Transferrin: structure, function and potential therapeutic actions

Parkkinen, 2002, Function and therapeutic development of apotransferrin, Vox Sang., 83, 321, 10.1111/j.1423-0410.2002.tb05327.x

MacGillivray, 1998, Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release, Biochemistry, 37, 7919, 10.1021/bi980355j

Hirose, 2000, The structural mechanism for iron uptake and release by transferrins, Biosci. Biotechnol. Biochem., 64, 1328, 10.1271/bbb.64.1328

He, 2000, The chloride effect is related to anion binding in determining the rate of iron release from the human transferrin N-lobe, Biochem. J., 350, 909, 10.1042/0264-6021:3500909

Welch, 1990, A comparison of the structure and properties of normal human transferrin and a genetic variant of human transferrin, Int. J. Biochem., 22, 275, 10.1016/0020-711X(90)90340-9

Kasvosve, 2002, Effect of transferrin polymorphism on the metabolism of vitamin C in Zimbabwean adults, Am. J. Clin. Nutr., 75, 321, 10.1093/ajcn/75.2.321

Beutler, 2000, Molecular characterization of a case of atransferrinemia, Blood, 96, 4071, 10.1182/blood.V96.13.4071

Wells, 2004, The combined effect of transferrin saturation and low density lipoprotein on mortality, Fam. Med., 36, 324

Robson, 2004, Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease, J. Med. Genet., 41, 261, 10.1136/jmg.2003.015552

Kim, 2001, Transferrin C2 variant does not confer a risk for Alzheimer's disease in Koreans, Neurosci. Lett., 308, 45, 10.1016/S0304-3940(01)01985-1

Lecureuil, 2004, Transgenic mice as a model to study the regulation of human transferrin expression in Sertoli cells, Hum. Reprod., 6, 1300, 10.1093/humrep/deh297

Suire, 1997, Transferrin gene expression and secretion in rat Sertoli cells, Mol. Reprod. Dev., 48, 168, 10.1002/(SICI)1098-2795(199710)48:2<168::AID-MRD4>3.0.CO;2-Q

Tsutsumi, 1989, Transferrin gene expression and synthesis by cultured choroid plexus epithelial cells. Regulation by serotonin and cyclic adenosine 3′,5′-monophosphate, J. Biol. Chem., 264, 9626, 10.1016/S0021-9258(18)60576-9

Bloch, 1985, Transferrin gene expression visualised in oligodendrocytes of the rat brain by using in situ hybridization and immunohistochemistry, Proc. Natl. Acad. Sci. U. S. A., 82, 6706, 10.1073/pnas.82.19.6706

Nicolson, 1990, Differential expression of a Mr approximately 90,000 cell surface transferrin receptor-related glycoprotein on murine B16 metastatic melanoma sublines selected for enhanced brain or ovary colonization, Cancer Res., 50, 515

Inoue, 1993, Differences in transferrin response and numbers of transferrin receptors in rat and human mammary carcinoma lines of different metastatic potentials, J. Cell. Physiol., 156, 212, 10.1002/jcp.1041560128

Qian, 2002, Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway, Pharmacol. Rev., 54, 561, 10.1124/pr.54.4.561

Van Campenhout, 2003, Transferrin modifications and lipid peroxidation: Implications in diabetes mellitus, Free Radic. Res., 37, 1069, 10.1080/10715760310001600390

Hayashi, 1993, Studies on familial hypotransferrinemia: unique clinical course and molecular pathology, Am. J. Hum. Genet., 53, 201

Li, 2002, Transferrin/transferrin receptor-mediated drug delivery, Med. Res. Rev., 22, 225, 10.1002/med.10008

Rice-Evans, 1993, Oxidised low density lipoproteins, 323

Wolff, 1987, Glucose autooxidation and protein modification. The potential role of ‘autooxidive glycosylation’ in diabetes, Biochem. J., 245, 243, 10.1042/bj2450243

