Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms
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Hachem, 2017, Assessment and management of acute spinal cord injury: from point of injury to rehabilitation, J Spinal Cord Med, 40, 665, 10.1080/10790268.2017.1329076
WHO | Spinal Cord Injury2013
Stein, 2015, Emergency neurological life support: traumatic spine injury, Neurocrit Care, 23, S155, 10.1007/s12028-015-0169-y
Wilson, 2012, Clinical predictors of neurological outcome, functional status, and survival after traumatic spinal cord injury: a systematic review, J Neurosurg Spine, 17, 11, 10.3171/2012.4.AOSPINE1245
Middleton, 2012, Life expectancy after spinal cord injury: a 50-year study, Spinal Cord, 50, 803, 10.1038/sc.2012.55
Shavelle, 2015, Mobility, continence, and life expectancy in persons with Asia Impairment Scale Grade D spinal cord injuries, Am J Phys Med Rehabil, 94, 180, 10.1097/PHM.0000000000000140
Oyinbo, 2011, Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade, Acta Neurobiol Exp, 71, 281, 10.55782/ane-2011-1848
Dumont, 2001, Acute spinal cord injury, part I: pathophysiologic mechanisms, Clin Neuropharmacol, 24, 254, 10.1097/00002826-200109000-00002
Sekhon, 2001, Epidemiology, demographics, and pathophysiology of acute spinal cord injury, Spine, 26, S2, 10.1097/00007632-200112151-00002
Tator, 1991, Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms, J Neurosurg, 75, 15, 10.3171/jns.1991.75.1.0015
Rowland, 2008, Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon, Neurosurg Focus, 25, E2, 10.3171/FOC.2008.25.11.E2
Choo, 2009, Modeling spinal cord contusion, dislocation, and distraction: characterization of vertebral clamps, injury severities, and node of Ranvier deformations, J Neurosci Methods, 181, 6, 10.1016/j.jneumeth.2009.04.007
Fehlings, 2012, Perioperative and delayed complications associated with the surgical treatment of cervical spondylotic myelopathy based on 302 patients from the AOSpine North America Cervical Spondylotic Myelopathy Study, J Neurosurg Spine., 16, 425, 10.3171/2012.1.SPINE11467
Szuflita, 2016, Spine injuries sustained by U.S. military personnel in combat are different from non-combat spine injuries, Mil Med, 181, 1314, 10.7205/MILMED-D-15-00332
Blair, 2012, Are spine injuries sustained in battle truly different?, Spine J, 12, 824, 10.1016/j.spinee.2011.09.012
Figley, 2014, Characterization of vascular disruption and blood-spinal cord barrier permeability following traumatic spinal cord injury, J Neurotrauma, 31, 541, 10.1089/neu.2013.3034
Fehlings, 2002, Restoration of spinal cord function, Am Academy of Orthopaedic Surgeons, 483
Fehlings, 2012, Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS), PLoS ONE, 7, e32037, 10.1371/journal.pone.0032037
Wilson, 2017, Timing of decompression in patients with acute spinal cord injury: a systematic review, Global Spine J, 7, 95S, 10.1177/2192568217701716
Michael Fehlings, 2013, Burns Essentials of Spinal Cord Injury Basic Research to Clinical Practice
Wilson, 2011, Spinal cord injury and quality of life: a systematic review of outcome measures, Evid Based Spine Care J, 2, 37, 10.1055/s-0030-1267085
Frankel, 1969, The value of postural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia, Paraplegia, 7, 179, 10.1038/sc.1969.30
Bracken, 1978, Classification of the severity of acute spinal cord injury: implications for management, Paraplegia, 15, 319, 10.1038/sc.1977.48
Lucas, 1979, Motor classification of spinal cord injuries with mobility, morbidity and recovery indices, Am Surg, 45, 151
Klose, 1980, University of Miami Neuro-Spinal Index (UMNI): a quantitative method for determining spinal cord function, Paraplegia, 18, 331
Chehrazi, 1981, A scale for evaluation of spinal cord injury, J Neurosurg, 54, 310, 10.3171/jns.1981.54.3.0310
Waters, 1994, Motor and sensory recovery following incomplete tetraplegia, Arch Phys Med Rehabil, 75, 306, 10.1016/0003-9993(94)90034-5
Brown, 1991, The 72-hour examination as a predictor of recovery in motor complete quadriplegia, Arch Phys Med Rehabil, 72, 546
Waters, 1992, Recovery following complete paraplegia, Arch Phys Med Rehabil, 73, 784
Ditunno, 1987, Wrist extensor recovery in traumatic quadriplegia, Arch Phys Med Rehabil, 68, 287
Folman, 1989, Spinal cord injury: prognostic indicators, Injury, 20, 92, 10.1016/0020-1383(89)90148-4
Fawcett, 2007, Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials, Spinal Cord, 45, 190, 10.1038/sj.sc.3102007
Kirshblum, 1998, Predicting neurologic recovery in traumatic cervical spinal cord injury, Arch Phys Med Rehabil, 79, 1456, 10.1016/S0003-9993(98)90244-1
Stauffer, 1984, Neurologic recovery following injuries to the cervical spinal cord and nerve roots, Spine, 9, 532, 10.1097/00007632-198407000-00024
Oleson, 2005, Prognostic value of pinprick preservation in motor complete, sensory incomplete spinal cord injury, Arch Phys Med Rehabil, 86, 988, 10.1016/j.apmr.2004.09.031
Nardone, 2017, Rodent, large animal and non-human primate models of spinal cord injury, Zoology, 123, 101, 10.1016/j.zool.2017.06.004
Kwon, 2002, Animal models used in spinal cord regeneration research, Spine, 27, 1504, 10.1097/00007632-200207150-00005
Kjell, 2016, Rat models of spinal cord injury: from pathology to potential therapies, Dis Model Mech, 9, 1125, 10.1242/dmm.025833
Noble, 1985, Spinal cord contusion in the rat: morphometric analyses of alterations in the spinal cord, Exp Neurol, 88, 135, 10.1016/0014-4886(85)90119-0
Blight, 1986, Morphometric analysis of experimental spinal cord injury intensity to survival of myelinated axons, Neuroscience, 19, 321, 10.1016/0306-4522(86)90025-4
Bresnahan, 1976, A neuroanatomical analysis of spinal cord injury in the rhesus monkey (Macaca mulatta), J Neurol Sci, 28, 521, 10.1016/0022-510X(76)90122-2
Metz, 2000, Validation of the weight-drop contusion model in rats: a comparative study of human spinal cord injury, J Neurotrauma, 17, 1, 10.1089/neu.2000.17.1
