Transgenerational carcinogenesis: induction and transmission of genetic alterations and mechanisms of carcinogenesis

Nomura, 1975, Transmission of tumors and malformations to the next generation of mice subsequent to urethan treatment, Cancer Res., 35, 264 T. Nomura, Changed urethan and radiation response of the mouse germ cell to tumor induction, in: L. Severi (Ed.), Tumors of Early Life in Man and Animals, Perugia University Press, Perugia, 1978, pp. 873–891. Nomura, 1982, Parental exposure to X rays and chemicals induces heritable tumors and anomalies in mice, Nature, 296, 575, 10.1038/296575a0 Nomura, 1983, X-ray induced germ-line mutation leading to tumors: its manifestation in mice given urethane post-natally, Mutat. Res., 121, 59, 10.1016/0165-7992(83)90087-8 T. Nomura, Further studies on X-ray and chemically induced germ-line alterations causing tumors and malformations in mice, in: C. Ramel (Ed.), Genetic Toxicology of Environmental Chemicals, Part B: Genetic Effects and Applied Mutagenesis, Alan R. Liss, New York, 1986, pp. 13–20. Kirk, 1984, Induction of congenital malformations in the offspring of male mice treated with X-rays at pre-meiotic and post-meiotic stages, Mutat. Res., 125, 75, 10.1016/0027-5107(84)90034-4 Evans, 1982, Parental mutagenesis and familial cancer, Nature, 296, 488, 10.1038/296488a0 Brown, 1985, Are offspring at risk from their father’s exposure to toxins?, Nature, 316, 110, 10.1038/316110a0 Nomura, 1988, X-ray and chemically induced germ-line mutation causing phenotypical anomalies in mice, Mutat. Res., 198, 309, 10.1016/0027-5107(88)90008-5 Russell, 1958, Dependence of mutation rate on radiation intensity, Science, 128, 1546, 10.1126/science.128.3338.1546 Lyon, 1972, Dose-rate and mutation frequency after irradiation of mouse spermatogonia, Nature (London), New Biol., 238, 101, 10.1038/newbio238101a0 Russell, 1982, Specific-locus mutation frequencies in mouse stem-cell spermatogonia at very low radiation dose rates, Proc. Natl. Acad. Sci. U.S.A., 79, 539, 10.1073/pnas.79.2.539 Russell, 1982, Mutation frequencies in male mice and the estimation of genetic hazards of radiation in men, Proc. Natl. Acad. Sci. U.S.A., 79, 542, 10.1073/pnas.79.2.542 U.H. Ehling, Methods to estimate the genetic risk, in: G. Obe (Ed.), Mutations in Man, Springer-Verlag, Berlin, 1984, pp. 292–318. T. Nomura, Role of radiation-induced mutations in multigeneration carcinogenesis, in: N.P. Napalkov, J.M. Rice, L. Tomatis, H. Yamasaki (Eds.), Perinatal and Multigeneration Carcinogenesis, IARC Scientific Publication No. 96, IARC, Lyon, 1989, pp. 375–387. IARC, IARC Monograph on the Evaluation of Carcinogenic Risks to Humans, vol. 75, Physical Agents: Ionizing Radiation, Part I, X-rays, γ-Rays and Neutrons, IARC, Lyon, 1999. Gardner, 1990, Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria, Br. Med. J., 300, 423, 10.1136/bmj.300.6722.423 Nomura, 2000, Transplacental and transgenerational late effects of radiation and chemicals, Congenit. Anom., 40, S54 Takahashi, 1992, 252Cf relative biological effectiveness and inheritable effects of fission neutrons in mouse liver tumorigenesis, Cancer Res., 52, 1948 Watanabe, 1996, Influence of paternal 252Cf neutron exposure on abnormal sperm, embryonal lethality, and liver tumorigenesis in the Fl offspring of mice, Jpn. J. Cancer Res., 87, 51, 10.1111/j.1349-7006.1996.tb00199.x Cattanach, 1995, Investigation of lung tumor induction in BALB/cJ mice following paternal X-irradiation, Int. J. Radiat. Biol., 67, 607, 10.1080/09553009514550721 Cattanach, 