Triglyceride-Rich Lipoprotein Cholesterol, Small Dense LDL Cholesterol, and Incident Cardiovascular Disease

Journal of the American College of Cardiology - Tập 75 - Trang 2122-2135 - 2020
Edward K. Duran1, Aaron W. Aday2, Nancy R. Cook1, Julie E. Buring1, Paul M Ridker1,3, Aruna D. Pradhan1,4
1Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston Massachusetts
2Vanderbilt Translational and Clinical Cardiovascular Research Center, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
3Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical, School, Boston, Massachusetts
4Division of Cardiovascular Medicine, VA Boston Medical Center, Boston, Massachusetts

Tài liệu tham khảo

Grundy, 2019, J Am Coll Cardiol, 73, e285, 10.1016/j.jacc.2018.11.003 Baigent, 2010, Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials, Lancet, 376, 1670, 10.1016/S0140-6736(10)61350-5 Fruchart, 2008, The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patient, Diab Vasc Dis Res, 5, 319, 10.3132/dvdr.2008.046 Xiao, 2016, Pharmacological targeting of the atherogenic dyslipidemia complex: the next frontier in CVD prevention beyond lowering LDL Ccholesterol, Diabetes, 65, 1767, 10.2337/db16-0046 Otvos, 2002, Measurement issues related to lipoprotein heterogeneity, Am J Cardiol, 90, 22i, 10.1016/S0002-9149(02)02632-2 Packard, 2003, Triacylglycerol-rich lipoproteins and the generation of small, dense low-density lipoprotein, Biochem Soc Trans, 31, 1066, 10.1042/bst0311066 Adiels, 2008, Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome, Arterioscler Thromb Vasc Biol, 28, 1225, 10.1161/ATVBAHA.107.160192 Berneis, 2002, Metabolic origins and clinical significance of LDL heterogeneity, J Lipid Res, 43, 1363, 10.1194/jlr.R200004-JLR200 Mora, 2007, LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA), Atherosclerosis, 192, 211, 10.1016/j.atherosclerosis.2006.05.007 Lawler, 2017, Atherogenic lipoprotein determinants of cardiovascular disease and residual risk among individuals with low low-density lipoprotein cholesterol, J Am Heart Assoc, 6 Mora, 2009, Lipoprotein particle profiles by nuclear magnetic resonance compared with standard lipids and apolipoproteins in predicting incident cardiovascular disease in women, Circulation, 119, 931, 10.1161/CIRCULATIONAHA.108.816181 Aday, 2018, Lipoprotein particle profiles, standard lipids, and peripheral artery disease incidence, Circulation, 138, 2330, 10.1161/CIRCULATIONAHA.118.035432 Varbo, 2013, Remnant cholesterol as a causal risk factor for ischemic heart disease [published correction in J Am Coll Cardiol 2019;73:987–8], J Am Coll Cardiol, 61, 427, 10.1016/j.jacc.2012.08.1026 Varbo, 2014, Remnant cholesterol as a cause of ischemic heart disease: evidence, definition, measurement, atherogenicity, high risk patients, and present and future treatment, Pharmacol Ther, 141, 358, 10.1016/j.pharmthera.2013.11.008 Varbo, 2013, Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation, Circulation, 128, 1298, 10.1161/CIRCULATIONAHA.113.003008 Varbo, 2015, Extreme nonfasting remnant cholesterol vs extreme LDL cholesterol as contributors to cardiovascular disease and all-cause mortality in 90000 individuals from the general population, Clin Chem, 61, 533, 10.1373/clinchem.2014.234146 Varbo, 2014, Remnant cholesterol and ischemic heart disease, Curr Opin Lipidol, 25, 266, 10.1097/MOL.0000000000000093 Hoogeveen, 2014, Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study, Arterioscler Thromb Vasc Biol, 34, 1069, 10.1161/ATVBAHA.114.303284 Varbo, 2018, Remnant cholesterol and myocardial infarction in normal weight, overweight, and obese individuals from the copenhagen general population study, Clin Chem, 64, 219, 10.1373/clinchem.2017.279463 