Treatment strategies and overall survival for incurable metastatic colorectal cancer – A EURECCA international comparison including 21,196 patients from the Netherlands and Norway

Ferlay, 2015, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012, Int J Canc, 136, E359, 10.1002/ijc.29210 Siegel, 2016, Cancer statistics, Ca - Cancer J Clin, 66, 7, 10.3322/caac.21332 Van Cutsem, 2016, ESMO consensus guidelines for the management of patients with metastatic colorectal cancer, Ann Oncol, 27, 1386, 10.1093/annonc/mdw235 Sorbye, 2013, Age-dependent improvement in median and long-term survival in unselected population-based Nordic registries of patients with synchronous metastatic colorectal cancer, Ann Oncol, 24, 2354, 10.1093/annonc/mdt197 Scheithauer, 1993, Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer, BMJ (Clinical research ed), 306, 752, 10.1136/bmj.306.6880.752 de Gramont, 2000, Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer, J Clin Oncol : Off J Am Soc Clin Oncol, 18, 2938, 10.1200/JCO.2000.18.16.2938 Saltz, 2000, Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group, N Engl J Med, 343, 905, 10.1056/NEJM200009283431302 Koopman, 2007, Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial, Lancet (London, England), 370, 135, 10.1016/S0140-6736(07)61086-1 Hurwitz, 2004, Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer, N Engl J Med, 350, 2335, 10.1056/NEJMoa032691 Vale, 2012, Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis, Canc Treat Rev, 38, 618, 10.1016/j.ctrv.2011.11.002 Soreide, 2016, Resection of asymptomatic primary tumour in unresectable stage IV colorectal cancer: time to move on from propensity matched scores to randomized controlled trials, Int J Canc, 139, 1927, 10.1002/ijc.30244 Patel, 2015, Primary tumor resection in metastatic colorectal cancer: please pass the salt, JAMA Oncol., 1, 1213, 10.1001/jamaoncol.2015.2757 Arbman, 2013, The rise and fall of a longed for clinical trial in patients with generalized colorectal cancer, Acta Oncol, 52, 1779, 10.3109/0284186X.2013.812794 Brookhart, 2010, Instrumental variable methods in comparative safety and effectiveness research, Pharmacoepidemiol Drug Saf, 19, 537, 10.1002/pds.1908 Boef, 2013, [Instrumental variable analysis], Ned Tijdschr Geneeskd, 157 Guren, 2015, Nationwide improvement of rectal cancer treatment outcomes in Norway, 1993-2010, Acta Oncol, 54, 1714, 10.3109/0284186X.2015.1034876 Schemper, 1996, A note on quantifying follow-up in studies of failure time, Contr Clin Trials, 17, 343, 10.1016/0197-2456(96)00075-X Cook, 2005, Surgical resection of primary tumors in patients who present with stage IV colorectal cancer: an analysis of surveillance, epidemiology, and end results data, 1988 to 2000, Ann Surg Oncol, 12, 637, 10.1245/ASO.2005.06.012 Sarela, 2001, Non-operative management of the primary tumour in patients with incurable stage IV colorectal cancer, Br J Surg, 88, 1352, 10.1046/j.0007-1323.2001.01915.x Ruo, 2003, Elective bowel resection for incurable stage IV colorectal cancer: prognostic variables for asymptomatic patients, J Am Coll Surg, 196, 722, 10.1016/S1072-7515(03)00136-4 Tebbutt, 2003, Intestinal complications after chemotherapy for patients with unresected primary colorectal cancer and synchronous metastases, Gut, 52, 568, 10.1136/gut.52.4.568 Sigurdsson, 2008, Palliative surgery for rectal cancer in a national cohort, Colorectal Dis, 10, 336, 10.1111/j.1463-1318.2007.01376.x Cameron, 2016, Palliative pelvic radiotherapy for symptomatic rectal cancer - a prospective multicenter study, Acta Oncol, 55, 1400, 10.1080/0284186X.2016.1191666 Tyc-Szczepaniak, 2013, Palliative radiotherapy and chemotherapy instead of surgery in symptomatic rectal cancer with synchronous unresectable metastases: a phase II study, Ann Oncol, 24, 2829, 10.1093/annonc/mdt363 Hu, 2015, Time trend analysis of primary tumor resection for stage IV colorectal cancer: less surgery, improved survival, JAMA Surg, 150, 245, 10.1001/jamasurg.2014.2253 Clancy, 2014, A meta-analysis to determine the effect of primary tumor resection for stage IV colorectal cancer with unresectable metastases on patient survival, Ann Surg Oncol, 21, 3900, 10.1245/s10434-014-3805-4 Cirocchi, 2012, Non-resection versus resection for an asymptomatic primary tumour in patients with unresectable stage IV colorectal cancer, Cochrane Database Syst Rev Alawadi, 2017, Comparative effectiveness of primary tumor resection in patients with stage IV colon cancer, Cancer, 123, 1124, 10.1002/cncr.30230 Lam-Boer J, 2016, Palliative resection of the primary tumor is associated with improved overall survival in incurable stage IV colorectal cancer: a nationwide population-based propensity-score adjusted study in The Netherlands, Int J Canc, 139, 2082, 10.1002/ijc.30240 Xu, 2015, Primary tumor resection is associated with improved survival in stage IV colorectal cancer: an instrumental variable analysis, Sci Rep, 5, 16516, 10.1038/srep16516 Tarantino, 2015, Prognostic relevance of palliative primary tumor removal in 37,793 metastatic colorectal cancer patients: a population-based, propensity score-adjusted trend analysis, Ann Surg, 262, 112, 10.1097/SLA.0000000000000860 Rahbari, 2012, Resection of the primary tumour versus no resection prior to systemic therapy in patients with colon cancer and synchronous unresectable metastases (UICC stage IV): SYNCHRONOUS--a randomised controlled multicentre trial (ISRCTN30964555), BMC Canc, 12, 142, 10.1186/1471-2407-12-142 Lam-Boer J, 2014, The CAIRO4 study: the role of surgery of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastases of colorectal cancer--a randomized phase III study of the Dutch Colorectal Cancer Group (DCCG), BMC Canc, 14, 741, 10.1186/1471-2407-14-741 Kim, 2016, The role of primary tumor resection in colorectal cancer patients with asymptomatic, synchronous unresectable metastasis: study protocol for a randomized controlled trial, Trials, 17, 34, 10.1186/s13063-016-1164-0 Dekker, 2011, Importance of the first postoperative year in the prognosis of elderly colorectal cancer patients, Ann Surg Oncol, 18, 1533, 10.1245/s10434-011-1671-x Mehta, 2017, Comparative effectiveness of chemotherapy vs resection of the primary tumour as the initial treatment in older patients with Stage IV colorectal cancer, Colorectal Dis, 19, O210, 10.1111/codi.13659 Storm, 2015, Less pitfalls and variation in population based cancer survival comparisons within the European Union: lessons from colorectal cancer patients in neighbouring regions in Denmark and Germany - the Fehmarn Belt project, Eur J Canc, 51, 1188, 10.1016/j.ejca.2014.11.006