Transgenic overexpression of human lecithin: cholesterol acyltransferase (LCAT) in mice does not increase aortic cholesterol deposition

Atherosclerosis - Tập 165 - Trang 89-100 - 2002
James W Furbee1, John S Parks1
1Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1040, USA

Tài liệu tham khảo

Glomset, 1968, The plasma lecithin:cholesterol acyltransferase reaction, J. Lipid Res., 9, 155, 10.1016/S0022-2275(20)43114-1 Jonas, 2000, Lecithin cholesterol acyltransferase, Biochim. Biophys. Acta, 1529, 245, 10.1016/S1388-1981(00)00153-0 Glomset, 1966, Role of plasma lecithin:cholesterol acyltransferase in the metabolism of high density lipoproteins, J. Lipid Res., 7, 638, 10.1016/S0022-2275(20)39245-2 McLean, 1986, Cloning and expression of human lecithin-cholesterol acyltransferase cDNA, Proc. Natl. Acad. Sci. USA, 83, 2335, 10.1073/pnas.83.8.2335 Cheung, 1986, Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins, J. Lipid Res., 27, 1135, 10.1016/S0022-2275(20)38747-2 Francone, 1989, Distribution and functions of lecithin: cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins. Evidence for a functional unit containing these activities together with apolipoproteins A-I and D that catalyzes the esterification and transfer of cell-derived cholesterol, J. Biol. Chem., 264, 7066, 10.1016/S0021-9258(18)83541-4 Fielding, 1972, A protein cofactor of lecithin:cholesterol acyltransferase, Biochem. Biophys. Res. Commun., 46, 1493, 10.1016/0006-291X(72)90776-0 Jonas, 1986, Synthetic substrates of lecithin: cholesterol acyltransferase, J. Lipid Res., 27, 689, 10.1016/S0022-2275(20)38794-0 Fielding, 1995, Molecular physiology of reverse cholesterol transport, J. Lipid Res., 36, 211, 10.1016/S0022-2275(20)39898-9 Hill, 1997, Reverse cholesterol transport—a review of the process and its clinical implications, Clin. Biochem., 30, 517, 10.1016/S0009-9120(97)00098-2 Rothblat, 1999, Cell cholesterol efflux: integration of old and new observations provides new insights, J. Lipid Res., 40, 781, 10.1016/S0022-2275(20)32113-1 Mehlum, 1997, Mice overexpressing human lecithin: cholesterol acyltransferase are not protected against diet-induced atherosclerosis, APMIS, 105, 861, 10.1111/j.1699-0463.1997.tb05095.x Berard, 1997, High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithin-cholesteryl acyltransferase, Nat. Med., 3, 744, 10.1038/nm0797-744 Foger, 1999, Cholesteryl ester transfer protein corrects dysfunctional high density lipoproteins and reduces aortic atherosclerosis in lecithin cholesterol acyltransferase transgenic mice, J. Biol. Chem., 274, 36912, 10.1074/jbc.274.52.36912 Hoeg, 1996, Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis, Proc. Natl. Acad. Sci. USA, 93, 11448, 10.1073/pnas.93.21.11448 Portman, 1964, Factors influencing the level and fatty acid specificity of the cholesterol esterification activity in human plasma, Arch. Biochem. Biophys., 105, 532, 10.1016/0003-9861(64)90048-7 Liu, 1995, Specificity of lecithin:cholesterol acyltransferase and atherogenic risk: comparative studies on the plasma composition and in vitro synthesis of cholesteryl esters in 14 vertebrate species, J. Lipid Res., 36, 1813, 10.1016/S0022-2275(20)41500-7 Pownall, 1985, Isolation and specificity of rat lecithin: cholesterol acyltransferase: comparison with the human enzyme using reassembled high-density lipoproteins containing ether analogs of phosphatidylcholine, Biochim. Biophys. Acta, 833, 456, 10.1016/0005-2760(85)90103-1 Mehlum, 1995, Tissue-specific expression of the human gene for lecithin: cholesterol acyltransferase in transgenic mice alters blood lipids, lipoproteins and lipases towards a less atherogenic profile, Eur. J. Biochem., 230, 567, 10.1111/j.1432-1033.1995.tb20597.x Furbee, 2001, Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT, J. Lipid Res., 42, 1626, 10.1016/S0022-2275(20)32217-3 Kingsbury, 1974, Abnormal fatty acid composition and human atherosclerosis, Postgrad. Med. J., 50, 425, 10.1136/pgmj.50.585.425 Kingsbury, 1969, The relationships between plasma cholesteryl polyunsaturated fatty acids, age and atherosclerosis, Postgrad. Med. J., 45, 591, 10.1136/pgmj.45.527.591 Parks, 1990, Effect of dietary fish oil on coronary artery and aortic atherosclerosis in African green monkeys, Arteriosclerosis, 10, 1102, 10.1161/01.ATV.10.6.1102 Rudel, 1986, Low density lipoproteins in atherosclerosis, J. Lipid Res., 27, 465, 10.1016/S0022-2275(20)35191-9 Rudel, 1995, Compared with dietary monounsaturated and saturated fat, polyunsaturated fat protects African green monkeys from coronary artery atherosclerosis, Arterioscler. Thromb. Vasc. Biol., 15, 2101, 10.1161/01.ATV.15.12.2101 Rudel, 1998, Dietary monounsaturated fatty acids promote aortic atherosclerosis