Transport of the placental estriol precursor 16α-hydroxy-dehydroepiandrosterone sulfate (16α-OH-DHEAS) by stably transfected OAT4-, SOAT-, and NTCP-HEK293 cells

H. Schweigmann1, A. Sánchez-Guijo2, B. Ugele3, K. Hartmann4, M.F. Hartmann2, M. Bergmann4, C. Pfarrer5, B. Döring1, S.A. Wudy2, E. Petzinger1, J. Geyer1, G. Grosser1
1Institute of Pharmacology and Toxicology, Justus Liebig University of Giessen, 35392 Giessen, Germany
2Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University of Giessen, 35392 Giessen, Germany
3University Hospital, Ludwig Maximilians University of Munich, 80337 Munich, Germany
4Institute of Veterinary Anatomy, Histology and Embryology, Justus Liebig University of Giessen, 35392 Giessen, Germany
5Department of Anatomy, University of Veterinary Medicine, 30173 Hannover, Germany

Tài liệu tham khảo

Kuijper, 2013, Reproductive hormone concentrations in pregnancy and neonates: a systematic review, Reprod. Biomed. Online, 27, 33, 10.1016/j.rbmo.2013.03.009 Siiteri, 1963, The utilization of circulating dehydroisoandrosterone sulfate for estrogen synthesis during human pregnancy, Steroids, 2, 713, 10.1016/0039-128X(63)90044-8 Frandsen, 1964, The site of production of oestrogenic hormones in human pregnancy. Hormone excretion in pregnancy with anencephalic foetus, Acta Endocrinol. (Copenh), 47, 265, 10.1530/acta.0.0470265 Newby, 2000, Placental synthesis of oestriol in Down's syndrome pregnancies, Placenta, 21, 263, 10.1053/plac.1999.0469 France, 1969, Placental sulfatase deficiency, J. Clin. Endocrinol. Metab., 29, 138, 10.1210/jcem-29-1-138 France, 1973, A study of pregnancy with low estrogen production due to placental sulfatase deficiency, J. Clin. Endocrinol. Metab., 36, 1, 10.1210/jcem-36-1-1 Laatikainen, 1980, Fetal and maternal serum levels of steroid sulfates, unconjugated steroids, and prolactin at term pregnancy and in early spontaneous labor, J. Clin. Endocrinol. Metab., 50, 489, 10.1210/jcem-50-3-489 Kojima, 1981, Serum steroid levels in children at birth and in early neonatal period, Am. J. Obstet. Gynecol., 140, 961, 10.1016/0002-9378(81)90092-2 Siiteri, 1966, Placental estrogen biosynthesis during human pregnancy, J. Clin. Endocrinol. Metab., 26, 751, 10.1210/jcem-26-7-751 Kitada, 1987, P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate, J. Biol. Chem., 262, 13534, 10.1016/S0021-9258(19)76460-6 Ryan, 1959, Metabolism of C-16-oxygenated steroids by human placenta: the formation of estriol, J. Biol. Chem., 234, 2006, 10.1016/S0021-9258(18)69857-6 Milewich, 1986, Estrogen 16 alpha-hydroxylase activity in human fetal tissues, J. Clin. Endocrinol. Metab., 63, 404, 10.1210/jcem-63-2-404 Dibbelt, 1989, Human placental sterylsulfatase: immunocytochemical and biochemical localization, Biol. Chem. Hoppe Seyler, 370, 1093, 10.1515/bchm3.1989.370.2.1093 Albrecht, 1990, Placental steroid hormone biosynthesis in primate pregnancy, Endocr. Rev., 11, 124, 10.1210/edrv-11-1-124 Strauss, 1996, Placental steroid hormone synthesis: unique features and unanswered questions, Biol. Reprod., 54, 303, 10.1095/biolreprod54.2.303 Cha, 2000, Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta, J. Biol. Chem., 275, 4507, 10.1074/jbc.275.6.4507 Tamai, 2000, Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family, Biochem. Biophys. Res. Commun., 273, 251, 10.1006/bbrc.2000.2922 Kullak-Ublick, 2001, Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver, Gastroenterology, 120, 525, 10.1053/gast.2001.21176 Ugele, 2008, Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta, J. Steroid Biochem. Mol. Biol., 111, 1, 10.1016/j.jsbmb.2008.04.001 Geyer, 2007, Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6), J. Biol. Chem., 282, 19728, 10.1074/jbc.M702663200 Zbella, 1986, Competitive studies with dehydroepiandrosterone sulfate and 16 alpha-hydroxydehydroepiandrosterone