Transitions between epithelial and mesenchymal states in development and disease
Tóm tắt
Từ khóa
Tài liệu tham khảo
Shook, 2003, Mechanisms, mechanics and function of epithelial–mesenchymal transitions in early development, Mech Dev, 120, 1351, 10.1016/j.mod.2003.06.005
Thiery, 2006, Complex networks orchestrate epithelial-mesenchymal transitions, Nat Rev Mol Cell Biol, 7, 131, 10.1038/nrm1835
Hay, 1995, Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced, Am J Kidney Dis, 26, 678, 10.1016/0272-6386(95)90610-X
Duband, 1995, Epithelium–mesenchyme transition during neural crest development, Acta Anat, 154, 63, 10.1159/000147752
Lecuit, 2007, Orchestrating size and shape during morphogenesis, Nature, 450, 189, 10.1038/nature06304
Bilder, 2004, Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors, Genes Dev, 18, 1909, 10.1101/gad.1211604
Lu, 2001, Adherens junctions inhibit asymmetric division in the Drosophila epithelium, Nature, 409, 522, 10.1038/35054077
Gonzalez, 2007, Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells, Nat Rev Genet, 8, 462, 10.1038/nrg2103
Redd, 2004, Wound healing and inflammation: embryos reveal the way to perfect repair, Philos Trans R Soc Lond B Biol Sci, 359, 777, 10.1098/rstb.2004.1466
Rosenblatt, 2001, An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism, Curr Biol, 11, 1847, 10.1016/S0960-9822(01)00587-5
Gibson, 2005, Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing, Science, 307, 1785, 10.1126/science.1104751
Shen, 2005, Extrusion of cells with inappropriate Dpp signaling from Drosophila wing disc epithelia, Science, 307, 1789, 10.1126/science.1104784
Sahai, 2003, Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis, Nat Cell Biol, 5, 711, 10.1038/ncb1019
Hay, 2005, The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it, Dev Dyn, 233, 706, 10.1002/dvdy.20345
Rorth, 2007, Collective guidance of collective cell migration, Trends Cell Biol, 17, 575, 10.1016/j.tcb.2007.09.007
Baas, 2004, Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD, Cell, 116, 457, 10.1016/S0092-8674(04)00114-X
Young, 1991, Dynamic changes in the distribution of cytoplasmic myosin during Drosophila embryogenesis, Development, 111, 1, 10.1242/dev.111.1.1
Wu, 2007, The Snail repressor is required for PMC ingression in the sea urchin embryo, Development, 134, 1061, 10.1242/dev.02805
Sweeton, 1991, Gastrulation in Drosophila: the formation of the ventral furrow and posterior midgut invaginations, Development, 112, 775, 10.1242/dev.112.3.775
Sternlicht, 2000, The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter, Oncogene, 19, 1102, 10.1038/sj.onc.1203347
Przybylo, 2007, Matrix metalloproteinase-induced epithelial–mesenchymal transition: tumor progression at Snail's pace, Int J Biochem Cell Biol, 39, 1082, 10.1016/j.biocel.2007.03.002
Vega, 2004, Snail blocks the cell cycle and confers resistance to cell death, Genes Dev, 18, 1131, 10.1101/gad.294104
Oda, 1998, Dynamic behavior of the cadherin-based cell–cell adhesion system during Drosophila gastrulation, Dev Biol, 203, 435, 10.1006/dbio.1998.9047
Moore, 2001, The role of chemoattraction in cancer metastases, Bioessays, 23, 674, 10.1002/bies.1095
Zeitlinger, 2007, Whole-genome chip–chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo, Genes Dev, 21, 385, 10.1101/gad.1509607
Glinsky, 2005, Death-from-cancer signatures and stem cell contribution to metastatic cancer, Cell Cycle, 4, 1171, 10.4161/cc.4.9.2001
Stathopoulos, 2004, Whole-genome analysis of Drosophila gastrulation, Curr Opin Genet Dev, 14, 477, 10.1016/j.gde.2004.07.004
