Treating Circadian Rhythm Disruption in Bipolar Disorder

Alexandra K. Gold1, Gustavo Kinrys2,3
1Department of Psychological and Brain Sciences, Boston University, Boston, USA
2Harvard Medical School, Boston, USA
3Massachusetts General Hospital, Boston, USA

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Murray G, Harvey A. Circadian rhythms and sleep in bipolar disorder. Bipolar Disord. 2010;12(5):459–72.

Soreca I. Circadian rhythms and sleep in bipolar disorder: implications for pathophysiology and treatment. Curr Opin Psychiatry. 2014;27(6):467–71.

Gold AK, Sylvia LG. The role of sleep in bipolar disorder. Nat Sci Sleep. 2016;8:207–14.

Hastings M, O’Neill JS, Maywood ES. Circadian clocks: regulators of endocrine and metabolic rhythms. J Endocrinol. 2007;195(2):187–98.

Richardson GS. The human circadian system in normal and disordered sleep. J Clin Psychiatry. 2005;66:3–9 quiz 42-3.

Wehrens SM, Christou S, Isherwood C, Middleton B, Gibbs MA, Archer SN, et al. Meal timing regulates the human circadian system. Curr Biol. 2017;27(12):1768–75.e3.

Richards J, Gumz ML. Advances in understanding the peripheral circadian clocks. FASEB J. 2012;26(9):3602–13.

Harvey AG. Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation. Am J Psychiatr. 2008;165(7):820–9.

Plante DT, Winkelman JW. Sleep disturbance in bipolar disorder: therapeutic implications. Am J Psychiatry. 2008;165(7):830–43.

•• Takaesu Y. Circadian Rhythm in Bipolar Disorder: A review of the literature. Psychiatry Clin Neurosci. 2018. This recent review discusses mechanisms underlying circadian rhythm disruption in BD, as well as interventions for treating circadian dysfunction.

Brown GM. Light, melatonin and the sleep-wake cycle. J Psychiatry Neurosci. 1994;19(5):345–53.

Mitchell HA, Weinshenker D. Good night and good luck: norepinephrine in sleep pharmacology. Biochem Pharmacol. 2010;79(6):801–9.

Kennedy SH, Tighe S, McVEY G, Brown GM. Melatonin and cortisol" switches" during mania, depression, and euthymia in a drug-free bipolar patient. J Nerv Ment Dis. 1989;177:300–3.

Lewy AJ. Biochemistry and regulation of mammalian melatonin production: Elsevier biomedical. New York; 1983.

Post RM, Stoddard FJ, Gillin JC, Buchsbaum MS, Runkle DC, Black KE, et al. Alterations in motor activity, sleep, and biochemistry in a cycling manic-depressive patient. Arch Gen Psychiatry. 1977;34(4):470–7.

Juckel G, Hegerl U, Mavrogiorgou P, Gallinat J, Mager T, Tigges P, et al. Clinical and biological findings in a case with 48-hour bipolar ultrarapid cycling before and during valproate treatment. J Clin Psychiatry. 2000;61(8):585–93.

Kurita M. Noradrenaline plays a critical role in the switch to a manic episode and treatment of a depressive episode. Neuropsychiatr Dis Treat. 2016;12:2373–80.

Dell'Osso B, Palazzo MC, Oldani L, Altamura AC. The noradrenergic action in antidepressant treatments: pharmacological and clinical aspects. CNS Neurosci Ther. 2011;17(6):723–32.

Robillard R, Naismith SL, Hickie IB. Recent advances in sleep-wake cycle and biological rhythms in bipolar disorder. Curr Psychiatry Rep. 2013;15(10):402.

Harvey AG, Schmidt DA, Scarnà A, Semler CN, Goodwin GM. Sleep-related functioning in euthymic patients with bipolar disorder, patients with insomnia, and subjects without sleep problems. Am J Psychiatr. 2005;162(1):50–7.

Harvey AG, Lee J, Williams J, Hollon SD, Walker MP, Thompson MA, et al. Improving outcome of psychosocial treatments by enhancing memory and learning. Perspect Psychol Sci. 2014;9(2):161–79.

