Treatment Options for Anemia in Kidney Transplant Patients: A Review

Bonomini, 2016, New treatment approaches for the anemia of CKD, Am J Kidney Dis, 67, 133, 10.1053/j.ajkd.2015.06.030 Schechter, 2019, Post renal transplantation anemia: causes, severity and their association with graft and patient survival, BMC Nephrol, 20, 51, 10.1186/s12882-019-1244-y Winkelmayer, 2006, A prospective study of anaemia and long-term outcomes in kidney transplant recipients, Nephrol Dial Transplant, 21, 3559, 10.1093/ndt/gfl457 Gafter-Gvili, 2017, Posttransplantation anemia in kidney transplant recipients: a retrospective cohort study, Medicine, 96, 10.1097/MD.0000000000007735 Gafter-Gvili, 2019, Posttransplantation anemia in kidney transplant recipients, Acta Haematol, 142, 37, 10.1159/000496140 Malyszko, 2022, Haematological disorders following kidney transplantation, Nephrol Dial Transplant, 37, 409, 10.1093/ndt/gfaa219 Kawada, 2009, Negative effects of anemia on quality of life and its improvement by complete correction of anemia by administration of recombinant human erythropoietin in posttransplant patients, Clin Exp Nephrol, 13, 355, 10.1007/s10157-009-0170-x Molina, 2022, Quality of life in long-term renal transplant patients: a controversial subject, Transplant Proc, 54, 91, 10.1016/j.transproceed.2021.11.025 2009, KDIGO Clinical Practice Guideline for the care of kidney transplant recipients, Am J Transplant, 9, S1 Locatelli, 2009, Anaemia management in patients with chronic kidney disease: a position statement by the Anaemia Working Group of European Renal Best Practice (ERBP), Nephrol Dial Transplant, 24, 348, 10.1093/ndt/gfn653 Guzzo I, Atkinson MA. Anemia after kidney transplantation. Pediatr Nephrol. Published online October 25, 2022. https://doi.org/10.1007/s00467-022-05743-7 Vanrenterghem, 2003, Prevalence and management of anemia in renal transplant recipients: a European survey, Am J Transplant, 3, 835, 10.1034/j.1600-6143.2003.00133.x Shah, 2006, Posttransplantation anemia in adult renal allograft recipients: prevalence and predictors, Transplantation, 81, 1112, 10.1097/01.tp.0000205174.97275.b5 Kalantzi, 2014, Parameters influencing blood erythropoietin levels of renal transplant recipients during the early post-transplantation period, Transplant Proc, 46, 3179, 10.1016/j.transproceed.2014.10.035 Afzali, 2006, Anemia after renal transplantation, Am J Kidney Dis, 48, 519, 10.1053/j.ajkd.2006.07.006 Besarab, 1987, Dynamics of erythropoiesis following renal transplantation, Kidney Int, 32, 526, 10.1038/ki.1987.241 Vinke, 2021, Iron deficiency after kidney transplantation, Nephrol Dial Transplant, 36, 1976, 10.1093/ndt/gfaa123 Moore, 1994, Factors affecting erythropoietin production and correction of anemia in kidney transplant recipients, Clin Transplant, 8, 358 Smith, 2010, Hematologic disorders after solid organ transplantation, Hematology Am Soc Hematol Educ Program, 2010, 281, 10.1182/asheducation-2010.1.281 Nissaisorakarn, 2023, The current therapeutic approach for anaemia after kidney transplant, Curr Opin Nephrol Hypertens, 32, 35, 10.1097/MNH.0000000000000842 Saad, 2020, Infections in the first year after renal transplant, Medicina (B Aires), 80, 611 Huang, 2022, Parvovirus B19 infection in kidney transplant recipients: A prospective study in a teaching hospital in Shanghai, China, Transpl Immunol, 74, 10.1016/j.trim.2022.101667 Baradaran, 2022, Management of drug-induced neutropenia, thrombocytopenia, and anaemia after solid organ transplantation: a comprehensive review, J Clin Pharm Ther, 47, 1895, 10.1111/jcpt.13775 Al Qahtani, 2018, Drug-induced megaloblastic, aplastic, and hemolytic anemias: current concepts of pathophysiology and