Treatment with carvedilol improves survival of patients with acute-on-chronic liver failure: a randomized controlled trial

Hepatology International - Tập 13 Số 6 - Trang 800-813 - 2019
Manoj Kumar1, Sumit Kainth, Ashok Choudhury1, Rakhi Maiwall1, Lalita Gouri Mitra2, Vandana Saluja2, Prashant Agarwal2, Saggere Muralikrishna Shasthry1, Ankur Jindal1, Ankit Bhardwaj3, Guresh Kumar4, Shiv Kumar Sarin1
1Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India
2Department of Critical Care Medicine, Institute of Liver and Biliary Sciences, New Delhi, India
3Department of Clinical Research, Institute of Liver and Biliary Sciences, New Delhi, India
4Department of Biostatistics, Institute of Liver and Biliary Sciences, New Delhi, India

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Lebrec D, Nouel O, Bernuau J, Bouygues M, Rueff B, Benhamou JP. Propranolol in prevention of recurrent gastrointestinal bleeding in cirrhotic patients. Lancet. 1981;1:920–1.

de Montmollin E, Aboab J, Mansart A, Annane D. Bench-to-bedside review: betaadrenergic modulation in sepsis. Crit Care. 2009;13:230.

Perez-Paramo M, Munoz J, Albillos A, Freile I, Portero F, Santos M, et al. Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites. Hepatology. 2000;31:43–8.

Reiberger T, Ferlitsch A, Payer BA, Mandorfer M, Heinisch BB, Hayden H, et al. Non-selective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis. J Hepatol. 2013;58:911–21.

Abraldes JG, Tarantino I, Turnes J, Garcia-Pagan JC, Rodes J, Bosch J. Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis. Hepatology. 2003;37:902–8.

D’Amico G, Garcia-Pagan JC, Luca A, Bosch J. HVPG reduction and prevention of variceal bleeding in cirrhosis. A systematic review. Gastroenterology. 2006;131:1611–24.

Senzolo M, Cholongitas E, Burra P, Leandro G, Thalheimer U, Patch D, et al. Beta-blockers protect against spontaneous bacterial peritonitis in cirrhotic patients: a meta-analysis. Liver Int. 2009;29:1189–93.

Kumar A, Das K, Sharma P, Mehta V, Sharma BC, Sarin SK. Hepatic venous pressure gradient, systemic and pulmonary hemodynamics in patients with acute-on-chronic liver failure. Dig Dis Sci. 2009;54:869–78.

Garg H, Kumar A, Garg V, Kumar M, Kumar R, Sharma BC, et al. Hepatic and systemic hemodynamic derangements predict early mortality and recovery in patients with acute-on-chronic liver failure. J Gastroenterol Hepatol. 2013;28(8):1361–7.

Mookerjee RP. Acute-on-chronic liver failure: liver and portal haemodynamics. Curr Opin Crit Care. 2011;17(2):170–6.

Mookerjee RP, Pavesi M, Thomsen KL, Mehta G, Macnaughtan J, Bendtsen F, et al. Treatment with non-selective beta-blockers is associated with reduced severity of systemic inflammation and improved survival of patients with acute-on-chronic liver failure. J Hepatol. 2016;64:574–82.

Sarin SK, Kedarisetty CK, Abbas Z, Amarapurkar D, Bihari C, Chan AC, et al. APASL ACLF Working Party. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014. Hepatol Int. 2014;8(4):453–71.

Louvet A, Naveau S, Abdelnour M, Ramond MJ, Diaz E, Fartoux L, et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology. 2007;45:1348–54.

Choudhury A, Jindal A, Maiwall R, Sharma MK, Sharma BC, Pamecha V, et al. Liver failure determines the outcome in patients of acute-on-chronic liver failure (ACLF): comparison of APASL ACLF research consortium (AARC) and CLIF-SOFA models. Hepatol Int. 2017;11(5):461–71.

http://www.aclf.in/?page=doctor_aarc_grade_cal .