•• Alloy LB, Ng TH, Titone MK, Boland EM. Circadian rhythm dysregulation in bipolar spectrum disorders. Curr Psychiatry Rep. 2017;19(4):21. This manuscript synthesizes the evidence base supporting circadian rhythm disruption as a relevant mechanism in BD.

Adan A, Archer SN, Hidalgo MP, Di Milia L, Natale V, Randler C. Circadian typology: a comprehensive review. Chronobiol Int. 2012;29(9):1153–75.

Melo MC, Abreu RL, Neto VBL, de Bruin PF, de Bruin VM. Chronotype and circadian rhythm in bipolar disorder: a systematic review. Sleep Med Rev. 2017;34:46–58.

Moon JH, Cho CH, Son GH, Geum D, Chung S, Kim H, et al. Advanced circadian phase in mania and delayed circadian phase in mixed mania and depression returned to Normal after treatment of bipolar disorder. EBioMedicine. 2016;11:285–95.

Hickie IB, Naismith SL, Robillard R, Scott EM, Hermens DF. Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression. BMC Med. 2013;11:79.

Ehlers CL, Frank E, Kupfer DJ. Social zeitgebers and biological rhythms: a unified approach to understanding the etiology of depression. Arch Gen Psychiatry. 1988;45(10):948–52.

Grandin LD, Alloy LB, Abramson LY. The social zeitgeber theory, circadian rhythms, and mood disorders: review and evaluation. Clin Psychol Rev. 2006;26(6):679–94.

Haynes PL, Gengler D, Kelly M. Social rhythm therapies for mood disorders: an update. Curr Psychiatry Rep. 2016;18(8):75.

Klerman GL, Weissman MM. Interpersonal psychotherapy of depression: a brief, focused, specific strategy. Jason Aronson, Incorporated; 1994.

Frank E. Interpersonal and social rhythm therapy: a means of improving depression and preventing relapse in bipolar disorder. J Clin Psychol. 2007;63(5):463–73.

Frank E, Swartz HA, Boland E. Interpersonal and social rhythm therapy: an intervention addressing rhythm dysregulation in bipolar disorder. Dialogues Clin Neurosci. 2007;9(3).

Frank E, Hlastala S, Ritenour A, Houck P, Tu XM, Monk TH, et al. Inducing lifestyle regularity in recovering bipolar disorder patients: results from the maintenance therapies in bipolar disorder protocol. Biol Psychiatry. 1997;41(12):1165–73.

Frank E, Kupfer DJ, Thase ME, Mallinger AG, Swartz HA, Fagiolini AM, et al. Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder. Arch Gen Psychiatry. 2005;62(9):996–1004.

Frank E, Soreca I, Swartz HA, Fagiolini AM, Mallinger AG, Thase ME, et al. The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder. Am J Psychiatry. 2008;165(12):1559–65.

Sachs GS, Thase ME, Otto MW, Bauer M, Miklowitz D, Wisniewski SR, et al. Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry. 2003;53(11):1028–42.

Miklowitz DJ, Otto MW, Frank E, Reilly-Harrington NA, Wisniewski SR, Kogan JN, et al. Psychosocial treatments for bipolar depression: a 1-year randomized trial from the systematic treatment enhancement program. Arch Gen Psychiatry. 2007;64(4):419–26.

Swartz HA, Frank E, O'Toole K, Newman N, Kiderman H, Carlson S, et al. Implementing interpersonal and social rhythm therapy for mood disorders across a continuum of care. Psychiatr Serv. 2011;62(11):1377–80.

Hoberg AA, Ponto J, Nelson PJ, Frye MA. Group interpersonal and social rhythm therapy for bipolar depression. Perspect Psychiatr Care. 2013;49(4):226–34.

Monk TK, Flaherty JF, Frank E, Hoskinson K, Kupfer DJ. The Social Rhythm Metric: An instrument to quantify the daily rhythms of life. J Nerv Ment Dis. 1990.

Bouwkamp CG, de Kruiff ME, van Troost TM, Snippe D, Blom MJ, de Winter RF, et al. Interpersonal and social rhythm group therapy for patients with bipolar disorder. Int J Group Psychother. 2013;63(1):97–115.