treatment, Int J Clin Exp Med, 11, 5501 Douwes, 2019, Chronic use of proton-pump inhibitors and iron status in renal transplant recipients, J Clin Med, 8, 1382 Vlahakos, 2010, The role of the renin-angiotensin system in the regulation of erythropoiesis, Am J Kidney Dis, 56, 558, 10.1053/j.ajkd.2009.12.042 Mrug, 1997, Angiotensin II stimulates proliferation of normal early erythroid progenitors, J Clin Invest, 100, 2310, 10.1172/JCI119769 Tajima, 2015, Angiotensin II alters the expression of duodenal iron transporters, hepatic hepcidin, and body iron distribution in mice, Eur J Nutr, 54, 709, 10.1007/s00394-014-0749-1 Pratt, 1992, Effect of angiotensin converting enzyme inhibitors on erythropoietin concentrations in healthy volunteers, Br J Clin Pharmacol, 34, 363, 10.1111/j.1365-2125.1992.tb05644.x Marathias, 2020, Competing effects of renin angiotensin system blockade and sodium-glucose cotransporter-2 inhibitors on erythropoietin secretion in diabetes, Am J Nephrol, 51, 349, 10.1159/000507272 Vlahakos, 2003, Posttransplant erythrocytosis, Kidney Int, 63, 1187, 10.1046/j.1523-1755.2003.00850.x Kamar, 2011, Impact of post-transplant anemia on patient and graft survival rates after kidney transplantation: a meta-analysis, Clin Transplant, 26, 461, 10.1111/j.1399-0012.2011.01545.x Marcén, 2012, Anemia at 1 year after kidney transplantation has a negative long-term impact on graft and patient outcomes, Transplant Proc, 44, 2593, 10.1016/j.transproceed.2012.09.033 De Andrade, 2012, Anemia at one year is an independent risk factor of graft survival, Int Urol Nephrol, 44, 263, 10.1007/s11255-010-9854-0 Mekraksakit, 2023, A systematic review and meta-analysis of posttransplant anemia with overall mortality and cardiovascular outcomes among kidney transplant recipients, Prog Transplant, 33, 78, 10.1177/15269248221145046 Goldman, 2022, Absence of hemoglobin increase is associated with reduced graft survival after kidney transplantation, Clin Transplant, 36, 10.1111/ctr.14602 Hart, 2015, Cardiovascular risk assessment in kidney transplantation, Kidney Int, 87, 527, 10.1038/ki.2014.335 Reggiani, 2022, Cardiovascular risk after kidney transplantation: causes and current approaches to a relevant burden, J Pers Med, 12, 1200 Rigatto, 2002, Congestive heart failure in renal transplant recipients: risk factors, outcomes, and relationship with ischemic heart disease, J Am Soc Nephrol, 13, 1084, 10.1681/ASN.V1341084 Lentine, 2005, De novo congestive heart failure after kidney transplantation: a common condition with poor prognostic implications, Am J Kidney Dis, 46, 720, 10.1053/j.ajkd.2005.06.019 Rigatto, 2003, Electrocardiographic left ventricular hypertrophy in renal transplant recipients: prognostic value and impact of blood pressure and anemia, J Am Soc Nephrol, 14, 462, 10.1097/01.ASN.0000043141.67989.39 Hsu, 2021, Association of post transplantation anaemia and persistent secondary hyperparathyroidism with diastolic function in stable kidney transplant recipients, Int J Nephrol Renovasc Dis, 14, 211, 10.2147/IJNRD.S314313 Molnar, 2007, Anemia is associated with mortality in kidney-transplanted patients—a prospective cohort study, Am J Transplant, 7, 818, 10.1111/j.1600-6143.2006.01727.x Heinze, 2006, Angiotensin-converting enzyme inhibitor or angiotensin II type 1 receptor antagonist therapy is associated with prolonged patient and graft survival after renal transplantation, J Am Soc Nephrol, 17, 889, 10.1681/ASN.2005090955 Imoagene-Oyedeji, 2006, Posttransplantation anemia at 12 months in kidney recipients treated with mycophenolate mofetil: risk factors and implications for mortality, J Am Soc Nephrol, 17, 3240, 10.1681/ASN.2006010027 Majernikova, 2017, Posttransplant