Tridimensional configurations of human mesenchymal stem/stromal cells to enhance cell paracrine potential towards wound healing processes

Arnaoutova, 2010, In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract, Nat. Protoc., 5, 628, 10.1038/nprot.2010.6 Bartosh, 2010, Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties, Proc. Natl. Acad. Sci., 107, 13724, 10.1073/pnas.1008117107 Bartosh, 2013, Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1): activation of IL1-signaling in MSC Spheres, Stem Cells, 31, 2443, 10.1002/stem.1499 Bhang, 2011, Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells, Biomaterials, 32, 2734, 10.1016/j.biomaterials.2010.12.035 Bhang, 2012, Transplantation of cord blood mesenchymal stem cells as spheroids enhances vascularization, Tissue Eng. Part A, 18, 2138, 10.1089/ten.tea.2011.0640 Bidarra, 2010, Immobilization of human mesenchymal stem cells within RGD-Grafted alginate microspheres and assessment of their angiogenic potential, Biomacromolecules, 11, 1956, 10.1021/bm100264a Blacher, 2014, Cell invasion in the spheroid sprouting assay: a spatial organisation analysis adaptable to cell behaviour, PLoS One, 9, e97019, 10.1371/journal.pone.0097019 Broughton, 2006, Wound healing: an overview, Plast. Reconstr. Surg., 117, 1e, 10.1097/01.prs.0000222562.60260.f9 Bussche, 2015, Microencapsulated equine mesenchymal stromal cells promote cutaneous wound healing in vitro, Stem Cell Res. Ther., 6 Caplan, 2006, Mesenchymal stem cells as trophic mediators, J. Cell. Biochem., 98, 1076, 10.1002/jcb.20886 Ceccaldi, 2012, Alginate scaffolds for mesenchymal stem cell cardiac therapy: influence of alginate composition, Cell Transplant., 21, 1969, 10.3727/096368912X647252 Cerwinka, 2012, Differentiation of human mesenchymal stem cell spheroids under microgravity conditions, Cell Regen., 1, 2, 10.1186/2045-9769-1-2 Di Nicola, 2002, Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli, Blood, 99, 3838, 10.1182/blood.V99.10.3838 Ding, 2003, HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro, Blood, 101, 4816, 10.1182/blood-2002-06-1731 Djouad, 2007, Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleukin-6-dependent mechanism, Stem Cells, 25, 2025, 10.1634/stemcells.2006-0548 Eftekharzadeh, 2010, Alginate protects NT2 neurons against H2O2-induced neurotoxicity, Carbohydr. Polym., 79, 1063, 10.1016/j.carbpol.2009.10.040 Ferrara, 2001, Role of vascular endothelial growth factor in regulation of physiological angiogenesis, Am. J. Physiol.-Cell Physiol., 280, C1358, 10.1152/ajpcell.2001.280.6.C1358 Follin, 2016, Increased paracrine immunomodulatory potential of mesenchymal stromal cells in three-dimensional culture, Tissue Eng. Part B Rev., 22, 322, 10.1089/ten.teb.2015.0532 Freeman, 2009, The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization, Biomaterials, 30, 2122, 10.1016/j.biomaterials.2008.12.057 Freyer, 1986, Proliferative and clonogenic heterogeneity of cells from EMT6/Ro multicellular spheroids induced by the glucose and oxygen supply, Cancer Res., 46, 3513 Gerritsen, 2005, HGF and VEGF: a dynamic duo, Circ. Res., 96, 272, 10.1161/01.RES.0000157575.66295.e0 Gnecchi, 2006, Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement, FASEB J., 20, 661, 10.1096/fj.05-5211com Hashimoto, 2004, Development of alginate wound dressings linked with hybrid peptides derived from laminin and elastin, Biomaterials, 25, 1407, 10.1016/j.biomaterials.2003.07.004 Ho, 2016, Increased survival and function of mesenchymal stem cell spheroids entrapped in instructive alginate hydrogels, Stem Cells Transl. Med., 5, 773, 10.5966/sctm.2015-0211 Janssens, 2015, Immunomodulatory properties of the IL-6 cytokine family in multiple sclerosis: immunomodulatory role of the IL-6 family in MS, Ann. N. Y. Acad. Sci., 1351, 52, 10.1111/nyas.12821 Johnson, 2009, Oxygen consumption and diffusion in assemblages of respiring spheres: performance enhancement of a bioartificial pancreas, Chem. Eng. Sci., 64, 4470, 10.1016/j.ces.2009.06.028 Khanna, 2010, Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice, PLoS One, 5, e9539, 10.1371/journal.pone.0009539 Kinney, 2012, Systematic analysis of embryonic stem cell differentiation in hydrodynamic environments with controlled embryoid body size, Integr. Biol., 4, 641, 10.1039/c2ib00165a Kwon, 2014, Multiple paracrine factors secreted by mesenchymal stem cells contribute to angiogenesis, Vascul. Pharmacol., 63, 19, 10.1016/j.vph.2014.06.004 Kwon, 2015, Conditioned medium of adipose-derived stromal cell culture in three-dimensional bioreactors for enhanced wound healing, J. Surg. Res., 194, 8, 10.1016/j.jss.2014.10.053 Landázuri, 2012, Alginate microencapsulation of human mesenchymal stem cells as a strategy to enhance paracrine-mediated vascular recovery after hindlimb ischaemia: encapsulated human MSCs enhance revascularization, J. Tissue Eng. Regen. Med., 222 Lee, 2009, Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6, Cell