Transplanted mesenchymal stromal cells are unable to migrate to the bone surface and subsequently improve osteogenesis in glucocorticoid-induced osteoporosis

Cytotherapy - Tập 25 - Trang 472-482 - 2023
Xueling Zheng1, Wanyuji Wang1, Sisi Chen2, Bin Zuo2, Jiao Li1
1Department of Cell Biology, Zunyi Medical University, Zunyi, Guizhou Province, China
2Department of Orthopedic Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

Tài liệu tham khảo

Zaidi, 2007, Skeletal remodeling in health and disease, Nat Med, 13, 791, 10.1038/nm1593 Hadjidakis, 2006, Bone remodeling, Ann N Y Acad Sci, 1092, 385, 10.1196/annals.1365.035 Manolagas, 1995, Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis, N Engl J Med, 332, 305, 10.1056/NEJM199502023320506 Yao, 2013, Reversing bone loss by directing mesenchymal stem cells to bone, Stem Cells, 31, 2003, 10.1002/stem.1461 Guan, 2012, Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass, Nat Med, 18, 456, 10.1038/nm.2665 Tang, 2009, TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation, Nat Med, 15, 757, 10.1038/nm.1979 Erlebacher, 1998, Osteoblastic responses to TGF-beta during bone remodeling, Mol Biol Cell, 9, 1903, 10.1091/mbc.9.7.1903 Alliston, 2001, TGF-beta–induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation, EMBO J, 20, 2254, 10.1093/emboj/20.9.2254 Maeda, 2004, Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells, EMBO J, 23, 552, 10.1038/sj.emboj.7600067 Halleux, 2001, Multi-lineage potential of human mesenchymal stem cells following clonal expansion, J Musculoskelet Neuronal Interact, 2, 71 Chen, 2007, Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts, J Bone Miner Res, 22, 1943, 10.1359/jbmr.070725 Engler, 2006, Matrix elasticity directs stem cell lineage specification, Cell, 126, 677, 10.1016/j.cell.2006.06.044 Zhang, 2017, Effect of matrix stiffness on osteoblast functionalization, Cell Prolif, 50, e12338, 10.1111/cpr.12338 Dallas, 2002, Proteolysis of latent transforming growth factor-beta (TGFbeta)-binding protein-1 by osteoclasts. A cellular mechanism for release of TGFbeta from bone matrix, J Biol Chem, 277, 21352, 10.1074/jbc.M111663200 Ota, 2013, Transforming growth factor beta1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors, Bone, 57, 68, 10.1016/j.bone.2013.07.023 Dallas, 1995, Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein, J Cell Biol, 131, 539, 10.1083/jcb.131.2.539 Chandra, 2021, Skeletal aging and osteoporosis: mechanisms and therapeutics, Int J Mol Sci, 22, 3553, 10.3390/ijms22073553 Almeida, 2017, Estrogens and androgens in skeletal physiology and pathophysiology, Physiol Rev, 97, 135, 10.1152/physrev.00033.2015 Rauch, 2010, Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor, Cell Metab, 11, 517, 10.1016/j.cmet.2010.05.005 Li, 2013, Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C/EBPalpha promoter methylation, Cell Death Dis, 4, e832, 10.1038/cddis.2013.348 Bikle, 2003, The impact of skeletal unloading on bone formation, Gravit Space Biol Bull, 16, 45 Khosla, 2017, Osteoporosis treatment: recent developments and ongoing challenges, Lancet Diabetes Endocrinol, 5, 898, 10.1016/S2213-8587(17)30188-2 Rachner, 2011, Osteoporosis: now and the future, Lancet, 377, 1276, 10.1016/S0140-6736(10)62349-5 Jiang, 2021, Advances in mesenchymal stem cell transplantation for the treatment of osteoporosis, Cell Prolif, 54, e12956, 10.1111/cpr.12956 Kiernan, 2017, Concise review: musculoskeletal stem cells to treat age-related osteoporosis, Stem Cells Transl Med, 6, 1930, 10.1002/sctm.17-0054 Sui, 2019, Stem cell-based regeneration in diseased microenvironments: challenges and solutions, Biomaterials, 196, 18, 10.1016/j.biomaterials.2017.10.046 Su, 2018, Mesenchymal stem cell migration during bone formation and