Hèmadi, 2004, Transferrin's mechanism of interaction with receptor 1, Biochemistry, 43, 1736, 10.1021/bi030142g

Paterson, 1984, Intravesicular pH and iron uptake by immature erythroid cells, J. Cell. Physiol., 120, 225, 10.1002/jcp.1041200217

Harford, 1994, (1994) Molecular mechanisms of iron metabolism, 351

Fleming, 2000, Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis, Proc. Natl. Acad. Sci. U. S. A., 97, 2214, 10.1073/pnas.040548097

Teehan, 2004, Iron storage indices: novel predictors of bacteremia in hemodialysis patients initiating intravenous iron therapy, Clin. Infect. Dis., 38, 1090, 10.1086/382878

Beutler, 2003, Iron deficiency and overload, Hematology Am. Soc. Hematol. Educ. Program, 40, 61

Von Bonsdorff, 2003, Apotransferrin administration prevents growth of Staphylococcus epidermidis in serum of stem cell transplant patients by binding of free iron, FEMS Immunol. Med. Microbiol., 37, 45, 10.1016/S0928-8244(03)00109-3

Ardehali, 2003, The inhibitory activity of serum to prevent bacterial adhesion is mainly due to apo-transferrin, J. Biomed. Mater. Res., 66A, 21, 10.1002/jbm.a.10493

Shimo-Oka, 1986, Class specificity of transferrin as a muscle trophic factor, J. Cell. Physiol., 126, 341, 10.1002/jcp.1041260304

Ohtsuka, 2001, Induction of bud formation of embryonic mouse tracheal epithelium by fibroblast growth factor plus transferrin in mesenchyme-free culture, Dev. Dyn., 222, 263, 10.1002/dvdy.1206

Paez, 2002, Apotransferrin decreases migration and enhances differentiation of oligodendroglial progenitor cells in an in vitro system, Dev. Neurosci., 24, 47, 10.1159/000064945

Sirbasku, 1991, Thyroid hormone dependent pituitary tumor cell growth in serum-free chemically defined culture. A new regulatory role for apo-transferrin, Biochemistry, 30, 7466, 10.1021/bi00244a015

Bruinink, 1996, Neurotrophic effects of transferrin on embryonic chick brain and neural retinal cell cultures, Int. J. Dev. Neurosci., 14, 785, 10.1016/S0736-5748(96)00035-4

Carlevaro, 1997, Transferrin promotes endothelial cell migration and invasion: implication in cartilage neovascularization, J. Cell Biol., 136, 1375, 10.1083/jcb.136.6.1375

Garcia, 2003, Differential effects of apotransferrin on two populations of oligodendroglial cells, Glia, 42, 406, 10.1002/glia.10227

Gentili, 1994, Ovotransferrin and ovotransferrin receptor expression during chondrogenesis and endochrondral bone formation in developing chick embryo, J. Cell Biol., 124, 579, 10.1083/jcb.124.4.579

Menter, 1995, The role of trophic factors and autocrine/paracrine growth factors in brain metastasis, Clin. Exp. Metastasis, 13, 67, 10.1007/BF00133612

Zirvi, 1991, Development of serum-free media for the growth of human gastrointestinal adenocarcinoma xenografts as primary tissue cultures, J. Cancer Res. Clin. Oncol., 117, 515, 10.1007/BF01613281

Yeoman, 1996, Transferrin and insulin enhance human colon tumor cell growth by differentiation class specific mechanisms, Oncol. Res., 8, 273

Fassl, 2003, Transferrin ensures survival of ovarian carcinoma cells when apoptosis is induced by TNF alpha, FasL, TRAIL, or Myc, Oncogene, 22, 8343, 10.1038/sj.onc.1207047

Lesnikov, 2001, Pro-apoptotic and anti-apoptotic effects of transferrin and transferrin-derived glycans on hematopoietic cells and lymphocytes, Exp. Hematol., 29, 477, 10.1016/S0301-472X(00)00687-1