Kiemer, 2001, Identification of genes involved in epithelial–mesenchymal transition and tumor progression, Oncogene, 20, 6679, 10.1038/sj.onc.1204872
Moreno-Bueno, 2006, Genetic profiling of epithelial cells expressing e-cadherin repressors reveals a distinct role for snail, slug, and e47 factors in epithelial–mesenchymal transition, Cancer Res, 66, 9543, 10.1158/0008-5472.CAN-06-0479
Barrallo-Gimeno, 2005, The Snail genes as inducers of cell movement and survival: implications in development and cancer, Development, 132, 3151, 10.1242/dev.01907
Carmany-Rampey, 2001, Single-cell internalization during zebrafish gastrulation, Curr Biol, 11, 1261, 10.1016/S0960-9822(01)00353-0
Joshi, 2005, Nematode gastrulation: having a BLASTocoel!, Curr Biol, 15, R495, 10.1016/j.cub.2005.06.030
Costa, 1993, Gastrulation in Drosophila: cellular mechanisms of morphogenetic movements, 425
Leptin, 1990, Cell shape changes during gastrulation in Drosophila, Development, 110, 73, 10.1242/dev.110.1.73
Smallhorn, 2004, The epithelial-mesenchymal transition of the Drosophila mesoderm requires the Rho GTP exchange factor Pebble, Development, 131, 2641, 10.1242/dev.01150
Schumacher, 2004, The RhoGEF Pebble is required for cell shape changes during cell migration triggered by the Drosophila FGF receptor Heartless, Development, 131, 2631, 10.1242/dev.01149
Murray, 2007, Photoactivatable GFP resolves Drosophila mesoderm migration behaviour, Development, 134, 3975, 10.1242/dev.005389
Seher, 2007, Analysis and reconstitution of the genetic cascade controlling early mesoderm morphogenesis in the Drosophila embryo, Mech Dev, 124, 167, 10.1016/j.mod.2006.12.004
Castanon, 2002, A Twist in fate: evolutionary comparison of Twist structure and function, Gene, 287, 11, 10.1016/S0378-1119(01)00893-9
Ip, 1994, Uncoupling gastrulation and mesoderm differentiation in the Drosophila embryo, EMBO J, 13, 5826, 10.1002/j.1460-2075.1994.tb06926.x
Ip, 2002, Cell movements during gastrulation: snail dependent and independent pathways, Curr Opin Genet Dev, 12, 423, 10.1016/S0959-437X(02)00320-9
Magie, 2007, Gastrulation in the cnidarian Nematostella vectensis occurs via invagination not ingression, Dev Biol, 305, 483, 10.1016/j.ydbio.2007.02.044
Fritzenwanker, 2004, Analysis of forkhead and snail expression reveals epithelial–mesenchymal transitions during embryonic and larval development of Nematostella vectensis, Dev Biol, 275, 389, 10.1016/j.ydbio.2004.08.014
Hayward, 2004, snail expression during embryonic development of the coral Acropora: blurring the diploblast/triploblast divide?, Dev Genes Evol, 214, 257, 10.1007/s00427-004-0398-0
Cano, 2000, The transcription factor snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression, Nat Cell Biol, 2, 76, 10.1038/35000025
Bolos, 2003, The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors, J Cell Sci, 116, 499, 10.1242/jcs.00224
LaBonne, 2000, Snail-related transcriptional repressors are required in Xenopus for both the induction of the neural crest and its subsequent migration, Dev Biol, 221, 195, 10.1006/dbio.2000.9609
Ashraf, 1999, The mesoderm determinant snail collaborates with related zinc-finger proteins to control Drosophila neurogenesis, EMBO J, 18, 6426, 10.1093/emboj/18.22.6426
Leptin, 1994, Autonomy and non-autonomy in Drosophila mesoderm determination and morphogenesis, Development, 120, 853, 10.1242/dev.120.4.853
Hemavathy, 2004, The repressor function of snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu, Dev Biol, 269, 411, 10.1016/j.ydbio.2004.01.029
