Transient anti-cytokine autoantibodies superimpose the hyperinflammatory response in Kawasaki disease and multisystem inflammatory syndrome in children: a comparative cohort study on correlates of disease
Stejara A. Netea1, Giske Biesbroek1, Diana van Stijn1, Hanna Ijspeert2, Caspar I. van der Made3, Machiel H. Jansen4, Judy Geissler5, J.M. (Merlijn) van den Berg1, Martijn van der Kuip1, Mariken P. Gruppen1, Dieneke Schonenberg-Meinema1, Berber Kapitein6, A.M. (Marceline) Tutu van Furth1, Sietse Q. Nagelkerke1,2, Dasja Pajkrt1, Frans B. Plötz7, M.E.J. (Lisette) den Boer8, Gijs W. Landman9, Marlies A. van Houten10, Ines Goetschalckx5
1Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children’s Hospital, Amsterdam University Medical Center (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, the Netherlands
2Laboratory Medical Immunology, Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
3Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands
4Department of Experimental Immunology, Amsterdam UMC, UvA, Amsterdam, the Netherlands
5Department of Blood Cell Research, Sanquin Research Institute, UvA, Amsterdam, the Netherlands
6Pediatric Intensive Care Unit, Emma Children’s Hospital, Amsterdam UMC, UvA, Amsterdam, the Netherlands
7Department of Pediatrics, Tergooi Hospital, Hilversum, the Netherlands
8Department of Pediatrics, Medical Spectrum Twente (MST), Enschede, the Netherlands
9Department of Internal Medicine, Gelre Hospital, Apeldoorn, the Netherlands
10Department of Pediatrics, Spaarne Hospital, Haarlem, The Netherlands