Lesnikov, 2004, Prevention of Fas-mediated hepatic failure by transferrin, Lab. Invest., 84, 342, 10.1038/labinvest.3700035

Weinzimer, 2001, Transferrin is an insulin-like growth factor-binding protein-3 binding protein, J. Clin. Endocrinol. Metab., 86, 1806, 10.1210/jc.86.4.1806

Heilmeyer, 1961, Kongenitale Atransferrinaemie bei einem sieben Jahre alten, Kind. Dtsch. Med. Wschr, 86, 1745, 10.1055/s-0028-1113001

Westerhausen, 1977, Transferrin-immune complex disease, Acta Haematol, 57, 96, 10.1159/000207865

Oliva, 1968, Sindrome nefrosica atransferrinemia. Clinical contribution and etiopathogenetic evaluation, Minerva Med., 59, 1297

Hitzig, 1960, Erythroleukemie mit hämoglobinopathie und Eisenstoffwechselstörung, Helv. Paediatr. Acta, 15, 203

Kaminski, 2002, Oxidative stress and neutrophil activation–the two keystones of ischemia/reperfusion injury, Int. J. Cardiol., 86, 41, 10.1016/S0167-5273(02)00189-4

Schaller, 2004, Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy, J. Cereb. Blood Flow Metab., 24, 351, 10.1097/00004647-200404000-00001

Wernly, 2004, Ischemia, reperfusion, and the role of surgery in the treatment of cardiogenic shock secondary to acute myocardial infarction: an interpretative review, J. Surg. Res., 117, 6, 10.1016/j.jss.2003.12.024

Lien, 2003, Pathogenesis of renal ischemia/reperfusion injury: lessons from knockout mice, Life Sci., 74, 543, 10.1016/j.lfs.2003.08.001

Saikumar, 2003, Role of apoptosis in hypoxic/ischemic damage in the kidney, Semin. Nephrol., 23, 511, 10.1053/S0270-9295(03)00130-X

Ohkohchi, 1999, Kupffer's cells modulate neutrophile activity by superoxide anion and tumor necrosis factor-delta in reperfusion injury of liver transplantation-mechanisms of radical generation and reperfusion injury after cold ischemia, Transplant. Proc., 31, 1055, 10.1016/S0041-1345(98)01902-2

De Vries, 2004, Reduction of circulating redox-active iron by apotransferrin protects against renal ischemia-reperfusion injury, Transplantation, 77, 669, 10.1097/01.TP.0000115002.28575.E7

Koc, 2003, Levels of some acute-phase proteins in the serum of patients with cancer during radiotherapy, Biol. Pharm. Bull., 26, 1494, 10.1248/bpb.26.1494

Kar, 1999, Release of iron from haemoglobin – a possible source of free radicals in diabetes mellitus, Indian J. Exp. Biol., 37, 190

Van Campenhout, 2004, Effects of in vitro glycation on Fe3+ binding and Fe3+ isoforms of transferrin, Clin. Chem., 50, 1640, 10.1373/clinchem.2004.033811

Koterov, 2003, The radiation-modifying capacity of xenogenic apotransferrin for the number of endogenous colony forming units in the spleen of irradiated mice, Radiats. Biol. Radioecol., 43, 647

Kruger, 1999, Early infections in patients undergoing bone marrow or blood stem cell transplantation–a 7 year single centre investigation of 409 cases, Bone Marrow Transplant., 23, 589, 10.1038/sj.bmt.1701614

Durken, 1997, Nontransferrin-bound iron in serum of patients receiving bone marrow transplants, Free Radic. Biol. Med., 22, 1159, 10.1016/S0891-5849(96)00497-2

Sahlstedt, 2002, Effective binding of free iron by a single intravenous dose of human apotransferrin in haematological stem cell transplant patients, Br. J. Haematol., 119, 547, 10.1046/j.1365-2141.2002.03836.x