Kolsch, 2007, Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2, Science, 315, 384, 10.1126/science.1134833
Costa, 1994, A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation, Cell, 76, 1075, 10.1016/0092-8674(94)90384-0
Dawes-Hoang, 2005, folded gastrulation, cell shape change and the control of myosin localization, Development, 132, 4165, 10.1242/dev.01938
Nikolaidou, 2004, A Rho GTPase signaling pathway is used reiteratively in epithelial folding and potentially selects the outcome of Rho activation, Curr Biol, 14, 1822, 10.1016/j.cub.2004.09.080
Leptin, 1991, twist and snail as positive and negative regulators during Drosophila mesoderm development, Genes Dev, 5, 1568, 10.1101/gad.5.9.1568
Shishido, 1993, Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos, Development, 117, 751, 10.1242/dev.117.2.751
Vincent, 1998, The Drosophila protein Dof is specifically required for FGF signaling, Mol Cell, 2, 515, 10.1016/S1097-2765(00)80151-3
Leptin, 2004, Drosophila gastrulation: identification of a missing link, Curr Biol, 14, R480, 10.1016/j.cub.2004.06.016
Gryzik, 2004, FGF8-like1 and FGF8-like2 encode putative ligands of the FGF receptor Htl and are required for mesoderm migration in the Drosophila gastrula, Curr Biol, 14, 659, 10.1016/j.cub.2004.03.058
Stathopoulos, 2004, pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos, Genes Dev, 18, 687, 10.1101/gad.1166404
Frasch, 1995, Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo, Nature, 374, 464, 10.1038/374464a0
Peinado, 2004, Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex, Mol Cell Biol, 24, 306, 10.1128/MCB.24.1.306-319.2004
Jankowski, 1997, Cadherin and catenin biology represent a global mechanism for epithelial cancer progression, Mol Pathol, 50, 289, 10.1136/mp.50.6.289
Nollet, 2000, Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members, J Mol Biol, 299, 551, 10.1006/jmbi.2000.3777
Peyrieras, 1983, Uvomorulin: a nonintegral membrane protein of early mouse embryo, Proc Natl Acad Sci U S A, 80, 6274, 10.1073/pnas.80.20.6274
Vestweber, 1987, Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos, Dev Biol, 124, 451, 10.1016/0012-1606(87)90498-2
Hay, 1995, An overview of epithelio-mesenchymal transformation, Acta Anat, 154, 8, 10.1159/000147748
Derycke, 2004, N-cadherin in the spotlight of cell–cell adhesion, differentiation, embryogenesis, invasion and signalling, Int J Dev Biol, 48, 463, 10.1387/ijdb.041793ld
Nakagawa, 1995, Neural crest cell–cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins, Development, 121, 1321, 10.1242/dev.121.5.1321
Takeichi, 1988, The cadherins: cell–cell adhesion molecules controlling animal morphogenesis, Development, 102, 639, 10.1242/dev.102.4.639
Takeichi, 1995, Morphogenetic roles of classic cadherins, Curr Opin Cell Biol, 7, 619, 10.1016/0955-0674(95)80102-2
Panorchan, 2006, Single-molecule analysis of cadherin-mediated cell–cell adhesion, J Cell Sci, 119, 66, 10.1242/jcs.02719
Prakasam, 2006, Similarities between heterophilic and homophilic cadherin adhesion, Proc Natl Acad Sci U S A, 103, 15434, 10.1073/pnas.0606701103
Leckband, 2006, Mechanism and dynamics of cadherin adhesion, Annu Rev Biomed Eng, 8, 259, 10.1146/annurev.bioeng.8.061505.095753
Niewiadomska, 1999, DE-Cadherin is required for intercellular motility during Drosophila oogenesis, J Cell Biol, 144, 533, 10.1083/jcb.144.3.533
Hayashi, 2004, Surface mechanics mediate pattern formation in the developing retina, Nature, 431, 647, 10.1038/nature02952
