Translational control during early development

BioEssays - Tập 13 Số 4 - Trang 179-183 - 1991
Joel D. Richter

Tóm tắt

AbstractEarly development in many animals is programmed by maternally inherited messenger RNAs. Many of these mRNAs are translationally dormant in immature oocytes, but are recruited onto polysomes during meiotic maturation, fertilization, or early embryogenesis. In contrast, other mRNAs that are translated in oocytes are released from polysomes during these later stages of development. Recent studies have begun to define the cis and trans elements that regulate both translational repression and translational induction of maternal mRNA. The inhibition of translation of some mRNAs during early development is controlled by discrete sequences residing in the 3′ and 5′ untranslated regions, respectively. The translation of other RNAs is due to polyadenylation which, at least in oocytes of the frog Xenopus laevis, is regulated by a U‐rich cytoplasmic polyadenylation element (CPE). Although similar, the CPE sequences of various mRNAs are sufficiently different to be bound by different proteins. Two of these proteins and their interactions are described here.

Từ khóa


Tài liệu tham khảo

10.1002/mrd.1080260310

10.1016/0014-4827(63)90081-8

10.1093/nar/12.18.7057

10.1093/nar/12.18.7035

10.1007/978-1-4684-5365-2_6

10.1007/978-1-4684-5365-2_5

10.1038/309378a0

10.1093/nar/15.10.4099

10.1083/jcb.107.1.45

Crawford D. R., 1987, An RNA binding protein from Xenopus oocytes is associated with specific message sequences, Development, 101, 741, 10.1242/dev.101.4.741

10.1016/0012-1606(90)90070-Y

10.1016/0092-8674(80)90635-2

10.1101/gad.4.12a.2157

10.1016/0092-8674(86)90801-9

Standardt N. M., 1985, The small subunit of ribonucleotide reductase is encoded by one of the most abundant translationally regulated maternal RNAs in clam and sea urchin eggs, J. Cell Biol., 100

10.1101/gad.2.5.598

10.1016/0968-0004(90)90022-4

Varnum S. M.andWormington W. M.(1990). Deadenylation of maternal mRNAs duringXenopusoocyte maturation does not require specificcis‐sequences: A default mechanism for translational control.Genes Dev. in press.

10.1128/MCB.10.2.816

10.1016/0378-1119(88)90009-1

10.1016/S0022-2836(83)80087-4

10.1101/gad.3.6.803

10.1016/0167-4781(88)90067-X

10.1016/0968-0004(90)90054-F

10.1002/j.1460-2075.1990.tb07587.x

10.1101/gad.3.12b.2151

10.1128/MCB.10.11.5634

10.1101/gad.1.10.1201

10.1101/gad.3.12b.2163

10.1038/339275a0

10.1021/bi00465a001

10.1016/0092-8674(90)90463-O

10.1016/0968-0004(90)90235-4

10.1016/0012-1606(88)90377-6

Thông tin
Thông tin xuất bản

BioEssays

Tập 13 Số 4

179-183

Thông tin tác giả