Jakeman, 2000, Traumatic spinal cord injury produced by controlled contusion in mouse, J Neurotrauma, 17, 299, 10.1089/neu.2000.17.299
Ma, 2001, Behavioral and histological outcomes following graded spinal cord contusion injury in the C57Bl/6 mouse, Exp Neurol, 169, 239, 10.1006/exnr.2001.7679
Kuhn, 1998, A mouse model of graded contusive spinal cord injury, J Neurotrauma, 15, 125, 10.1089/neu.1998.15.125
Byrnes, 2010, Neuropathological differences between rats and mice after spinal cord injury, J Magn Reson Imaging, 32, 836, 10.1002/jmri.22323
Sroga, 2003, Rats and mice exhibit distinct inflammatory reactions after spinal cord injury, J Comp Neurol, 462, 223, 10.1002/cne.10736
Taoka, 1997, Role of neutrophils in spinal cord injury in the rat, Neuroscience, 79, 1177, 10.1016/S0306-4522(97)00011-0
Kigerl, 2006, Comparative analysis of lesion development and intraspinal inflammation in four strains of mice following spinal contusion injury, J Comp Neurol, 494, 578, 10.1002/cne.20827
Kwon, 2015, Large animal and primate models of spinal cord injury for the testing of novel therapies, Exp Neurol, 269, 154, 10.1016/j.expneurol.2015.04.008
Lee, 2013, A novel porcine model of traumatic thoracic spinal cord injury, J Neurotrauma, 30, 142, 10.1089/neu.2012.2386
Nout, 2012, Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury, Neurotherapeutics, 9, 380, 10.1007/s13311-012-0114-0
Beattie, 1997, Endogenous repair after spinal cord contusion injuries in the rat, Exp Neurol, 148, 453, 10.1006/exnr.1997.6695
Constantini, 1994, The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats, J Neurosurg, 80, 97, 10.3171/jns.1994.80.1.0097
Basso, 1996, MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability, J Neurotrauma, 13, 343, 10.1089/neu.1996.13.343
Scheff, 2003, Experimental modeling of spinal cord injury: characterization of a force-defined injury device, J Neurotrauma, 20, 179, 10.1089/08977150360547099
Stokes, 1992, Experimental spinal cord injury: a dynamic and verifiable injury device, J Neurotrauma, 9, 129, 10.1089/neu.1992.9.129
Somerson, 1987, Functional analysis of an electromechanical spinal cord injury device, Exp Neurol, 96, 82, 10.1016/0014-4886(87)90170-1
Stokes, 1987, Spinal cord extracellular microenvironment. Can the changes resulting from trauma be graded?, Neurochem Pathol, 7, 47, 10.1007/BF02834291
Rivlin, 1978, Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat, Surg Neurol, 10, 38
Joshi, 2002, Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 1. Clip design, behavioral outcomes, and histopathology, J Neurotrauma, 19, 175, 10.1089/08977150252806947
Marcol, 2012, Air gun impactor–a novel model of graded white matter spinal cord injury in rodents, J Reconstr Microsurg, 28, 561, 10.1055/s-0032-1315779
Blight, 1991, Morphometric analysis of a model of spinal cord injury in guinea pigs, with behavioral evidence of delayed secondary pathology, J Neurol Sci, 103, 156, 10.1016/0022-510X(91)90159-5
Plemel, 2008, A graded forceps crush spinal cord injury model in mice, J Neurotrauma, 25, 350, 10.1089/neu.2007.0426
Tarlov, 1953, Spinal cord compression studies, AMA Arch Neurol Psychiatry, 70, 813, 10.1001/archneurpsyc.1953.02320360128010
Bao, 2002, Peroxynitrite generated in the rat spinal cord induces neuron death and neurological deficits, Neuroscience, 115, 839, 10.1016/S0306-4522(02)00506-7
da Costa, 2008, Strapping the spinal cord: an innovative experimental model of CNS injury in rats, J Neurosci Methods, 170, 130, 10.1016/j.jneumeth.2008.01.004
Dabney, 2004, A model of experimental spinal cord trauma based on computer-controlled intervertebral distraction: characterization of graded injury, Spine, 29, 2357, 10.1097/01.brs.0000143108.65385.74
Seifert, 2011, Characterization of a novel bidirectional distraction spinal cord injury animal model, J Neurosci Methods, 197, 97, 10.1016/j.jneumeth.2011.02.003
Fiford, 2004, A vertebral dislocation model of spinal cord injury in rats, J Neurotrauma, 21, 451, 10.1089/089771504323004593
Heimburger, 2005, Return of function after spinal cord transection, Spinal Cord, 43, 438, 10.1038/sj.sc.3101748
Dyer, 1998, Regeneration of brainstem-spinal axons after lesion and immunological disruption of myelin in adult rat, Exp Neurol, 154, 12, 10.1006/exnr.1998.6905
Seitz, 2002, Recovery from spinal cord injury: a new transection model in the C57Bl/6 mouse, J Neurosci Res, 67, 337, 10.1002/jnr.10098
Inman, 2002, Genetic influences on secondary degeneration and wound healing following spinal cord injury in various strains of mice, J Comp Neurol, 451, 225, 10.1002/cne.10340
Hall, 1971, The in vivo and ultrastructural effects of injection of lysophosphatidyl choline into myelinated peripheral nerve fibres of the adult mouse, J Cell Sci, 9, 769, 10.1242/jcs.9.3.769
Dubois-Dalcq, 1982, Cell tropism and expression of mouse hepatitis viruses (MHV) in mouse spinal cord cultures, Virology, 119, 317, 10.1016/0042-6822(82)90092-7
Matsushima, 2001, The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system, Brain Pathol, 11, 107, 10.1111/j.1750-3639.2001.tb00385.x
Woodruff, 1999, Demyelination and remyelination of the caudal cerebellar peduncle of adult rats following stereotaxic injections of lysolecithin, ethidium bromide, and complement/anti-galactocerebroside: a comparative study, Glia, 10.1002/(SICI)1098-1136(19990201)25:3<216::AID-GLIA2>3.0.CO;2-L
Barbeau, 1999, Tapping into spinal circuits to restore motor function, Brain Res Brain Res Rev, 30, 27, 10.1016/S0165-0173(99)00008-9
Gruner, 1992, A monitored contusion model of spinal cord injury in the rat, J Neurotrauma, 9, 123, 10.1089/neu.1992.9.123
Petteys, 2017, Design and testing of a controlled electromagnetic spinal cord impactor for use in large animal models of acute traumatic spinal cord injury, J Clin Neurosci, 43, 229, 10.1016/j.jocn.2017.04.031
Poon, 2007, Clip compression model is useful for thoracic spinal cord injuries: histologic and functional correlates, Spine, 32, 2853, 10.1097/BRS.0b013e31815b7e6b
