Transplantation of chemically-induced liver progenitor cells ameliorates hepatic fibrosis in mice with diet-induced nonalcoholic steatohepatitis

Nicolas, 2016, Cell therapy in chronic liver disease, Curr Opin Gastroenterol, 32, 189 Horslen, 2003, Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder, Pediatrics, 111, 1262, 10.1542/peds.111.6.1262 Barone, 2004, Ursodeoxycholate further increases bile-duct cell proliferative response induced by partial bile-duct ligation in rats, Virchows Arch, 444, 554, 10.1007/s00428-004-0998-0 Enosawa, 2014, Hepatocyte transplantation using a living donor reduced graft in a baby with ornithine transcarbamylase deficiency: a novel source of hepatocytes, Liver Transplant, 20, 391, 10.1002/lt.23800 Si-Tayeb, 2010, Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells, Hepatology, 51, 297, 10.1002/hep.23354 Kido, 2015, CPM is a useful cell surface marker to isolate expandable Bi-potential liver progenitor cells derived from human iPS cells, Stem Cell Rep, 5, 508, 10.1016/j.stemcr.2015.08.008 Katsuda, 2017, Conversion of terminally committed hepatocytes to culturable bipotent progenitor cells with regenerative capacity, Cell Stem Cell, 20, 41, 10.1016/j.stem.2016.10.007 Katsuda, 2019, Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes, Elife, 8, 10.7554/eLife.47313 Katsuda, 2017, Biological and clinical insights offered by chemically induced liver progenitors (CLiPs), Stem Cell Invest, 4, 68, 10.21037/sci.2017.08.04 Rezvani, 2016, Assessing the therapeutic potential of lab-made hepatocytes, Hepatology, 64, 287, 10.1002/hep.28569 Burra, 2019, The ILTS consensus conference on NAFLD/NASH and liver transplantation: setting the stage, Transplantation, 103, 19, 10.1097/TP.0000000000002507 Younossi, 2018, Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: implications for liver transplantation, Liver Transplant, 24, 166, 10.1002/lt.25003 Sakai, 2018, Controlled cell morphology and liver-specific function of engineered primary hepatocytes by fibroblast layer cell densities, J Biosci Bioeng, 126, 249, 10.1016/j.jbiosc.2018.02.006 Katsuda, 2018, Generation of chemically induced liver progenitors (CLiPs) from rat adult hepatocytes, Bio Protoc, 8, e2689, 10.21769/BioProtoc.2689 Katsuda, 2019, Chemically induced liver progenitors (CLiPs): a novel cell source for hepatocytes and biliary epithelial cells, Methods Mol Biol, 1905, 117, 10.1007/978-1-4939-8961-4_11 Huang, 2019, Development of bifunctional three-dimensional cysts from chemically induced liver progenitors, Stem Cell Int, 2019 Huang, 2021, Bioengineering of a CLiP-derived tubular biliary-duct-like structure for bile transport in vitro, Biotechnol Bioeng, 118, 2572, 10.1002/bit.27773 Miyoshi, 2022, Successful induction of human chemically induced liver progenitors with small molecules from damaged liver, J Gastroenterol, 57, 441, 10.1007/s00535-022-01869-5 Azuma, 2021, IL-19 contributes to the development of nonalcoholic steatohepatitis by altering lipid metabolism, Cells, 10 Huang, 2021, Chemical conversion of aged hepatocytes into bipotent liver progenitor cells, Hepatol Res, 51, 323, 10.1111/hepr.13609 Loomba, 2014, Serum alanine aminotransferase as a biomarker of treatment response in nonalcoholic steatohepatitis, Clin Gastroenterol Hepatol, 12, 1731, 10.1016/j.cgh.2014.03.026 Sanyal, 2011, Endpoints and clinical trial design for nonalcoholic steatohepatitis, Hepatology, 54, 344, 10.1002/hep.24376 Hoofnagle, 2013, Vitamin E and changes in serum alanine aminotransferase levels in patients with non-alcoholic steatohepatitis, Aliment Pharmacol Ther, 38, 134, 10.1111/apt.12352 Chen, 2019, Combatting fibrosis: exosome-based therapies in the regression of liver fibrosis, Hepatol Commun, 3, 180, 10.1002/hep4.1290 Meng, 2012, Epigenetic regulation of miR-34a expression in alcoholic liver injury, Am J Pathol, 181, 804, 10.1016/j.ajpath.2012.06.010 Hyung, 2020, Exosomes derived from chemically induced human hepatic progenitors inhibit oxidative stress induced cell death, Biotechnol Bioeng, 117, 2658, 10.1002/bit.27447 Rong, 2019, Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/beta-catenin pathway, Stem Cell Res Ther, 10, 98, 10.1186/s13287-019-1204-2 Bosma, 1983, A severe combined immunodeficiency mutation in the mouse, Nature, 301, 527, 10.1038/301527a0