Varbo, 2019, Remnant cholesterol and risk of ischemic stroke in 112,512 individuals from the general population, Ann Neurol, 85, 550, 10.1002/ana.25432 Saeed, 2018, Remnant-like particle cholesterol, low-density lipoprotein triglycerides, and incident cardiovascular disease, J Am Coll Cardiol, 72, 156, 10.1016/j.jacc.2018.04.050 Vallejo-Vaz, 2018, Triglyceride-rich lipoprotein cholesterol and risk of cardiovascular events among patients receiving statin therapy in the TNT Trial, Circulation, 138, 770, 10.1161/CIRCULATIONAHA.117.032318 Ridker, 2005, A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women, N Engl J Med, 352, 1293, 10.1056/NEJMoa050613 Lee, 2005, Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial, JAMA, 294, 56, 10.1001/jama.294.1.56 Ridker, 1999, Homocysteine and risk of cardiovascular disease among postmenopausal women, JAMA, 281, 1817, 10.1001/jama.281.19.1817 Duran, 2019, Plasma placental growth factor concentrations are elevated well in advance of type 2 diabetes mellitus onset: prospective data from the WHS, J Am Heart Assoc, 8 Ito, 2011, Development of a homogeneous assay for measurement of small dense LDL cholesterol, Clin Chem, 57, 57, 10.1373/clinchem.2010.149559 Pradhan, 2008, Symptomatic peripheral arterial disease in women: nontraditional biomarkers of elevated risk, Circulation, 117, 823, 10.1161/CIRCULATIONAHA.107.719369 Therneau, 1999, Computing the Cox model for case cohort designs, Lifetime Data Anal, 5, 99, 10.1023/A:1009691327335 Barlow, 1994, Robust variance estimation for the case-cohort design, Biometrics, 50, 1064, 10.2307/2533444 Langholz, 2007, Computational methods for case-cohort studies, Computational Statistics & Data Analysis, 51, 3737, 10.1016/j.csda.2006.12.028 Wolkewitz, 2016, A full competing risk analysis of hospital-acquired infections can easily be performed by a case-cohort approach, J Clin Epidemiol, 74, 187, 10.1016/j.jclinepi.2015.11.011 Durrleman, 1989, Flexible regression models with cubic splines, Stat Med, 8, 551, 10.1002/sim.4780080504 Adiels, 2006, Overproduction of large VLDL particles is driven by increased liver fat content in man, Diabetologia, 49, 755, 10.1007/s00125-005-0125-z Mamo, 1998, Retention of chylomicron remnants by arterial tissue; importance of an efficient clearance mechanism from plasma, Atherosclerosis, 141, S63, 10.1016/S0021-9150(98)00220-2 Zilversmit, 1973, A proposal linking atherogenesis to the interaction of endothelial lipoprotein lipase with triglyceride-rich lipoproteins, Circ Res, 33, 633, 10.1161/01.RES.33.6.633 Mahley, 1985, Lipoproteins of special significance in atherosclerosis. Insights provided by studies of type III hyperlipoproteinemia, Ann N Y Acad Sci, 454, 209, 10.1111/j.1749-6632.1985.tb11860.x Nordestgaard, 1995, Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo. Molecular size as a determinant of fractional loss from the intima-inner media, Arterioscler Thromb Vasc Biol, 15, 534, 10.1161/01.ATV.15.4.534 Nordestgaard, 1996, The vascular endothelial barrier--selective retention of lipoproteins, Curr Opin Lipidol, 7, 269, 10.1097/00041433-199610000-00002 Rutledge, 2000, Direct visualization of lipid deposition and reverse lipid transport in a perfused artery: roles of VLDL and HDL, Circ Res, 86, 768, 10.1161/01.RES.86.7.768 Shaikh, 1991, Quantitative studies of transfer in vivo of low density, Sf 12-60, and Sf 60-400 lipoproteins between plasma and arterial intima in humans, Arterioscler Thromb, 11, 569, 10.1161/01.ATV.11.3.569 Takahashi, 2004, The very low-density lipoprotein (VLDL) receptor: characterization and functions as a peripheral lipoprotein receptor, J Atheroscler Thromb, 11, 200, 10.5551/jat.11.200 Moore, 2013, Macrophages in