Trapped Ion Mobility Spectrometry: past, present and future trends

Benigni P, Fernandez-Lima F (2016) Oversampling selective accumulation trapped ion mobility spectrometry coupled to FT-ICR MS: fundamentals and applications. Anal Chem 88:7404–7412. doi:10.1021/acs.analchem.6b01946 Benigni P, Thompson CJ, Ridgeway ME, Park MA, Fernandez-Lima F (2015) Targeted high-resolution ion mobility separation coupled to ultrahigh-resolution mass spectrometry of endocrine disruptors in complex mixtures. Anal Chem 87:4321–4325. doi:10.1021/ac504866v Castellanos A, Benigni P, Hernandez DR, DeBord JD, Ridgeway ME, Park MA, Fernandez-Lima FA (2014) Fast screening of polycyclic aromatic hydrocarbons using trapped ion mobility spectrometry – mass spectrometry. Anal Meth 6:9328–9332 Fernandez-Lima F, Kaplan D, Suetering J, Park M (2011a) Gas-phase separation using a trapped ion mobility spectrometer. Int J Ion Mobility Spectrom 14:93–98. doi:10.1007/s12127–011–0067-8 Fernandez-Lima FA, Kaplan DA, Park MA (2011b) Note: Integration of trapped ion mobility spectrometry with mass spectrometry. Rev Sci Instr 82:126106 Hernandez DR, DeBord JD, Ridgeway ME, Kaplan DA, Park MA, Fernandez-Lima FA (2014) Ion dynamics in a trapped ion mobility spectrometer. Analyst 139:1913–1921. doi:10.1039/C3AN02174B Liu FC, Kirk SR, Bleiholder C (2016) On the structural denaturation of biological analytes in trapped ion mobility spectrometry–mass spectrometry. Analyst 141:3722–3730 McKenzie A, DeBord JD, Ridgeway ME, Park MA, Eiceman GA, Fernandez-Lima F (2015) Lifetimes and Stabilities of familiar explosives molecular adduct complexes during ion mobility measurements. Analyst 140:5692–5699. doi:10.1039/c5an00527b Meier F, Beck S, Grassl N, Lubeck M, Park MA, Raether O, Mann M (2015) Parallel accumulation–serial fragmentation (PASEF): multiplying sequencing speed and sensitivity by synchronized scans in a trapped ion mobility device. J Proteome Res 14:5378–5387. doi:10.1021/acs.jproteome.5b00932 Michelmann K, Silveira JA, Ridgeway ME, Park MA (2015) Fundamentals of trapped ion mobility spectrometry. J Am Soc Mass Spectrom 26:14–24. doi:10.1007/s13361–014–0999-4 Molano-Arevalo JC, Hernandez DR, Gonzalez WG, Miksovska J, Ridgeway ME, Park MA, Fernandez-Lima F (2014) Flavin adenine dinucleotide structural motifs: from solution to gas-phase. Anal Chem 86:10223–10230 Pu Y, Ridgeway ME, Glaskin RS, Park MA, Costello CE, Lin C (2016) Separation and identification of isomeric Glycans by selected accumulation-trapped ion mobility spectrometry-electron activated dissociation tandem mass spectrometry. Anal Chem 88:3440–3443. doi:10.1021/acs.analchem.6b00041 Ridgeway ME, Silveira JA, Meier JE, Park MA (2015) Microheterogeneity within conformational states of ubiquitin revealed by high resolution trapped ion mobility spectrometry. Analyst 140:6964–6972. doi:10.1039/C5AN00841G Schenk ER, Almeida R, Miksovska J, Ridgeway ME, Park MA, Fernandez-Lima F (2015a) Kinetic intermediates of Holo- and Apo-myoglobin studied using HDX-TIMS-MS and molecular dynamic simulations. J Am Soc Mass Spectrom 26:555–563. doi:10.1007/s13361-014-1067-9 Schenk ER, Mendez V, Landrum JT, Ridgeway ME, Park MA, Fernandez-Lima F (2014a) Direct observation of differences of carotenoid polyene chain cis/trans isomers resulting from structural topology. Anal Chem 86:2019–2024. doi:10.1021/ac403153m Schenk ER, Nau F, Fernandez-Lima F (2015b) Theoretical predictor for candidate structure assignment from IMS data of biomolecule-related conformational space. Int J Ion Mobility Spectrom 18:23–29. doi:10.1007/s12127–015–0165-0 Schenk ER, Ridgeway ME, Park MA, Leng F, Fernandez-Lima F (2014b) Isomerization kinetics of AT hook Decapeptide solution structures. Anal Chem 86:1210–1214. doi:10.1021/ac403386q Silveira JA, Michelmann K, Ridgeway ME, Park MA (2016a) Fundamentals of Trapped Ion Mobility Spectrometry Part II: Fluid Dynamics. J Am Soc Mass Spectrom 27:585–595. doi:10.1007/s13361–015-1310-z Silveira JA, Ridgeway ME, Laukien FH, Mann M, Park MA (2016b) Parallel accumulation for 100 % duty cycle trapped ion mobility-mass spectrometry. Int J Mass Spectrom. doi:10.1016/j.ijms.2016.03.004 Silveira JA, Ridgeway ME, Park MA (2014) High resolution trapped ion mobility Spectrometery of peptides. Anal Chem 86:5624–5627. doi:10.1021/ac501261h Zeleny J (1898) On the ratio of velocities of the two ions produced in gases by Röngten radiation, and on some related phenomena. Philos Mag 46:120–154