Fischer, 1998, Identification of a novel mechanism of regulation of the adherens junction by E1A, Rac1, and cortical actin filaments that contributes to tumor progression, Cell Growth Differ, 9, 905
Quinlan, 1999, Establishment of the circumferential actin filament network is a prerequisite for localization of the cadherin-catenin complex in epithelial cells, Cell Growth Differ, 10, 839
Pappas, 2006, Direct interaction of the C-terminal domain of alpha-catenin and F-actin is necessary for stabilized cell–cell adhesion, Cell Commun Adhes, 13, 151, 10.1080/15419060600726142
Kobielak, 2004, Alpha-catenin: at the junction of intercellular adhesion and actin dynamics, Nat Rev Mol Cell Biol, 5, 614, 10.1038/nrm1433
Anastasiadis, 2007, p120-ctn: a nexus for contextual signaling via Rho GTPases, Biochim Biophys Acta, 1773, 34, 10.1016/j.bbamcr.2006.08.040
El-Bahrawy, 1998, E-cadherin and catenins: molecules with versatile roles in normal and neoplastic epithelial cell biology, Microsc Res Tech, 43, 224, 10.1002/(SICI)1097-0029(19981101)43:3<224::AID-JEMT4>3.0.CO;2-Q
Harrington, 2000, The role of E-cadherin–catenin complex: more than an intercellular glue?, Ann Surg Oncol, 7, 783, 10.1007/s10434-000-0783-5
Wijnhoven, 2000, E-cadherin–catenin cell–cell adhesion complex and human cancer, Br J Surg, 87, 992, 10.1046/j.1365-2168.2000.01513.x
Gooding, 2004, The cadherin–catenin complex as a focal point of cell adhesion and signalling: new insights from three-dimensional structures, Bioessays, 26, 497, 10.1002/bies.20033
Fujita, 2002, Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex, Nat Cell Biol, 4, 222, 10.1038/ncb758
Yanagisawa, 2006, p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness, J Cell Biol, 174, 1087, 10.1083/jcb.200605022
Brembeck, 2006, Balancing cell adhesion and Wnt signaling, the key role of beta-catenin, Curr Opin Genet Dev, 16, 51, 10.1016/j.gde.2005.12.007
Novak, 1999, Signaling through beta-catenin and Lef/Tcf, Cell Mol Life Sci, 56, 523, 10.1007/s000180050449
Polakis, 2007, The many ways of Wnt in cancer, Curr Opin Genet Dev, 17, 45, 10.1016/j.gde.2006.12.007
Jamora, 2003, Links between signal transduction, transcription and adhesion in epithelial bud development, Nature, 422, 317, 10.1038/nature01458
Gavard, 2005, Once upon a time there was beta-catenin in cadherin-mediated signalling. Biology of the cell/under the auspices of the European, Cell Biol Organ, 97, 921, 10.1042/BC20040531
Farge, 2003, Mechanical induction of Twist in the Drosophila foregut/stomodeal primordium, Curr Biol, 13, 1365, 10.1016/S0960-9822(03)00576-1
Roth, 2004, 105
Essex, 1993, Expression of Xenopus snail in mesoderm and prospective neural fold ectoderm, Dev Dyn, 198, 108, 10.1002/aja.1001980205
Mayor, 1993, Distinct elements of the xsna promoter are required for mesodermal and ectodermal expression, Development, 119, 661, 10.1242/dev.119.3.661
Carver, 2001, The mouse snail gene encodes a key regulator of the epithelial–mesenchymal transition, Mol Cell Biol, 21, 8184, 10.1128/MCB.21.23.8184-8188.2001
Carl, 1999, Inhibition of neural crest migration in Xenopus using antisense slug RNA, Dev Biol, 213, 101, 10.1006/dbio.1999.9320
Blanco, 2007, Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo, Development, 134, 4073, 10.1242/dev.006858
LaBonne, 1998, Neural crest induction in Xenopus: evidence for a two-signal model, Development, 125, 2403, 10.1242/dev.125.13.2403
del Barrio, 2002, Overexpression of Snail family members highlights their ability to promote chick neural crest formation, Development, 129, 1583, 10.1242/dev.129.7.1583
Batlle, 2000, The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells, Nat Cell Biol, 2, 84, 10.1038/35000034
