Treadmill Exercise Alters Histone Acetyltransferases and Histone Deacetylases Activities in Frontal Cortices from Wistar Rats

Springer Science and Business Media LLC - Tập 34 - Trang 1097-1101 - 2014
Christiano Spindler1, Laura Reck Cechinel2, Carla Basso2, Felipe Moysés1,3, Karine Bertoldi1, Rafael Roesler2, Gisele Agustini Lovatel4, Viviane Rostirola Elsner1,5, Ionara Rodrigues Siqueira1,2
1Programa de Pós-Graduação Em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
2Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
3Universidade Regional Integrada do Alto Uruguai e das Missões, Campus Erechim, Erechim , Brazil
4Curso de Fisioterapia, Universidade Federal de Santa Catarina, Campus Araranguá, Brazil
5Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista do IPA, Porto Alegre, Brazil

Tóm tắt

Studies have pointed out the relationship between neuroprotective exercise effects and epigenetic mechanisms on the hippocampus. Considering the role of frontal cortex on brain functions, we investigated the impact of different exercise protocols on enzymatic system involved with histone acetylation status, histone acetyltransferases (HATs), and histone desacetylases (HDACs) in frontal cortices from Wistar rats. Male Wistar rats aged 3 months were submitted to a single session or a daily running protocol during 2 weeks. The single session enhanced HAT activity, while the moderate daily exercise protocol reduced the HDAC activity. Our results indicate that frontal cortex is susceptible to epigenetic modulation following exercise and that both exercise protocols seem to induce a histone hyperacetylation condition in this brain area.

Tài liệu tham khảo

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