Swartz HA, Frank E, Frankel DR, Novick D, Houck P. Psychotherapy as monotherapy for the treatment of bipolar II depression: a proof of concept study. Bipolar Disord. 2009;11(1):89–94.

Swartz HA, Frank E, Cheng Y. A randomized pilot study of psychotherapy and quetiapine for the acute treatment of bipolar II depression. Bipolar Disord. 2012;14(2):211–6.

•• Swartz HA, Rucci P, Thase ME, Wallace M, Carretta E, Celedonia KL, et al. Psychotherapy Alone and Combined With Medication as Treatments for Bipolar II Depression: A Randomized Controlled Trial. J Clin Psychiatry. 2018;79(2). This RCT evaluates IPSRT adjunctive to pharmacotherapy for patients with bipolar II depression.

Hlastala SA, Kotler JS, McClellan JM, McCauley EA. Interpersonal and social rhythm therapy for adolescents with bipolar disorder: treatment development and results from an open trial. Depress Anxiety. 2010;27(5):457–64.

Goldstein TR, Fersch-Podrat R, Axelson DA, Gilbert A, Hlastala SA, Birmaher B, et al. Early intervention for adolescents at high risk for the development of bipolar disorder: Pilot study of Interpersonal and Social Rhythm Therapy (IPSRT). Psychotherapy. 2014;51(1).

Goldstein TR, Merranko J, Krantz M, Garcia M, Franzen P, Levenson J, et al. Early intervention for adolescents at-risk for bipolar disorder: a pilot randomized trial of interpersonal and social rhythm therapy (IPSRT). J Affect Disord. 2018;235:348–56.

Inder ML, Crowe MT, Luty SE, Carter JD, Moor S, Frampton CM, et al. Randomized, controlled trial of interpersonal and social rhythm therapy for young people with bipolar disorder. Bipolar Disord. 2015;17(2):128–38.

Inder ML, Crowe MT, Moor S, Carter JD, Luty SE, Frampton CM, et al. Three-year follow-up after psychotherapy for young people with bipolar disorder. Bipolar disorders. 2017.

Miklowitz DJ, Price J, Holmes EA, Rendell J, Bell S, Budge K, et al. Facilitated integrated mood management for adults with bipolar disorder. Bipolar Disord. 2012;14(2):185–97.

Bilderbeck AC, Atkinson LZ, McMahon HC, Voysey M, Simon J, Price J, et al. Psychoeducation and online mood tracking for patients with bipolar disorder: a randomised controlled trial. J Affect Disord. 2016;205:245–51.

Buijink A, Visser BJ, Marshall L. Medical apps for smartphones: lack of evidence undermines quality and safety. Evid Based Med. 2013;18(3):90–2.

Harvey AG, Soehner AM, Kaplan KA, Hein K, Lee J, Kanady J, et al. Treating insomnia improves mood state, sleep, and functioning in bipolar disorder: a pilot randomized controlled trial. J Consult Clin Psychol. 2015;83(3):564–77.

Sylvia LG, Salcedo S, Bianchi MT, Urdahl A, Nierenberg AA, Deckersbach T. A novel home sleep monitoring device and brief sleep intervention for bipolar disorder: feasibility, tolerability, and preliminary effectiveness. Cognit Ther Res. 2014;38(1):55–61.

Faria AD, de Mattos Souza LD, de Azevedo CT, Pinheiro KA, Pinheiro RT, da Silva RA, et al. The influence of psychoeducation on regulating biological rhythm in a sample of patients with bipolar II disorder: a randomized clinical trial. Psychol Res Behav Manag. 2014;7:167–74.

de Azevedo CT, Mondin TC, Reyes AN, Zeni CP, de Mattos Souza LD, da Silva RA, et al. Biological rhythm and bipolar disorder: twelve-month follow-up of a randomized clinical trial. J Nerv Ment Dis. 2015;203(10):792–7.

Dinan TG. Lithium in bipolar mood disorder: evidence suggests that lithium should still be first choice for prophylactic treatment. British Medical Journal Publishing Group; 2002.

Moreira J, Geoffroy PA. Lithium and bipolar disorder: impacts from molecular to behavioural circadian rhythms. Chronobiol Int. 2016;33(4):351–73.