Aslan, 2009, Does dexmedetomidine reduce secondary damage after spinal cord injury?, Eur Spine J, 18, 336, 10.1007/s00586-008-0872-x
Nesathurai, 2006, Model of traumatic spinal cord injury in Macaca fascicularis: similarity of experimental lesions created by epidural catheter to human spinal cord injury, J Med Primatol, 35, 401, 10.1111/j.1600-0684.2006.00162.x
Fukuda, 2005, New canine spinal cord injury model free from laminectomy, Brain Res Brain Res Protoc, 14, 171, 10.1016/j.brainresprot.2005.01.001
Alfred Reginald, 1911, Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column, JAMA, 57, 878
von Leden, 2017, Central nervous system injury and nicotinamide adenine dinucleotide phosphate oxidase: oxidative stress and therapeutic targets, J Neurotrauma, 34, 755, 10.1089/neu.2016.4486
Tran, 2018, The biology of regeneration failure and success after spinal cord injury, Physiol Rev, 98, 881, 10.1152/physrev.00017.2017
Dyck, 2015, Chondroitin sulfate proteoglycans: key modulators in the developing and pathologic central nervous system, Exp Neurol, 269, 169, 10.1016/j.expneurol.2015.04.006
Alizadeh, 2016, Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury, J Physiol, 594, 3539, 10.1113/JP270895
Alizadeh, 2015, Myelin damage and repair in pathologic CNS: challenges and prospects, Front Mol Neurosci, 8, 35, 10.3389/fnmol.2015.00035
Couillard-Despres, 2017, Pathophysiology of traumatic spinal cord injury, Neurological Aspects of Spinal Cord Injury, 10.1007/978-3-319-46293-6_19
Koyanagi, 1993, Silicone rubber microangiography of acute spinal cord injury in the rat, Neurosurgery, 32, 260, 10.1227/00006123-199302000-00015
Tator, 1997, Vascular mechanisms in the pathophysiology of human spinal cord injury, J Neurosurg, 86, 483, 10.3171/jns.1997.86.3.0483
Rivlin, 1978, Regional spinal cord blood flow in rats after severe cord trauma, J Neurosurg, 49, 844, 10.3171/jns.1978.49.6.0844
Hayashi, 1983, Simultaneous measurement of local blood flow and tissue oxygen in rat spinal cord, Neurol Res, 5, 49, 10.1080/01616412.1983.11758588
Turnbull, 1971, Microvasculature of the human spinal cord, J Neurosurg, 35, 141, 10.3171/jns.1971.35.2.0141
Balentine, 1978, Pathology of experimental spinal cord trauma, Lab Invest, 39, 236
Ahuja, 2016, Recent advances in managing a spinal cord injury secondary to trauma, F1000Res, 5, F1000, 10.12688/f1000research.7586.1
Agrawal, 1996, Mechanisms of secondary injury to spinal cord axons in virto: role of Na+, Na(+)-K(+)-ATPase, the Na(+)-H+ exchanger, and the Na(+)-Ca2+ exchanger, J Neurosci, 16, 545, 10.1523/JNEUROSCI.16-02-00545.1996
Anwar, 2016, Inflammogenesis of secondary spinal cord injury, Front Cell Neurosci, 10, 98, 10.3389/fncel.2016.00098
Karadottir, 2007, Neurotransmitter receptors in the life and death of oligodendrocytes, Neuroscience, 145, 1426, 10.1016/j.neuroscience.2006.08.070
Verkhratsky, 2000, Ion channels in glial cells, Brain Res Brain Res Rev, 32, 380, 10.1016/S0165-0173(99)00093-4
Gottlieb, 1997, Expression of ionotropic glutamate receptor subunits in glial cells of the hippocampal CA1 area following transient forebrain ischemia, J Cereb Blood Flow Metab, 17, 290, 10.1097/00004647-199703000-00006
Vanzulli, 2015, mGluR5 protect astrocytes from ischemic damage in postnatal CNS white matter, Cell Calcium, 58, 423, 10.1016/j.ceca.2015.06.010
Xu, 2004, Concentrations of glutamate released following spinal cord injury kill oligodendrocytes in the spinal cord, Exp Neurol, 187, 329, 10.1016/j.expneurol.2004.01.029
Panter, 1990, Alteration in extracellular amino acids after traumatic spinal cord injury, Ann Neurol, 27, 96, 10.1002/ana.410270115
Fernyhough, 2010, Abnormal calcium homeostasis in peripheral neuropathies, Cell Calcium, 47, 130, 10.1016/j.ceca.2009.11.008
Verkhratsky, 2002, The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death, Eur J Pharmacol, 447, 141, 10.1016/S0014-2999(02)01838-1
Verkhratsky, 2003, Endoplasmic reticulum Ca(2+) homeostasis and neuronal death, J Cell Mol Med, 7, 351, 10.1111/j.1582-4934.2003.tb00238.x
Pivovarova, 2010, Calcium-dependent mitochondrial function and dysfunction in neurons, FEBS J, 277, 3622, 10.1111/j.1742-4658.2010.07754.x
Duchen, 2012, Mitochondria, calcium-dependent neuronal death and neurodegenerative disease, Pflugers Arch, 464, 111, 10.1007/s00424-012-1112-0
Li, 2000, Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter, J Neurosci, 20, 1190, 10.1523/JNEUROSCI.20-03-01190.2000
Xu, 2008, Glutamate-induced losses of oligodendrocytes and neurons and activation of caspase-3 in the rat spinal cord, Neuroscience, 153, 1034, 10.1016/j.neuroscience.2008.02.065
Dingledine, 1999, The glutamate receptor ion channels, Pharmacol Rev, 51, 7
MacDermott, 1986, NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones, Nature, 321, 519, 10.1038/321519a0
Li, 2001, Na(+)-K(+)-ATPase inhibition and depolarization induce glutamate release via reverse Na(+)-dependent transport in spinal cord white matter, Neuroscience, 107, 675, 10.1016/S0306-4522(01)00385-2
Faden, 1988, A potential role for excitotoxins in the pathophysiology of spinal cord injury, Ann Neurol, 23, 623, 10.1002/ana.410230618
Wada, 1999, Apoptosis following spinal cord injury in rats and preventative effect of N-methyl-D-aspartate receptor antagonist, J Neurosurg, 91, 98
Duchen, 2004, Mitochondria in health and disease: perspectives on a new mitochondrial biology, Mol Aspects Med, 25, 365, 10.1016/j.mam.2004.03.001
Starkov, 2004, Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury, Cell Calcium, 36, 257, 10.1016/j.ceca.2004.02.012
Pandya, 2013, Concentration dependent effect of calcium on brain mitochondrial bioenergetics and oxidative stress parameters, Front Neuroenergetics, 5, 10, 10.3389/fnene.2013.00010
LoPachin, 1999, Experimental spinal cord injury: spatiotemporal characterization of elemental concentrations and water contents in axons and neuroglia, J Neurophysiol, 82, 2143, 10.1152/jn.1999.82.5.2143