Jalan R, Saliba F, Pavesi M, Amoros A, Moreau R, Ginès P, et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. 2014;61:1038–47.

https://www.clifresearch.com/ToolsCalculators.aspx .

Angeli P, Gines P, Wong F, et al. Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites. J Hepatol. 2015;62:986-74.

Jindal A, Vashistha C, Sharma MK, Sarin SK. Acute-on-chronic liver failure- does etiology really matter? J Clin Exp Hepatol. 2013;3:S18–20.

Sarin SK, Choudhury A. Acute-on-chronic liver failure: terminology, mechanisms and management. Nat Rev Gastroenterol Hepatol. 2016;13(3):131–4.

Turnes J, Garcia-Pagan JC, Abraldes JG, Hernandez-Guerra M, Dell’Era A, Bosch J, et al. Pharmacological reduction of portal pressure and long-term risk of first variceal bleeding in patients with cirrhosis. Am J Gastroenterol. 2006;101:506–12.

De Franchis R. Evolving consensus in portal hypertension. Report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2005;43:167–76.

Senzolo M, Cholongitas E, Marelli L, Thalheimer U, Patch D, Burroughs AK, et al. The low incidence of bacterial infections could be a protective factor against variceal bleeding per se in hemodynamic responders to propranolol. Am J Gastroenterol. 2006;101:2436–7.

Straub RH, Pongratz G, Weidler C, Linde HJ, Kirschning CJ, Glück T, et al. Ablation of the sympathetic nervous system decreases gram-negative and increases gram-positive bacterial dissemination: key roles for tumor necrosis factor/phagocytes and interleukin-4/lymphocytes. J Infect Dis. 2005;192:560–72.

Worlicek M, Knebel K, Linde HJ, Moleda L, Schölmerich J, Straub RH, et al. Splanchnic sympathectomy prevents translocation and spreading of E. coli but not S. aureus in liver cirrhosis. Gut. 2010;59:1127–34.

Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve–an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev. 2000;52:595–638.

Peuschel KE. Antiviral therapy with non-selective beta blockers: preliminary experimental and clinical corroboration. Med Hypotheses. 2005;64:256–60.

Morelli A, Ertmer C, Westphal M, Rehberg S, Kampmeier T, Ligges S, et al. Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA. 2013;310:1683–91.

Sersté T, Njimi H, Degré D, Deltenre P, Schreiber J, Lepida A, et al. The use of beta-blockers is associated with the occurrence of acute kidney injury in severe alcoholic hepatitis. Liver Int. 2015;35:1974–82.

Umgelter A, Reindl W, Franzen M, Lenhardt C, Huber W, Schmid RM. Renal resistive index and renal function before and after paracentesis in patients with hepatorenal syndrome and tense ascites. Intensive Care Med. 2009;35:152–6.

Rezayat KA, Zeraati AA, Pezeshki Rad M, Chogan J, Davoudian N, Akhavan Rezayat A, et al. Impact of propranolol on preventing renal dysfunction in patients with cirrhosis. Middle East J Dig Dis. 2017;9(4):206–11.

Kastelan S, Ljubicic N, Kastelan Z, Ostojic R, Uravic M. The role of duplex-doppler ultrasonography in the diagnosis of renal dysfunction and hepatorenal syndrome in patients with liver cirrhosis. Hepatogastroenterology. 2004;51:1408–12.

Ozcan H, Aytac SK, Yagmurlu B, Erten A. Effect of propranolol on renal hemodynamics in patients with cirrhosis: assessment with Doppler US. Tani Girisim Radyol. 2004;10:230–3.

Kumar A, Sharma P, Anikhindi SA, Prajapati R, Agarwal R, Sharma B, Bansal N, Singla V, Arora A. Can non-selective beta-blockers (NSBBs) prevent enlargement of small esophageal varices in patients with cirrhosis? A Meta-analysis. J Clin Exp Hepatol. 2017;7(4):275–83.