside, Diabetes Metab., 39, 16, 10.1016/j.diabet.2012.11.002 Spahis, 2017, Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis, Antioxid. Redox Signal., 26, 519, 10.1089/ars.2016.6776 Paschos, 2009, Non alcoholic fatty liver disease and metabolic syndrome, Hippokratia, 13, 9 Paradies, 2014, Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease, World J. Gastroenterol., 20, 14205, 10.3748/wjg.v20.i39.14205 Marí, 2015, Oxidative stress in nonalcoholic fatty liver disease, 279 Tan, 2010, Non-alcoholic fatty liver disease, Proc. Singap. Healthc., 19, 36, 10.1177/201010581001900106 Nakajima, 2012, Multidisciplinary pharmacotherapeutic options for nonalcoholic fatty liver disease, Int. J. Hepatol., 2012, 950693, 10.1155/2012/950693 Malinowski, 2013, Pharmacologic therapy for nonalcoholic fatty liver disease in adults, Pharmacotherapy, 33, 223, 10.1002/phar.1190 Xie, 2015, Preparation, characterization and antioxidant activities of acetylated polysaccharides from Cyclocarya paliurus leaves, Carbohydr. Polym., 133, 596, 10.1016/j.carbpol.2015.07.031 Xie, 2015, Extraction, chemical composition and antioxidant activity of flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja leaves, Food Chem., 186, 97, 10.1016/j.foodchem.2014.06.106 Yang, 2016, Structural characterization and hypolipidemic effect of Cyclocarya paliurus polysaccharide in rat, Int. J. Biol. Macromol., 91, 1073, 10.1016/j.ijbiomac.2016.06.063 Jiang, 2014, Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice, J. Ethnopharmacol., 153, 344, 10.1016/j.jep.2014.02.003 Li, 2011, Hypoglycemic effects and constituents of the barks of Cyclocarya paliurus and their inhibiting activities to glucosidase and glycogen phosphorylase, Fitoterapia, 82, 1081, 10.1016/j.fitote.2011.07.002 Wang, 2013, Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats, J. Ethnopharmacol., 150, 1119, 10.1016/j.jep.2013.10.040 Lin, 2016, The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats, Phytomedicine, 23, 1475, 10.1016/j.phymed.2016.08.003 Wu, 2017, Antihyperlipidaemic effect of triterpenic acid-enriched fraction from Cyclocarya paliurus leaves in hyperlipidaemic rats, Pharm. Biol., 55, 712, 10.1080/13880209.2016.1267231 Hernandez, 2015, Free fatty acids enhance the oxidative damage induced by ethanol metabolism in an in vitro model, Food Chem. Toxicol., 76, 109, 10.1016/j.fct.2014.12.005 Zeng, 2016, Alisol A 24-acetate prevents hepatic steatosis and metabolic disorders in HepG2 cells, Cell. Physiol. Biochem., 40, 453, 10.1159/000452560 Yang, 2015, Evidence of ATP assay as an appropriate alternative of MTT assay for cytotoxicity of secondary effluents from WWTPs, Ecotoxicol. Environ. Saf., 122, 490, 10.1016/j.ecoenv.2015.09.006 Yin, 2014, Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPARalpha pathways in L02 cells and HepG2 cells, J. Ethnopharmacol., 154, 229, 10.1016/j.jep.2014.04.011 Wang, 2017, Hepatoprotective effect of 2′-O-galloylhyperin against oxidative stress-induced liver damage through induction of Nrf2/ARE-mediated antioxidant pathway, Food Chem. Toxicol., 102, 129, 10.1016/j.fct.2017.02.016 Kumar, 2014, Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases, Nat. Prod. Rep., 31, 109, 10.1039/C3NP70065H Mantena, 2008, Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases, Free Radic. Biol. Med., 44, 1259, 10.1016/j.freeradbiomed.2007.12.029 Rolo, 2012, Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis, Free Radic. Biol. Med., 52, 59, 10.1016/j.freeradbiomed.2011.10.003 Zou, 2014, Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin, Antioxid. Redox Signal., 21, 1557, 10.1089/ars.2013.5538 Xin, 2014, Treatment with baicalein attenuates methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats, Eur. J. Pharmacol., 738, 310, 10.1016/j.ejphar.2014.06.006 Day, 1998, Steatohepatitis: a tale of two “hits”?, Gastroenterology, 114, 842, 10.1016/S0016-5085(98)70599-2 Zhang, 2013, Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats, Food Chem., 141, 2108, 10.1016/j.foodchem.2013.05.019 Grattagliano, 2012, Role of mitochondria in nonalcoholic fatty liver disease—from origin to propagation, Clin. Biochem., 45, 610, 10.1016/j.clinbiochem.2012.03.024 Koliaki, 2015, Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis, Cell Metab., 21, 739, 10.1016/j.cmet.2015.04.004 Abdelmegeed, 2015, Role of CYP2E1 in mitochondrial dysfunction and hepatic tissue injury in alcoholic and non-alcoholic diseases, Curr. Mol. Pharmacol., 10, 207, 10.2174/1874467208666150817111114 Leung, 2013, CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease, J. Hepatol., 58, 395, 10.1016/j.jhep.2012.08.018 Bryan, 2013, The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation, Biochem. Pharmacol., 85, 705, 10.1016/j.bcp.2012.11.016 Chambel, 2015, The dual role of Nrf2 in nonalcoholic fatty liver disease: regulation of antioxidant defenses and hepatic lipid metabolism, Biomed. Res. Int., 2015, 597134, 10.1155/2015/597134 Ma, 2013, Role of nrf2 in oxidative stress and toxicity, Annu. Rev. Pharmacol. Toxicol., 53, 401, 10.1146/annurev-pharmtox-011112-140320 Engin, 2017, Non-alcoholic fatty liver disease, 443 Gomez-Lechon, 2007, A human hepatocellular in vitro model to investigate steatosis, Chem. Biol. Interact., 165, 106, 10.1016/j.cbi.2006.11.004 Dinkova-Kostova, 2015, The emerging role of Nrf2 in mitochondrial function, Free Radic. Biol. Med., 88, 179, 10.1016/j.freeradbiomed.2015.04.036 Xie, 2015, Extraction, chemical composition and antioxidant activity of flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja leaves, Food Chem., 186, 97, 10.1016/j.foodchem.2014.06.106 Tang, 2016, Effect of ultrasonic treatment on the physicochemical properties and antioxidant activities of polysaccharide from Cyclocarya paliurus, Carbohydr. Polym., 151, 305, 10.1016/j.carbpol.2016.05.078