Sun, 1999, Transferrin as a metal ion mediator, Chem. Rev., 99, 2817, 10.1021/cr980430w

Jakupec, 2004, Gallium and other main group metal compounds as antitumor agents, Met. Ions Biol. Syst., 42, 425, 10.1201/b12414-13

Van Hulle, 2001, In vivo distribution and speciation of [114mIn]InCl3 in the Wistar rat, J. Environ. Monit., 3, 86, 10.1039/b006870p

Beamish, 1974, A comparison of the behavior of 111In and 59Fe-labeled transferrin on incubation with human and rat reticulocytes, Blood, 43, 703, 10.1182/blood.V43.5.703.703

Slikkerveer, 1989, Pharmacokinetics and toxicity of bismuth compounds, Med. Toxicol. Adverse Drug Exp., 4, 303, 10.1007/BF03259915

Maruyama, 2004, Intracellular targeting of sodium mercaptoundecahydrododecaborate (BSH) to solid tumours by transferrin-PEG liposomes, for boron neutron-capture therapy (BNCT), J. Control. Release, 98, 195, 10.1016/j.jconrel.2004.04.018

Kratz, 1994, The binding properties of two antitumor ruthenium (III) complexes to apotransferrin, J. Biol. Chem., 269, 2581, 10.1016/S0021-9258(17)41984-3

Bergamo, 2003, Biological role of adduct formation of the ruthenium (III) complex NAMI-A with serum albumin and serum transferrin, Invest. New Drugs, 21, 401, 10.1023/A:1026243000320

Smith, 2004, 99mTc-labelled human serum transferrin for tumour imaging: an in vitro and in vivo study of the complex, Nucl. Med. Commun., 25, 387, 10.1097/00006231-200404000-00012

Laske, 1994, Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice, J. Neurosurg., 80, 520, 10.3171/jns.1994.80.3.0520

Weaver, 2003, Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) for therapy of malignant gliomas, J. Neurooncol., 65, 3, 10.1023/A:1026246500788

Wang, 2000, Doxorubicin-gallium-transferrin conjugate overcomes multidrug resistance: evidence for drug accumulation in the nucleus of drug resistant MCF-7/ADR cells, Anticancer Res., 20, 799

Beyer, 1998, Synthesis and in vitro efficacy of transferrin conjugates of the anticancer drug chlorambucil, J. Med. Chem., 41, 2701, 10.1021/jm9704661

Sahoo, 2004, Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer, Int. J. Cancer, 112, 335, 10.1002/ijc.20405

Ali, 1999, Transferrin Trojan horses as a rational approach for the biological delivery of therapeutic peptide domains, J. Biol. Chem., 274, 24066, 10.1074/jbc.274.34.24066

Schnierle, 1996, Retroviral targeted delivery, Gene Ther., 3, 1069

Okamoto, 1996, Effects of insulin and transferrin on the generation of lymphokine-activated killer cells in serum-free medium, J. Immunol. Methods, 195, 7, 10.1016/0022-1759(96)00081-6

Sadava, 2002, Transferrin overcomes drug resistance to artemisinin in human small-cell lung carcinoma cells, Cancer Lett., 179, 151, 10.1016/S0304-3835(02)00005-8

Efferth, 2004, Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron, Free Radic. Biol. Med., 37, 998, 10.1016/j.freeradbiomed.2004.06.023

Gomme, 2004, Therapeutic potential of vitamin D-binding protein, Trends Biotechnol., 22, 340, 10.1016/j.tibtech.2004.05.001

Von Bonsdorff, 2001, Development of a pharmaceutical apotransferrin product for iron binding therapy, Biologicals, 29, 27, 10.1006/biol.2001.0273

He, 1997, Inequivalence of the two tyrosine ligands in the N-lobe of human serum transferrin, Biochemistry, 36, 14853, 10.1021/bi9719556