Transport and Localization of the DEG/ENaC Ion Channel BNaC1α to Peripheral Mechanosensory Terminals of Dorsal Root Ganglia Neurons

Journal of Neuroscience - Tập 21 Số 8 - Trang 2678-2686 - 2001
Jaime Garcı́a-Añoveros1, Tarek A. Samad2, Ljiljana Žuvela-Jelaska1, Clifford J. Woolf2, David P. Corey1
1Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, and
2Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129

Tóm tắt

Mammalian brain sodium channel (BNaC, also known as BNC/ASIC) proteins form acid-sensitive and amiloride-blockable sodium channels that are related to putative mechanosensory channels. Certain BNaC isoforms are expressed exclusively in dorsal root ganglia (DRG) and have been proposed to form the ion channels mediating tissue acidosis-induced pain. With antibody labeling, we find that the BNaC1α isoform is expressed by most large DRG neurons (low-threshold mechanosensors not involved in acid-induced nociception) and few small nociceptor neurons (which include high-threshold mechanoreceptors). BNaC1α is transported from DRG cell bodies to sensory terminals in the periphery, but not to the spinal cord, and is located specifically at specialized cutaneous mechanosensory terminals, including Meissner, Merkel, penicillate, reticular, lanceolate, and hair follicle palisades as well as some intraepidermal and free myelinated nerve endings. Accordingly, BNaC1α channels might participate in the transduction of touch and painful mechanical stimuli.

Từ khóa


Tài liệu tham khảo

Adams, 1998, Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons., J Cell Biol, 1, 143, 10.1083/jcb.140.1.143

10.1006/mcne.1999.0828

10.1016/S0896-6273(00)81144-7

10.1085/jgp.112.2.97

10.1046/j.1471-4159.1999.0720051.x

10.1161/01.RES.84.8.921

10.1016/0166-2236(94)90149-X

10.1113/jphysiol.1991.sp018419

10.1136/jnnp.43.3.235

10.1038/361467a0

10.1038/367463a0

10.1038/39807

10.1126/science.288.5464.306

Cauna, 1973, The free penicillate nerve endings of the human hairy skin., J Anat, 115, 277

10.1083/jcb.8.2.467

10.1073/pnas.95.17.10240

10.1126/science.273.5273.323

10.1006/bbrc.1998.8183

10.1038/349588a0

10.1016/S0896-6273(00)80661-3

10.1016/S0960-9822(00)00478-4

Fricke, 2000, Epithelial Na+ channels and stomatin are expressed in rat trigeminal mechanosensory neurons., Cell Tissue Res, 299, 327

10.1016/S0960-9822(02)00537-7

10.1146/annurev.neuro.20.1.567

10.1016/S0960-9822(95)00085-6

10.1073/pnas.94.4.1459

10.1016/S0896-6273(00)80503-6

10.1002/jnr.490300111

10.1046/j.1460-9568.1999.00503.x

10.1038/367467a0

10.1006/bbrc.1998.8483

10.1002/cne.901980112

10.1113/jphysiol.1991.sp018497

10.1002/cne.902280211

10.1126/science.273.5273.361

10.1016/S0304-3940(99)00665-5

10.1002/cne.902770203

10.1007/BF01872883

10.1074/jbc.271.14.7879

10.1038/35039512

10.1016/S0079-6123(08)61085-7

10.1002/cne.903370303

10.1002/(SICI)1096-9861(19970825)385:2<149::AID-CNE1>3.0.CO;2-1

Sann, 1995, RT97: a marker for capsaicin-insensitive sensory endings in the rat skin., Cell Tissue Res, 282, 155, 10.1007/BF00319142

Sinclair DC (1982) Mechanisms of cutaneous sensation. (Oxford UP, London).

10.1523/JNEUROSCI.12-01-00086.1992

10.1146/annurev.physiol.59.1.633

10.1016/S0896-6273(01)80050-7

10.1016/0006-8993(83)90241-X

10.1016/S0896-6273(00)80564-4

10.1046/j.1460-9568.1998.00355.x

10.1016/S0959-4388(98)80070-6

10.1074/jbc.271.18.10433

10.1074/jbc.272.34.20975

Thông tin
Thông tin xuất bản

Journal of Neuroscience

Tập 21 Số 8

2678-2686

Thông tin tác giả