Tremelimumab as second-line or third-line treatment in relapsed malignant mesothelioma (DETERMINE): a multicentre, international, randomised, double-blind, placebo-controlled phase 2b trial

The Lancet Oncology - Tập 18 Số 9 - Trang 1261-1273 - 2017
Michele Maio1, Arnaud Scherpereel2, Luana Calabrò1, Joachim G.J.V. Aerts3, S. Cedrés4, Alessandra Bearz5, Kristiaan Nackaerts6, Dean A. Fennell7, Dariusz Kowalski8, Anne S. Tsao9, Paul Taylor10, Federica Grosso11, Scott Antonia12, Anna K. Nowak13,14, Maria Taboada15, M. Puglisi16, Paul K. Stockman15, Hedy L. Kindler17
1Medical Oncology and Immunotherapy, Center for Immuno-Oncology, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy
2Pulmonary and Thoracic Oncology, University of Lille, CHU de Lille, Lille, France
3Erasmus Medical Center, Rotterdam, Netherlands
4Vall d'Hebron Institute of Oncology, Barcelona, Spain
5Centro di Riferimento Oncologico di Aviano, Pordenone, Italy
6KU Leuven-University of Leuven, University Hospitals, Leuven, Belgium
7University Hospitals of Leicester, Leicester, UK
8Maria Sklodowska-Curie Institute of Oncology, Warsaw, Poland
9The University of Texas MD Anderson Cancer Center, Houston, TX, USA
10University Hospital of South Manchester, Manchester, UK
11Mesothelioma Unit—Medical Oncology Department, SS Antonio e Biagio General Hospital, Alessandria, Italy
12H. Lee Moffitt Cancer Center, Tampa, FL, USA.
13Department of Medical Oncology, Sir Charles Gairdner Hospital, Perth, WA, Australia
14School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia.
15AstraZeneca, Alderley Park, Macclesfield, UK
16AstraZeneca, Cambridge, UK
17Department of Medicine, University of Chicago, Chicago, IL, USA

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