1998, Investigation of lung tumor induction of C3H/HeH mice, with and without tumor promotion with urethane, following paternal X-irradiation, Mutat. Res., 403, 1, 10.1016/S0027-5107(97)00322-9 Nakajima, 1994, Enhancement of tumor growth under short light/dark cycle in the mouse lung, Cancer Lett., 78, 127, 10.1016/0304-3835(94)90041-8 Daher, 1998, Effect of pre-conceptional external or internal irradiation of N5 male mice and the risk of leukemia in their offspring, Carcinogenesis, 19, 1553, 10.1093/carcin/19.9.1553 Mohr, 1999, Possible carcinogenic effects of X-rays in a transgenerational study with CBA mice, Carcinogenesis, 20, 325, 10.1093/carcin/20.2.325 Vorobstova, 1988, Urethane-induced lung adenomas in the first-generation progeny of irradiated male mice, Carcinogenesis, 9, 1931, 10.1093/carcin/9.11.1931 Vorobstova, 1993, Promotion of skin tumors by 12-0-tetradecanoyl phorbol-13-acetate in two generations of descendants of male mice exposed to X-ray irradiation, Mutat. Res., 287, 207, 10.1016/0027-5107(93)90013-6 Lord, 1998, Tumour induction by methyl-nitrosourea following preconceptional paternal contamination with plutonium-239, Br. J. Cancer, 78, 301, 10.1038/bjc.1998.491 Nomura, 1997, Comparative study on germ cell mutation induced by urethane (ethyl carbamate) gas and X-rays in Drosophila melanogaster, Jpn. J. Cancer Res., 88, 461, 10.1111/j.1349-7006.1997.tb00404.x Dubrova, 1993, Mouse minisatellite mutations induced by ionizing radiation, Nat. Genet., 5, 92, 10.1038/ng0993-92 Dubrova, 1998, Stage specificity, dose-response and doubling dose for mouse minisatellite germline mutation induced by acute radiation, Proc. Natl. Acad. Sci. U.S.A., 95, 6251, 10.1073/pnas.95.11.6251 Dubrova, 1998, Radiation-induced germline instability at minisatellite loci, Int. J. Radiat. Biol., 74, 689, 10.1080/095530098140952 Dubrova, 2000, Induction of minisatellite mutations in the mouse germline by low-dose chronic exposure to γ-radiation and fission neutrons, Mutat. Res., 453, 17, 10.1016/S0027-5107(00)00068-3 Dubrova, 2000, Transgenerational mutation by radiation, Nature, 405, 37, 10.1038/35011135 Sadamoto, 1994, Radiation induction of germline mutation at a hypervariable mouse minisatellite locus, Int. J. Radiat. Biol., 65, 549, 10.1080/09553009414550641 Niwa, 1996, Induction of a germline mutation at a hypervariable mouse minisatellite locus by 252Cf radiation, J. Radiat. Res., 37, 217, 10.1269/jrr.37.217 Nomura, 1999, Concern for the hereditary effects of dioxins, Environ. Mutagen. Res., 21, 207 Nomura, 1990, Of mice and men?, Nature, 345, 671, 10.1038/345671a0 Yoshimoto, 1991, Mortality and cancer risk among the offspring (F1) of atomic bomb survivors, J. Radiat. Res., 32, 294, 10.1269/jrr.32.SUPPLEMENT_294 Yoshimoto, 1991, Cancer risk among in utero-exposed survivors, J. Radiat. Res., 32, 231, 10.1269/jrr.32.SUPPLEMENT_231 Graham, 1966, Preconception, intrauterine, and postnatal irradiation as related to leukemia, Natl. Cancer Inst. Monogr., 19, 347 Shiono, 1980, Preconception radiation, intrauterine diagnostic radiation, and childhood neoplasia, J. Natl. Cancer Inst., 65, 681, 10.1093/jnci/65.4.681 Shu, 1988, A population-based case-control study of childhood leukemia in Shanghai, Cancer, 62, 635, 10.1002/1097-0142(19880801)62:3<635::AID-CNCR2820620332>3.0.CO;2-3 COMARE, Committee on Medical Aspects of Radiation in the Environment, Fourth Report, Dept Health, London, 1996. Nomura, 1993, Leukemia in children whose parents have been exposed to radiation, Br. Med. J., 306, 1412, 10.1136/bmj.306.6889.1412-a