McAdoo, 2005, The effect of glutamate receptor blockers on glutamate release following spinal cord injury, Brain Res, 1038, 92, 10.1016/j.brainres.2005.01.024
Stys, 1992, Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger, Neurosci J., 12, 430, 10.1523/JNEUROSCI.12-02-00430.1992
Regan, 1991, Glutamate neurotoxicity in spinal cord cell culture, Neuroscience, 43, 585, 10.1016/0306-4522(91)90317-H
Reithmeier, 1994, Mammalian exchangers and co-transporters, Curr Opin Cell Biol, 6, 583, 10.1016/0955-0674(94)90080-9
Shimizu, 2018, Prophylactic riluzole attenuates oxidative stress damage in spinal cord distraction, J Neurotrauma, 35, 1319, 10.1089/neu.2017.5494
Satkunendrarajah, 2016, Riluzole promotes motor and respiratory recovery associated with enhanced neuronal survival and function following high cervical spinal hemisection, Exp Neurol, 276, 59, 10.1016/j.expneurol.2015.09.011
Fehlings, 2012, Riluzole for the treatment of acute traumatic spinal cord injury: rationale for and design of the NACTN Phase I clinical trial, J Neurosurg Spine, 17, 151, 10.3171/2012.4.AOSPINE1259
Nagoshi, 2015, Riluzole as a neuroprotective drug for spinal cord injury: from bench to bedside, Molecules, 20, 7775, 10.3390/molecules20057775
Pruss, 2011, Non-resolving aspects of acute inflammation after spinal cord injury (SCI): indices and resolution plateau, Brain Pathol, 21, 652, 10.1111/j.1750-3639.2011.00488.x
Bains, 2012, Antioxidant therapies in traumatic brain and spinal cord injury, Biochim Biophys Acta, 1822, 675, 10.1016/j.bbadis.2011.10.017
Christie, 2008, Duration of lipid peroxidation after acute spinal cord injury in rats and the effect of methylprednisolone, Neurosurg Focus, 25, E5, 10.3171/FOC.2008.25.11.E5
Barut, 1993, Lipid peroxidation in experimental spinal cord injury: time-level relationship, Neurosurg Rev, 16, 53, 10.1007/BF00308614
Hall, 2011, Antioxidant therapies for acute spinal cord injury, Neurotherapeutics, 8, 152, 10.1007/s13311-011-0026-4
Hall, 2015, Chapter 6: The contributing role of lipid peroxidation and protein oxidation in the course of CNS injury neurodegeneration and neuroprotection: an overview, Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects, 10.1201/b18126-8
Springer, 1997, 4-hydroxynonenal, a lipid peroxidation product, rapidly accumulates following traumatic spinal cord injury and inhibits glutamate uptake, J Neurochem, 68, 2469, 10.1046/j.1471-4159.1997.68062469.x
Cuzzocrea, 2001, Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury, Pharmacol Rev, 53, 135
Beattie, 2002, Cell death in models of spinal cord injury, Prog Brain Res, 137, 37, 10.1016/S0079-6123(02)37006-7
Almad, 2011, Oligodendrocyte fate after spinal cord injury, Neurotherapeutics, 8, 262, 10.1007/s13311-011-0033-5
Casha, 2001, Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat, Neuroscience, 103, 203, 10.1016/S0306-4522(00)00538-8
Dyck, 2019, LAR and PTPsigma receptors are negative regulators of oligodendrogenesis and oligodendrocyte integrity in spinal cord injury, Glia, 67, 125, 10.1002/glia.23533
Crowe, 1997, Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys, Nat Med, 3, 73, 10.1038/nm0197-73
Lou, 1998, Apoptosis as a mechanism of neuronal cell death following acute experimental spinal cord injury, Spinal Cord, 36, 683, 10.1038/sj.sc.3100632
Wang, 2013, C/EBP homologous protein (CHOP) mediates neuronal apoptosis in rats with spinal cord injury, Exp Ther Med, 5, 107, 10.3892/etm.2012.745
Galluzzi, 2012, Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012, Cell Death Differ, 19, 107, 10.1038/cdd.2011.96
Liu, 2015, Necroptosis, a novel type of programmed cell death, contributes to early neural cells damage after spinal cord injury in adult mice, J Spinal Cord Med, 38, 745, 10.1179/2045772314Y.0000000224
Juliet, 2009, Toxic effect of blood components on perinatal rat subventricular zone cells and oligodendrocyte precursor cell proliferation, differentiation and migration in culture, J Neurochem, 109, 1285, 10.1111/j.1471-4159.2009.06060.x
Gudz, 2006, Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex, J Neurosci, 26, 2458, 10.1523/JNEUROSCI.4054-05.2006
Matute, 2007, P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis, J Neurosci, 27, 9525, 10.1523/JNEUROSCI.0579-07.2007
Antel, 1994, Oligodendrocyte lysis by CD4+ T cells independent of tumor necrosis factor, Ann Neurol, 35, 341, 10.1002/ana.410350315
Takahashi, 2003, Interleukin-1beta promotes oligodendrocyte death through glutamate excitotoxicity, Ann Neurol, 53, 588, 10.1002/ana.10519
Beattie, 2000, Review of current evidence for apoptosis after spinal cord injury, J Neurotrauma, 17, 915, 10.1089/neu.2000.17.915
Jana, 2007, Oxidative stress kills human primary oligodendrocytes via neutral sphingomyelinase: implications for multiple sclerosis, J Neuroimmune Pharmacol, 2, 184, 10.1007/s11481-007-9066-2
Thorburne, 1996, Low glutathione and high iron govern the susceptibility of oligodendroglial precursors to oxidative stress, J Neurochem, 67, 1014, 10.1046/j.1471-4159.1996.67031014.x
Fujikawa, 2000, Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms, Neuroscience, 98, 41, 10.1016/S0306-4522(00)00085-3
Dunai, 2011, Necroptosis: biochemical, physiological and pathological aspects, Pathol Oncol Res, 17, 791, 10.1007/s12253-011-9433-4
Liu, 2018, Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis, Cell Death Dis, 9, 476, 10.1038/s41419-018-0469-1
McTigue, 2001, Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord, J Neurosci, 21, 3392, 10.1523/JNEUROSCI.21-10-03392.2001
Mizuno, 1998, Apoptosis in neurodegenerative disorders, Intern Med, 37, 192, 10.2169/internalmedicine.37.192
Liu, 1997, Neuronal and glial apoptosis after traumatic spinal cord injury, J Neurosci, 17, 5395, 10.1523/JNEUROSCI.17-14-05395.1997
Guest, 2005, Demyelination and Schwann cell responses adjacent to injury epicenter cavities following chronic human spinal cord injury, Exp Neurol, 192, 384, 10.1016/j.expneurol.2004.11.033
Elmore, 2007, Apoptosis: a review of programmed cell death, Toxicol Pathol, 35, 495, 10.1080/01926230701320337
