Treatment of human T-cell acute lymphoblastic leukemia cells with CFTR inhibitor CFTRinh-172

Gadsby, 2006, The ABC protein turned chloride channel whose failure causes cystic fibrosis, Nature, 440, 477, 10.1038/nature04712 Sun, 2018, CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis, Cell Death Dis., 9, 275, 10.1038/s41419-018-0311-9 Yang, 2017, High CFTR expression in Philadelphia chromosome-positive acute leukemia protects and maintains continuous activation of BCR-ABL and related signaling pathways in combination with PP2A, Oncotarget, 8, 24437, 10.18632/oncotarget.15510 Yan, 2017, High-expressing cystic fibrosis transmembrane conductance regulator interacts with histone deacetylase 2 to promote the development of Ph+ leukemia through the HDAC2-mediated PTEN pathway, Leuk. Res., 57, 9, 10.1016/j.leukres.2017.02.004 Karrman, 2017, Pediatric T-cell acute lymphoblastic leukemia, Genes Chromosomes Cancer, 56, 89, 10.1002/gcc.22416 Raetz, 2016, T-cell acute lymphoblastic leukemia, Hematol. Am. Soc. Hematol. Educ. Program, 2016, 580, 10.1182/asheducation-2016.1.580 Song, 2017, Relationship between PPP1R15A gene polymorphism (rs611251) and Epstein-Barr virus-associated tumors, Acta Virol., 61, 445, 10.4149/av_2017_407 Guo, 2015, RNAi-mediated knockdown of the c-jun gene sensitizes radioresistant human nasopharyngeal carcinoma cell line CNE-2R to radiation, Oncol. Rep., 33, 1155, 10.3892/or.2014.3692 Bai, 2016, C/EBP beta mediates endoplasmic reticulum stress regulated inflammatory response and extracellular matrix degradation in LPS-stimulated human periodontal ligament cells, Int. J. Mol. Sci., 17, 385, 10.3390/ijms17030385 Chen, 2016, ESM1 mediates NGFR-induced invasion and metastasis in murine oral squamous cell carcinoma, Oncotarget, 7, 70738, 10.18632/oncotarget.12210 Xu, 2019, Verapamil attenuated prediabetic neuropathy in high-fat diet-fed mice through inhibiting TXNIP-mediated apoptosis and inflammation, Oxid. Med. Cell. Longev., 2019, 10.1155/2019/1896041 You, 2019, The mechanism of ATF3 repression of epithelial-mesenchymal transition and suppression of cell viability in cholangiocarcinoma via p53 signal pathway, J. Cell. Mol. Med., 23, 2184, 10.1111/jcmm.14132 Wang, 2014, Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nat. Genet., 46, 573, 10.1038/ng.2983 Ma, 2018, Positive expression of Midkine predicts early recurrence and poor prognosis of initially resectable combined hepatocellular cholangiocarcinoma, BMC Cancer, 18, 227, 10.1186/s12885-018-4146-7 Bhowmick, 2003, TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest, Proc. Natl. Acad. Sci. U. S. A., 100, 15548, 10.1073/pnas.2536483100 Chen, 2009, Immunoglobulin expression in non-lymphoid lineage and neoplastic cells, Am. J. Pathol., 174, 1139, 10.2353/ajpath.2009.080879 Syc-Mazurek, 2017, Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury, Mol. Neurodegener., 12, 71, 10.1186/s13024-017-0214-8 Khan, 2007, Activation of Wnt/beta-catenin pathway mediates growth and survival in B-cell progenitor acute lymphoblastic leukaemia, Br. J. Haematol., 138, 338, 10.1111/j.1365-2141.2007.06667.x Luis, 2012, Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development, Leukemia, 26, 414, 10.1038/leu.2011.387 Bornhauser, 2007, Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway, Blood, 110, 2084, 10.1182/blood-2006-12-060970 Bomberger, 2012, Arsenic promotes ubiquitinylation and lysosomal degradation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels in human airway epithelial cells, J. Biol. Chem., 287, 17130, 10.1074/jbc.M111.338855