sulfate in cultured human choriocarcinoma JEG-3 cells: effect on estrone, 17 beta-estradiol, and estriol secretion, J. Clin. Endocrinol. Metab., 63, 751, 10.1210/jcem-63-3-751 Ugele, 2003, Characterization and identification of steroid sulfate transporters of human placenta, Am. J. Physiol. Endocrinol. Metab., 284, E390, 10.1152/ajpendo.00257.2002 Grosser, 2013, Cloning and functional characterization of the mouse sodium-dependent organic anion transporter Soat (Slc10a6), J. Steroid Biochem. Mol. Biol., 138, 90, 10.1016/j.jsbmb.2013.03.009 Galuska, 2013, Profiling intact steroid sulfates and unconjugated steroids in biological fluids by liquid chromatography–tandem mass spectrometry (LC–MS–MS), Analyst, 138, 3792, 10.1039/c3an36817c Fietz, 2013, Membrane transporters for sulfated steroids in the human testis – cellular localization, expression pattern and functional analysis, PLoS ONE, 8, e62638, 10.1371/journal.pone.0062638 Han, 2010, Transporter studies with the 3-O-sulfate conjugate of 17alpha-ethinylestradiol: assessment of human liver drug transporters, Drug Metab. Dispos., 38, 1072, 10.1124/dmd.109.031518 Geyer, 2006, The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships, Naunyn Schmiedebergs Arch. Pharmacol., 372, 413, 10.1007/s00210-006-0043-8 St-Pierre, 2002, Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta, J. Clin. Endocrinol. Metab., 87, 1856, 10.1210/jcem.87.4.8431 Grube, 2007, Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta, Drug Metab. Dispos., 35, 30, 10.1124/dmd.106.011411 Craddock, 1998, Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter, Am. J. Physiol., 274, G157 Döring, 2012, The SLC10 carrier family: transport functions and molecular structure, Curr. Top. Membr., 70, 105, 10.1016/B978-0-12-394316-3.00004-1 Patel, 2003, Semi quantitative expression analysis of MDR3, FIC1, BSEP, OATP-A, OATP-C, OATP-D, OATP-E and NTCP gene transcripts in 1st and 3rd trimester human placenta, Placenta, 24, 39, 10.1053/plac.2002.0879 Marin, 1990, Bile acid transport by basal membrane vesicles of human term placental trophoblast, Gastroenterology, 99, 1431, 10.1016/0016-5085(90)91172-3 Yamashita, 2006, Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4, J. Pharm. Pharmacol., 58, 1499, 10.1211/jpp.58.11.0011 Hagos, 2007, Human renal organic anion transporter 4 operates as an asymmetric urate transporter, J. Am. Soc. Nephrol., 18, 430, 10.1681/ASN.2006040415 Brant, 1995, Cloning, tissue distribution, and functional analysis of the human Na+/H+ exchanger isoform, NHE3, Am. J. Physiol., 269, C198, 10.1152/ajpcell.1995.269.1.C198 Lang, 2003, Intracellular pH activates membrane-bound Na+/H+ exchanger and vacuolar H+-ATPase in human embryonic kidney (HEK) cells, Cell. Physiol. Biochem., 13, 257, 10.1159/000074540 Johansson, 2002, Activity and protein expression of the Na+/H+ exchanger is reduced in syncytiotrophoblast microvillous plasma membranes isolated from preterm intrauterine growth restriction pregnancies, J. Clin. Endocrinol. Metab., 87, 5686, 10.1210/jc.2002-020214 Pepe, 2001, Expression of the mRNAs and proteins for the Na+/H+ exchangers and their regulatory factors in baboon and human placental syncytiotrophoblast, Endocrinology, 142, 3685, 10.1210/endo.142.8.8343 Speake, 2005, Activity and expression of Na+/H+ exchanger isoforms in the syncytiotrophoblast of the human placenta, Eur. J. Physiol., 450, 123, 10.1007/s00424-005-1382-x Reed, 2005, Steroid sulfatase: molecular biology, regulation, and inhibition, Endocr. Rev., 26, 171, 10.1210/er.2004-0003 Santner, 1984, In situ estrogen production via the estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway, J. Clin. Endocrinol. Metab., 59, 29, 10.1210/jcem-59-1-29 Vähäkangas, 2009, Drug transporters in the human blood-placental barrier, Br. J. Pharm., 158, 665, 10.1111/j.1476-5381.2009.00336.x