Zhang, 2012, Inflammation & apoptosis in spinal cord injury, Indian J Med Res, 135, 287
Amemiya, 2005, Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats, Eur J Pharmacol, 516, 125, 10.1016/j.ejphar.2005.04.036
Davis, 2007, FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury, J Neurotrauma, 24, 823, 10.1089/neu.2006.0227
Casha, 2005, FAS deficiency reduces apoptosis, spares axons and improves function after spinal cord injury, Exp Neurol, 196, 390, 10.1016/j.expneurol.2005.08.020
Robins-Steele, 2012, The delayed post-injury administration of soluble fas receptor attenuates post-traumatic neural degeneration and enhances functional recovery after traumatic cervical spinal cord injury, J Neurotrauma, 29, 1586, 10.1089/neu.2011.2005
Ackery, 2006, Inhibition of Fas-mediated apoptosis through administration of soluble Fas receptor improves functional outcome and reduces posttraumatic axonal degeneration after acute spinal cord injury, J Neurotrauma, 23, 604, 10.1089/neu.2006.23.604
Yu, 2011, Fas/FasL-mediated apoptosis and inflammation are key features of acute human spinal cord injury: implications for translational, clinical application, Acta Neuropathol, 122, 747, 10.1007/s00401-011-0882-3
Liu, 2015, Autosis and autophagic cell death: the dark side of autophagy, Cell Death Differ, 22, 367, 10.1038/cdd.2014.143
Zhou, 2017, The temporal pattern, flux, and function of autophagy in spinal cord injury, Int J Mol Sci, 18, E466, 10.3390/ijms18020466
Xu, 2013, Active autophagy in the tumor microenvironment: a novel mechanism for cancer metastasis, Oncol Lett, 5, 411, 10.3892/ol.2012.1015
Ogata, 2006, Autophagy is activated for cell survival after endoplasmic reticulum stress, Mol Cell Biol, 26, 9220, 10.1128/MCB.01453-06
He, 2016, Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury, Proc Natl Acad Sci USA, 113, 11324, 10.1073/pnas.1611282113
Chen, 2015, Increased oligodendrogenesis by humanin promotes axonal remyelination and neurological recovery in hypoxic/ischemic brains, Hippocampus, 25, 62, 10.1002/hipo.22350
Liu, 2016, Nitric oxide interacts with caveolin-1 to facilitate autophagy-lysosome-mediated claudin-5 degradation in oxygen-glucose deprivation-treated endothelial cells, Mol Neurobiol, 53, 5935, 10.1007/s12035-015-9504-8
Mizushima, 2011, Autophagy: renovation of cells and tissues, Cell, 147, 728, 10.1016/j.cell.2011.10.026
Mizushima, 2008, Autophagy fights disease through cellular self-digestion, Nature, 451, 1069, 10.1038/nature06639
Winslow, 2008, Autophagy in neurodegeneration and development, Biochim Biophys Acta, 1782, 723, 10.1016/j.bbadis.2008.06.010
Zhang, 2013, Regulation of autophagy and ubiquitinated protein accumulation by bFGF promotes functional recovery and neural protection in a rat model of spinal cord injury, Mol Neurobiol, 48, 452, 10.1007/s12035-013-8432-8
Yu, 2013, Induction of neuronal mitophagy in acute spinal cord injury in rats, Neurotox Res, 24, 512, 10.1007/s12640-013-9397-0
Popovich, 2001, Alterations in immune cell phenotype and function after experimental spinal cord injury, J Neurotrauma, 18, 957, 10.1089/089771501750451866
Donnelly, 2008, Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury, Exp Neurol, 209, 378, 10.1016/j.expneurol.2007.06.009
Jones, 2005, Inflammatory-mediated injury and repair in the traumatically injured spinal cord, Curr Pharm Des, 11, 1223, 10.2174/1381612053507468
Kigerl, 2009, Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord, J Neurosci, 29, 13435, 10.1523/JNEUROSCI.3257-09.2009
Jones, 2005, Molecular control of physiological and pathological T-cell recruitment after mouse spinal cord injury, J Neurosci, 25, 6576, 10.1523/JNEUROSCI.0305-05.2005
Beck, 2010, Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment, Brain, 133, 433, 10.1093/brain/awp322
Jones, 2014, Lymphocytes and autoimmunity after spinal cord injury, Exp Neurol, 258, 78, 10.1016/j.expneurol.2014.03.003
Abul Abbas, 2018, Cellualar and Molecular Immunology.
Ankeny, 2006, Spinal cord injury triggers systemic autoimmunity: evidence for chronic B lymphocyte activation and lupus-like autoantibody synthesis, J Neurochem, 99, 1073, 10.1111/j.1471-4159.2006.04147.x
Vazquez, 2015, B cells responses and cytokine production are regulated by their immune microenvironment, Cytokine, 74, 318, 10.1016/j.cyto.2015.02.007
Walsh, 2011, Regulatory T cells in CNS injury: the simple, the complex and the confused, Trends Mol Med, 17, 541, 10.1016/j.molmed.2011.05.012
Wattananit, 2016, Monocyte-derived macrophages contribute to spontaneous long-term functional recovery after stroke in mice, J Neurosci, 36, 4182, 10.1523/JNEUROSCI.4317-15.2016
Colombo, 2016, Astrocytes: key regulators of neuroinflammation, Trends Immunol, 37, 608, 10.1016/j.it.2016.06.006
Cekanaviciute, 2016, Astrocytes: integrative regulators of neuroinflammation in stroke and other neurological diseases, Neurotherapeutics, 13, 685, 10.1007/s13311-016-0477-8
Pineau, 2010, Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion, Brain Behav Immun, 24, 540, 10.1016/j.bbi.2009.11.007
Pineau, 2007, Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved, J Comp Neurol, 500, 267, 10.1002/cne.21149
Sun, 1995, Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus, Virology, 213, 482, 10.1006/viro.1995.0021
Constantinescu, 2005, Astrocytes as antigen-presenting cells: expression of IL-12/IL-23, J Neurochem, 95, 331, 10.1111/j.1471-4159.2005.03368.x
Park, 2006, TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression, Glia, 53, 248, 10.1002/glia.20278
Zamanian, 2012, Genomic analysis of reactive astrogliosis, J Neurosci, 32, 6391, 10.1523/JNEUROSCI.6221-11.2012
Brambilla, 2005, Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury, J Exp Med, 202, 145, 10.1084/jem.20041918
Haroon, 2011, Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation, J Immunol, 186, 6521, 10.4049/jimmunol.1001135