Stoker, 1985, An epithelial scatter factor released by embryo fibroblasts, J Cell Sci, 77, 209, 10.1242/jcs.77.1.209
Taneyhill, 2007, Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest, Development, 134, 1481, 10.1242/dev.02834
Miller, 1997, Characterization of the role of cadherin in regulating cell adhesion during sea urchin development, Dev Biol, 192, 323, 10.1006/dbio.1997.8740
Miller, 1997, Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo, Dev Biol, 192, 310, 10.1006/dbio.1997.8739
Ciruna, 2001, FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak, Dev Cell, 1, 37, 10.1016/S1534-5807(01)00017-X
Deng, 1994, Murine FGFR-1 is required for early postimplantation growth and axial organization, Genes Dev, 8, 3045, 10.1101/gad.8.24.3045
Yamaguchi, 1994, fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation, Genes Dev, 8, 3032, 10.1101/gad.8.24.3032
Beiman, 1996, Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages, Genes Dev, 10, 2993, 10.1101/gad.10.23.2993
Gisselbrecht, 1996, heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo, Genes Dev, 10, 3003, 10.1101/gad.10.23.3003
Meyers, 1998, An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination, Nat Genet, 18, 136, 10.1038/ng0298-136
Thomson, 1998, Embryonic stem cell lines derived from human blastocysts, Science, 282, 1145, 10.1126/science.282.5391.1145
Ullmann, 2007, Epithelial-mesenchymal transition process in human embryonic stem cells cultured in feeder-free conditions, Mol Hum Reprod, 13, 21, 10.1093/molehr/gal091
Spencer, 2007, E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells, Mol Biol Cell, 18, 2838, 10.1091/mbc.E06-09-0875
Cairns, 1975, Mutation selection and the natural history of cancer, Nature, 255, 197, 10.1038/255197a0
Li, 2007, Beyond tumorigenesis: cancer stem cells in metastasis, Cell Res, 17, 3, 10.1038/sj.cr.7310118
Brabletz, 2005, Opinion: migrating cancer stem cells—an integrated concept of malignant tumour progression, Nat Rev Cancer, 5, 744, 10.1038/nrc1694
Hamburger, 1977, Primary bioassay of human tumor stem cells, Science, 197, 461, 10.1126/science.560061
Cho, 1992, Genetic alterations in the adenoma—carcinoma sequence, Cancer, 70, 1727, 10.1002/1097-0142(19920915)70:4+<1727::AID-CNCR2820701613>3.0.CO;2-P
Fearon, 1990, A genetic model for colorectal tumorigenesis, Cell, 61, 759, 10.1016/0092-8674(90)90186-I
Miller, 2005, Interpreting epithelial cancer biology in the context of stem cells: tumor properties and therapeutic implications, Biochim Biophys Acta, 1756, 25
Al-Hajj, 2004, Therapeutic implications of cancer stem cells, Curr Opin Genet Dev, 14, 43, 10.1016/j.gde.2003.11.007
Locke, 2005, Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines, Cancer Res, 65, 8944, 10.1158/0008-5472.CAN-05-0931
Tarin, 2005, The fallacy of epithelial mesenchymal transition in neoplasia, Cancer Res, 65, 5996, 10.1158/0008-5472.CAN-05-0699
Jankowski, 1997, Changes in gene structure and regulation of E-cadherin during epithelial development, differentiation, and disease, Prog Nucl Acid Res Mol Biol, 57, 187, 10.1016/S0079-6603(08)60281-0
Peinado, 2006, New potential therapeutic targets to combat epithelial tumor invasion, Clin Transl Oncol, 8, 851, 10.1007/s12094-006-0148-z
Peinado, 2007, Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?, Nat Rev Cancer, 7, 415, 10.1038/nrc2131
Peinado, 2004, Transcriptional regulation of cadherins during development and carcinogenesis, Int J Dev Biol, 48, 365, 10.1387/ijdb.041794hp