atherosclerosis: a dynamic balance, Nat Rev Immunol, 13, 709, 10.1038/nri3520 Chen, 2016, Atherosclerotic plaque rupture: identifying the straw that breaks the camel's back, Arterioscler Thromb Vasc Biol, 36, e63, 10.1161/ATVBAHA.116.307993 Bentzon, 2014, Mechanisms of plaque formation and rupture, Circ Res, 114, 1852, 10.1161/CIRCRESAHA.114.302721 Matsuo, 2012, Plaque characteristics and arterial remodeling in coronary and peripheral arterial systems, Atherosclerosis, 223, 365, 10.1016/j.atherosclerosis.2012.05.023 Polonsky, 2014, High-risk plaque in the superficial femoral artery of people with peripheral artery disease: prevalence and associated clinical characteristics, Atherosclerosis, 237, 169, 10.1016/j.atherosclerosis.2014.08.034 Carmena, 2004, Atherogenic lipoprotein particles in atherosclerosis, Circulation, 109, III2 Austin, 1988, Low-density lipoprotein subclass patterns and risk of myocardial infarction, JAMA, 260, 1917, 10.1001/jama.1988.03410130125037 Ehara, 2002, Pathophysiological role of oxidized low-density lipoprotein in plaque instability in coronary artery diseases, J Diabetes Complications, 16, 60, 10.1016/S1056-8727(01)00210-0 Nishi, 2002, Oxidized LDL in carotid plaques and plasma associates with plaque instability, Arterioscler Thromb Vasc Biol, 22, 1649, 10.1161/01.ATV.0000033829.14012.18 Sigala, 2010, Oxidized LDL in human carotid plaques is related to symptomatic carotid disease and lesion instability, J Vasc Surg, 52, 704, 10.1016/j.jvs.2010.03.047 Otvos, 1999, Measurement of triglyceride-rich lipoproteins by nuclear magnetic resonance spectroscopy, Clin Cardiol, 22, II21 Everett, 2006, The relative strength of C-reactive protein and lipid levels as determinants of ischemic stroke compared with coronary heart disease in women, J Am Coll Cardiol, 48, 2235, 10.1016/j.jacc.2006.09.030 Willey, 2013, Cholesterol level and stroke: a complex relationship, JAMA Intern Med, 173, 1765, 10.1001/jamainternmed.2013.10100 Imamura, 2009, LDL cholesterol and the development of stroke subtypes and coronary heart disease in a general Japanese population: the Hisayama study, Stroke, 40, 382, 10.1161/STROKEAHA.108.529537 Valdes-Marquez, 2019, Relative effects of LDL-C on ischemic stroke and coronary disease: a Mendelian randomization study, Neurology, 92, e1176 Ference, 2019, Association of triglyceride-lowering LPL variants and LDL-C-lowering LDLR variants with risk of coronary heart disease, JAMA, 321, 364, 10.1001/jama.2018.20045 Hansen, 2019, Low-grade inflammation in the association between mild-to-moderate hypertriglyceridemia and risk of acute pancreatitis: a study of more than 115000 individuals from the general population, Clin Chem, 65, 321, 10.1373/clinchem.2018.294926 Nordestgaard, 2016, Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology, Circ Res, 118, 547, 10.1161/CIRCRESAHA.115.306249 Bhatt, 2019, Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia, N Engl J Med, 380, 11, 10.1056/NEJMoa1812792 Rajamani, 2009, Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial, Lancet, 373, 1780, 10.1016/S0140-6736(09)60698-X Fruchart, 2017, Pemafibrate (K-877), a novel selective peroxisome proliferator-activated receptor alpha modulator for management of atherogenic dyslipidaemia, Cardiovasc Diabetol, 16, 124, 10.1186/s12933-017-0602-y Arai, 2017, Efficacy and safety of K-877, a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), in combination with statin treatment: Two randomised, double-blind, placebo-controlled clinical trials in patients with dyslipidaemia, Atherosclerosis, 261, 144, 10.1016/j.atherosclerosis.2017.03.032 Pradhan, 2018, Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study, Am Heart J, 206, 80, 10.1016/j.ahj.2018.09.011