Cho, 2006, Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression, Immunol Lett, 105, 159, 10.1016/j.imlet.2006.02.003
Okada, 2006, onditional ablation of Stat3 or Socs3 discloses a dual role of reactive astrocytes after spinal cord injury, Nat Med, 12, 829, 10.1038/nm1425
Colombo, 2014, Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide, Ann Neurol, 76, 325, 10.1002/ana.24217
Dusart, 1994, Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord, Eur J Neurosci, 6, 712, 10.1111/j.1460-9568.1994.tb00983.x
Neirinckx, 2014, Neutrophil contribution to spinal cord injury and repair, J Neuroinflammation, 11, 150, 10.1186/s12974-014-0150-2
Farooque, 1999, Improved recovery after spinal cord trauma in ICAM-1 and P-selectin knockout mice, Neuroreport, 10, 131, 10.1097/00001756-199901180-00024
Stirling, 2009, Depletion of Ly6G/Gr-1 leukocytes after spinal cord injury in mice alters wound healing and worsens neurological outcome, J Neurosci, 29, 753, 10.1523/JNEUROSCI.4918-08.2009
Schroder, 2006, Polymorphonuclear leucocytes selectively produce anti-inflammatory interleukin-1 receptor antagonist and chemokines, but fail to produce pro-inflammatory mediators, Immunology, 119, 317, 10.1111/j.1365-2567.2006.02435.x
Perry, 2013, Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration, Semin Immunopathol, 35, 601, 10.1007/s00281-013-0382-8
Herz, 2017, Myeloid cells in the central nervous system, Immunity, 46, 943, 10.1016/j.immuni.2017.06.007
Greenhalgh, 2014, Differences in the phagocytic response of microglia and peripheral macrophages after spinal cord injury and its effects on cell death, J Neurosci, 34, 6316, 10.1523/JNEUROSCI.4912-13.2014
Ginhoux, 2013, Origin and differentiation of microglia, Front Cell Neurosci, 7, 45, 10.3389/fncel.2013.00045
Zhou, 2014, Function of microglia and macrophages in secondary damage after spinal cord injury, Neural Regen Res, 9, 1787, 10.4103/1673-5374.143423
Epelman, 2014, Origin and functions of tissue macrophages, Immunity, 41, 21, 10.1016/j.immuni.2014.06.013
David, 2011, Repertoire of microglial and macrophage responses after spinal cord injury, Nat Rev Neurosci, 12, 388, 10.1038/nrn3053
Elkabes, 1996, Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function, J Neurosci, 16, 2508, 10.1523/JNEUROSCI.16-08-02508.1996
Chamak, 1994, Brain macrophages stimulate neurite growth and regeneration by secreting thrombospondin, J Neurosci Res, 38, 221, 10.1002/jnr.490380213
Davalos, 2005, ATP mediates rapid microglial response to local brain injury in vivo, Nat Neurosci, 8, 752, 10.1038/nn1472
David, 2015, Macrophage and microglial plasticity in the injured spinal cord, Neuroscience, 307, 311, 10.1016/j.neuroscience.2015.08.064
Orr, 2018, Spinal cord injury scarring and inflammation: therapies targeting glial and inflammatory responses, Neurotherapeutics, 15, 541, 10.1007/s13311-018-0631-6
Murray, 2014, Macrophage activation and polarization: nomenclature and experimental guidelines, Immunity, 41, 14, 10.1016/j.immuni.2014.07.009
Kroner, 2014, TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord, Neuron, 83, 1098, 10.1016/j.neuron.2014.07.027
Greenhalgh, 2018, Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury, PLoS Biol, 16, e2005264, 10.1371/journal.pbio.2005264
Orihuela, 2016, Microglial M1/M2 polarization and metabolic states, Br J Pharmacol, 173, 649, 10.1111/bph.13139
Mikita, 2011, Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis, Mult Scler, 17, 2, 10.1177/1352458510379243
Rathore, 2008, Ceruloplasmin protects injured spinal cord from iron-mediated oxidative damage, J Neurosci, 28, 12736, 10.1523/JNEUROSCI.3649-08.2008
Bao, 2004, Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats, J Neurochem, 88, 1335, 10.1046/j.1471-4159.2003.02240.x
Martinez, 2006, Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression, J Immunol, 177, 7303, 10.4049/jimmunol.177.10.7303
Busch, 2009, Overcoming macrophage-mediated axonal dieback following CNS injury, Neurosci J., 29, 9967, 10.1523/JNEUROSCI.1151-09.2009
Hata, 2006, RGMa inhibition promotes axonal growth and recovery after spinal cord injury, J Cell Biol, 173, 47, 10.1083/jcb.200508143
Schwab, 2005, Spinal cord injury-induced lesional expression of the repulsive guidance molecule (RGM), Eur J Neurosci, 21, 1569, 10.1111/j.1460-9568.2005.03962.x
Dyck, 2018, Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPsigma receptors promotes a beneficial inflammatory response following spinal cord injury, J Neuroinflammation, 15, 90, 10.1186/s12974-018-1128-2
Knoblach, 1998, Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury, Exp Neurol, 153, 143, 10.1006/exnr.1998.6877
Thompson, 2013, The therapeutic role of interleukin-10 after spinal cord injury, J Neurotrauma, 30, 1311, 10.1089/neu.2012.2651
Zhou, 2009, IL-10 promotes neuronal survival following spinal cord injury, Exp Neurol, 220, 183, 10.1016/j.expneurol.2009.08.018
Genovese, 2009, Absence of endogenous interleukin-10 enhances secondary inflammatory process after spinal cord compression injury in mice, J Neurochem, 108, 1360, 10.1111/j.1471-4159.2009.05899.x
Braga, 2015, Macrophages during the fibrotic process: M2 as friend and foe, Front Immunol, 6, 602, 10.3389/fimmu.2015.00602
Lech, 2013, Macrophages and fibrosis: how resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair, Biochim Biophys Acta, 1832, 989, 10.1016/j.bbadis.2012.12.001
Lin, 2014, Aldosterone induced galectin-3 secretion in vitro and in vivo: from cells to humans, PLoS ONE, 9, e95254, 10.1371/journal.pone.0095254
Brennan, 2018, Emerging targets for reprograming the immune response to promote repair and recovery of function after spinal cord injury, Curr Opin Neurol, 31, 334, 10.1097/WCO.0000000000000550
Chen, 2013, Molecular mechanisms of T cell co-stimulation and co-inhibition, Nat Rev Immunol, 13, 227, 10.1038/nri3405
Popovich, 2008, Can the immune system be harnessed to repair the CNS?, Nat Rev Neurosci, 9, 481, 10.1038/nrn2398
Jones, 2002, Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapy, J Neurosci, 22, 2690, 10.1523/JNEUROSCI.22-07-02690.2002
