Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles
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Caroni, 1997, Overexpression of growth-associated proteins in the neurons of adult transgenic mice, J. Neurosci. Methods, 71, 3, 10.1016/S0165-0270(96)00121-5
Chapman, 1999, Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice, Nat. Neurosci., 2, 271, 10.1038/6374
Chui, 1999, Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation, Nat. Med., 5, 560, 10.1038/8438
DeKosky, 1990, Synapse loss in frontal cortex biopsies in Alzheimer's disease, Ann. Neurol., 27, 457, 10.1002/ana.410270502
Dickson, 1995, Correlations of synaptic and pathological markers with cognition of the elderly, Neurobiol. Aging, 16, 285, 10.1016/0197-4580(95)00013-5
Fitzjohn, 2001, Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein, J. Neurosci., 21, 4691, 10.1523/JNEUROSCI.21-13-04691.2001
Flood, 1990, Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease, Prog. Brain Res., 83, 435, 10.1016/S0079-6123(08)61267-4
Gotz, 2001, Tau filament formation in transgenic mice expressing P301L tau, J. Biol. Chem., 276, 529, 10.1074/jbc.M006531200
Gotz, 2001, Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils, Science, 293, 1491, 10.1126/science.1062097
Gouras, 2000, Intraneuronal Abeta42 accumulation in human brain, Am. J. Pathol., 156, 15, 10.1016/S0002-9440(10)64700-1
Grundke-Iqbal, 1989, Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 86, 2853, 10.1073/pnas.86.8.2853
Guo, 1999, Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice, Nat. Med., 5, 101, 10.1038/4789
Gyure, 2001, Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome, Arch. Pathol. Lab. Med., 125, 489, 10.5858/2001-125-0489-IAAPDO
Hardy, 2002, The amyloid hypothesis of Alzheimer's disease, Science, 297, 353, 10.1126/science.1072994
Higuchi, 2002, Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration, Neuron, 35, 433, 10.1016/S0896-6273(02)00789-4
Hsia, 1999, Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models, Proc. Natl. Acad. Sci. USA, 96, 3228, 10.1073/pnas.96.6.3228
Kamenetz, 2003, APP processing and synaptic function, Neuron, 37, 925, 10.1016/S0896-6273(03)00124-7
Kayed, 2003, Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis, Science, 300, 486, 10.1126/science.1079469
Kuo, 2001, The evolution of A beta peptide burden in the APP23 transgenic mice, Mol. Med., 7, 609, 10.1007/BF03401867
LaFerla, 2002, Calcium dyshomeostasis and intracellular signaling in Alzheimer's disease, Nat. Rev. Neurosci., 3, 862, 10.1038/nrn960
LaFerla, 1995, The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice, Nat. Genet., 9, 21, 10.1038/ng0195-21
LaFerla, 1997, Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization, J. Clin. Invest., 100, 310, 10.1172/JCI119536
Leissring, 2000, Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice, J. Cell Biol., 149, 793, 10.1083/jcb.149.4.793
Lewis, 2000, Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein, Nat. Genet., 25, 402, 10.1038/78078
Lewis, 2001, Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP, Science, 293, 1487, 10.1126/science.1058189
Li, 1999, Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice, J. Neurochem., 72, 2479, 10.1046/j.1471-4159.1999.0722479.x
Masliah, 2001, Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease, Neurology, 56, 127, 10.1212/WNL.56.1.127
Mendell, 1991, Amyloid filaments in inclusion body myositis. Novel findings provide insight into nature of filaments, Arch. Neurol., 48, 1229, 10.1001/archneur.1991.00530240033013
Mesulam, 1999, Neuroplasticity failure in Alzheimer's disease, Neuron, 24, 521, 10.1016/S0896-6273(00)81109-5
Mesulam, 2000, A plasticity-based theory of the pathogenesis of Alzheimer's disease, Ann. N Y Acad. Sci., 924, 42, 10.1111/j.1749-6632.2000.tb05559.x
Moechars, 1999, Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain, J. Biol. Chem., 274, 6483, 10.1074/jbc.274.10.6483
Parent, 1999, Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1, Neurobiol. Dis., 6, 56, 10.1006/nbdi.1998.0207
Scheff, 1991, Quantitation of synaptic density in the septal nuclei of young and aged Fischer 344 rats, Neurobiol. Aging, 12, 3, 10.1016/0197-4580(91)90032-F
Schwab, 2000, Abeta42-carboxy-terminal-like immunoreactivity is associated with intracellular neurofibrillary tangles and pick bodies, Exp. Neurol., 161, 527, 10.1006/exnr.1999.7307
Sugarman, 2002, Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle, Proc. Natl. Acad. Sci. USA, 99, 6334, 10.1073/pnas.082545599
Suzuki, 1994, An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants, Science, 264, 1336, 10.1126/science.8191290
Sze, 1997, Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease, J. Neuropathol. Exp. Neurol., 56, 933, 10.1097/00005072-199708000-00011
Takahashi, 2002, Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology, Am. J. Pathol., 161, 1869, 10.1016/S0002-9440(10)64463-X
Terry, 1991, Physical basis of cognitive alterations in Alzheimer's disease, Ann. Neurol., 30, 572, 10.1002/ana.410300410
Thomson, 2000, Facilitation, augmentation and potentiation at central synapses, Trends Neurosci., 23, 305, 10.1016/S0166-2236(00)01580-0
Walsh, 2002, Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo, Nature, 416, 535, 10.1038/416535a
Wirths, 2001, Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice, Neurosci. Lett., 306, 116, 10.1016/S0304-3940(01)01876-6
Wong, 2002, Genetically engineered mouse models of neurodegenerative diseases, Nat. Neurosci., 5, 633, 10.1038/nn0702-633
Zhang, 2002, Selective cytotoxicity of intracellular amyloid beta peptide1–42 through p53 and Bax in cultured primary human neurons, J. Cell Biol., 156, 519, 10.1083/jcb.200110119