bone diseases therapy, Int J Mol Sci, 19, 2343, 10.3390/ijms19082343 Li, 2015, The role of bone marrow microenvironment in governing the balance between osteoblastogenesis and adipogenesis, Aging Dis, 7, 514, 10.14336/AD.2015.1206 Zhang, 2016, Effect of TGF-β1/SDF-1/CXCR4 signal on BM-MSCs homing in rat heart of ischemia/perfusion injury, Eur Rev Med Pharmacol Sci, 20, 899 Rath, 2016, Evidence of an interaction between TGF-β1 and SDF1/CXCR4/CXCR7 axis in human platelets, Thromb Res, 144, 79, 10.1016/j.thromres.2016.06.006 Halder, 2005, A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers, Neoplasia, 7, 509, 10.1593/neo.04640 Black, 2016, Clinical practice. Postmenopausal osteoporosis, N Engl J Med, 374, 254, 10.1056/NEJMcp1513724 Cosman, 2009, Treatment of osteoporosis and prevention of new fractures: role of intravenously administered bisphosphonates, Endocr Pract, 15, 483, 10.4158/EP08306.ORR1 Akesson, 2003, New approaches to pharmacological treatment of osteoporosis, Bull World Health Organ, 81, 657 Pittenger, 1999, Multilineage potential of adult human mesenchymal stem cells, Science, 284, 143, 10.1126/science.284.5411.143 Oh, 2021, Mesenchymal stromal cells for the treatment of ocular autoimmune diseases, Prog Retin Eye Res, 85, 10.1016/j.preteyeres.2021.100967 Götherström, 2020, Stem cell therapy as a treatment for osteogenesis imperfecta, Curr Osteoporos Res, 18, 337, 10.1007/s11914-020-00594-3 Langrzyk, 2018, Critical view on mesenchymal stromal cells in regenerative medicine, Antioxid Redox Signal, 29, 169, 10.1089/ars.2017.7159 Yagi, 2010, Mesenchymal stem cells: mechanisms of immunomodulation and homing, Cell Transplant, 19, 667, 10.3727/096368910X508762 Lien, 2009, Restoration of bone mass and strength in glucocorticoid-treated mice by systemic transplantation of CXCR4 and cbfa-1 co-expressing mesenchymal stem cells, J Bone Miner Res, 24, 837, 10.1359/jbmr.081257 Sui, 2016, Allogeneic mesenchymal stem cell therapy promotes osteoblastogenesis and prevents glucocorticoid-induced osteoporosis, Stem Cell Translational Medicine, 5, 1238, 10.5966/sctm.2015-0347 Becker, 2016, Homing and migration of mesenchymal stromal cells: how to improve the efficacy of cell therapy?, World J Stem Cells, 26, 73, 10.4252/wjsc.v8.i3.73 Fischer, 2009, Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect, Stem Cells Dev, 18, 683, 10.1089/scd.2008.0253 Fabian, 2017, Distribution pattern following systemic mesenchymal stem cell injection depends on the age of the recipient and neuronal health, Stem Cell Res Ther, 8, 85, 10.1186/s13287-017-0533-2 Zheng, 2021, The elevated level of IL-1α in the bone marrow of aged mice leads to MSC senescence partly by down-regulating Bmi-1, Exp Gerontol, 148, 10.1016/j.exger.2021.111313 Valenti, 2016, Osteogenic differentiation in healthy and pathological conditions, Int J Mol Sci, 18, 41, 10.3390/ijms18010041 Tikhonova, 2019, The bone marrow microenvironment at single-cell resolution, Nature, 569, 222, 10.1038/s41586-019-1104-8 Shen, 2021, A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis, Nature, 591, 438, 10.1038/s41586-021-03298-5 Sanghani-Kerai, 2017, Osteoporosis and ageing affects the migration of stem cells and this is ameliorated by transfection with CXCR4, Bone Joint Res, 6, 358, 10.1302/2046-3758.66.BJR-2016-0259.R1 Haasters, 2014, Mesenchymal stem cells from osteoporotic patients reveal reduced migration and invasion upon stimulation with BMP-2 or BMP-7, Biochem Biophys Res Commun, 452, 118, 10.1016/j.bbrc.2014.08.055 Nikolaou, 2009, The influence of osteoporosis in femoral fracture healing time, Injury, 40, 663, 10.1016/j.injury.2008.10.035 Pfeilschifter, 2002, Changes in Proinflammatory cytokine activity after menopause, Endocr Rev, 23, 90, 10.1210/edrv.23.1.0456