Birchmeier, 1994, Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness, Biochim Biophys Acta, 1198, 11
Burdsal, 1993, The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak, Development, 118, 829, 10.1242/dev.118.3.829
Guilford, 1999, E-cadherin downregulation in cancer: fuel on the fire?, Mol Med Today, 5, 172, 10.1016/S1357-4310(99)01461-6
Cavallaro, 2004, N-cadherin as an invasion promoter: a novel target for antitumor therapy?, Curr Opin Investig Drugs, 5, 1274
Strathdee, 2002, Epigenetic versus genetic alterations in the inactivation of E-cadherin, Semin Cancer Biol, 12, 373, 10.1016/S1044-579X(02)00057-3
Bryant, 2004, The ins and outs of E-cadherin trafficking, Trends Cell Biol, 14, 427, 10.1016/j.tcb.2004.07.007
Gopalakrishnan, 1995, Modulation of E-cadherin localization in cells expressing wild-type E1A 12S or hypertransforming mutants, Cell Growth Differ, 6, 985
Clayton, 1993, Cell surface localisation and stability of uvomorulin during early mouse development, Zygote, 1, 333, 10.1017/S0967199400001660
Quinlan, 1999, Rac regulates the stability of the adherens junction and its components, thus affecting epithelial cell differentiation and transformation, Oncogene, 18, 6434, 10.1038/sj.onc.1203026
Sefton, 1992, Synthesis and phosphorylation of uvomorulin during mouse early development, Development, 115, 313, 10.1242/dev.115.1.313
Nelson, 2004, Convergence of Wnt, beta-catenin, and cadherin pathways, Science, 303, 1483, 10.1126/science.1094291
Brooks-Wilson, 2004, Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria, J Med Genet, 41, 508, 10.1136/jmg.2004.018275
Debruyne, 1999, The role of the E-cadherin/catenin complex in gastrointestinal cancer, Acta Gastroenterol Belg, 62, 393
Lin, 2006, E-cadherin promoter polymorphism (C-160A) and risk of recurrence in patients with superficial bladder cancer, Clin Genet, 70, 240, 10.1111/j.1399-0004.2006.00666.x
Berx, 1998, Mutations of the human E-cadherin (CDH1) gene, Hum Mutat, 12, 226, 10.1002/(SICI)1098-1004(1998)12:4<226::AID-HUMU2>3.0.CO;2-D
Berx, 1998, Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas, Cell Adhes Commun, 6, 171, 10.3109/15419069809004474
Esteller, 2002, CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future, Oncogene, 21, 5427, 10.1038/sj.onc.1205600
Graff, 2000, Methylation patterns of the E-cadherin 5’ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression, J Biol Chem, 275, 2727, 10.1074/jbc.275.4.2727
Nass, 2000, Aberrant methylation of the estrogen receptor and E-cadherin 5’ CpG islands increases with malignant progression in human breast cancer, Cancer Res, 60, 4346
Koizume, 2002, Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells, Nucleic Acids Res, 30, 4770, 10.1093/nar/gkf593
Behrens, 1991, The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element, Proc Natl Acad Sci U S A, 88, 11495, 10.1073/pnas.88.24.11495
Faraldo, 1997, Analysis of the E-cadherin and P-cadherin promoters in murine keratinocyte cell lines from different stages of mouse skin carcinogenesis, Mol Carcinog, 20, 33, 10.1002/(SICI)1098-2744(199709)20:1<33::AID-MC5>3.0.CO;2-J
Hennig, 1996, Mechanisms identified in the transcriptional control of epithelial gene expression, J Biol Chem, 271, 595, 10.1074/jbc.271.1.595
Rodrigo, 1999, Regulation of E-cadherin gene expression during tumor progression: the role of a new Ets-binding site and the E-pal element, Exp Cell Res, 248, 358, 10.1006/excr.1999.4438
De Craene, 2006, Snail in the frame of malignant tumor recurrence, Breast Cancer Res, 8, 105, 10.1186/bcr1521