Geoffroy PA, Curis E, Courtin C, Moreira J, Morvillers T, Etain B, Laplanche JL, Bellivier F, Marie-Claire C Lithium response in bipolar disorders and core clock genes expression. World J Biol Psychiatry. 2017;1–14.

Geoffroy PA, Samalin L, Llorca PM, Curis E, Bellivier F. Influence of lithium on sleep and chronotypes in remitted patients with bipolar disorder. J Affect Disord. 2016;204:32–9.

De Berardis D, Marini S, Fornaro M, Srinivasan V, Iasevoli F, Tomasetti C, et al. The melatonergic system in mood and anxiety disorders and the role of agomelatine: implications for clinical practice. Int J Mol Sci. 2013;14(6):12458–83.

De Berardis D, Fornaro M, Serroni N, Campanella D, Rapini G, Olivieri L, et al. Agomelatine beyond borders: current evidences of its efficacy in disorders other than major depression. Int J Mol Sci. 2015;16(1):1111–30.

Calabrese JR, Guelfi JD, Perdrizet-Chevallier C, Group ABS. Agomelatine adjunctive therapy for acute bipolar depression: preliminary open data. Bipolar Disord. 2007;9(6):628–35.

Fornaro M, McCarthy MJ, De Berardis D, De Pasquale C, Tabaton M, Martino M, et al. Adjunctive agomelatine therapy in the treatment of acute bipolar II depression: a preliminary open label study. Neuropsychiatr Dis Treat. 2013;9:243.

Yatham LN, Vieta E, Goodwin GM, Bourin M, De Bodinat C, Laredo J, et al. Agomelatine or placebo as adjunctive therapy to a mood stabiliser in bipolar I depression: randomised double-blind placebo-controlled trial. Br J Psychiatry. 2016;208(1):78–86.

Norris ER, Burke K, Correll JR, Zemanek KJ, Lerman J, Primelo RA, et al. A double-blind, randomized, placebo-controlled trial of adjunctive ramelteon for the treatment of insomnia and mood stability in patients with euthymic bipolar disorder. J Affect Disord. 2013;144(1–2):141–7.

Mahableshwarkar AR, Calabrese JR, Macek TA, Budur K, Adefuye A, Dong X, et al. Efficacy and safety of sublingual ramelteon as an adjunctive therapy in the maintenance treatment of bipolar I disorder in adults: a phase 3, randomized controlled trial. J Affect Disord. 2017;221:275–82.

Phelps J. A powerful non-pharmacologic treatment for mania–virtually. Bipolar Disord. 2016;18(4):379–82.

Phelps J. Amber lenses for virtual darkness: confirmed as a mood stabilizer. Med Hypotheses. 2017;98:1.

Phelps J. Dark therapy for bipolar disorder using amber lenses for blue light blockade. Med Hypotheses. 2008;70(2):224–9.

•• Henriksen TE, Skrede S, Fasmer OB, Schoeyen H, Leskauskaite I, Bjørke-Bertheussen J, et al. Blue-blocking glasses as additive treatment for mania: a randomized placebo-controlled trial. Bipolar Disord. 2016;18(3):221–32. This paper describes results from a promising recent study of virtual darkness therapy in BD.

•• Sit DK, McGowan J, Wiltrout C, Diler RS, Dills J, Luther J, et al. Adjunctive bright light therapy for bipolar depression: a randomized double-blind placebo-controlled trial. Am J Psychiatr. 2017;175(2):131–9. This paper describes results from a promising recent study of bright light therapy in BD.

Hashimoto S, Kohsaka M, Nakamura K, Honma H, Honma S, Honma K. Midday exposure to bright light changes the circadian organization of plasma melatonin rhythm in humans. Neurosci Lett. 1997;221(2–3):89–92.

Sit D, Wisner KL, Hanusa BH, Stull S, Terman M. Light therapy for bipolar disorder: a case series in women. Bipolar Disord. 2007;9(8):918–27.

Keltner NL, Folks DG. Alternatives to lithium in the treatment of bipolar disorder. Perspect Psychiatr Care. 1991;27(2):36–7.