Transfusions of CPDA‐1 red blood cells stored for up to 28 days decrease donor exposures in very low‐birth‐weight premature infants

Transfusion Medicine - Tập 15 Số 6 - Trang 467-473 - 2005
Deyse Helena Fernandes da Cunha1, Amélia Miyashiro Nunes dos Santos1, Benjamin Israel Kopelman1, Kelsy Catherina Nema Areco1, Ruth Guinsburg1, Clóvis de Araújo Peres1, Akemi Kuroda Chiba1, Sachie T. Kuwano1, Claudia Cristina Naufel Terzian1, José Orlando Bordin1
1Division of Neonatal Medicine, Department of Pediatrics, Hematology and Transfusion Medicine Service, Department of Biostatistics, Federal University of São Paulo, São Paulo, Brazil.

Tóm tắt

summary.  The goal of this research was to study the safety and the efficacy of transfusing citrate‐phosphate‐adenine anticoagulant‐preservative (CPDA‐1) RBC stored for up to 28 days to reduce donor exposures in premature infants. A prospective randomized two‐group study was conducted with very low‐birth‐weight premature infants that received at least one RBC transfusion during hospital stay. Neonates randomly assigned to Group 1 (26 infants) were transfused with CPDA‐1 RBC stored for up to 28 days; those assigned to Group 2 (26 infants) received CPDA‐1 RBC stored for up to 3 days. Demographic and transfusion‐related data were collected. Neonates from both groups showed similar demographics and clinical characteristics. The number of transfusions per infant transfused was 4·4 ± 4·0 in Group 1 and 4·2 ± 3·1 in Group 2, and the number of donors per infant transfused was 1·5 ± 0·8 (Group 1) and 4·3 ± 3·4 (Group 2), P < 0·001. RBC transfusions containing 29·7 ± 18·3 mmol L−1 of potassium (RBC stored for up to 28 days) did not cause clinical or biochemical changes and reduced donor exposures by 70·2%, compared to transfusions containing 19·8 ± 12·3 mmol L−1 of potassium (RBC stored for up to 3 days), P < 0·001. In conclusion, RBC stored for up to 28 days safely reduced donor exposures in premature infants.

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Tài liệu tham khảo

10.1046/j.1365-3148.2003.00454.x

10.1046/j.1423-0410.2001.00022.x

10.1111/j.1365-2141.2004.04815.x

10.1046/j.1365-3148.2003.00455.x

10.1016/S1473-0502(01)00004-0

10.1016/S0022-3476(95)70561-9

10.1016/S0022-3476(94)70132-6

10.1038/sj.jp.7211201

10.1016/S0022-3476(00)70105-3

10.1016/S0887-7963(89)70067-5

10.1111/j.1423-0410.2005.00607.x

10.1053/j.seminhematol.2003.11.023

Shannon K.M., 1995, Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birthweight preterm infants, Pediatrics, 95, 1, 10.1542/peds.95.1.1

10.1016/S0955-3886(99)00063-6

10.1016/S0022-3476(00)70104-1

10.1046/j.1537-2995.1996.361097017172.x

10.1046/j.1537-2995.1996.36196190518.x

10.1016/S0022-3476(96)70150-6

10.1136/fn.72.1.F29

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Transfusion Medicine

Tập 15 Số 6

467-473

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