anemia as a prognostic factor of mortality in kidney-transplant recipients, Biomed Res Int, 2017, 10.1155/2017/6987240 Huang, 2015, Post-renal transplantation anemia at 12 months: prevalence, risk factors, and impact on clinical outcomes, Int Urol Nephrol, 47, 1577, 10.1007/s11255-015-1069-y Schjelderup, 2013, Anemia is a predictor of graft loss but not cardiovascular events and all-cause mortality in renal transplant recipients: follow-up data from the ALERT study, Clin Transplant, 27, E636, 10.1111/ctr.12220 Vaugier, 2017, Serum iron protects from renal postischemic injury, J Am Soc Nephrol, 28, 3605, 10.1681/ASN.2016080926 Winkelmayer, 2004, Percentage of hypochromic red blood cells is an independent risk factor for mortality in kidney transplant recipients, Am J Transplant, 4, 2075, 10.1046/j.1600-6143.2004.00604.x Eisenga, 2016, Iron deficiency, anemia, and mortality in renal transplant recipients, Transpl Int, 29, 1176, 10.1111/tri.12821 Eisenga, 2019, Iron deficiency, elevated erythropoietin, fibroblast growth factor 23, and mortality in the general population of the Netherlands: a cohort study, PLoS Med, 16, 10.1371/journal.pmed.1002818 Baia, 2013, Fibroblast growth factor 23 and cardiovascular mortality after kidney transplantation, Clin J Am Soc Nephrol, 8, 1968, 10.2215/CJN.01880213 Wolf, 2011, Elevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortality, J Am Soc Nephrol, 22, 956, 10.1681/ASN.2010080894 Bazeley, 2022, Recent and emerging therapies for iron deficiency in anemia of CKD: a review, Am J Kidney Dis, 79, 868, 10.1053/j.ajkd.2021.09.017 Ribeiro, 2021, Oral iron supplementation in patients with chronic kidney disease: can it be harmful to the gut microbiota?, Nutr Clin Pract, 37, 81, 10.1002/ncp.10662 Ardalan, 2017, Gut microbiota and renal transplant outcome, Biomed Pharmacother, 90, 229, 10.1016/j.biopha.2017.02.114 Shepshelovich, 2016, Intravenous versus oral iron supplementation for the treatment of anemia in CKD: an updated systematic review and meta-analysis, Am J Kidney Dis, 68, 677, 10.1053/j.ajkd.2016.04.018 Rozen-Zvi, 2012, Intravenous iron supplementation after kidney transplantation, Clin Transplant, 26, 608, 10.1111/j.1399-0012.2012.01602.x Mudge, 2012, A randomized controlled trial of intravenous or oral iron for posttransplant anemia in kidney transplantation, Transplantation, 93, 822, 10.1097/TP.0b013e318248375a Grimmelt, 2009, Safety and tolerability of ferric carboxymaltose (FCM) for treatment of iron deficiency in patients with chronic kidney disease and in kidney transplant recipients, Clin Nephrol, 71, 125, 10.5414/CNP71125 Schaefer, 2021, Hypophosphataemia after treatment of iron deficiency with intravenous ferric carboxymaltose or iron isomaltoside—a systematic review and meta-analysis, Br J Clin Pharmacol, 87, 2256, 10.1111/bcp.14643 Sari, 2017, Ferric carboxymaltose-induced hypophosphataemia after kidney transplantation, Neth J Med, 75, 65 Kassianides, 2021, Hypophosphataemia, fibroblast growth factor 23 and third-generation intravenous iron compounds: a narrative review, Drugs Context, 10, 10.7573/dic.2020-11-3 Alshamsi, 2022, Extended literature review of the role of erythropoietin stimulating agents (ESA) use in the management of post renal transplant anaemia, Transplant Rep, 7 Macdougall, 2019, Intravenous iron in patients undergoing maintenance hemodialysis, N Engl J Med, 380, 447, 10.1056/NEJMoa1810742 Van Biesen, 2005, Efficacy of erythropoietin administration in the treatment of anemia immediately after renal transplantation, Transplantation, 79, 367, 10.1097/01.TP.0000150370.51700.99 Nafar, 2012, Effect of erythropoietin on kidney allograft survival: early use after transplantation, Iran J Kidney