in LDL receptor-null, human ApoB100-overexpressing transgenic mice, Arterioscler. Thromb. Vasc. Biol., 18, 1818, 10.1161/01.ATV.18.11.1818 Francone, 1997, Expression of human lecithin:cholesterol acyltransferase in transgenic mice: effects on cholesterol efflux, esterification, and transport, J. Lipid Res., 38, 813, 10.1016/S0022-2275(20)37248-5 Carr, 1993, Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts, Clin. Biochem., 26, 39, 10.1016/0009-9120(93)90015-X Lowry, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 Parks, 1999, Lecithin-cholesterol acyltransferase. Assay of cholesterol esterification and phospholipase A2 activities, Methods Mol. Biol., 109, 123 Auerbach, 1990, A rapid and sensitive micro-assay for the enzymatic determination of plasma and lipoprotein cholesterol, J. Lipid Res., 31, 738, 10.1016/S0022-2275(20)42844-5 Bligh, 1959, A rapid method of total lipid extraction and purification, Can. J. Biochem. Physiol., 37, 911, 10.1139/o59-099 Gillotte, 1998, Dietary modification of high density lipoprotein phospholipid and influence on cellular cholesterol efflux, J. Lipid Res., 39, 2065, 10.1016/S0022-2275(20)32505-0 Vaisman, 1995, Overexpression of human lecithin cholesterol acyltransferase leads to hyperalphalipoproteinemia in transgenic mice, J. Biol. Chem., 270, 12269, 10.1074/jbc.270.20.12269 Parks, 1987, Effect of fish oil versus lard diets on the chemical and physical properties of low density lipoproteins of nonhuman primates, J. Lipid Res., 28, 173, 10.1016/S0022-2275(20)38720-4 Rudel, 1997, Hepatic origin of cholesteryl oleate in coronary artery atherosclerosis in African green monkeys—enrichment by dietary monounsaturated fat, J. Clin. Invest., 100, 74, 10.1172/JCI119524 Mehlum, 2000, Overexpression of human lecithin:cholesterol acyltransferase in mice offers no protection against diet-induced atherosclerosis, APMIS, 108, 336, 10.1034/j.1600-0463.2000.d01-65.x Brousseau, 2000, LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbits, Arterioscler. Thromb. Vasc. Biol., 20, 450, 10.1161/01.ATV.20.2.450 Marotti, 1993, Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein, Nature, 364, 73, 10.1038/364073a0 Escola-Gil, 1998, Human apolipoprotein A-II is a pro-atherogenic molecule when it is expressed in transgenic mice at a level similar to that in humans: evidence of a potentially relevant species-specific interaction with diet, J. Lipid Res., 39, 457, 10.1016/S0022-2275(20)33906-7 Plump, 1994, Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse, Proc. Natl. Acad. Sci. USA, 91, 9607, 10.1073/pnas.91.20.9607 Ueda, 2000, Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics, J. Biol. Chem., 275, 20368, 10.1074/jbc.M000730200 Schrade, 1961, Fatty-acid distribution in the lipid fractions of healthy persons of different age, patients with atherosclerosis and patients with idiopathic hyperlipidaemia, J. Atheroscler. Res., 1, 47, 10.1016/S0368-1319(61)80053-7 Lewis, 1958, Composition of plasma cholesterol ester in relation to coronary-artery disease and dietary fat, Lancet, 1, 71, 10.1016/S0140-6736(58)91243-1 Wolfe, 1994, Dietary polyunsaturated fat decreases coronary artery atherosclerosis in a pediatric-aged population of African green monkeys, Arterioscler. Thromb., 14, 587, 10.1161/01.ATV.14.4.587 Nishina, 1993, Effects of dietary fats from animal and plant sources on diet-induced fatty streak lesions in C57BL/6J mice, J. Lipid Res., 34, 1413, 10.1016/S0022-2275(20)36970-4 Tall, 1978, Studies on the structure of low density lipoproteins isolated from Macaca fascicularis fed an atherogenic diet, J. Clin. Invest., 62, 1354, 10.1172/JCI109256 Morton, 1996, Plasma cholesteryl ester transfer activity is modulated by the phase transition of the lipoprotein core, J. Lipid Res., 37, 1915, 10.1016/S0022-2275(20)37556-8 Manning, 1994, Dietary polyunsaturated fat decreases interaction between low density lipoproteins and arterial proteoglycans, Lipids, 29, 635, 10.1007/BF02536098 Glick, 1983, Cellular cholesteryl ester clearance. Relationship to the physical state of cholesteryl ester inclusions, J. Biol. Chem., 258, 13425, 10.1016/S0021-9258(17)43931-7 Adelman, 1984, Lipid composition and physical state effects on cellular cholesteryl ester clearance, J. Biol. Chem., 259, 13844, 10.1016/S0021-9258(18)89823-4 Deckelbaum, 1977, Interaction of cholesterol ester and triglyceride in human plasma very low density lipoprotein, J. Lipid Res., 18, 164, 10.1016/S0022-2275(20)41695-5 Thorngate, 2000, Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice, Arterioscler. Thromb. Vasc. Biol., 20, 1939, 10.1161/01.ATV.20.8.1939 Veniant, 2000, Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100, J. Clin. Invest., 106, 1501, 10.1172/JCI10695