Potas, 2006, Augmented locomotor recovery after spinal cord injury in the athymic nude rat, J Neurotrauma, 23, 660, 10.1089/neu.2006.23.660
Walsh, 2014, Regulatory T cells in central nervous system injury: a double-edged sword, J Immunol, 193, 5013, 10.4049/jimmunol.1302401
Ankeny, 2009, B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice, J Clin Invest, 119, 2990, 10.1172/JCI39780
Kil, 1999, T cell responses to myelin basic protein in patients with spinal cord injury and multiple sclerosis, J Neuroimmunol, 98, 201, 10.1016/S0165-5728(99)00057-0
Zajarias-Fainsod, 2012, Autoreactivity against myelin basic protein in patients with chronic paraplegia, Eur Spine J, 21, 964, 10.1007/s00586-011-2060-7
Hayes, 2002, Elevated serum titers of proinflammatory cytokines and CNS autoantibodies in patients with chronic spinal cord injury, J Neurotrauma, 19, 753, 10.1089/08977150260139129
Popovich, 1996, Concept of autoimmunity following spinal cord injury: possible roles for T lymphocytes in the traumatized central nervous system, J Neurosci Res, 45, 349, 10.1002/(SICI)1097-4547(19960815)45:4<349::AID-JNR4>3.0.CO;2-9
Lund, 2010, Effector and regulatory B cells: modulators of CD4+ T cell immunity, Nat Rev Immunol, 10, 236, 10.1038/nri2729
Ankeny, 2010, B cells and autoantibodies: complex roles in CNS injury, Trends Immunol, 31, 332, 10.1016/j.it.2010.06.006
Lucin, 2007, Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation, Exp Neurol, 207, 75, 10.1016/j.expneurol.2007.05.019
Ren, 2011, Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke, J Neurosci, 31, 8556, 10.1523/JNEUROSCI.1623-11.2011
Yoshizaki, 2012, Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions, Nature, 491, 264, 10.1038/nature11501
Kahn, 2005, Appearance of a novel prostacyclin receptor antibody and duration of spinal cord injury, J Spinal Cord Med, 28, 97, 10.1080/10790268.2005.11753805
Fitch, 2007, CNS injury, glial scars, and inflammation: inhibitory extracellular matrices and regeneration failure, Exp Neurol, 209, 294, 10.1016/j.expneurol.2007.05.014
Cregg, 2014, Functional regeneration beyond the glial scar, Exp Neurol, 253, 197, 10.1016/j.expneurol.2013.12.024
Soderblom, 2013, Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury, J Neurosci, 33, 13882, 10.1523/JNEUROSCI.2524-13.2013
Silver, 2016, The glial scar is more than just astrocytes, Exp Neurol, 286, 147, 10.1016/j.expneurol.2016.06.018
Goritz, 2011, A pericyte origin of spinal cord scar tissue, Science, 333, 238, 10.1126/science.1203165
Adams, 2018, The diversity and disparity of the glial scar, Nat Neurosci, 21, 9, 10.1038/s41593-017-0033-9
Dyck, 2015, Chondroitin sulfate proteoglycans negatively modulate spinal cord neural precursor cells by signaling through LAR and RPTPsigma and modulation of the Rho/ROCK Pathway, Stem Cells, 33, 2550, 10.1002/stem.1979
Noble, 2002, Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events, J Neurosci, 22, 7526, 10.1523/JNEUROSCI.22-17-07526.2002
Agrawal, 2008, MMPs in the central nervous system: where the good guys go bad, Semin Cell Dev Biol, 19, 42, 10.1016/j.semcdb.2007.06.003
Wells, 2003, An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice, J Neurosci, 23, 10107, 10.1523/JNEUROSCI.23-31-10107.2003
Bundesen, 2003, Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats, J Neurosci, 23, 7789, 10.1523/JNEUROSCI.23-21-07789.2003
Pasterkamp, 1999, Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS, Mol Cell Neurosci, 13, 143, 10.1006/mcne.1999.0738
Barnabe-Heider, 2010, Origin of new glial cells in intact and injured adult spinal cord, Cell Stem Cell, 7, 470, 10.1016/j.stem.2010.07.014
Meletis, 2008, Spinal cord injury reveals multilineage differentiation of ependymal cells, PloS Biol, 6, e182, 10.1371/journal.pbio.0060182
Hughes, 2013, Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain, Nat Neurosci, 16, 668, 10.1038/nn.3390
Huang, 2014, Glial scar formation occurs in the human brain after ischemic stroke, Int J Med Sci, 11, 344, 10.7150/ijms.8140
Barrett, 1981, Astroglial reaction in the gray matter lumbar segments after midthoracic transection of the adult rat spinal cord, Exp Neurol, 73, 365, 10.1016/0014-4886(81)90272-7
Bignami, 1976, The astroglial response to stabbing, Neuropathol Appl Neurobiol, 2, 99, 10.1111/j.1365-2990.1976.tb00488.x
Wanner, 2013, Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury, J Neurosci, 33, 12870, 10.1523/JNEUROSCI.2121-13.2013
Faulkner, 2004, Reactive astrocytes protect tissue and preserve function after spinal cord injury, J Neurosci, 24, 2143, 10.1523/JNEUROSCI.3547-03.2004
Herrmann, 2008, STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury, Neurosci J., 28, 7231, 10.1523/JNEUROSCI.1709-08.2008
Yuan, 2013, The glial scar in spinal cord injury and repair, Neurosci Bull, 29, 421, 10.1007/s12264-013-1358-3
Wiese, 2012, Astrocytes as a source for extracellular matrix molecules and cytokines, Front Pharmacol, 3, 120, 10.3389/fphar.2012.00120
Bradbury, 2011, Manipulating the glial scar: chondroitinase ABC as a therapy for spinal cord injury, Brain Res Bull, 84, 306, 10.1016/j.brainresbull.2010.06.015
Galtrey, 2007, The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system, Brain Res Rev, 54, 1, 10.1016/j.brainresrev.2006.09.006
Bradbury, 2002, Chondroitinase ABC promotes functional recovery after spinal cord injury, Nature, 416, 636, 10.1038/416636a
Fournier, 2003, Rho kinase inhibition enhances axonal regeneration in the injury CNS, Neurosci J., 24, 1416, 10.1523/JNEUROSCI.23-04-01416.2003
Cafferty WB, 2007, -H, Duffy PJ, Li S, Strittmatter SM. Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycans, Neurosci J., 27, 2176, 10.1523/JNEUROSCI.5176-06.2007
Massey, 2008, Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3, Exp. Neurol, 209, 426, 10.1016/j.expneurol.2007.03.029
Tom, 2009, Combining peripheral nerve grafts and chondroitinase promotes functional axonal regeneration in the chronically injured spinal cord, Neurosci J., 29, 14881, 10.1523/JNEUROSCI.3641-09.2009