Blanco, 2002, Correlation of Snail expression with histological grade and lymph node status in breast carcinomas, Oncogene, 21, 3241, 10.1038/sj.onc.1205416
Yang, 2004, Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis, Cell, 117, 927, 10.1016/j.cell.2004.06.006
Comijn, 2001, The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion, Mol Cell, 7, 1267, 10.1016/S1097-2765(01)00260-X
Vandewalle, 2005, SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell–cell junctions, Nucleic Acids Res, 33, 6566, 10.1093/nar/gki965
Shirakihara, 2007, Differential Regulation of Epithelial and Mesenchymal Markers by {delta}EF1 Proteins in Epithelial Mesenchymal Transition Induced by TGF-beta, Mol Biol Cell, 18, 3533, 10.1091/mbc.E07-03-0249
Yang, 2006, Exploring a new twist on tumor metastasis, Cancer Res, 66, 4549, 10.1158/0008-5472.CAN-05-3850
Kang, 2004, Epithelial–mesenchymal transitions: twist in development and metastasis, Cell, 118, 277, 10.1016/j.cell.2004.07.011
Chua, 2007, NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2, Oncogene, 26, 711, 10.1038/sj.onc.1209808
Criswell, 2007, Modulation of NFkappa B activity and E-cadherin by the type III TGFbeta receptor regulates cell growth and motility, J Biol Chem, 10.1074/jbc.M704434200
Perez-Moreno, 2001, A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions, J Biol Chem, 276, 27424, 10.1074/jbc.M100827200
Slattery C, Ryan MP, McMorrow T. E2A proteins: regulators of cell phenotype in normal physiology and disease. Int J Biochem Cell Biol 2007, doi:10.1016/jbiocel.2007.05.014.
Dingli, 2007, (A)symmetric stem cell replication and cancer, PLoS Comput Biol, 3, e53, 10.1371/journal.pcbi.0030053
Fodde, 2007, Wnt/beta-catenin signaling in cancer stemness and malignant behavior, Curr Opin Cell Biol, 19, 150, 10.1016/j.ceb.2007.02.007
Taipale, 2001, The Hedgehog and Wnt signalling pathways in cancer, Nature, 411, 349, 10.1038/35077219
Robson, 2006, Epithelial-to-mesenchymal transition confers resistance to apoptosis in three murine mammary epithelial cell lines, Differentiation, 74, 254, 10.1111/j.1432-0436.2006.00075.x
Labbe, 2007, Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis, Cancer Res, 67, 75, 10.1158/0008-5472.CAN-06-2559
Shi, 2003, Mechanisms of TGF-beta signaling from cell membrane to the nucleus, Cell, 113, 685, 10.1016/S0092-8674(03)00432-X
Siegel, 2003, Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer, Nat Rev Cancer, 3, 807, 10.1038/nrc1208
Kondo, 2004, A role for Id in the regulation of TGF-beta-induced epithelial–mesenchymal transdifferentiation, Cell Death Differ, 11, 1092, 10.1038/sj.cdd.4401467
Logan, 2004, The Wnt signaling pathway in development and disease, Annu Rev Cell Dev Biol, 20, 781, 10.1146/annurev.cellbio.20.010403.113126
Lowry, 2005, Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells, Genes Dev, 19, 1596, 10.1101/gad.1324905
Willert, 2003, Wnt proteins are lipid-modified and can act as stem cell growth factors, Nature, 423, 448, 10.1038/nature01611
Medici, 2006, Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial–mesenchymal transition, Mol Biol Cell, 17, 1871, 10.1091/mbc.E05-08-0767
Conacci-Sorrell, 2003, Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK, J Cell Biol, 163, 847, 10.1083/jcb.200308162
Nawshad, 2007, TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex, J Cell Sci, 120, 1646, 10.1242/jcs.003129
Bachelder, 2005, Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial–mesenchymal transition, J Cell Biol, 168, 29, 10.1083/jcb.200409067
Katoh, 2006, Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades, Cancer Biol Ther, 5, 1059, 10.4161/cbt.5.9.3151