Dis, 6, 44 Pile, 2020, Treating posttransplant anemia with erythropoietin improves quality of life but does not affect progression of chronic kidney disease, Exp Clin Transplant, 18, 27, 10.6002/ect.2018.0283 Choukroun, 2012, Correction of postkidney transplant anemia reduces progression of allograft nephropathy, J Am Soc Nephrol, 23, 360, 10.1681/ASN.2011060546 Tsujita, 2019, The effect of maintaining high hemoglobin levels on long-term kidney function in kidney transplant recipients: a randomized controlled trial, Nephrol Dial Transplant, 34, 1409, 10.1093/ndt/gfy365 Obi, 2021, CANDLE-KIT Trial Investigators. Correcting anemia and native vitamin D supplementation in kidney transplant recipients: a multicenter, 2 × 2 factorial, open-label, randomized clinical trial, Transpl Int, 34, 1212, 10.1111/tri.13885 Elliott, 2017, Erythropoiesis stimulating agents and reno-protection: a meta-analysis, BCM Nephrol, 18, 14 Cassis, 2012, Erythropoietin, but not the correction of anemia alone, protects from chronic kidney allograft injury, Kidney Int, 81, 903, 10.1038/ki.2011.473 Purroy, 2017, Erythropoietin receptor-mediated molecular crosstalk promotes T cell immunoregulation and transplant survival, J Am Soc Nephrol, 28, 2377, 10.1681/ASN.2016101100 Vlachopanos, 2015, Perioperative administration of high-dose recombinant human erythropoietin for delayed graft function prevention in kidney transplantation: a meta-analysis, Transpl Int, 28, 330, 10.1111/tri.12506 2012, KDIGO clinical practice guideline for anemia in chronic kidney disease, Kidney Int, 2, 279 Kliger, 2013, KDOQI US commentary on the 2012 KDIGO Clinical Practice Guideline for anemia in CKD, Am J Kidney Dis, 62, 849, 10.1053/j.ajkd.2013.06.008 Singh, 2006, CHOIR Investigators: Correction of anemia with epoetin alfa in chronic kidney disease, N Engl J Med, 355, 2085, 10.1056/NEJMoa065485 Pfeffer, 2009, TREAT Investigators: A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease, N Engl J Med, 361, 2019, 10.1056/NEJMoa0907845 Drüeke, 2006, CREATE Investigators: Normalization of hemoglobin level in patients with chronic kidney disease and anemia, N Engl J Med, 355, 2071, 10.1056/NEJMoa062276 Gaiffe, 2022, Early post-transplant red blood cell transfusion is associated with an increased risk of transplant failure: a nationwide French study, Front Immunol, 13, 10.3389/fimmu.2022.854850 Silva, 2023, Impact of early blood transfusion after kidney transplantation on the clinical outcomes and allograft survival, Transpl Immunol, 77, 10.1016/j.trim.2023.101807 Goel, 2018, Association of perioperative red blood cell transfusions with venous thromboembolism in a north American registry, JAMA Surg, 153, 826, 10.1001/jamasurg.2018.1565 Massicotte-Azarniouch, 2022, The association of venous thromboembolism with blood transfusion in kidney transplant patients, Transfusion, 62, 2480, 10.1111/trf.17154 Lam, 2017, Venous thromboembolism and the risk of death and graft loss in kidney transplant recipients, Am J Nephrol, 46, 343, 10.1159/000480304 Koury, 2015, Anaemia in kidney disease: harnessing hypoxia responses to therapy, Nat Rev Nephrol, 11, 394, 10.1038/nrneph.2015.82 Miki, 2022, Therapeutic effect of roxadustat on patients with posttransplant anemia, Transplant Proc, 54, 671, 10.1016/j.transproceed.2022.02.004 Li, 2021, Efficacy and safety of roxadustat in the treatment of renal allograft anemia patients: a case series, Ann Palliat Med, 10, 11859, 10.21037/apm-21-2916 Naganuma, 2022, Experience with the use of a novel agent, hypoxia-inducible factor prolyl hydroxylase inhibitor, for posttransplant anemia in renal transplant recipients: a case report, Transplant Proc, 54, 544, 10.1016/j.transproceed.2021.10.022