Chen, 2002, Oligodendrocyte precursor cells: reactive cells that inhibit axon growth and regeneration, Neurocytol J., 31, 481, 10.1023/A:1025791614468
Barritt, 2006, Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury, J Neurosci, 26, 10856, 10.1523/JNEUROSCI.2980-06.2006
Massey, 2006, Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury, Neurosci J., 26, 4406, 10.1523/JNEUROSCI.5467-05.2006
Alilain, 2011, Functional regeneration of respiratory pathways after spinal cord injury, Nature, 475, 196, 10.1038/nature10199
Petrosyan, 2013, Neutralization of inhibitory molecule NG2 improves synaptic transmission, retrograde transport, and locomotor function after spinal cord injury in adult rats, J Neurosci, 33, 4032, 10.1523/JNEUROSCI.4702-12.2013
Arvantan, 2009, Chronic spinal hemisection in rats induces a progressive decline in transmission in uninjured fiber to motorneurons, Exp. Neurol, 216, 471, 10.1016/j.expneurol.2009.01.004
Hunanyan, 2010, Role of chondroitin sulfate proteoglycans in axonal conduction in Mammalian spinal cord, J Neurosci, 30, 7761, 10.1523/JNEUROSCI.4659-09.2010
Karimi-Abdolrezaee, 2010, Synergistic effects of transplanted adult neural stem/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord, Neurosci J., 30, 1657, 10.1523/JNEUROSCI.3111-09.2010
Karimi-Abdolrezaee, 2012, Chondroitinase and growth factors enhance activation and oligodendrocyte differentiation of endogenous neural precursor cells after spinal cord injury, PLos ONE, 7, 1, 10.1371/journal.pone.0037589
Pendleton, 2013, Chondroitin sulfate proteoglycans inhibit oligodendrocyte myelination through PTPσ, Exp Neurol, 247, 113, 10.1016/j.expneurol.2013.04.003
Lau, 2012, Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination, Ann Neurol, 72, 419, 10.1002/ana.23599
Larsen, 2003, Matrix metalloproteinase-9 facilitates remyelination in part by processing the inhibitory NG2 proteoglycan, J Neurosci, 23, 11127, 10.1523/JNEUROSCI.23-35-11127.2003
Kurazono, 2001, Expression of brain specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the developing and adult hippocampus of Ihara's epileptic rats, Brain Res, 898, 36, 10.1016/S0006-8993(01)02128-X
Asher, 2002, Versican is upregulated in CNS injury and is a product of oligodendrocyte lineage cells, Neurosci J., 22, 2225, 10.1523/JNEUROSCI.22-06-02225.2002
Buss, 2009, NG2 and phosphacan are present in the astroglial scar after human traumatic spinal cord injury, BMC Neurol, 9, 32, 10.1186/1471-2377-9-32
Schachtrup, 2010, fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-B after vascular damage, Neurosci J., 30, 5843, 10.1523/JNEUROSCI.0137-10.2010
Hellal, 2011, Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury, Science, 331, 928, 10.1126/science.1201148
Jahan, 2014, Transforming growth factor β-induced expression of chondroitin sulfate proteoglycans is mediated through non-Smad signaling pathways, Exp Neurol, 263, 372, 10.1016/j.expneurol.2014.10.023
Levine, 1994, Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury, J Neurosci, 14, 4716, 10.1523/JNEUROSCI.14-08-04716.1994
Asher, 2000, Neurocan is upregulated in injured brain and in cytokine-treated astrocytes, J Neurosci, 20, 2427, 10.1523/JNEUROSCI.20-07-02427.2000
Cafferty, 2008, Chondroitinase ABC-Mediated Plasticity of Spinal Sensory Function, Neurosci J., 28, 11998, 10.1523/JNEUROSCI.3877-08.2008
Wang, 2011, Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury, Neurosci J., 31, 9332, 10.1523/JNEUROSCI.0983-11.2011
Yick, 2007, Lithium chloride reinforces the regeneration-promoting effect of chondroitinase ABC on rubrospinal neurons after spinal cord injury, Neurotrauma J., 21, 932, 10.1089/0897715041526221
Carter, 2011, Delayed treatment with chondroitinase ABC reverses chronic atrophy of rubrospinal neurons following spinal cord injury, Exp Neurol, 228, 149, 10.1016/j.expneurol.2010.12.023
Carter, 2008, The Yellow Fluorescent Protein (YFP-H) mouse reveals neuroprotection as a novel mechanism underlying chondroitinase ABC-mediated repair after spinal cord injury, Neurosci J., 28, 14107, 10.1523/JNEUROSCI.2217-08.2008
Anderson, 2016, Astrocyte scar formation aids central nervous system axon regeneration, Nature, 532, 195, 10.1038/nature17623
Karimi-Abdolrezaee, 2012, Reactive astrogliosis after spinal cord injury-beneficial and detrimental effects, Mol Neurobiol, 46, 251, 10.1007/s12035-012-8287-4
Horn, 2008, Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions, J Neurosci, 28, 9330, 10.1523/JNEUROSCI.2488-08.2008
McTigue, 2008, The life, death, and replacement of oligodendrocytes in the adult CNS, J Neurochem, 107, 1, 10.1111/j.1471-4159.2008.05570.x
Wang, 2011, Astrocytes from the contused spinal cord inhibit oligodendrocyte differentiation of adult oligodendrocyte precursor cells by increasing the expression of bone morphogenetic proteins, Neurosci J., 31, 6053, 10.1523/JNEUROSCI.5524-09.2011
Lang, 2015, Modulation of the proteoglycan receptor PTPsigma promotes recovery after spinal cord injury, Nature, 518, 404, 10.1038/nature13974
Fry, 2010, Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice, Glia, 58, 423, 10.1002/glia.20934
McLean, 2002, Enhanced rate of nerve regeneration and directional errors after sciatic nerve injury in receptor protein tyrosine phosphatase σ knock-out mice, J Neurosci, 22, 5481, 10.1523/JNEUROSCI.22-13-05481.2002
Fisher, 2011, Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors, Neurosci J., 31, 14051, 10.1523/JNEUROSCI.1737-11.2011
Dyck, 2018, Role of chondroitin sulfate proteoglycan signaling in regulating neuroinflammation following spinal cord injury, Neural Regen Res, 13, 2080, 10.4103/1673-5374.241452
Stephenson, 2018, Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis, Brain, 141, 1094, 10.1093/brain/awy033
Rolls, 2008, Two faces of chondroitin sulfate proteoglycan in spinal cord repair: a role in microglia/macrophage activation, PLoS Med, 5, e171, 10.1371/journal.pmed.0050171