Stem Cell, 5, 54, 10.1016/j.stem.2009.05.003 Lee, 2010, Growth factor delivery-based tissue engineering: general approaches and a review of recent developments, J. R. Soc. Interface, 8, 153, 10.1098/rsif.2010.0223 Lee, 2012, Spherical bullet formation via E-cadherin promotes therapeutic potency of mesenchymal stem cells derived from human umbilical cord blood for myocardial infarction, Mol. Ther., 20, 1424, 10.1038/mt.2012.58 Lee, 2014, TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo, Proc. Natl. Acad. Sci., 111, 16766, 10.1073/pnas.1416121111 Liang, 2007, In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro, Nat. Protoc., 2, 329, 10.1038/nprot.2007.30 Liu, 2012, The role of SDF-1-CXCR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injury, PLoS One, 7, e34608, 10.1371/journal.pone.0034608 Matyash, 2012, Novel soft alginate hydrogel strongly supports neurite growth and protects neurons against oxidative stress, Tissue Eng. Part A, 18, 55, 10.1089/ten.tea.2011.0097 Nauta, 2014, Hypoxic signaling during tissue repair and regenerative medicine, Int. J. Mol. Sci., 15, 19791, 10.3390/ijms151119791 Potier, 2007, Prolonged hypoxia concomitant with serum deprivation induces massive human mesenchymal stem cell death, Tissue Eng., 13, 1325, 10.1089/ten.2006.0325 Ryan, 2014, Chondrogenic differentiation increases antidonor immune response to allogeneic mesenchymal stem cell transplantation, Mol. Ther., 22, 655, 10.1038/mt.2013.261 Safley, 2008, Biocompatibility and immune acceptance of adult porcine islets transplanted intraperitoneally in diabetic NOD mice in calcium alginate poly-l-lysine microcapsules versus barium alginate microcapsules without poly-l-lysine, J. Diabetes Sci. Technol., 2, 760, 10.1177/193229680800200503 Sala, 2015, Mesenchymal stem cells reduce colitis in mice via release of TSG6, independently of their localization to the intestine, Gastroenterology, 149, 163, 10.1053/j.gastro.2015.03.013 Santos, 2015, Three-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healing, Stem Cell Res. Ther., 6 Schafer, 2008, Oxidative stress in normal and impaired wound repair, Pharmacol. Res., 58, 165, 10.1016/j.phrs.2008.06.004 Sen, 2001, Effects of hydrodynamics on cultures of mammalian neural stem cell aggregates in suspension bioreactors, Ind. Eng. Chem. Res., 40, 5350, 10.1021/ie001107y Song, 2010, Reactive oxygen species inhibit adhesion of mesenchymal stem cells implanted into ischemic myocardium via interference of focal adhesion complex, Stem Cells, 555, 10.1002/stem.302 Strand, 2002, Alginate-polylysine-alginate microcapsules: effect of size reduction on capsule properties, J. Microencapsul., 19, 615, 10.1080/02652040210144243 Tandara, 2004, Oxygen in wound healing − more than a nutrient, World J. Surg., 28, 294, 10.1007/s00268-003-7400-2 Tsai, 2015, Compaction, fusion, and functional activation of three-dimensional human mesenchymal stem cell aggregate, Tissue Eng. Part A, 21, 1705, 10.1089/ten.tea.2014.0314 Ungrin, 2008, Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-Derived human embryonic stem cell aggregates, PLoS One, 3, e1565, 10.1371/journal.pone.0001565 Wang, 2009, Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2, J. Leukoc. Biol., 86, 981, 10.1189/jlb.0708454 Wong, 2011, Pullulan hydrogels improve mesenchymal stem cell delivery into high-oxidative-stress wounds, Macromol. Biosci., 1458 Wu, 2014, Oxygen transport and stem cell aggregation in stirred-suspension bioreactor cultures, PLoS One, 9, e102486, 10.1371/journal.pone.0102486 Yagi, 2010, Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn, Cell Transplant., 19, 823, 10.3727/096368910X508942 YlÖstalo, 2012, Human mesenchymal Stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype: hMSC spheroids promote M2 macrophage phenotype, Stem Cells, 30, 2283, 10.1002/stem.1191 Zanoni, 2016, 3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained, Sci. Rep., 6, 19103, 10.1038/srep19103 Zhang, 2012, Three-dimensional spheroid culture of human gingiva-derived mesenchymal stem cells enhances mitigation of chemotherapy-induced oral mucositis, Stem Cells Dev., 21, 937, 10.1089/scd.2011.0252 Zhao, 2015, Large-scale expansion of Wharton’s jelly-derived mesenchymal stem cells on gelatin microbeads, with retention of self-renewal and multipotency characteristics and the capacity for enhancing skin wound healing, Stem Cell Res. Ther., 6 Zhao, 2015, Three-dimensional aggregates enhance the therapeutic effects of adipose mesenchymal stem cells for ischemia-reperfusion induced kidney injury in rats, Stem Cells Int. Zimmermann, 2014, Pre-conditioning mesenchymal stromal cell spheroids for immunomodulatory paracrine factor secretion, Cytotherapy, 16, 331, 10.1016/j.jcyt.2013.09.004 dos Santos, 2010, Ex vivo expansion of human mesenchymal stem cells: a more effective cell proliferation kinetics and metabolism under hypoxia, J. Cell. Physiol., 223, 27